Underwriter

Biotechnology
Company

Date Priced

Offering
Price Per Share**

8/20/03 Share
Price

Offering Gross
(M)

After-Market
Performance
(%)

Adams,
Harkness
& Hill

AtheroGenics Inc.
(AGIX)

1/29/03

$6.25

$12.89

$51.875

+106%

Martek Biosciences
Corp. (MATK)

4/22/03

$30.25

$49.04

$87.725

+62%

Banc of
America Securities

Amylin Pharmaceuticals
Inc. (AMLN) (co-lead)

1/17/03

$16.60

$25.35

$174.96

+53%

Bear
Stearns &
Co. Inc.

The Medicines Co.
(MDCO) (co-lead)

3/14/03

$17.50

$28.61

$85.75

+63%

Canaccord
Capital

ID Biomedical Corp.
(Canada; IDBE;
TSE:IDB)

5/28/03

$8.50

$12.19

$25.5

+43%

C.E. Unterberg, Towbin

MGI Pharma
Inc. (MOGN)

8/8/03

$35.50

$38.23

$181.05

+8%

CIBC World Markets Corp.

BioMarin
Pharmaceuticals
Inc. (BMRN)

2/21/03

$10

$8.18

$75

-18%

ID Biomedical
Corp. (Canada;
IDBE; TSE:IDB)
(lead)

5/28/03

$8.50

$12.19

$25.5

+43%

ILEX Oncology
Inc. (ILXO)

7/30/03

$17

$15.99

$93.5

-6%

Lexicon Genetics
Inc. (LEXG)

7/24/03

$5.25

$5.15

$52.5

-2%

The Medicines
Co. (MDCO)

3/14/03

$17.50

$28.61

$85.75

+63%

Citigroup
Global Markets

Esperion
Therapeutics
Inc. (ESPR)

8/1/03

$16

$17.16

$64

+7%

Martek Biosciences
Corp. (MATK)
(lead)

4/22/03

$30.25

$49.04

$87.725

+62%

Desjardins Securities

ID Biomedical
Corp. (Canada;
IDBE; TSE:IDB)

5/28/03

$8.50

$12.19

$25.5

+43%

Deutsche Bank Securities

Inspire Pharmaceuticals
Inc. (ISPH) (co-lead)

3/14/03

$13.50

$15.50

$77.63

+15%

Dlouhy
Merchant
Group

ID Biomedical Corp. (Canada; IDBE;
TSE:IDB)

5/28/03

$8.50

$12.19

$25.5

+43%

Fortis Securities Inc.

Amylin Pharmaceuticals
Inc. (AMLN)

1/17/03

$16.60

$25.35

$174.96

+53%

Goldman
Sachs & Co.

Amylin Pharmaceuticals
Inc. (AMLN) (co-lead)

1/17/03

$16.60

$25.35

$174.96

+53%

Exelixis Inc. (EXEL)
(lead)

6/20/03

$7.10

$7.74

$80.23

+9%

Harris Nesbitt Gerard

Vicuron Pharmaceuticals
Inc. (MICU)

7/18/03

$13.85

$13.87

$83.1

+0%

Lazard
Freres & Co. LLC

AtheroGenics Inc.
(AGIX)

1/29/03

$6.25

$12.89

$51.875

+106%

MGI Pharma Inc.
(MOGN)

8/8/03

$35.50

$38.23

$181.05

+8%

Vicuron Pharmaceuticals
Inc. (MICU)

7/18/03

$13.85

$13.87

$83.1

+0%

Lehman
Brothers Inc.

Amylin Pharmaceuticals
Inc. (AMLN) (co-lead)

1/17/03

$16.60

$25.35

$174.96

+53%

AtheroGenics Inc.
(AGIX) (co-lead)

1/29/03

$6.25

$12.89

$51.875

+106%

Esperion Therapeutics
Inc. (ESPR) (lead)

8/1/03

$16

$17.16

$64

+7%

ILEX Oncology Inc.
(ILXO)

7/30/03

$17

$15.99

$93.5

-6%

Onyx Pharmaceuticals
Inc. (ONXX)

7/22/03

$15.25

$16.50

$76.25

+8%

Merrill
Lynch & Co.

MGI Pharma Inc.
(MOGN) (co-lead)

8/8/03

$35.50

$38.23

$181.05

+8%

Morgan
Keegan
& Co. Inc.

Antigenics
Inc. (AGEN)

1/23/03

$9.92

$12.29

$34.22

+24%

Morgan
Stanley and
Co.

Amylin
Pharmaceuticals Inc. (AMLN) (co-lead)

1/17/03

$16.60

$25.35

$174.96

+53%

AtheroGenics Inc.
(AGIX) (co-lead)

1/29/03

$6.25

$12.89

$51.875

+106%

Cerus Corp.
(CERS) (lead)

6/6/03

$9.63

$7.38

$57.78

-23%

Lexicon Genetics Inc. (LEXG) (co-lead)

7/24/03

$5.25

$5.15

$52.5

-2%

Onyx Pharmaceuticals
Inc. (ONXX) (lead)

7/22/03

$15.25

$16.50

$76.25

+8%

The Medicines Co. (MDCO) (co-lead)

3/14/03

$17.50

$28.61

$85.75

+63%

Vicuron Pharmaceuticals
Inc. (MICU) (co-lead)

7/18/03

$13.85

$13.87

$83.1

+0%

Needham & Co.

Antigenics Inc.
(AGEN)

1/23/03

$9.92

$12.29

$34.22

+24%

EPIX Medical Inc.
(EPIX)

8/7/03

$15

$16.23

$64.5

+8%

Esperion Therapeutics
Inc. (ESPR)

8/1/03

$16

$17.16

$64

+7%

Martek Biosciences
Corp. (MATK)

4/22/03

$30.25

$49.04

$87.725

+62%

Pacific Growth Equities Inc.

La Jolla Pharmaceutical
Co. (LJPC) (lead)

8/7/03

$2.75

$3.37

$22.4

+23%

Vicuron Pharmaceuticals Inc. (MICU) (co-lead)

7/18/03

$13.85

$13.87

$83.1

+0%

Punk, Ziegel
& Co.

Lexicon Genetics
Inc. (LEXG)

7/24/03

$5.25

$5.15

$52.5

-2%

RBC Capital Markets

ID Biomedical Corp. (Canada; IDBE;
TSE:IDB)

5/28/03

$8.50

$12.19

$25.5

+43%

Ryan Beck &
Co.

Antigenics Inc.
(AGEN)

1/23/03

$9.92

$12.29

$34.22

+24%

S.G. Cowen Securities Corp.

BioMarin
Pharmaceuticals Inc. (BMRN)

2/21/03

$10

$8.18

$75

-18%

EPIX Medical
Inc. (EPIX) (lead)

8/7/03

$15

$16.23

$64.5

+8%

Esperion
Therapeutics Inc.
(ESPR)

8/1/03

$16

$17.16

$64

+7%

Exelixis
Inc. (EXEL)

6/20/03

$7.10

$7.74

$80.23

+9%

Onyx Pharmaceuticals
Inc. (ONXX)

7/22/03

$15.25

$16.50

$76.25

+8%

TD Securities

ID Biomedical
Corp. (Canada;
IDBE; TSE:IDB)

5/28/03

$8.50

$12.19

$25.5

+43%

UBS Securities

Antigenics Inc.
(AGEN) (lead)

1/23/03

$9.92

$12.29

$34.22

+24%

BioMarin
Pharmaceuticals Inc. (BMRN) (lead)

2/21/03

$10

$8.18

$75

-18%

ILEX Oncology Inc. (ILXO) (lead)

7/30/03

$17

$15.99

$93.5

-6%

Lexicon Genetics Inc. (LEXG) (co-lead)

7/24/03

$5.25

$5.15

$52.5

-2%

U.S. Bancorp Piper Jaffray

Esperion
Therapeutics Inc.
(ESPR)

8/1/03

$16

$17.16

$64

+7%

ILEX Oncology Inc. (ILXO)

7/30/03

$17

$15.99

$93.5

-6%

Inspire Pharmaceuticals
Inc. (ISPH) (co-lead)

3/14/03

$13.50

$15.50

$77.63

+15%

MGI Pharma Inc.
(MOGN) (co-lead)

8/8/03

$35.50

$38.23

$181.05

+8%

Wells Fargo Securities

EPIX Medical
Inc. (EPIX)

8/7/03

$15

$16.23

$64.5

+8%

ID Biomedical
Corp. (Canada; IDBE; TSE:IDB)

5/28/03

$8.50

$12.19

$25.5

+43%

WR Hambrecht + Co.

EPIX Medical
Inc. (EPIX)

8/7/03

$15

$16.23

$64.5

+8%

Notes:

* The financings in this chart are for public offerings in the U.S. only. The data were compiled primarily from BioWorld Financial Watch's monthly financing charts covering the period from Jan. 1 to Aug. 20, 2003. Those charts were published on Feb. 10, March 10, April 7, May 5, June 9, July 7 and Aug. 4, 2003. The gross proceed totals listed reflect only those shares sold by companies. They include money raised through overallotment options, when disclosed.

** Offering price per share is adjusted to reflect any post-offering splits.

All prices and totals in U.S. dollars. Unless otherwise noted, shares are traded on the Nasdaq exchange.

TSE = Toronto Stock Exchange.