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Cancer

Sravathi AI Technology patents new ENPP1 inhibitors for cancer

March 1, 2024
Sravathi AI Technology Pvt Ltd. has disclosed ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) inhibitors reported to be useful for the treatment of cancer.
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Illustration of DNA, digestive system
Biomarkers

miR-21, miR-135b as biomarkers of IBD-related colorectal cancer

March 1, 2024
Researchers from University of Padova have presented data from a study that aimed to investigate the role of microRNAs (miRs) in the development and progression of inflammatory bowel disease (IBD)-related colorectal cancer (CRC).
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Cancer

Jacobio’s P53 Y220C activator gains FDA clearance to enter clinic for advanced solid tumors

March 1, 2024
Jacobio Pharmaceuticals Group Co. Ltd. has received FDA approval of its IND application for JAB-30300, allowing it begin a phase I/IIa trial in the U.S. in advanced solid tumors.
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Infant examination
Gastrointestinal

Neurenati Therapeutics secures funding to advance candidate for Hirschsprung’s disease

March 1, 2024
Neurenati Therapeutics has closed its seed funding round, securing CA$1.2 million (US$884,000) to advance development of therapies for various rare diseases, including pediatric conditions.
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Dollar sign droplet above test tube
Neurology/Psychiatric

Coave’s CTx-TFEB program for ALS supported by new grant

March 1, 2024
Coave Therapeutics SA’s CTx-TFEB program has received support through a grant from the ALS Association.
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Cancer

GT-19630 inhibits proliferation, promotes apoptosis and blocks migration of breast cancer cells

March 1, 2024
At this week’s EACR-AACR-ICAR meeting in Dublin, Suzhou Kintor Pharmaceuticals Inc. presented preclinical data for the novel MYC- and GSPT1-targeting molecular glue candidate, GT-19630, being developed for the treatment of breast cancer.
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Immuno-oncology

Preclinical data support ongoing clinical development of MAb and ADC for CLDN18.2+ tumors

March 1, 2024
Tumors in the stomach and pancreas are known to express claudin 18.2 (CLDN18.2) and the absence of expression in normal tissues makes it an attractive therapeutic target.
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Neurology/Psychiatric

Igc Pharma reports enhanced memory function with TGR-63 an Alzheimer’s mouse model

March 1, 2024
Igc Pharma Inc. has reported results of preclinical studies investigating TGR-63 as a treatment for Alzheimer’s disease, showing enhanced memory function in an Alzheimer’s mouse model, including improved memory acquisition, consolidation and retrieval.
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DNA illustration
Biomarkers

First susceptibility gene for rare form of psoriatic arthritis identified

March 1, 2024
Psoriatic arthritis mutilans (PAM) is a rare variant and the most severe form of psoriatic arthritis where patients present erosions of the small joints and osteolysis leading to joint disruption and shortening of one or more digits. To date, no susceptibility genes have been determined.
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Creative rendition of SARS-CoV-2 virus particles.
Immune

Imunon reports findings with IMNN-101 from live virus challenge study against SARS-CoV-2 variant XBB.1.5

March 1, 2024
Imunon Inc. has released promising results from a live virus challenge study conducted by the Wistar Institute with IMNN-101 against the SARS-CoV-2 variant XBB.1.5. This study was conducted using the clinical vector that Imunon intends to bring into its phase I study during the second quarter, and showed IMNN-101 immunogenicity and protective activity in a live viral mouse challenge.
Read More
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