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Brain waves
Neurology/psychiatric

ECTRIMS 2024: Time for neuroprotection

Sep. 19, 2024
By Coia Dulsat
The Annual Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting in Copenhagen this week is celebrating its 40th edition. In recognition of this landmark, the plenary session and opening lecture were attended by Queen Margrethe of Denmark. Afterward, the hot topic session on neuroprotective therapies set the stage for the subsequent discussions on the latest trends in the management and treatment of multiple sclerosis (MS).
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Cancer

Turkish researchers discover new EGFR inhibitors and apoptosis inducers for lung cancer

Sep. 18, 2024
Researchers at Anadolu University and Bilecik Seyh Edebali University have described quinazolinone derivative compounds acting as EGFR (HER1; erbB1) inhibitors and apoptosis inducers reported to be useful for the treatment of lung cancer.
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Cancer

New TEAD inhibitors disclosed in Signet Therapeutics patent

Sep. 18, 2024
Signet Therapeutics Co. Ltd. has divulged α, β-unsaturated amide compounds acting as transcriptional enhancer factor (TEAD) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Chinese and US researchers describe new CDK12/13 degradation inducers

Sep. 18, 2024
Scientists at Livzon Pharmaceutical Group Inc., Shanghai Institute of Organic Chemistry and the University of Michigan have identified proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety covalently bound to a cyclin-dependent kinase 12 (CDK12) and 13 (CDK13) targeting moiety through a linker reported to be useful for the treatment of cancer.
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Infection

Rutgers University divulges new PL-pro inhibitors

Sep. 18, 2024
The State University of New Jersey (Rutgers) has synthesized non-structural protein 3 (nsp3; PL-pro) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of viral infections.
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Cancer

KU Leuven patents new exportin-1 receptor antagonists

Sep. 18, 2024
KU Leuven has disclosed exportin-1 (CRM1; XPO1) receptor antagonists reported to be useful for the treatment of cancer, among others.
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Test tubes, dropper
Endocrine/metabolic

Astrazeneca’s AZD-6234 prompts body weight loss due to reduced food intake

Sep. 18, 2024
Amylin is a hormone co-secreted with insulin in the pancreas that has anorexigenic effects, since it promotes satiety and reduces food intake. Amylin analogs and dual agonists of the amylin and calcitonin receptors have been developed for treating obesity. Astrazeneca plc reported results with their AMYR3 agonist AZD-6234.
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Molecular research art concept
Drug design, drug delivery & technologies

Candidate milestone achieved under X-Chem’s collaboration with Astrazeneca

Sep. 18, 2024
X-Chem Inc. has announced the achievement of a drug discovery milestone under its collaboration agreement with Astrazeneca plc.
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Prostate cancer cells
Cancer

Inhibiting miR-1271-5p reduces growth of hormone sensitive prostate cancer cell lines

Sep. 18, 2024
Researchers from Imperial College London presented data from a study that aimed to assess the role of miR-1271-5p in prostate cancer (PCa) progression.
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Drug design, drug delivery & technologies

Orbis to use Vivtex platform for gut permeability screening

Sep. 18, 2024
Orbis Medicines SA has announced a research collaboration and option to an exclusive license with Vivtex Corp.
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