The rare, deadly neurological disease called hereditary sensory and autonomic neuropathy 9 (HSAN9) is caused by mutations in the gene that encodes tectonin β-propeller repeat-containing protein 2 (TECPR2).
Since episodes of idiopathic anaphylaxis (IA) are often accompanied by gastrointestinal (GI) manifestations, researchers from the National Institutes of Health aimed to investigate whether surrogate markers of GI permeability are aberrant in patients with IA.
Autifony Therapeutics Ltd. has described compounds acting as modulators of voltage-gated potassium channels from the Kv3 subfamily, such as Kv3.1, Kv3.2 and/or Kv3.3, reported to be useful for the treatment of myoclonic epilepsy, among others.
Medshine Discovery Inc. has divulged nuclear receptor ROR-γ (RORC) agonists or RORC inverse agonists reported to be useful for the treatment of cancer.
Bugworks Research India Pvt. Ltd. has identified oxazolidinone compounds acting as DNA gyrase and DNA topoisomerase IV (Escherichia coli) inhibitors reported to be useful for the treatment of bacterial infections, in particular gram-positive and gram-negative, as well as viral, fungal and protozoal infections.
Lymphatic malformation (LM), a vascular anomaly originating from lymphatic endothelial cells, can progress to malignant lymphangiosarcoma (LAS) in a fraction of patients. Scientists from the University of Cincinnati College of Medicine recently conducted a study to unveil the mechanisms underlying LM malignant transformation to LAS and found that inhibiting autophagy can prevent this malignant transformation.
Radiotherapy is commonly used to treat solid tumors; promoting DNA damage in tumoral cells is the main mechanism for its cytotoxic effect, and its potential to induce innate and adaptive immune responses is being explored.
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