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Home » Newsletters » BioWorld

BioWorld

July 29, 2022

View Archived Issues
3D model of a protein molecule

‘3D view of the protein universe’ as Deepmind reveals 200M protein structures

It is now possible to look up the 3D structure of every known protein following the latest release of Alphafold, an open database run in partnership by Deepmind, the London-based artificial intelligence company owned by Google parent Alphabet and the European Molecular Biology Laboratory’s European Bioinformatics Institute in Cambridge, U.K. Read More

Pipeline beefed for Elevation with CSPC deal but competition Claudin sky

Wall Street must wait to learn more about factors that might distinguish the Claudin18.2-targeting asset at the center of Elevation Oncology Inc.’s $1.2 billion license deal with CSPC Megalith Biopharmaceutical Co. Ltd., a subsidiary of CSPC Pharmaceutical Group Ltd. Read More
Coronavirus spike protein

Targeting S2 could lead to broad coronavirus protection

Since the very beginning of the COVID-19 pandemic, in addition to the attempts to rapidly develop a vaccine that was effective against current strains, researchers have been looking for a vaccine that could protect more broadly against multiple coronaviruses. That has prompted attempts to harness the potential of the more conserved S2 subunit of the spike protein via which SARS-CoV-2 enters human host cells. Read More

Sarepta shares jump as it plots fast FDA review for DMD gene therapy

Sarepta Therapeutics Inc. said it plans to file a BLA for its gene therapy for Duchenne muscular dystrophy (DMD), SRP-9001, with the U.S. FDA, potentially setting up a decision in the first half of 2023 for the therapy developed in partnership with Switzerland’s Roche Holding AG. The Cambridge, Mass.-based biotech said the BLA will seek accelerated approval for the therapy, also known as delandistrogene moxeparvovec, for ambulant individuals with DMD. Read More
DNA and cancer cells

Setting cancer cells on the road to ruin is Modifi’s goal

Exploiting deficiencies in tumor cells’ inability to repair damage to their DNA has been one of the most successful endeavors of oncology research in recent memory. There are four approved PARP inhibitors to treat certain types of breast, ovarian, pancreatic and prostate cancers. Multiple other synthetic lethal combinations that might push repair-deficient tumors into cell death are being investigated. In the July 29, 2022, issue of Science, researchers at Yale University have described another approach to turning DNA repair defect against itself. Startup Modifi Biosciences Inc. is now on course to translate that work. Read More
Professor Hugh Watkins, lead investigator at Cureheart

Scientists to test whether base editing could cure killer heart diseases

Scientists will investigate whether cutting-edge technology such as base editing could be used to cure inherited heart muscle conditions after an international team co-led by Harvard Medical School won a research challenge. The $36 million Big Beat Challenge, run by the British Heart Foundation, is one of the largest non-commercial awards ever given and will focus on inherited heart muscle diseases known as genetic cardiomyopathies. Read More

OIG draws new lines around CME programs sponsored by drug, device makers

Drug and device makers that offer health care professionals opportunities to earn continuing medical education (CME) points have a fine line to walk when sponsoring those programs, but a new advisory opinion by the Office of Inspector General (OIG) at the Department of Health and Human Services seems to draw a very clear line around those programs. Read More
Metformin

Extending the human lifespan: For preventing aging, some decades old drugs?

The U.S. NIH’s National Institute on Aging’s Intervention Testing Program has been searching for ways to extend lifespan for more than two decades by now. And in its animal studies, it has been successful multiple times. There are half a dozen drugs, and a few lifestyle interventions, that reliably extend lifespan in one or both sexes by up to 30%. Read more in part four and five of BioWorld’s multipart series on extending the human lifespan. Read More

The BioWorld Insider Podcast

In Extending the human lifespan, a BioWorld special report, the team examined the latest science, the key biological drivers that can be targeted pharmacologically and the companies developing potential “Fountain of Youth” candidate drugs. In this episode of the BioWorld Insider Podcast, the team discussed the report’s highlights and key takeaways.  

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Please take a few minutes to fill out this short survey to help us provide you with the best possible source of news. Customer feedback is critical so that we can make BioWorld a valuable component of your daily workflow. We want to continue to evolve to serve you. The survey should take just 5 minutes. You can click through to the questions here. Read More

Appointments and advancements for July 29, 2022

New hires and promotions in the biopharma industry, including: Astrazeneca, Generate, Nicox. Read More

Financings for July 29, 2022

Biopharmas raising money in public or private financings, including: Novasenta, Trevena. Read More

In the clinic for July 29, 2022

Clinical updates, including trial initiations, enrollment status and data readouts and publications: Acasti, ADC, Algernon, Biogen, Celularity, Compass, Cortexyme, Cyclerion, Cytoimmune, Denovo, Editas, Ensysce, Ideaya, In8bio, Ionis, Medicenna, Merakris, Moleculin, Mustang, Newamsterdam, Sound, Sutro, Tallac, Valbiotis, Viiv.

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Other news to note for July 29, 2022

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Gigagen, Neophore, Nervgen, Novartis, Sunshine, Therapeutic Solutions, Tonix, Trevena, Viiv. Read More

Regulatory actions for July 29, 2022

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Acer, Astria, Kira, Marinus, Quoin, Sareum, Step, Turning Point. Read More

Money raised by biopharma: 2022 vs. 2021 vs. 2020 vs. 2019

Total raised in public, private and other financings of biopharma companies, comparing 2022 vs. 2021 vs. 2020 vs. 2019. Read More

Biopharma money raised: Jan. 1-July 28, 2022

Year-to-date money raised in public, private and other financings of biopharma companies. Read More

Biggest gainers and losers for the week of July 25-29, 2022

The top 10 biopharma stock gainers and losers for the week. Read More

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