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Cardiovascular

Opna Bio designs new YAP1/TEAD interaction inhibitors

Aug. 30, 2024
Recent patents from Opna Bio AG detail new transcriptional coactivator YAP1/transcriptional enhancer factor (TEAD) interaction inhibitors reported to be useful for the treatment of arrhythmogenic right ventricular cardiomyopathy, cancer, Holt-Oram syndrome, neurofibromatosis type 2, polycystic kidney and Alzheimer’s disease.
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Cancer

Contineum Therapeutics discloses crystalline compound of LPAR1 antagonists

Aug. 30, 2024
A Contineum Therapeutics Inc. patent describes a crystalline form of lysophosphatidic acid receptor 1 (LPAR1; EDG2) antagonists reported to be useful for the treatment of brain cancer, glioblastoma, idiopathic pulmonary fibrosis, inflammatory disorders, multiple sclerosis, neurodegeneration, neuropathic pain and scleroderma, among others.
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Cancer

TNKS inhibitors described in Korea Research Institute patent

Aug. 30, 2024
Work at the Korea Institute of Radiological and Medical Sciences and Korea Research Institute of Chemical Technology has led to the identification of new poly(ADP-ribose) polymerase tankyrase (TNKS) inhibitors potentially useful for the treatment of cancer.
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Diagnostics

Lilly reports new compounds for tau imaging

Aug. 30, 2024
Eli Lilly & Co. has patented new fluorine-radiolabeled compounds targeting microtubule-associated protein tau (PHF-tau; MAPT).
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Illustration of zebrafish, gene editing.
Hematologic

Zebrafish lacking Dnajc21 show cytopenia and impaired nucleotide metabolism

Aug. 30, 2024
Shwachman-Diamond syndrome is an inherited bone marrow failure syndrome characterized by exocrine pancreatic insufficiency, cytopenia, growth restriction and skeletal abnormalities, and for which primary treatment is allogeneic hematopoietic stem cell transplantation, which is associated with significant toxicity.
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Steadying hand while reaching for glass
Neurology/psychiatric

PGK1 boosts energy production, avoiding synaptic dysfunction in Parkinson's

Aug. 30, 2024
The brain is a vulnerable organ that is compromised in the absence of energy production. Reduced fuel delivery to the brain correlates with aging and is an early predictor of potential neurological dysfunction, such as what occurs in Parkinson’s disease.
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PC-3 human prostate cancer cells
Cancer

MYH6 acts as a tumor suppressor in prostate cancer, study finds

Aug. 30, 2024
The mechanisms contributing to prostate cancer progression are still incompletely understood. There has been increasing attention on myosin heavy chain 6 (MYH6) for its involvement in cellular processes beyond the heart.
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Hands holding petri dish
Infection

Broad-spectrum polyphenol-derived antibacterial divulged

Aug. 30, 2024
Antimicrobial peptides, existing in animals and plants, are the first line of defense of the organisms against bacteria. Thymol and carvacrol are two monoterpenoids with known antibacterial activity exerted through bacterial cell membrane structural disruption, which contributes to a lower risk of developing resistance compared to antibiotics acting against specific targets on cells.
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Cancer

Preclinical characterization of NDI-101150 presented

Aug. 30, 2024
Hematopoietic progenitor kinase 1 (HPK1) plays a relevant role in regulating T-cell, B-cell and dendritic cell function. As its inactivation both in vitro and in vivo contributes to tumor growth inhibition, HPK1 is considered a therapeutic target to explore in cancer immunotherapy.
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Test tube, dropper
Cancer

BRD-810 shows optimized in vivo clearance and potent efficacy in xenograft models

Aug. 30, 2024
Trueline Therapeutics Inc. and Broad Institute Inc. have reported preclinical data for the novel myeloid cell leukemia 1 (MCL1) inhibitor, BRD-810, being developed for the treatment of cancer.
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