BOSTON – Mind the gap. It's not enough to chart a regulatory pathway and see biosimilar products through to approval; there remain problems with promoting uptake and delivering the promised cost savings to payers, as experience in Europe illustrates. Read More

LONDON – The neurotransmitter dopamine has a direct influence on the production and release of the hormone melatonin, which helps to regulate the body's circadian rhythm, researchers have found. Read More

BOSTON – 2012 may be the year that the patent cliff reaches its height – with $33 billion of sales at risk – but the impact of loss of exclusivity will continue to reverberate across the decade, with more than $290 billion of prescription drugs sales due to be exposed to generic competition between now and 2018. Read More

BOSTON – LEO Pharma is launching a new search for products and partners at BIO 2012 this week, with a four-strong business development team looking to in-license programs that will advance the company's ambition to become the global leader in dermatology. Read More

LONDON – Proximagen Group plc has fallen into the arms of its long-term partner and 16 percent shareholder, Upsher-Smith Laboratories Ltd., in a deal worth up to £356.8 million (US$554.7 million). Read More

• Bavarian Nordic A/S, of Kvistgaard, Denmark, received a $17.9 million five-year contract from the National Institute of Allergy and Infectious Diseases to support development of candidate vaccine technologies to combat the intentional release of pathogens considered a threat to public health. Read More