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BioWorld - Saturday, February 28, 2026
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Cancer

Novel T cell reprogramming strategy enhances immunotherapy effects

Oct. 16, 2024
In recent years, immune checkpoint inhibitors have had great success in the treatment of advanced cancers, but often, they are only effective in a minority of patients. Researchers from Weill Cornell Medicine have discovered that the activation of the pentose phosphate pathway (PPP) in combination with standard immune checkpoint inhibitors resulted in enhanced antitumor efficacy both in vitro and in vivo.
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Illustrated map of Indonesia showing connected dots
Genetic/congenital

Alternative splicing study reveals genetic variants across Indonesian archipelago

Oct. 16, 2024
By Tamra Sami
A new study helps explain the role of genetic variation in shaping gene regulation in the Indonesian archipelago, one of the most diverse regions in the world. “This study is the only study of splicing from Southeast Asian populations. There is basically no data from this part of the world,” study author Irene Gallego Romero told BioWorld. For drug discovery, most of the people that have historically participated in clinical trials are of European ancestry, and scientists are just beginning to study African populations to better understand genetic differences in these populations, said Romero, a population geneticist and biological anthropologist at the University of Melbourne.
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Illustration of proteins and year they were developed
Drug design, drug delivery & technologies

Chemistry Nobel awarded for 3D protein design, prediction work

Oct. 15, 2024
By Mar de Miguel
David Baker, Demis Hassabis and John Jumper share the 2024 Nobel Prize in Chemistry for their contributions to the science of protein structure. David Baker was awarded half the prize “for computational protein design,” according to the Royal Swedish Academy of Sciences. Hassabis and Jumper shared the other half “for protein structure prediction.”
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Other news to note for Oct. 15, 2024

Oct. 15, 2024
Additional early-stage research and drug discovery news in brief, from: Alterity Therapeutics, Gen1e Lifesciences.
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Neurology/psychiatric

McGill University and Neurasic Therapeutics discover new ASIC1 blockers for pain

Oct. 15, 2024
Researchers at McGill University and Neurasic Therapeutics Inc. have described substituted thiophene fused cyclohexanone derivatives acting as acid-sensing ion channel 1 (ASIC1) blockers reported to be useful for the treatment of pain, particularly neuropathic and inflammatory pain.
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Ear, nose & throat

Antioxidants for hearing loss and Meniere’s disease disclosed in Primemupharma patent

Oct. 15, 2024
Primemupharma Co. Ltd. has divulged compounds comprising a novel polyester linker acting as antioxidants reported to be useful for the treatment of hearing loss and Meniere’s disease.
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Cancer

Shanghai Helioson Pharmaceutical describes new IKZF1 and IKZF3 degradation inducers

Oct. 15, 2024
Shanghai Helioson Pharmaceutical Co. Ltd. has identified molecular glue degraders acting as DNA-binding protein Ikaros (IKZF1) and/or zinc finger protein Aiolos (IKZF3) degradation inducers reported to be useful for the treatment of cancer, autoimmune disease and inflammatory disorders.
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Endocrine/metabolic

Insilico Medicine divulges new NLRP3 inflammasome inhibitors

Oct. 15, 2024
Insilico Medicine Inc. has synthesized NLRP3 inflammasome inhibitors reported to be useful for the treatment of obesity, autoimmune disease and inflammatory disorders.
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Musculoskeletal

Cellus patents new ADAMTS4 and ADAMTS5 inhibitors

Oct. 15, 2024
Cellus Inc. has disclosed compounds acting as disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4; aggrecanase-1) and 5 (ADAMTS5; aggrecanase-2) inhibitors reported to be useful for the treatment of septic arthritis, osteoarthritis, osteonecrosis, rheumatoid arthritis and tuberculosis.
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Cancer cell, dropper, test tubes
Cancer

Anti-protocadherin antisense oligonucleotides display antitumor efficacy

Oct. 15, 2024
Protocadherin alpha 11 (PCDHA11) is a cell surface protein member of the cadherin superfamily overexpressed in advanced gastric cancer tissues.
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