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BioWorld - Monday, July 7, 2025
Breaking News: Trump administration impacts continue to roil the life sciences sectorBreaking News: Trump administration impacts continue to roil the life sciences sectorBreaking News: House passes H.R. 1, restoring R&D tax cutsBreaking News: Self-amplifying mRNA technology underscored for next big pandemic
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Red blood cell infected with malaria parasites
Infection

Novartis synthesizes fast-acting intravenous agents for malaria

Sep. 18, 2024
The increasing resistance to intravenous artemisinin therapy for malaria highlights the urgent need for new treatments that offer better patient compliance and a single-dose cure to address this global health threat. Novartis AG recently presented the discovery, development and evaluation of aminoisoquinolines as fast-acting intravenous therapeutic agents for severe malaria treatment.
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Endocrine/metabolic

RKER-065 fights fat, preserves muscle in mice on semaglutide

Sep. 18, 2024
Incretin therapies based on GLP-1 receptor agonism aid in the loss of weight in obesity, but a relevant part of this loss (25%-40%) is attributed to loss of lean muscle mass, which raises the risk of sarcopenia. Keros Therapeutics Inc. has presented data on RKER-065, a novel modified ActRII-Fc ligand trap that inhibits myostatin and activins and promotes muscle formation.
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Juleen Zierath on stage at EASD 2024
Endocrine/metabolic

Studies on exercise and health win EASD prize

Sep. 18, 2024
By Mar de Miguel
How do exercise and insulin collaborate in metabolism? The European Association for the Study of Diabetes (EASD) and the Novo Nordisk Foundation recognized the work of Juleen Zierath in this topic with the Diabetes Prize for Excellence at their recent annual meeting.
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Cancer

Jiangsu Chia Tai Fenghai Pharmaceutical discovers new CDK7 inhibitors

Sep. 17, 2024
Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd. has described cyclin-dependent kinase 7 (CDK7) inhibitors reported to be useful for the treatment of cancer.
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Neurology/psychiatric

New 5-HT2A and 5-HT2C receptor agonists disclosed in 2A Biosciences patent

Sep. 17, 2024
2A Biosciences Inc. has divulged compounds acting as 5-HT2A and 5-HT2C receptor agonists reported to be useful for the treatment of atopic dermatitis, conjunctivitis, Crohn’s disease, type 2 diabetes, obsessive-compulsive disorder, rheumatoid arthritis, schizophrenia and traumatic brain injury, among others.
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Cancer

Chia Tai Tianqing Pharmaceutical describes new PRMT5/MEP50 interaction inhibitors

Sep. 17, 2024
Chia Tai Tianqing Pharmaceutical Group Co. Ltd. has identified protein arginine N-methyltransferase 5 (PRMT5)/methylosome protein 50 (MEP50) interaction inhibitors reported to be useful for the treatment of cancer.
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Cancer

Shanghai Jemincare Pharmaceuticals patents new bicyclic compounds for cancer

Sep. 17, 2024
Shanghai Jemincare Pharmaceuticals Co. Ltd. has synthesized bicyclic compounds reported to be useful for the treatment of cancer.
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Cancer

Shenzhen Genuine Biotech divulges new STING agonists

Sep. 17, 2024
Shenzhen Genuine Biotech Co. Ltd. has disclosed stimulator of interferon genes protein (STING; TMEM173) agonists reported to be useful for the treatment of cancer. An exemplified compound significantly reduced tumor growth in experiments.
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Microscope with slide
Inflammatory

Discovery of MRTF/SRF pathway inhibitor for the treatment of fibrotic diseases

Sep. 17, 2024
Cincera Therapeutics Pty Ltd. and Monash University co-presented the phenotypic drug discovery of CIN-244, a novel MRTF/SRF pathway inhibitor reported to be potentially useful for the treatment of fibrotic disease, particularly liver, lung and renal fibrosis.
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3D representation of tumor
Cancer

PK-TE model translates nonclinical data to inform on clinical dosing for KK-2269

Sep. 17, 2024
Researchers from Kyowa Kirin Co. Ltd. presented preclinical data for the novel bispecific CD40-EpCAM antibody KK-2269, being developed for the treatment of cancer.
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