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Home » Topics » Science » Drug design, drug delivery and technologies

Drug design, drug delivery and technologies
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3D Rendering of tumor microenvironment
Drug design, drug delivery & technologies

AI-based spatial omics unveils molecular talks in tumors

March 25, 2025
By Mar de Miguel
The three-dimensional analysis of cell types and their locations by spatial transcriptomics provides key information of their interactions within tissues or organs. Based on this technology, scientists at the Wellcome Sanger Institute have developed an AI tool called Nichecompass, which shows a comprehensive view of the cancer microenvironments, the different cells, their locations, and how they communicate with each other through different molecules inside the tumor. This AI could process data in an hour and compare samples before and after a treatment.
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Digital cancer cells illustration
Drug design, drug delivery & technologies

AI reads cancer cells’ 3D shape to predict their drug response

March 24, 2025
By Mar de Miguel
Scientists at the Institute of Cancer Research (ICR) in the U.K. are developing a technology that analyzes, in vitro, how the 3D morphology of cancer cells changes when exposed to a compound, using AI to predict their response to new treatments. The researchers estimate that their methodology could accelerate drug development by 6 years, by ruling out unsuccessful drugs and thus reducing the number of preclinical trials.
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AI-generated illustration of DNA double helix
Genetic/congenital

Methylated DNA epigenetic map pinpoints on-and-off switches of genes

March 21, 2025
By Mar de Miguel
The first complete DNA methylation atlas of 39 human cell types reveals which genes can talk or are silenced, depending on whether their sequence is linked to methyl group epigenetic modification that regulates their expression. This map of on-and-off switches shows differences between the alleles inherited from the father and those from the mother, providing a view of gene expression that can be explored in health and disease independently of the information contained in the DNA sequence.
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Cross section illustration of ion channel in cell membrane
Drug design, drug delivery & technologies

Series A financing at Maxion Therapeutics to advance Knotbodies for ion channel and GPCR-driven diseases

March 17, 2025
Maxion Therapeutics Ltd. has raised $72 million (£58 million) in a series A financing to support its development of antibody-based Knotbody drugs for ion channel- and G protein-coupled receptor (GPCR)-driven diseases.
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Lab glassware and antibodies art concept
Cancer

Pierre Fabre and Redridge Bio to develop biparatopic antibody drug candidates

March 12, 2025
Pierre Fabre SA and Redridge Bio AG have signed an exclusive R&D collaboration and license agreement to identify and develop biparatopic antibody drug candidates against multiple targets, with a focus on precision oncology, dermatology and rare diseases. The agreement provides for participation by Pierre Fabre in Redridge’s series A financing, as well as up-front, milestone and future sales royalty payments.
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Medtronic Prevail

SCAAR data Prevails for Medtronic paclitaxel-coated balloon

March 11, 2025
By Holland Johnson
Medtronic plc reported results from a registry highlighting the effectiveness of the Prevail paclitaxel-coated balloon. The findings from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) were presented by Sacharias von Koch of the department of cardiology and clinical sciences at Lund University, Skåne University Hospital in Sweden at the Cardiovascular Research Technologies 2025 meeting in Washington.
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Cancer cell and DNA
Immuno-oncology

Calidi’s Rtnova platform delivers transient gene therapy payloads to tumors

March 11, 2025
Calidi Biotherapeutics Inc. has released promising preclinical results for its systemic Rtnova platform showing its ability to successfully deliver transient gene therapy payloads to targeted tumors. Moreover, the company’s tumor-specific virotherapy has demonstrated efficacy in killing over 60 different tumor cell lines.
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Close-up of nasal drug spraying

Aspargo Companion can spray most meds, alert to missed doses

March 5, 2025
By Annette Boyle
In an advance that could significantly lighten the load for caretakers in the “sandwich generation” and reduce loneliness in elderly patients, Aspargo Labs Inc. developed a metered delivery device that optimizes absorption of pharmaceuticals and reminds users to take their medications.
Read More
Close-up of nasal drug spraying

Aspargo Companion can spray most meds, alert to missed doses

March 4, 2025
By Annette Boyle
In an advance that could significantly lighten the load for caretakers in the “sandwich generation” and reduce loneliness in elderly patients, Aspargo Labs Inc. developed a metered delivery device that optimizes absorption of pharmaceuticals and reminds users to take their medications.
Read More
vaporized ophthalmic drug delivery
Patents

Verily developing vaporized ophthalmic drug delivery device

Feb. 28, 2025
By Simon Kerton
A recent patent filing from Verily Life Sciences LLC seeks protection for the development of an ophthalmic drug delivery device with sensors and a camera which allow the delivery of a specific or controlled dose of a therapeutic agent in vapor form to a patient’s eye.
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