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BioWorld - Sunday, June 22, 2025

CAR T

Home » Topics » Immunotherapy » CAR T
  • Car t
    June 16, 2025

    Myrio’s PHOX2B PC-CAR T for neuroblastoma gains IND clearance

    Myrio Therapeutics Pty Ltd. is set to advance lead product PHOX2B PC-CAR T (PHOX2B peptide-centric chimeric antigen receptor autologous T cells) into clinical trials for relapsed neuroblastoma following IND clearance by the FDA. The first patient will be enrolled around mid-year.
  • June 13, 2025

    CD97-targeting CAR T cells with enhanced persistence show promise in AML xenograft models

    Acute myeloid leukemia (AML) is an aggressive blood cancer characterized by the accumulation of immature myeloid cells. Current treatments often fail to achieve durable remission, underscoring the need for innovative therapeutic approaches. CD97 is a cell surface protein with broad, increased expression on AML cells compared to normal blood stem and progenitor cells. Moreover, CD97 overexpression in AML patients has been associated with poor survival, thus emerging as a potential therapeutic target.
  • Liver and dna
    May 28, 2025

    Armored anti-GPC3 JW-004 shows increased potency against HCC

    Hepatocellular carcinoma (HCC) is a fatal cancer and the third cause of cancer-related deaths worldwide. Current therapies have focused on CAR T cells for treating HCC. Glypican-3 (GPC3) is a membrane protein that is overexpressed in HCC but not in healthy adult liver tissue, thus becoming a promising therapeutic target for HCC management.
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