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BioWorld - Friday, April 17, 2026
Home » Authors » Brian Orelli

Articles by Brian Orelli

TFF inhales another $8.2M to support thin film freezing tech

June 3, 2019
By Brian Orelli

TFF inhales another $8.2M to support thin film freezing tech

May 31, 2019
By Brian Orelli
Adding on to its $14 million series A round in April 2018, TFF Pharmaceuticals Inc. has secured another $8.17 million for the round to support development of its namesake thin film freezing (TFF) technology that was developed to increase the solubility of drugs.
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Clinical trial productivity on the decline, hope for a turnaround

May 28, 2019
By Brian Orelli
Despite the strong growth in the number of drugs approved by the FDA over the last few years, clinical trial productivity fell 27% from 2013 to 2018, according to a report from the Iqvia Institute for Human Data Science.
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Clinical trial productivity on decline, hope for a turnaround

May 28, 2019
By Brian Orelli
Despite the strong growth in the number of drugs approved by the FDA over the last few years, clinical trial productivity fell 27% from 2013 to 2018, according to a report from the Iqvia Institute for Human Data Science.
Read More

Takeda and Frazier establish Phathom for acid-related diseases

May 22, 2019
By Brian Orelli
Rather than develop vonoprazan in the U.S., Europe and Canada on its own, Takeda Pharmaceutical Co. Ltd. decided to spin the drug out into a new company, Phathom Pharmaceuticals Inc., with the help of venture capitalists at Frazier Healthcare Partners.
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Actuate brings in $21.7M for GSK-3beta inhibitor program

May 20, 2019
By Brian Orelli
Looking to expand its glycogen synthase kinase-3 beta (GSK-3beta) inhibitor program, Northwestern University spinout Actuate Therapeutics Inc. has secured $21.7 million in a series B round led by Kairos Ventures. Defta Partners and Tech Coast Angels, with existing investor Bios Partners also participated in the round.
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Takeda and Frazier establish Phathom for acid-related diseases

May 16, 2019
By Brian Orelli
Rather than develop vonoprazan in the U.S., Europe and Canada on its own, Takeda Pharmaceutical Co. Ltd. decided to spin the drug out into a new company, Phathom Pharmaceuticals Inc., with the help of venture capitalists at Frazier Healthcare Partners.
Read More

Effectiveness of big biotech's pipelines varies; M&A to blame?

May 6, 2019
By Brian Orelli
About one in four drugs made it from being a new molecular entity (NME) in 2013 to approval in five years, according to a report on the pipeline progress for eight large biotechs analyzed by SVB Leerink analyst Geoffrey Porges. Externally acquired NMEs had a higher conversion rate, with 32% making it to market, compared to 21% of internally developed drugs.
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Effectiveness of big biotech's pipelines varies; M&A to blame?

May 6, 2019
By Brian Orelli
About one in four drugs made it from being a new molecular entity (NME) in 2013 to approval in five years, according to a report on the pipeline progress for eight large biotechs analyzed by SVB Leerink analyst Geoffrey Porges. Externally acquired NMEs had a higher conversion rate, with 32% making it to market, compared to 21% of internally developed drugs.
Read More

Four companies look to join public markets for a combined $345M

April 16, 2019
By Brian Orelli
Looking to join the 12 drug companies that have gone public this year, Cortexyme Inc., Milestone Pharmaceuticals Inc., Applied Therapeutics Inc. and Nextcure Inc. all filed preliminary prospectuses with the SEC on Friday.
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