In a study published in Nature on Oct. 11, coinciding with the beginning of IDWeek 2023 in Boston, researchers from Harvard Medical School described EVEscape, a method for anticipating the movements of SARS‑CoV‑2 by predicting potential mutations likely to escape current vaccines and treatments. Read More
At the ECNP meeting this week in Barcelona, researchers from Cerevance Inc. presented preclinical data for the selective orexin OX1 receptor (OX1R) antagonist CVN-766, following evaluation in models of schizophrenia. The potency and selectivity of CVN-766 were assessed in recombinant cells overexpressing either human or mouse OXR1 or OXR2. Read More
Scholar Rock Inc. has announced plans to advance SRK-439, a novel investigational myostatin inhibitor for the treatment of obesity, toward an IND submission in 2025. Read More
Researchers working at with Seoul National University together with GPCR Therapeutics Inc. have focused on targeting pairs of G protein-coupled receptors (GPCRs) starting with the CXC chemokine receptor 4 (CXCR4), which is well known to serve hematopoietic and early developmental functions, while also being required for cancer metastasis. Read More
Research at Purdue Research Foundation has led to the identification of SYK kinase inhibitors reported to be useful for the treatment of glucose-6-phosphate dehydrogenase deficiency, sickle cell disease, α- and β-thalassemia. Read More
Imidomics Inc. has entered into a strategic license and collaboration agreement with the University of Barcelona under which Imidomics has licensed technology and expertise to advance research aimed at understanding and treating immune-mediated inflammatory diseases. Read More
Researchers from Panolos Bioscience Inc. and affiliated organizations have published preclinical data for PB-101, a novel glycosylated decoy protein targeting both vascular endothelial growth factor (VEGF) and placental growth factor (PlGF). Read More
In the U.S., hospital-borne antimicrobial-resistant nosocomial infections affect over 700,000 people every year causing more than 90,000 deaths along with a $28-45 billion financial burden. This commonly involves either methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus or carbapenem-resistant Acinetobacter baumannii. Read More
Daegu-Gyeongbuk Medical Innovation Foundation has patented new thiadiazole compounds acting as peroxisome proliferator-activated receptors δ (PPARδ) agonists reported to be useful to be useful for the treatment of inflammation. Read More
Immetas Therapeutics Inc. and GC Biopharma Corp. have entered into a research collaboration to discover and develop novel mRNA therapeutics for the treatment of a broad range of autoimmune diseases. The collaboration combines Immetas’ proprietary platform for modulating innate immune pathways with GC Biopharma’s mRNA therapeutic and lipid nanoparticle (LNP) delivery platforms. Read More
Molecular glues acting as zinc finger protein Helios (IKZF2) degradation inducers are described in a Gilead Sciences Inc. patent and reported to be useful for the treatment of cancer. Read More
Medilink Therapeutics (Suzhou) Co. Ltd. has entered into a strategic research collaboration and worldwide license agreement with Biontech SE for the development of a next-generation antibody-drug conjugate candidate (ADC) against HER3. Read More
Jiangsu Hengrui Medicine Co. Ltd. and Shanghai Hengrui Pharmaceutical Co. Ltd. have described fused heterocyclic compounds acting as receptor-interacting serine/threonine-protein kinase 1 (RIPK1; RIP-1) inhibitors. Read More
