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Cancer

Tessellate Bio, CMRI and Omico collaborate to target ALT-positive cancers

Sep. 30, 2024
Tessellate Bio BV has announced it is collaborating with CMRI (Children’s Medical Research Institute) and Omico (Australian Genomic Cancer Medicine Centre) to advance the understanding of the prevalence of alternative lengthening of telomeres (ALT) across tumor types and the genetic factors involved.
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Gene editing illustration
Infection

Precision Biosciences files CTAs for PBGENE-HBV for chronic HBV

Sep. 30, 2024
Precision Biosciences Inc. has submitted its first clinical trial applications (CTAs) to initiate a phase I study evaluating PBGENE-HBV, an in vivo gene editing program designed to potentially cure chronic hepatitis B virus (HBV).
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Close up of hand scratching arm with psoriasis patches
Dermatologic

Anti-IL-23 antibody demonstrates potential for long-term dosing

Sep. 30, 2024
Researchers from Paragon Therapeutics Inc. presented the preclinical characterization of ORKA-001 (PR-035), a novel half-life extended monoclonal antibody targeting the p19 subunit of IL-23, designed to treat chronic skin disorders such as plaque psoriasis.
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Illustration of bacteriophage landing on rod-shaped bacteria
Infection

Phylogeographics, phage typing combo fights antibiotic resistance

Sep. 30, 2024
By Xavier Bofill Bruna
The spread of drug-resistant bacteria is a global health concern and could once again become a leading cause of mortality. The World Health Organization has flagged carbapenem-resistant Acinetobacter baumannii (CRAB), which has a mortality rate of 25%-60%, as a top priority pathogen requiring innovative therapies for its management. Researchers from the HUN-REN Biological Research Centre in Hungary have published a paper in Cell in which they describe designing and developing phage cocktails that target the most prevalent CRAB strains within specific geographic regions by using phylogeographic analysis and mapping the pathogen’s genetic diversity.
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Handshake with tech background
Respiratory

Generate:Biomedicines signs up Novartis to $1B+ multitarget deal

Sep. 27, 2024
By Brian Orelli
Novartis AG is enlisting the help of Generate:Biomedicines Inc. and its artificial intelligence platform to generate drugs for multiple undisclosed targets. The number of targets and therapeutic areas also weren’t disclosed. Novartis will pick the targets, although the targets Generate has been working on are off limits. Generate will be responsible for creating the lead candidate, at which point Novartis will take over development.
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Other news to note for Sept. 27, 2024

Sep. 27, 2024
Additional early-stage research and drug discovery news in brief, from: Abivax, Ovid Therapeutics.
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Cancer

Cancer Research Technology, My-T Bio identify new PKMYT1 inhibitors

Sep. 27, 2024
Cancer Research Technology Ltd. and My-T Bio Ltd. have jointly developed biarylamide derivatives acting as membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) inhibitors with potential for the treatment of cancer.
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Cancer

Axcynsis Therapeutics patents new ADCs for treatment of cancer

Sep. 27, 2024
Work at Axcynsis Therapeutics Pte. Ltd. has led to the creation of antibody-drug conjugates (ADCs) comprising antibodies covalently linked to ecteinascidin and lurbinectedin derivatives through a linker; they are reported to be useful for the treatment of cancer.
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Cancer

STAT3 inhibitors named in Vividion Therapeutics patent

Sep. 27, 2024
Vividion Therapeutics Inc. has patented 2-azaspiro[3.3]heptane derivatives acting as signal transducer and activator of transcription 3 (STAT3) inhibitors potentially useful for the treatment of cancer.
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Cancer

Breakpoint Therapeutics presents new POLθ inhibitors

Sep. 27, 2024
Breakpoint Therapeutics GmbH has identified DNA polymerase θ (POLθ) inhibitors reported to be useful for the treatment of cancer.
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