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Home » Newsletters » BioWorld

BioWorld

March 30, 2023

View Archived Issues
Brexafemme

Scynexis makes good on Brexafemme out-licensing promise in $593M GSK pact

The advance of antifungals – a class long needful of new therapies – continued with Scynexis Inc.’s potential $593 million exclusive license agreement with GSK plc for Brexafemme (ibrexafungerp), first cleared by the U.S. FDA in June 2021 and indicated for vulvovaginal candidiasis (VVC) as well as for reduction of recurrent VVC. Read More

EIP and Diffusion will merge to become Cervomed with Lewy body disease study set for this year

It’s been nearly 10 years since John Alam co-founded privately held EIP Pharma Inc. and the company’s upcoming merger with publicly traded Diffusion Pharmaceuticals Inc. will add scientific and financial muscle to its drive for a successful Lewy body treatment. To him, dealing with groundbreaking science requires patience. Read More
Brain illustration

Building ‘Confodence’: Confo enters potential $182M GPCR pact with Daiichi Sankyo

Confo Therapeutics NV closed out March in much the same way as it began the month – with a deal. The Ghent, Belgium-based company has entered a collaboration agreement with Daiichi Sankyo Co. Ltd. to generate brain-penetrant small-molecule agonists to an undisclosed G protein-coupled receptor (GPCR) implicated in central nervous system diseases. Read More
Digestive system

Alternative, antagonist approach to GI diseases unveiled by ThirtyFiveBio

The role of G protein-coupled receptor 35 (GPR35) in gastrointestinal (GI) diseases has been genetically validated for some time, with several pharmaceutical companies advancing programs designed to tackle the target; however, most of these efforts to date have focused on increasing GPR35 activity. ThirtyFiveBio’s approach is different: The newly founded virtual biotech company believes that antagonizing the target and thereby blocking unwanted GPR35 signaling may be a more appropriate way to address GI conditions, including digestive tract cancers. Read More
Drug-prices-blister-pack

US Congress on path to revise the ‘rules of the road’ for PBMs

Whether it’s legislation calling for more transparency from pharmacy benefit managers (PBMs) or hearings held in search of a new roadmap to modernize the U.S. drug supply chain, Congress is scrutinizing and looking to clamp down on the role PBMs are playing in raising drug prices. Read More

Shares slide as Avidity identifies ‘extremely rare’ SAE in DM1 trial

Shares of Avidity Biosciences Inc. (NASDAQ:RNA) dropped 15% March 30 as the company disclosed details of the serious adverse event (SAE) that prompted a partial clinical hold in September 2023 on the phase I/II trial testing AOC-1001 in adults with myotonic dystrophy type 1 (DM1). Read More

Appointments and advancements for March 30, 2023

New hires and promotions in the biopharma industry, including: Aim, Citryll, Eterna, Flare, Fogpharma, Janssen, Projenx, Syndax. Read More

Financings for March 30, 2023

Biopharmas raising money in public or private financings, including: Akari, Avadel, Biomea Fusion, Redhill, Salubris, Smart Immune, Sorrento, Trobix and Viking. Read More

In the clinic for March 30, 2023

Clinical updates, including trial initiations, enrollment status and data readouts and publications: Achieve, Affimed, Biogen, Bioxytran, Caribou, Corcept, Evaxion, Harmony, Netris, Precigen, Rapt. Read More

Other news to note for March 30, 2023

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Alector, Apollomics, Aquestive, Aridis, Astrazeneca, Celularity, Galimedix, Otonomy, Pharmanovia, Smart Immune, Spiral, Thea, Unravel. Read More

Regulatory actions for March 30, 2023

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Blueprint, Eloxx, Epicentrx, Hansa, Juno, Pharmather, Regeneron, Transcenta. Read More

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