Despite the strong growth in the number of drugs approved by the FDA over the last few years, clinical trial productivity fell 27% from 2013 to 2018, according to a report from the Iqvia Institute for Human Data Science.
Rather than develop vonoprazan in the U.S., Europe and Canada on its own, Takeda Pharmaceutical Co. Ltd. decided to spin the drug out into a new company, Phathom Pharmaceuticals Inc., with the help of venture capitalists at Frazier Healthcare Partners.
Looking to expand its glycogen synthase kinase-3 beta (GSK-3beta) inhibitor program, Northwestern University spinout Actuate Therapeutics Inc. has secured $21.7 million in a series B round led by Kairos Ventures. Defta Partners and Tech Coast Angels, with existing investor Bios Partners also participated in the round.
Rather than develop vonoprazan in the U.S., Europe and Canada on its own, Takeda Pharmaceutical Co. Ltd. decided to spin the drug out into a new company, Phathom Pharmaceuticals Inc., with the help of venture capitalists at Frazier Healthcare Partners.
About one in four drugs made it from being a new molecular entity (NME) in 2013 to approval in five years, according to a report on the pipeline progress for eight large biotechs analyzed by SVB Leerink analyst Geoffrey Porges. Externally acquired NMEs had a higher conversion rate, with 32% making it to market, compared to 21% of internally developed drugs.
About one in four drugs made it from being a new molecular entity (NME) in 2013 to approval in five years, according to a report on the pipeline progress for eight large biotechs analyzed by SVB Leerink analyst Geoffrey Porges. Externally acquired NMEs had a higher conversion rate, with 32% making it to market, compared to 21% of internally developed drugs.
Looking to join the 12 drug companies that have gone public this year, Cortexyme Inc., Milestone Pharmaceuticals Inc., Applied Therapeutics Inc. and Nextcure Inc. all filed preliminary prospectuses with the SEC on Friday.
Last week, the FDA approved Dovato, the first two-drug, fixed-dose, complete regimen for HIV-infected adults who have never received treatment for HIV. The drug combines dolutegravir, an integrase strand transfer inhibitor, and lamivudine, a nucleoside reverse transcriptase inhibitor (nuc).
Last week, the FDA approved Dovato, the first two-drug, fixed-dose, complete regimen for HIV-infected adults who have never received treatment for HIV. The drug combines dolutegravir, an integrase strand transfer inhibitor, and lamivudine, a nucleoside reverse transcriptase inhibitor (nuc).
