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Dermatologic

Shanghai Pharmaceuticals describes new CCR4 antagonists

April 16, 2025
Shanghai Pharmaceuticals Holding Co. Ltd. has identified C-C chemokine receptor type 4 (CCR4) antagonists reported to be useful for the treatment of asthma, allergic rhinitis, atopic dermatitis, cancer, systemic lupus erythematosus, rheumatoid arthritis and drug-induced rash. 
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Cancer

Canadian scientists divulge new radiolabeled peptides targeting GRPR

April 16, 2025
Researchers at Provincial Health Services Authority and University of British Columbia have synthesized radiolabeled peptides targeting gastrin-releasing peptide receptor (GRPR) reported to be useful for the diagnosis and treatment of cancer.
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Cancer

Samjin Pharmaceutical patents new STING agonists

April 16, 2025
Samjin Pharmaceutical Co. Ltd. has disclosed stimulator of interferon genes protein (STING; TMEM173) agonists reported to be useful for the treatment of cancer, allergy, autoimmune diseases and inflammatory disorders.
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Microscope with slide
Immuno-oncology

Targeting GPX4 palmitoylation enhances ferroptosis sensitivity and improves antitumor immunity

April 16, 2025

A new study published in Nature Cancer reveals a novel regulatory mechanism of ferroptosis resistance that may help overcome therapeutic barriers in cancer treatment. 


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Induced pluripotent stem cells
Neurology/psychiatric

Xellsmart announces US IND clearances for iPSC-derived cell therapies for Parkinson’s disease and ALS

April 16, 2025
Xellsmart Biopharmaceutical (Suzhou) Co. Ltd. has announced IND clearances by the FDA for its XS-411 and XS-228 cell therapies, for Parkinson’s disease and amyotrophic lateral sclerosis (ALS), respectively.
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3D representation of tumor
Cancer

Hansoh Pharma’s HS-10529 cleared to enter clinic in China for advanced solid tumors

April 16, 2025
Hansoh Pharmaceutical Group Co. Ltd. has obtained clinical trial clearance from China’s National Medical Products Administration (NMPA) for HS-10529 tablets.
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Microscope with beakers and flasks
Drug design, drug delivery & technologies

Elix and Prism Biolab establish AI-driven drug discovery collaboration

April 16, 2025
Elix Inc. has entered into a drug discovery collaboration with Prism Biolab Co. Ltd. to accelerate AI-driven drug discovery for challenging protein-protein interaction targets. The partnership will combine Elix’s AI drug discovery platform with Prism’s proprietary small-molecule peptide mimetic Pepmetics technology for controlling protein-protein interactions.
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Scientist with vial
Infection

Preclinical data on new composite peptide vaccine from Longhorn

April 16, 2025
At the recent European Society of Clinical Microbiology and Infectious Diseases (ESCMID) meeting in Vienna, Longhorn Vaccines & Diagnostics LLC presented data on the neutralizing antibody responses of LHNVD-202, an unconjugated composite peptide vaccine.
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Neurology/psychiatric

Preclinical profile of LY-3954065, a pioneering siRNA for Alzheimer’s disease

April 16, 2025
Researchers from Eli Lilly & Co. reported preclinical data on LY-3954068, a MAPT small-interference RNA (siRNA) strategy in AD models. The therapy is designed to reduce tau protein synthesis by inhibiting the translation of MAPT mRNA, with the goal of effectively lowering all forms of tau.
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Illustration of antibodies attacking nerve cells
Immune

Biohaven’s BHV-1310 shows promise for autoimmune disorders

April 16, 2025
Biohaven Pharmaceuticals Inc. has presented preclinical data on their novel bispecific degrader BHV-1310 for the potential treatment of autoimmune disorders. To date, about 10% of the global population is affected by autoimmune diseases. IgG-lowering agents have suboptimal pharmacology and pharmacodynamic effects and have safety and tolerability challenges.
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