Recent findings suggest gut microbiota dysbiosis may be behind the inflammation in diabetic nephropathy (DN), the leading cause of end-stage renal disease (ESRD).
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion involved in controlling blood pressure and volume in the cardiovascular system. Antagonists of the angiotensin II type 1 (AT1) receptor are used for the management of hypertension with proven efficacy.
Innovec Pharmaceutical Technology Co. Ltd. (Innovec Biotherapeutics) has received FDA clearance for its IND application for IVB-103, an AAV-based gene therapy for neovascular age-related macular degeneration (AMD).
Pregnane X receptor (PXR) is a transcription factor that plays a crucial role in maintaining bile acid homeostasis by regulating major metabolizing enzymes and transporters.
Tonix Pharmaceuticals Holding Corp. is advancing development of its live attenuated virus vaccine, TNX-801 (recombinant horsepox virus), for preventing mpox and other infectious diseases.
Immunesensor Therapeutics Inc. has received Human Research Ethics Committee (HREC) approval and clinical trial notification (CTN) clearance by Australia’s Therapeutic Goods Administration (TGA) to initiate a phase I study of IMSB-301, a novel, orally available small-molecule cGAS inhibitor that is being developed for the treatment of inflammatory and autoimmune diseases.
The hyperactivation of the Wnt/β-catenin signaling pathway plays a central role in the progression and expansion of colorectal cancer (CRC). The suppression of this pathway may contribute to the control of the proliferation, survival and metastasis of CRC.
Shanghai Micurx Pharmaceutical Co. Ltd. has discovered peptide-drug conjugates consisting of peptide-targeting kidney cells covalently linked to anti-inflammatory or immunomodulating or nephron-protective drugs through linkers reported to be useful for the treatment of acute kidney injury, nephritis, chronic kidney disease, chronic glomerulonephritis, diabetic nephropathy and systemic lupus erythematosus, among others.
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