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Cancer

Janssen Biotech and Yuhan disclose new EGFR mutant inhibitors

Sep. 13, 2024
Researchers from Janssen Biotech Inc. and Yuhan Corp. have synthesized EGFR (HER1; erbB1) (mutant) inhibitors reported to be useful for the treatment of cancer and immunological disorders.
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Inflammatory

Allorion Therapeutics presents new TYK2 inhibitors for inflammatory and autoimmune disorders

Sep. 13, 2024
Allorion Therapeutics (Guangzhou) Co. Ltd. has divulged non-receptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of psoriasis, psoriatic arthritis, ulcerative colitis, Crohn’s disease and systemic lupus erythematosus.
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Cancer

Chia Tai Tianqing Pharmaceutical describes Bcl-xl degradation inducers

Sep. 13, 2024
Chia Tai Tianqing Pharmaceutical Group Co. Ltd. has discovered proteolysis targeting chimeras (PROTACs) compounds comprising Von Hippel-Lindau disease tumor suppressor (VHL)-binding moiety covalently linked to Bcl-2-like protein 1 (Bcl-xl; Bcl-X; BCL2L1)-targeting moiety through a linker. They are reported to be useful for the treatment of cancer.
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Cancer

The University of Michigan patents STAT3 degradation inducers

Sep. 13, 2024
The University of Michigan has identified proteolysis targeting chimeras (PROTACs) comprising cereblon (CRBN) ligands coupled to signal transducer and activator of transcription 3 (STAT3)-targeting moiety via linker acting as STAT3 degradation inducers.
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Cancer

SETDB1 inhibition as therapeutic strategy against monocytic AML

Sep. 13, 2024
Researchers from The University of Tokyo and affiliated organizations sought to identify molecules within AML cells that suppress NK cell activity, and as such, fully harness the antileukemic functions of NK cells.
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Heart and kidneys
Cardiovascular

Targeting GPR183 improves endothelial senescence in hypertensive mice

Sep. 13, 2024
G protein-coupled receptor 183 (GPR183) is a recently identified G protein-coupled receptor (GPCR) for oxysterols and hydroxylated metabolites of cholesterol, which plays multiple roles in lipid metabolism and immune responses.
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Pain illustration
Neurology/psychiatric

Synerkine Pharma’s SK-01 designated orphan drug in EU for complex regional pain syndrome

Sep. 13, 2024
The European Commission has granted EU orphan drug designation to Synerkine Pharma BV’s SK-01 to treat complex regional pain syndrome.
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Antibodies attacking cancer cell
Immuno-oncology

SNS-201, a CD28xVISTA bispecific antibody with promising efficacy and safety profile

Sep. 13, 2024
Researchers from Sensei Biotherapeutics Inc. presented preclinical data for the novel CD28xVISTA bispecific antibody (BsAb), SNS-201, being developed for the treatment of prostate cancer.
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AI-generated image of illustration of MRI of lungs with fibrosis
Respiratory

Tankyrase inhibitor exerts robust preclinical antifibrotic effects

Sep. 13, 2024
Tankyrases (TNKS) are involved in relevant cellular functions such as telomere maintenance or Wnt signaling, and their inhibition may be a potential treatment strategy for the management of hyperproliferative disorders because it counteracts profibrotic changes and blocks the synthesis of extracellular matrix proteins.
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Liver illustration
Endocrine/metabolic

JNJ-75220795 demonstrates rapid systemic absorption and elimination

Sep. 13, 2024
Researchers from Janssen Research & Development LLC presented preclinical data for JNJ-75220795 (ARO-PNPLA3), a GalNAc-conjugated small interfering RNA (siRNA) therapeutic targeting the PNPLA3 gene, being developed for the treatment of metabolic dysfunction-associated steatohepatitis (MASH).
Read More
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