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Home » Newsletters » BioWorld

BioWorld

April 14, 2025

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Illustration of human heart with DNA structure background

Early stage cardio data from Verve bump the stock

Positive early stage data for Verve Therapeutics Inc.’s base editing therapy points to a range of development options, including bringing partner Eli Lilly and Co. in a little closer. The new data helped ease the company’s pain from the April 2 enrollment pause of a similarly designed therapy from Verve. Verve’s Heart-2 phase Ib of VERVE-102 in treating 14 patients with heterozygous familial hypercholesterolemia and/or premature coronary artery disease showed one infusion led to dose-dependent decreases in blood PCSK9 protein levels and low density lipoprotein cholesterol. Read More

Pfizer’s loss offers boost to competitors in obesity space

Pfizer Inc. is ending work on oral GLP-1 candidate danuglipron for weight loss following the report of a single potentially drug-induced liver injury, a move that appears to open the door for other firms working on oral therapies in the high-dollar obesity space, even as industry watchers seek further details to determine whether similar safety signals could emerge for those competitors. Read More
Illustration of intestinal track

Ironwood: FDA nay on PK means another apraglutide study

More than a year after Ironwood Pharmaceuticals Inc.’s phase III hitch with apraglutide in short bowel syndrome, the other shoe fell from regulators as did the Boston-based firm’s shares (NASDAQ:IRWD), which ended April 14 at 64 cents, down 29 cents, or 31.5%. Read More

New UK law aims for ‘faster, fairer and more inclusive’ clinical trials

As new clinical trials regulations were signed into law in the U.K., an analysis of 4,616 submissions to conduct studies has highlighted what is required for the updated law to translate into a more efficient, streamlined and adaptable regulatory framework. Read More
Antibodies binding to spike proteins on the surface of SARS-CoV-2 virus

Australian researchers discover new compound to treat long COVID

Researchers have developed a new compound that can prevent long COVID symptoms in mice that could lead to a future drug for the debilitating condition in humans. Developed by researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, the world-first study found mice treated with the antiviral compound were protected from long-term brain and lung dysfunction, which are key symptoms of long COVID. Read More

ICYMI: Week in review, April 7-11, 2025

A quick look back at top stories. Read More

Biggest gainers and losers for April 7-11, 2025

The top 10 biopharma stock gainers and losers for the week. Read More

Appointments and advancements for April 14, 2025

New hires and promotions in the biopharma industry, including: Arcutis, Corvus, Evecxia, Harvard, Imbria. Read More

Financings for April 14, 2025

Biopharmas raising money in public or private financings, including: Imbria, Oncolytics. Read More

Other news to note for April 14, 2025

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Avernus, Opthea, Oncozenge. Read More

Regulatory actions for April 14, 2025

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Argenx, Verve. Read More

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