A proof of concept of ex vivo genetic modification of cells from patients and their transplantation in mice has demonstrated, for the first time, the therapeutic possibilities of prime editing in sickle cell disease (SCD).

Severe malaria infections caused by malaria could disrupt hematopoietic processes in mouse models, resulting in faster turnover of hematopoietic stem cells (HSCs) and drastically affecting their function, researchers from Imperial College London and The Francis Crick Institute reported in the November 23, 2020, online issue of Nature Cell Biology.