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Home » Newsletters » BioWorld

BioWorld

Feb. 28, 2024

View Archived Issues
Eye and financial charts

Palatin to tweak second PL-9643 phase III in dry eye disease

After trading as low as $2.04, shares of Palatin Technologies Inc. (NYSE:PTN) closed Feb. 28 down $1.57, or 39.7%, ending at $2.39 on word of results from the phase III pivotal Melody-1 trial with melanocortin pan-agonist PL-9643 vs. vehicle in dry eye disease. Read More

Deal activity continues as OSE, Abbvie ink $713M partnership

OSE Immunotherapeutics SA disclosed a $713 million deal with Abbvie Inc. for preclinical-stage monoclonal antibody OSE-230, a potentially first-in-class therapy for treating a range of inflammatory diseases, while Idorsia Ltd. found a partner for two phase III-stage assets in Viatris Inc., as dealmaking continues strong in 2024. Read More
Green strand of DNA

Pulsesight advancing eye therapies delivered via electroporation

Ocular gene therapy specialist Pulsesight Therapeutics SAS has launched with seed funding and is raising a series A to take forward two programs using electroporation to deliver plasmid DNA in the treatment of wet age-related macular degeneration and geographic atrophy. Read More

Small gains, but gloomy US IPO market prevails

“The market stinks,” Brian Johnson, a partner and vice chair of Wilmerhale’s corporate practice group, told a U.S. SEC advisory committee Feb. 27, as he painted a gloomy picture of last year’s IPO landscape in the U.S. While the scene was a little brighter than in 2022, a few key indicators could be worrisome, especially the median offering size, which is predictive of the strength of the IPO market, Johnson said Read More
Biocom 2024 panel

Biocom 2024: Developing new AI capabilities (and maybe going faster, too)

Biocom California’s Global Life Science Partnering & Investor Conference kicked off with a panel discussion focused on artificial intelligence (AI) in drug discovery. While there’s been a lot of hype over how AI and machine learning have the potential to help companies speed up drug development, panelists hypothesized the largest opportunities are in developing new capabilities, potentially increasing the success rate going from discovery to regulatory approval. Read More

Takeda, Biological E. partner to widen global access to Qdenga

In a move to widen global access to its Qdenga dengue vaccine, Takeda Pharmaceutical Co. Ltd. is partnering with India’s Biological E. Ltd. to manufacture Qdenga (TAK-003). Read More
Judge's gavel with US flag

New US PTO guide may spur more patent rejections for obviousness

The U.S. Patent and Trademark Office (PTO) has released a guidance to aid patent examiners in dealing with questions of obviousness in patent applications, but patent attorney Michael Borella told BioWorld that this new guidance could resurrect the law of unintended consequences. Borella, a partner in the Chicago office of McDonnell Boehnen Hulburt & Berghoff LLP, said the guidance might lead to more inappropriate rejections of patent claims for obviousness, and thus make the process of obtaining a clean patent more difficult, not less. Read More
Brush scrubbing brain figurine with soap

Studies bring insights into brain’s self-cleaning mechanisms

Separate teams of investigators have reported new insights into how the brain disposes of metabolic waste via the glia-based lymphatic system, or glymph system. In two papers published in Nature on Feb. 28, 2024, scientists from Washington University in St. Louis described how in sleeping animals, the synchronized activity of neurons drove ionic gradients that facilitated the movement of fluid through brain tissue. And researchers from the Massachusetts Institute of Technology showed that, in a mouse model of Alzheimer’s disease (AD), the glymphatic system mediated clearance of amyloid-β after sensory stimulation at a 40-Hertz rhythm. Read More
DNA with bar chart

Explore BioWorld’s comprehensive infographics collection

Discover a wealth of industry insights with BioWorld’s extensive collection of infographics, covering the latest trends and developments in both biopharma and med-tech. Our weekly infographics are curated to provide concise summaries of key topics: financings (IPOs, private financings, public/other and follow-on offerings), deals and M&As (top deals, and monthly value and volume), regulatory (including U.S. FDA and worldwide approvals), clinical trials and more. In addition, you’ll find access to BioWorld’s year-in-review reports, as well as special infographics about obesity, pain and addiction, biosimilars and the aging space. Read More

Appointments and advancements for Feb. 28, 2024

New hires and promotions in the biopharma industry, including: Bexion, Madrigal, Maia, Nicox, Oculis, Rapport, Umoja. Read More

Financings for Feb. 28, 2024

Biopharmas raising money in public or private financings, including: Applied, Crinetics, Janux, Nrx, Oragenics, Relief, Viking, Vtv. Read More

In the clinic for Feb. 28, 2024

Clinical updates, including trial initiations, enrollment status and data readouts and publications: Akston, CG Oncology, Curadev, Healis, Imunon, Janux, Recce, Tonix, Viking. Read More

Other news to note for Feb. 28, 2024

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Boostimmune, Isotherapeutics, Nona, Scilex, Sorrento, Telix, Virpax. Read More

Regulatory actions for Feb. 28, 2024

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Abbvie, AB Science, Acurx, Allecra, Arch, Beigene, Everest Medicines, Genmab, Gilead, Kezar, Mabwell, Minerva, Nuvalent, Theratechnologies. Read More

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