In a recent publication in iScience, researchers from Peking University First Hospital investigated the therapeutic potential of SLC7A11 CAR T therapy for solid tumors, particularly colorectal and pancreatic cancers.
Heme oxygenase 1 (HO-1) is a stress-inducible enzyme that plays a critical role in the pathogenesis of rheumatoid arthritis, a systemic autoimmune disease characterized by chronic synovial inflammation, immune cell infiltration and progressive joint destruction.
Overexpression of focal adhesion kinase (FAK) is linked to worse prognosis and greater risk of metastasis in colorectal, cervical, breast and skin cancers. Despite its attractiveness as a therapeutic target, no effective inhibitors of focal adhesion kinase have yet been described.
Researchers from Peking University and the China-Japan Friendship Hospital have gained new insights into the role of triggering receptor expressed on myeloid cells-1 (TREM-1) in traumatic brain injury (TBI). Cerebral damage resulting from external mechanical impacts causes TBI, which is a leading cause of morbidity and mortality worldwide.
Phosphatidylinositol 3-kinases (PI3Ks) are a family of enzymes that catalyze the phosphorylation of phosphatidylinositol at the D-3 position of the inositol ring, serving critical functions in cellular signaling pathways. Among them, the isoform PI3K class II γ (PI3KC2γ), which is predominantly expressed in the liver, regulates hepatic glycogen synthesis and thus plays a critical role in glucose homeostasis.
Researchers from Nanjing University and Peking University presented the discovery and preclinical characterization of novel NLRP3 inhibitors as potential therapeutic candidates for the treatment of gout.
Hypoxia, a hallmark of the tumor microenvironment (TME), promotes malignant progression and resistance to chemotherapy and radiotherapy and hence, should be delimitated before treatment initiation.
Immunoglobulin G (IgG), an antibody that participates in the response to infection, could have a specific role in metabolism. During aging, it accumulates in certain tissues inducing metabolic dysfunction and fibrosis of fat tissue. This effect could be prevented through an intracellular receptor that contributes to the delivery of IgG. A team of researchers from Columbia University and Peking University (PKU) demonstrated that reducing excess IgG improved the metabolic health of aged mice and increased their life expectancy.
Researchers from Peking University Cancer Hospital presented the discovery and preclinical evaluation of [124I]IMMU-132, a trophoblast cell surface antigen 2 (Trop2)-targeting molecular probe for micro-PET imaging.
Researchers from Peking University (PKU) recently presented the discovery and preclinical evaluation of a novel small-molecule inhibitor of pan-αv integrin, C19-9-21, being developed for the treatment of prostate cancer.
