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Colorized electron microscope image of transplanted pancreatic islets with functioning vasculature.
Immune

Immcelz gets US orphan drug designation for allograft rejection

March 7, 2024
Creative Medical Technology Holdings Inc.'s Immcelz (CELZ-101) has been awarded orphan drug designation by the FDA. Immcelz is aimed at preventing allograft rejection in patients undergoing pancreatic islet cell transplantation.
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Influenza virus
Immune

Broad antibodies target ‘dark side’ of flu’s neuraminidase

March 7, 2024
Neuraminidase (NA) is an essential surface protein of influenza viruses with potential as an effective drug and vaccine target. However, knowledge of the NA antigenic landscape remains limited, and most current influenza vaccines induce antibodies against the surface glycoprotein hemagglutinin.
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Endocrine/Metabolic

Bacterial toxin helps identify lipid synthesis inhibitors

March 7, 2024
In a recent study published in PNAS, researchers from the University of Texas Southwestern Medical Center investigated cholesterol-mimetic compounds specifically binding and inhibiting Scap. Their final goal was to understand cholesterol regulation by the Scap/SREBP system and identify potential therapeutics for dysregulated lipid metabolism.
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Cancer

Shanghai Huilun Pharmaceutical reports PARP-1 degradation PROTACs

March 6, 2024
Shanghai Huilun Pharmaceutical Co. Ltd. has patented proteolysis targeting chimeric compounds (PROTACs) comprising E3 ubiquitin ligase cereblon (CRBN)-binding moiety covalently linked to poly(ADP-ribose) polymerase 1 (PARP-1; ARTD1)-binding moiety through a linker.
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Neurology/Psychiatric

Chinese researchers prepare compounds for treatment of Parkinson’s disease

March 6, 2024
China State Institute of Pharmaceutical Industry and Jiangsu Nhwa Pharmaceutical Co. Ltd. have jointly described aromatic heterocyclic cyclohexyl aminoalkyl piperidine derivatives acting as serotonin 5-HT1A and/or dopamine D2 and/or D3 receptor agonists reported to be useful for the treatment of Parkinson’s disease.
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Neurology/Psychiatric

Remynd discloses new compounds for treatment of Alzheimer’s disease

March 6, 2024
Work at Remynd NV has led to the synthesis of (aza)spiroheptane derivatives potentially useful for the treatment of Alzheimer’s disease.
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Cancer

Nuvalent patents ROS1 and/or ALK inhibitors

March 6, 2024
Nuvalent Inc. has disclosed new heteroaromatic macrocyclic ether compounds acting as proto-oncogene tyrosine-protein kinase ROS (ROS1; MCF3) and/or ALK tyrosine kinase receptor inhibitors potentially useful for the treatment of cancer.
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Cancer

Bristol Myers Squibb patent describes new diacylglycerol kinase inhibitors

March 6, 2024
Bristol Myers Squibb Co. has identified tetrazole derivatives acting as diacylglycerol kinase α (DGK-α; DGKA) and/or diacylglycerol kinase ζ (DGK-ζ; DGKZ) inhibitors reported to be useful for the treatment of cancer and viral infections.
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Infection

Phase Genomics awarded funding to develop lysin-based antimicrobials

March 6, 2024
The company will use its proprietary global phage atlas, developed with support from the Gates Foundation and the National Institutes of Health (NIH).
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Antibodies attacking cancer cell
Immuno-oncology

Ono Pharmaceutical licenses NXI-101 from Nex-I

March 6, 2024
Ono Pharmaceutical Co. Ltd. has entered into a license agreement with Nex-I Inc. to develop and commercialize NXI-101.
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