Jbklab Co. Ltd. has synthesized compounds reported to be useful for the treatment of cancer.

Constellation Pharmaceuticals Inc. has presented three-prime repair exonuclease (TREX) inhibitors reported to be useful for the treatment of cancer.

Texas A&M University System has discovered 3C-like proteinase (3CLpro) (SARS-CoV-2; COVID-19 virus) and cytochrome P450 3A4 (CYP3A4) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection.

Merck Sharp & Dohme Corp. has described 3-oxopiperazine carboxamide derivatives acting as sodium channel protein type 10 subunit alpha (Nav1.8) blockers reported to be useful for the treatment of cough, pruritus, acute and neuropathic pain.

Carmot Therapeutics Inc. has divulged benzimidazoyl compounds acting as glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of metabolic diseases.

Alzheimer’s disease (AD) is still the most prevalent neurodegenerative disorder, with few FDA-approved treatments and many that have failed; further understanding of AD’s disease mechanisms is required. Investigators from Gempharmatech Inc. have developed a novel AD murine model (FAD4T) in which APP (Swedish and Indiana mutations) and PSEN1 M146L/L286V mutations were inserted into the mice’s genome.