Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestinal tract that often causes the development of colorectal cancer (CRC).

RNA interactome capture (RIC) was used by researchers from The Barcelona Institute of Science and Technology and their collaborators to examine the melanoma RNA-binding proteomes (RBPomes) of two melanoma cell lines: nontumoral melanocytic Mel-ST and metastatic SK-Mel-147.

Learning and memory are complex processes that involve many genes, cell types and brain circuits. Genetic screening performed by researchers have identified potassium voltage-gated channel subfamily C member 3 (KCNC3) to be involved in the hippocampal learning and memory processes in mice.

Two large-scale studies provide new data on genes, inherited variations, and de novo mutations associated with autism spectrum disorder (ASD). Some of them are also associated with other neurological conditions, like developmental delay (DD), or schizophrenia.

Yangtze River Pharmaceutical Group and Shanghai Haiyan Pharmaceutical Technology have discovered substituted pyrazolo[1,5-a]pyrimidine-7-amine derivatives acting as cyclin-dependent kinase 9 (CDK9) inhibitors reported to be useful for the treatment of cancer.

The University of Michigan, the University of Illinois and the Penn State Research Foundation have presented rifamycin derivatives acting as RNA polymerase (bacterial) inhibitors reported to be useful for the treatment of tuberculosis.

Insusense has divulged pyridine derivatives targeting sortilin (neurotensin NTR3; NT3; Gp95) receptors reported to be useful for the treatment of neurodegenerative disorders, cancer, pain, diabetes mellitus, diabetic retinopathy, cardiovascular disease, hereditary eye conditions and hearing loss.

Adiponectin (ADIPOQ) is an adipocyte-derived hormone that promotes insulin sensitivity, inhibits cell death and decreases inflammation. Previous studies identified common variants in the ADIPOQ gene that have been associated with aberrant adiponectin levels, obesity, type 2 diabetes and diabetic kidney disease. In a recent study, the first multigenerational family was identified as harboring a protein-truncating mutation in the ADIPOQ gene, p.Gly93GlufsTer73, that cosegregated with diabetes and end-stage renal disease.

Cold Spring Harbor Laboratory, Vichem Chemie Research and The Feinstein Institute for Medical Research have described dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) inhibitors reported to be useful for the treatment of cancer, Down syndrome, mild cognitive impairment and Alzheimer's disease.

TFChem SAS has described new cyclic glycoaminoacid derivatives reported to be useful for the treatment of dry skin, atopic dermatitis, aging, inflammatory disorders, fibrosis and psoriasis, among other disorders.