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BioWorld - Friday, January 9, 2026
Home » Authors » Brian Orelli

Brian Orelli

Articles

ARTICLES

AACR: Cancer deaths declining, but more funding needed

Sep. 18, 2024
By Brian Orelli
Scientists and doctors are getting much better at developing treatments for cancer. More than 18 million people with a history of cancer were alive in the U.S. at the beginning of 2022, up from just 3 million in 1971, according to the 14th edition of the American Association for Cancer Research (AACR) Cancer Progress Report. And that number is expected to rise to 26 million by 2040.
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Doctor and patient consultation

The massive, untapped opportunity in women’s health

Sep. 16, 2024
By Brian Orelli
Biocom California’s most recent edition of its Let's Talk About series covered the future of women’s health. The panel of executives from companies and investors in women’s health were frustrated about the state of funding for the space. “Only about 1% of health care R&D dollars go [specifically] to women’s health outside of oncology,” Jenn Kiang, director of corporate affairs and development at Daré Bioscience Inc. told the audience. But the opportunity is huge, she said.
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Adenovirus cells
Immuno-oncology

Vironexis exits stealth with 10+ AAV-delivered immuno-oncology candidates

Sep. 13, 2024
By Brian Orelli
Vironexis Biotherapeutics Inc. has come out of stealth mode, disclosing that it has more than 10 product candidates it’s been developing over the last three years. The therapies are built on the company’s AAV-based platform, Transjoin, which is designed to have patients' livers express bispecific antibodies that bind to both CD3 on T-cells and various targets on tumor cells.
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Adenovirus cells
Newco news

Vironexis exits stealth with 10+ AAV-delivered immuno-oncology candidates

Sep. 12, 2024
By Brian Orelli
Vironexis Biotherapeutics Inc. came out of stealth mode today, disclosing that it has more than 10 product candidates it’s been developing over the last three years. The therapies are built on the company’s AAV-based platform, Transjoin, which is designed to have patients' livers express bispecific antibodies that bind to both CD3 on T-cells and various targets on tumor cells.
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Immune

Candid launches with bispecific antibodies and $370M in hand

Sep. 10, 2024
By Brian Orelli
Candid Therapeutics Inc. launched with ex-China control of two bispecific T-cell engager antibodies that it plans to develop for autoimmune diseases. The San Diego-based company will start off with a pocketful of cash, having raised over $370 million for the development of the in-licensed candidates.
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Red rocket launch button on keyboard
Newco news

Candid launches with bispecific antibodies and $370M in hand

Sep. 9, 2024
By Brian Orelli
Candid Therapeutics Inc. launched with ex-China control of two bispecific T-cell engager antibodies that it plans to develop for autoimmune diseases. The San Diego-based company will start off with a pocketful of cash, having raised over $370 million for the development of the in-licensed candidates.
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U.S. flag and White House podium

How US politics could shape the future of biopharma

Aug. 29, 2024
By Brian Orelli
During a webinar arranged by Demy-Colton, panelists discussed a wide range of potential outcomes that might occur depending on which political party ends up in power next year. From tweaks to the Inflation Reduction Act to new laws to the Federal Trade Commission's regulation of M&As, there’s potential for the government to have substantial effects on the drug development industry.
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Dendritic cells
Newco news

Diakonos raises $11.4M for its dendritic cell vaccine

Aug. 27, 2024
By Brian Orelli
Diakonos Oncology Corp. has developed a process to manufacture dendritic cell vaccines that the company believes are substantially more potent than its predecessors.
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Ideaya opening a new market with its first-in-class MAT2A inhibitor

July 8, 2024
By Brian Orelli
Ideaya Biosciences Inc. appears to be in the lead to develop a treatment for tumors with deletions in both copies of methylthioadenosine phosphorylase (MTAP). Despite the large market with an estimated annual incidence rate in the U.S. of approximately 75,000 patients, there are no FDA approved therapies for MTAP-deleted solid tumors.
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mRNA on digital background
Newco news

Exsilio launches with $82M to develop mRNA-based gene therapies

July 2, 2024
By Brian Orelli
Exsilio Therapeutics emerged from stealth mode on June 25, 2024, with $82 million from a series A financing that was co-led by Novartis Venture Fund and Delos Capital. The company plans to use naturally occurring, mobile genetic elements to integrate therapeutic genes at a defined location in the genome, making it safer than random integration, which can cause tumor formation.
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