I. MODIFIED AGREEMENTS

Company*
(Country;
Symbol)

Company*
(Country;
Symbol)

Change from original
agreement

Terms/Details (Date)


Curis Inc.
(CRIS)

Genentech
Inc.
(NYSE:DNA)

They amended June 2003 deal to extend Genentech's funding of the development collaboration in cancer

Genentech is providing $2M to extend the Hedgehog-inhibition program, which was set to expire in June 2005, another six months, with a six-month option (4/14)

Lexicon
Genetics Inc.
(LEXG)

Deltagen Inc. (PK:DGENQ)

They settled Lexicon's claim in Deltagen's bankruptcy proceedings and agreed on Deltagen's assumption of a sublicense deal from Lexicon

Lexicon received $4M in the settlement and could get up to $6M more from Deltagen's licensing revenues from existing lines of knockout mice; Lexicon also is entitled to royalty payments (3/31)

Transgenomic
Inc.
(TBIO)

Geron Corp. (GERN)

Transgenomic will provide additional modified nucleic acid-building block compounds to Geron

The deal is an addendum to an existing master supply agreement between the companies; terms were not disclosed (4/20)

II. TERMINATED AGREEMENTS

Inex
Pharmaceuticals
Corp.
(Canada; TSE:IEX)

Enzon Pharmaceuticals Inc. (ENZN)

Enzon is ending deal to develop Inex's cancer product Marqibo

The product, vincristine sulfate liposomes injection, received a not- approvable letter from the FDA in January calling for more trials; Inex is due $5M under the deal (3/17)


Notes:

* Private companies are indicated with an asterisk.

Unless otherwise noted, stock symbols listed are on the Nasdaq market.

NYSE = New York Stock Exchange; PK = Pink Sheets.