Underwriter

Biotechnology Company

Date priced

Offering price per share**

8/31/00 Share Price

Offering Gross (M)**

After-Market Performance (%)

Adams, Harkness & Hill

Biopure Corp. (BPUR)

3/13

$35

$16

$87.5

-54%

Emisphere Technologies Inc. (EMIS)

3/14

$72.75

$33

$200.1

-55%

IntraBiotics Pharmaceuticals Inc. (IBPI) (IPO)

3/27

$15

$21

$112.5

+40%

Tanox Inc. (TNOX) (IPO)

4/6

$28.50

$46.50

$244.2

+63%

AtheroGenics Inc. (AGIX) (IPO)

8/9

$8

$9.875

$55.2

+23%

A.G. Edwards & Sons Inc.

AtheroGenics Inc. (AGIX) (IPO)

8/9

$8

$9.875

$55.2

+23%

Aragon Securities AB

Maxim Pharmaceuticals Inc. (MAXM)

2/22

$55

$61.187

$176.3

+11%

Bank of America Securities

SuperGen Inc. (SUPG) (Lead)

3/16

$45

$19.687

$90

-56%

Packard Bioscience Co. (PBSC) (IPO)

4/19

$9

$19.875

$111.24

+121%

EntreMed Inc. (ENMD)1

6/14

$22

$29.75

$22

+35%

Regeneration Technologies Inc. (RTIX) (Lead, IPO)

8/10

$14

$14.437

$79.8

+3%

Bank Vontobel

Centaur Pharmaceuticals Inc. (Lead)

3/30

$11.50

N/A

$21.9

N/A

Bear, Stearns & Co. Inc.

Diversa Corp. (DVSA) (Lead, IPO)

2/14

$24

$28.50

$200.1

+19%

Celera Genomics (NYSE:CRA)

3/1

$225

$108

$983.25

-52%

Bear, Stearns & Co. Inc. (Cont.)

Aviron (AVIR)

4/4

$22.50

$45

$51.75

+100%

Transgenomic Inc. (TBIO) (IPO)

7/19

$15

$21

$78.6

+40%

3-Dimensional Pharmaceuticals Inc. (DDDP) (Lead, IPO)

8/4

$15

$38.875

$86.25

+159%

Genaissance Pharmaceuticals Inc. (GNSC) (IPO)

8/2

$13

$22.312

$89.7

+72%

Chase H&Q

Gene Logic Inc. (GLGC)

1/27

$56

$24.562

$270

-56%

Sequenom Inc. (SQNM) (IPO)

2/1

$26

$30.125

$157

+16%

Genzyme Transgenics Corp. (GZTC)

2/4

$20

$37.187

$80.5

+86%

Diversa Corp. (DVSA) (IPO)

2/14

$24

$28.50

$200.1

+19%

Medarex Inc. (MEDX)

3/3

$172

$110.50

$412.7

-36%

Emisphere Technologies Inc. (EMIS) (Lead)

3/14

$72.75

$33

$200.1

-55%

Neose Technologies Inc. (NTEC) (Lead)

3/16

$32

$41

$73.6

+28%

Tularik Inc. (TLRK)

3/22

$35.125

$33.375

$100.1

-5%

InterMune Pharmaceuticals Inc. (ITMN) (IPO)

3/24

$20

$38.062

$125

+90%

Cubist Pharmaceuticals Inc. (CBST)

4/6

$33

$61.125

$94.9

85%

Ribozyme Pharmaceuticals Inc. (RZYM)

4/6

$18

$28.875

$65.2

+60%

Chase H&Q (Cont.)

Sangamo BioSciences Inc. (SGMO) (IPO)

4/6

$15

$49.25

$52.5

+228%

Packard Bioscience Co. (PBSC) (IPO)

4/19

$9

$19.875

$111.24

+121%

Paradigm Genetics Inc. (PDGM) (Lead, IPO)

5/5

$7

$16.50

$47.25

+136%

Transgenomic Inc. (TBIO) (Lead, IPO)

7/19

$15

$21

$78.6

+40%

Variagenics Inc. (VGNX) (IPO)

7/21

$14

$28.25

$80.5

+102%

Gemini Genomics plc (UK; GMNI) (IPO)

7/25

$14

$17.50

$96.6

+25%

Discovery Part- ners International Inc. (DPII) (Co-lead, IPO)

7/27

$18

$20.875

$103.5

+16%

Genencor International Inc. (GCOR) (IPO)

7/27

$18

$31.125

$144.9

+73%

Illumina Inc. (ILMN) (IPO)

7/27

$16

$44.75

$96

+180%

3-Dimensional Pharmaceuticals Inc. (DDDP) (IPO)

8/4

$15

$38.875

$86.25

+159%

Inspire Pharmaceuticals Inc. (ISPH) (IPO)

8/3

$12

$17.50

$75.9

+46%

Versicor Inc. (VERS) (IPO)

8/3

$11

$11.687

$58.2

+6%

AtheroGenics Inc. (AGIX) (Lead, IPO)

8/9

$8

$9.875

$55.2

+23%

Chase H&Q (Cont.)

Pharsight Corp. (PHST) (IPO)

8/9

$10

$9.625

$30

-4%

Esperion Therapeutics Inc. (ESPR) (IPO)

8/10

$9

$16.062

$62.1

+78%

Large Scale Biology Corp. (LSBC) (IPO)

8/10

$17

$30.906

$97.75

+82%

Telik Inc. (TELK) (IPO)

8/16

$7

$10.187

$40.25

+46%

CIBC World Markets

Enzon Inc. (ENZN)

3/21

$44.50

$60.875

$102.4

+37%

Tanox Inc. (TNOX) (Lead, IPO)

4/6

$28.50

$46.50

$244.2

+63%

Lexicon Genetics Inc. (LEXG) (IPO)

4/7

$22

$33.25

$220

+51%

Avigen Inc. (AVGN)

4/13

$26

$36.437

$29.9

+40%

Praecis Pharmaceuticals Inc. (PRCS) (IPO)

4/26

$10

$43.812

$92

+338%

ViroLogic Inc. (VLGC) (Lead, IPO)

5/2

$7

$20.375

$35

+191%

Pain Therapeutics Inc. (PTIE) (IPO)

7/13

$12

$19.25

$69

+60%

Applied Molecular Evolution Inc. (AMEV) (Lead, IPO)

7/26

$19

$32.187

$101.6

+69%

The Medicines Co. (MDCO) (IPO)

8/8

$16

$25

$110.4

+56%

Ista Pharmaceuticals Inc. (ISTA) (Lead, IPO)

8/22

$10.50

$13.187

$31.5

+26%

Credit Suisse First Boston

Maxygen Inc. (MAXY)

3/20

$97

$53.75

$145.5

-45%

Aradigm Corp. (ARDM) (Lead)

3/29

$16

$17.875

$46

+12%

Lexicon Genetics Inc. (LEXG) (Co-lead, IPO)

4/7

$22

$33.25

$220

+51%

Exelixis Pharmaceuticals Inc. (EXEL) (IPO)

4/10

$13

$45

$136

+246%

Praecis Pharmaceuticals Inc. (PRCS) (IPO)

4/26

$10

$43.812

$92

+338%

Orchid BioSciences Inc. (ORCH) (Lead, IPO)

5/4

$8

$44.937

$55.2

+462%

Variagenics Inc. (VGNX) (Lead, IPO)

7/21

$14

$28.25

$80.5

+102%

Genencor International Inc. (GCOR) (IPO)

7/27

$18

$31.125

$144.9

+73%

Dain, Rauscher Wessels

Gene Logic Inc. (GLGC)

1/27

$56

$24.56

$270

-56%

Medarex Inc. (MEDX)

3/3

$172

$110.50

$412.7

-36%

Nanogen Inc. (NGEN)

3/16

$55

$24.125

$82.5

-56%

Luminex Corp. (LMNX) (IPO)

3/30

$17

$40

$82.8

+135%

Genomic Solutions Inc. (GNSL) (IPO)

5/5

$8

$15.937

$64.4

+99%

Transgenomic Inc. (TBIO) (IPO)

7/19

$15

$21

$78.6

+40%

Deutsche Banc Alex. Brown

Sequenom Inc. (SQNM) (IPO)

2/1

$26

$30.125

$157

+16%

Diversa Corp. (DVSA) (IPO)

2/14

$24

$28.50

$200.1

+19%

Emisphere Technologies Inc. (EMIS)

3/14

$72.75

$33

$200.1

-55%

Aclara Biosciences Inc. (ACLA) (Co-lead, IPO)

3/20

$21

$39

$217.4

+86%

Angiotech Pharmaceuticals Inc. (Canada; ANPI)2 (Joint Lead)

3/22

$53.50

$45.25

$93.6

-15.4%

IntraBiotics Pharmaceuticals Inc. (IBPI) (Lead, IPO)

3/27

$15

$21

$112.5

+40%

Genaissance Pharmaceuticals Inc. (GNSC) (Lead, IPO)

8/2

$13

$22.312

$89.7

+72%

Inspire Pharmaceuticals Inc. (ISPH) (Lead, IPO)

8/3

$12

$17.50

$75.9

+46%

Lion Bioscience AG (Germany; LEON) (Joint lead, IPO)

8/10

$39.68

$87.375

$210.3

+120%

DLJ Direct Inc.

Charles River Laboratories Corp. (NYSE:CRL) (IPO)

6/23

$16

$27.437

$257.6

+71%

Pharsight Corp. (PHST) (IPO)

8/9

$10

$9.625

$30

-4%

Donaldson, Lufkin & Jenrette

Charles River Laboratories Corp. (NYSE: CRL) (Co-lead, IPO)

6/23

$16

$27.437

$257.6

+71%

Pharsight Corp. (PHST) (Lead, IPO)

8/9

$10

$9.625

$30

-4%

Fidelity Capital Markets

Versicor Inc. (VERS) (IPO)

8/3

$11

$11.687

$58.2

+6%

Rosetta Inpharmatics Inc. (RSTA) (IPO)

8/4

$14

$35.375

$115.9

+153%

Telik Inc. (TELK)

8/16

$7

$10.187

$40.25

+46%

First Colonial Securities First Union Securities Inc.

AVI BioPharma Inc. (AVII)

7/27

$7.25

$9.187

$21.75

+27%

Vical Inc. (VICL)

1/21

$36.50

$24.50

$125.9

-33%

Nanogen Inc. (NGEN)

3/16

$55

$24.125

$82.5

-56%

Texas Biotechnology Corp. (AMEX: TXB)

4/6

$12.50

$17.625

$71.875

+41%

First Security Van Kasper

The Immune Response Corp. (IMNR) (Lead)

8/8

$6

$9

$16.6

+50%

Gerard Klauer Mattison & Co.

OraPharma Inc. (OPHM) (IPO)

3/9

$18

$11.375

$82.8

-37%

Goldman, Sachs & Co.

Vical Inc. (VICL) (Lead)

1/21

$36.50

$24.50

$125.9

-33%

Celera Genomics (NYSE:CRA) (Co-lead)

3/1

$225

$108

$983.25

-52%

Maxygen Inc. (MAXY) (Lead)

3/20

$97

$53.75

$145.5

-45%

Genentech Inc. (NYSE:DNA)

3/23

$163

$190.50

$2,819.9

+17%

Exelixis Pharmaceuticals Inc. (EXEL) (Lead, IPO)

4/10

$13

$45

$136

+246%

Illumina Inc. (ILMN) (Lead, IPO)

7/27

$16

$44.75

$96

+180%

Gruntal & Co. LLC

Keryx Biopharmaceuticals Inc. (Israel; KERX)3 (IPO)

7/28

$10

$13.875

$52

+39%

The Immune Response Corp. (IMNR)

8/8

$6

$9

$16.6

+50%

I-Bankers Securities Inc.

AVI BioPharma Inc. (AVII)

7/27

$7.25

$9.1875

$21.75

+27%

ING Barings LLC

Gene Logic Inc. (GLGC) (Lead)

1/27

$56

$24.56

$270

-56%

Celera Genomics (NYSE:CRA)

3/1

$225

$108

$983.25

-52%

Cubist Pharmaceuticals Inc. (CBST)

4/6

$33

$61.125

$94.9

+85%

Ribozyme Pharmaceuticals Inc. (RZYM) (Lead)

4/6

$18

$28.875

$65.2

+60%

Sangamo BioSciences Inc. (SGMO) (IPO)

4/6

$15

$49.25

$52.5

+228%

Avigen Inc. (AVGN)

4/13

$26

$36.437

$29.9

+40%

ViroLogic Inc. (VLGC) (IPO)

5/2

$7

$20.375

$35

+191%

Charles River Laboratories Inc. (NYSE:CRL) (IPO)

6/23

$16

$27.437

$257.6

+71%

Argonaut Technologies Inc. (AGNT) (IPO)

7/24

$15

$17.375

$79.35

+16%

Arena Pharmaceuticals Inc. (ARNA) (Lead, IPO)

7/28

$18

$46.25

$124.2

+157%

Invemed Associates

Maxygen Inc. (MAXY)

3/20

$97

$53.75

$145.5

-45%

Aradigm Corp. (ARDM)

3/29

$16

$17.875

$46

+12%

Cepheid (CPHD) (IPO)

6/21

$6

$12.125

$34.5

+102%

Compugen Ltd. (Israel; CGEN) (IPO)

8/14

$10

$15.75

$57.5

+58%

J.P. Morgan & Co.

Celgene Corp. (CELG) (Co-lead)

2/10

$33.67

$74

$348.45

+120% (Split adjusted)4

Maxim Pharmaceuticals Inc. (MAXM) (Lead)

2/22

$55

$61.187

$176.3

+11%

Biopure Corp. (BPUR) (Lead)

3/13

$35

$16

$87.5

-54%

Tularik Inc. (TLRK)

3/22

$35.125

$33.375

$100.1

-5%

Genentech Inc. (NYSE:DNA) (Lead)

3/23

$163

$190.50

$2,819.9

+17%

Regeneron Pharmaceuticals Inc. (REGN)

3/29

$29.75

$35.437

$77.35

+19%

Lexicon Genetics Inc. (LEXG) (Co-lead, IPO)

4/7

$22

$33.25

$220

+51%

Paradigm Genetics Inc. (PDGM) (IPO)

5/5

$7

$16.50

$47.25

+136%

The Medicines Co. (MDCO) (Lead, IPO)

8/8

$16

$25

$110.4

+56%

Large Scale Biology Corp. (LSBC) (Lead, IPO)

8/10

$17

$30.906

$97.75

+82%

Dyax Corp. (DYAX) (Lead, IPO)

8/15

$15

$35

$69

+133%

KBC Securities

Tanox Inc. (TNOX) (IPO)

4/6

$28.50

$46.50

$244.2

+63%

Lazard Freres & Co. LLC

Cubist Pharmaceuticals Inc. (CBST)

4/6

$33

$61.125

$94.9

+85%

Rosetta Inpharmatics Inc. (RSTA) (IPO)

8/4

$14

$35.375

$115.9

+153%

Legg Mason Wood Walker

Telik Inc. (TELK) (IPO)

8/16

$7

$10.187

$40.25

+46%

Lehman Brothers Inc.

Abgenix Inc. (ABGX)

2/11

$52.50

$75.171

$724.46

+43% (Split adjusted)5

Nanogen Inc. (NGEN)

3/16

$55

$24.125

$82.5

-56%

SuperGen Inc. (SUPG)

3/16

$45

$19.69

$90

-56%

Tularik Inc. (TLRK) (Lead)

3/22

$35.125

$33.375

$100.1

-5%

Genentech Inc. (NYSE:DNA)

3/23

$163

$190.50

$2,819.9

+17%

Regeneron Pharmaceuticals Inc. (REGN)

3/29

$29.75

$35.437

$77.35

+19%

Luminex Corp. (LMNX) (IPO)

3/30

$17

$40

$82.8

+135%

Sangamo BioSciences Inc. (SGMO) (Lead, IPO)

4/6

$15

$49.25

$52.5

+228%

Corixa Corp. (CRXA)

4/7

$32

$51.187

$64

+60%

Genomic Solutions Inc. (GNSL) (IPO)

5/5

$8

$15.937

$64.4

+99%

Charles River Laboratories Corp. (NYSE:CRL) (Co-lead, IPO)

6/23

$16

$27.437

$257.6

+71%

Decode Genetics Genetics Inc. (Iceland; DCGN) (IPO)

7/21

$18

$27.625

$198.7

+53%

Discovery Partners International Inc. (DPII) (Co-lead, IPO)

7/27

$18

$20.875

$103.5

+16%

Lehman Brothers Inc. (Cont.)

Versicor Inc. (VERS) (Lead, IPO)

8/3

$11

$11.687

$58.2

+6%

Rosetta Inpharmatics Inc. (RSTA) (Lead, IPO)

8/4

$14

$35.375

$115.9

+153%

Regeneration Technologies Inc. (RTIX) (IPO)

8/10

$14

$14.437

$79.8

+3%

Dyax Corp. (DYAX) (IPO)

8/15

$15

$35

$69

+133%

Telik Inc. (TELK) (Lead, IPO)

8/16

$7

$10.187

$40.25

+46%

Merrill Lynch & Co.

Abgenix Inc. (ABGX)

2/11

$52.50

$75.171

$724.46

+43% (Split adjusted)5

Angiotech Pharmaceuticals Inc. (Canada; ANPI)2 (Joint Lead)

3/22

$53.50

$45.25

$93.6

-15.4%

Genentech Inc. (NYSE:DNA)

3/23

$163

$190.50

$2,819.9

+17%

Regeneron Pharmaceuticals Inc. (REGN) (Lead)

3/29

$29.75

$35.437

$77.35

+19%

Packard Bioscience Co. (PBSC) (Lead, IPO)

4/19

$9

$19.875

$111.24

+121%

Genencor International Inc. (GCOR) (Lead, IPO)

7/27

$18

$31.125

$144.9

+73%

Morgan Stanley Dean Witter Inc.

Celera Genomics (NYSE:CRA) (Co-lead)

3/1

$225

$108

$983.25

-52%

Medarex Inc. (MEDX) (Lead)

3/3

$172

$110.50

$412.7

-36%

Enzon Inc. (ENZN) (Lead)

3/21

$44.50

$60.875

$102.4

+37%

Aviron (AVIR) (Lead)

4/4

$22.50

$45

$51.75

+100%

Decode Genetics Inc. (Iceland; DCGN) (Lead, IPO)

7/21

$18

$27.625

$198.7

+53%

Lion Bioscience AG (Germany; LEON) (Lead, IPO)

8/10

$39.68

$87.375

$210.3

+120%

Neidiger Tucker Bruner Inc.

Entropin Inc. (OTC BB:ETOP) (Lead)

3/21

$7.25

$8.625

$16.2

+19%

Nomura International

Diacrin Inc. (DCRN)

3/22

$11.50

$9.062

$39.7

-21%

Pacific Growth Equities Inc.

Abgenix Inc. (ABGX)

2/11

$52.50

$75.171

$724.46

+43% (Split adjusted)5

Nanogen Inc. (NGEN)

3/16

$55

$24.125

$82.5

-56%

Cubist Pharmaceuticals Inc. (CBST)

4/6

$33

$61.125

$94.9

+85%

Corixa Corp. (CRXA)

4/7

$32

$51.187

$64

+60%

Paradigm Genetics Inc. (PDGM) (IPO)

5/5

$7

$16.50

$47.25

+136%

Dendreon Corp. (DNDN) (IPO)

6/16

$10

$20.50

$48.9

+105%

Charles River Laboratories Corp. (NYSE: CRL) (IPO)

6/23

$16

$27.437

$257.6

+71%

Versicor Inc. (VERS) (IPO)

8/3

$11

$11.687

$58.2

+6%

Dyax Corp. (DYAX) (IPO)

8/15

$15

$35

$69

+133%

PaineWebber Inc.

Diacrin Inc. (DCRN) (Lead)

3/22

$11.50

$9.062

$39.7

-21%

PaineWebber Inc. (Cont.)

Visible Genetics Inc. (VGIN)

3/29

$38

$47.875

$79.42

+26%

Texas Biotechnology Corp. (AMEX: TXB) (Lead)

4/6

$12.50

$17.625

$71.875

+41%

Applied Molecular Evolution Inc. (AMEV) (IPO)

7/26

$19

$32.187

$101.6

+69%

Paulson Investment Co.

AVI BioPharma Inc. (AVII) (Lead)

7/27

$7.25

$9.187

$21.75

+27%

Prudential Vector Healthcare Group

Celgene Corp. (CELG) (Co-lead)

2/10

$33.67

$74

$348.45

+120% (Split adjusted)4

Maxim Pharmaceuticals Inc. (MAXM)

2/22

$55

$61.187

$176.3

+11%

Neose Technologies Inc. (NTEC)

3/16

$32

$41

$73.6

+28%

SuperGen Inc. (SUPG)

3/16

$45

$19.687

$90

-56%

Allos Therapeutics Inc. (ALTH) (IPO)

3/28

$18

$11.75

$90

-35%

InterMune Pharmaceuticals Inc. (ITMN) (IPO)

3/24

$20

$38.062

$125

+90%

Texas Biotechnology Corp. (AMEX: TXB)

4/6

$12.50

$17.625

$71.875

+41%

Corixa Corp. (CRXA)

4/7

$32

$51.187

$64

+60%

ViroLogic Inc. (VLGC) (IPO)

5/2

$7

$20.375

$35

+191%

Dendreon Corp. (DNDN) (Lead, IPO)

6/16

$10

$20.50

$48.9

+105%

Cepheid (CPHD) (IPO)

6/21

$6

$12.125

$34.5

+102%

Arena Pharmaceuticals Inc. (ARNA) (IPO)

7/28

$18

$46.25

$124.2

+157%

Rosetta Inpharmatics Inc. (RSTA) (IPO)

8/4

$14

$35.375

$115.9

+153%

Ista Pharmaceuticals Inc. (ISTA) (IPO)

8/22

$10.50

$13.187

$31.5

+26%

Punk Ziegel & Co.

Lexicon Genetics Inc. (LEXG) (IPO)

4/7

$22

$33.25

$220

+51%

Robertson Stephens Inc.

Vical Inc. (VICL)

1/21

$36.50

$24.50

$125.9

-33%

Gene Logic Inc. (GLGC)

1/27

$56

$24.56

$270

-56%

Antigenics LLC (AGEN) (IPO)

2/3

$18

$16.875

$72.5

-6%

Abgenix Inc. (ABGX) (Lead)

2/11

$52.50

$75.171

$724.46

+43% (Split adjusted)5

OraPharma Inc. (OPHM) (Lead, IPO)

3/9

$18

$11.375

$82.8

-37%

Maxygen Inc. (MAXY)

3/20

$97

$53.75

$145.5

-45%

Genentech Inc. (NYSE:DNA)

3/23

$163

$190.50

$2,819.9

+17%

Regeneron Pharmaceuticals Inc. (REGN)

3/29

$29.75

$35.437

$77.35

+19%

Visible Genetics Inc. (VGIN) (Lead)

3/29

$38

$47.875

$79.42

+26%

Tanox Inc. (TNOX) (IPO)

4/6

$28.50

$46.50

$244.2

+63%

Cubist Pharmaceuticals Inc. (CBST) (Lead)

4/6

$33

$61.125

$94.9

+85%

Robertson Stephens Inc. (Cont.)

Orchid BioSciences Inc. (ORCH) (IPO)

5/4

$8

$44.937

$55.2

+462%

Deltagen Inc. (DGEN) (Co-lead, IPO)

8/3

$15

$28.875

$120.4

+93%

The Medicines Co. (MDCO) (Co-lead, IPO)

8/8

$16

$25

$110.4

+56%

AtheroGenics Inc. (AGIX) (IPO)

8/9

$8

$9.875

$55.2

+23%

Esperion Therapeutics Inc. (ESPR) (Lead, IPO)

8/10

$9

$16.062

$62.1

+78%

Compugen Ltd. (Israel; CGEN) (Lead, IPO)

8/14

$10

$15.75

$57.5

+58%

Robert W. Baird & Co.

Biopure Corp. (BPUR)

3/13

$35

$16

$87.5

-54%

Packard Bioscience Co. (PBSC) (IPO)

4/19

$9

$19.875

$111.24

+121%

Roth Capital Partners Inc.

Visible Genetics Inc. (VGIN)

3/29

$38

$47.875

$79.42

+26%

Keryx Biopharmaceuticals Inc. (Israel; KERX)3 (IPO) (U.S. lead)

7/28

$10

$13.875

$52

+39%

Salomon Smith Barney

Biopure Corp. (BPUR)

3/13

$35

$16

$87.5

-54%

Avigen Inc. (AVGN) (Lead)

4/13

$26

$36.437

$29.9

+40%

Praecis Pharmaceuticals Inc. (PRCS) (Lead, IPO)

4/26

$10

$43.812

$92

+338%

Orchid BioSciences Inc. (ORCH) (IPO)

5/4

$8

$44.937

$55.2

+462%

Genencor International Inc. (GCOR) (IPO)

7/27

$18

$31.125

$144.9

+73%

Genaissance Pharmaceuticals Inc. (GNSC) (IPO)

8/2

$13

$22.312

$89.7

+72%

Deltagen Inc. (DGEN) (Co-lead, IPO)

8/3

$15

$28.875

$120.4

+93%

Sanders Morris Harris

Texas Biotechnology Corp. (AMEX: TXB)

4/6

$12.50

$17.625

$71.875

+41%

S.G. Cowen Securities Corp.

Vical Inc. (VICL)

1/21

$36.50

$24.50

$125.9

-33%

Celera Genomics (NYSE:CRA)

3/1

$225

$108

$983.25

-52%

Enzon Inc. (ENZN)

3/21

$44.50

$60.875

$102.4

+37%

IntraBiotics Pharmaceuticals Inc. (IBPI) (IPO)

3/27

$15

$21

$112.5

+40%

Allos Therapeutics Inc. (ALTH) (Lead, IPO)

3/28

$18

$11.75

$90

-35%

Aradigm Corp. (ARDM)

3/29

$16

$17.875

$46

+12%

Exelixis Pharmaceuticals Inc. (EXEL) (IPO)

4/10

$13

$45

$136

+246%

Dendreon Corp. (DNDN) (IPO)

6/16

$10

$20.50

$48.9

+105%

Charles River Laboratories Corp. (NYSE: CRL) (IPO)

6/23

$16

$27.437

$257.6

+71%

Variagenics Inc. (VGNX) (IPO)

7/21

$14

$28.25

$80.5

+102%

Argonaut Technologies Inc. (AGNT) (IPO)

7/24

$15

$17.375

$79.35

+16%

Gemini Genomics plc (UK:GMNI) (Lead, IPO)

7/25

$14

$17.50

$96.6

+25%

Applied Molecular Evolution Inc. (AMEV) (IPO)

7/26

$19

$32.187

$101.6

+69%

Illumina Inc. (ILMN) (IPO)

7/27

$16

$44.75

$96

+180%

Arena Pharmaceuticals Inc. (ARNA)

7/28

$18

$46.25

$124.2

+157%

Stephens Inc.

Paradigm Genetics Inc. (PDGM) (IPO)

5/5

$7

$16.50

$47.25

+136%

Regeneration Technologies Inc. (RTIX) (IPO)

8/10

$14

$14.437

$79.8

+3%

Thomas Weisel Partners LLC

Tularik Inc. (TLRK)

3/22

$35.125

$33.375

$100.1

-5%

Packard Bioscience Co. (PBSC) (IPO)

4/19

$9

$19.875

$111.24

+121%

Pain Therapeutics Inc. (PTIE) (Lead, IPO)

7/13

$12

$19.25

$69

+60%

Ista Pharmaceuticals Inc. (ISTA) (IPO)

8/22

$10.50

$13.187

$31.5

+26%

Tucker Anthony Cleary Gull/ Tucker Anthony Inc.

Genome Therapeutics Corp. (GENE)6

7/10

$31.01

$25.125

$46.5

-19%

Pain Therapeutics Inc. (PTIE) (IPO)

7/13

$12

$19.25

$69

+60%

UBS Warburg/ Warburg Dillon Read LLC

Sequenom Inc. (SQNM) (Lead, IPO)

2/1

$26

$30.125

$157

+16%

Genzyme Transgenics Corp. (GZTC) (Lead)

2/4

$20

$37.187

$80.5

+86%

Medarex Inc. (MEDX)

3/3

$172

$110.50

$412.7

-36%

Emisphere Technologies Inc. (EMIS)

3/14

$72.75

$33

$200.1

-55%

Nanogen Inc. (NGEN) (Lead)

3/16

$55

$24.125

$82.5

-56%

Neose Technologies Inc. (NTEC)

3/16

$32

$41

$73.6

+28%

SuperGen Inc. (SUPG)

3/16

$45

$19.687

$90

-56%

Aclara Biosciences Inc. (ACLA) (Co-lead, IPO)

3/20

$21

$39

$217.4

+86%

Tularik Inc. (TLRK)

3/22

$35.125

$33.375

$100.1

-5%

Genentech Inc. (NYSE:DNA)

3/23

$163

$190.50

$2,819.9

+17%

InterMune Pharmaceuticals Inc. (ITMN) (Lead, IPO)

3/24

$20

$38.062

$125

+90%

IntraBiotics Pharmaceuticals Inc. (IBPI) (IPO)

3/27

$15

$21

$112.5

+40%

Aradigm Corp. (ARDM)

3/29

$16

$17.875

$46

+12%

Visible Genetics Inc. (VGIN)

3/29

$38

$47.875

$79.42

+26%

Luminex Corp. (LMNX) (Lead, IPO)

3/30

$17

$40

$82.8

+135%

Tanox Inc. (TNOX) (IPO)

4/6

$28.50

$46.50

$244.2

+63%

Corixa Corp. (CRXA) (Lead)

4/7

$32

$51.187

$64

+60%

Genomic Solutions Inc. (GNSL) (Lead, IPO)

5/5

$8

$15.937

$64.4

+99%

Cepheid (CPHD) (Lead, IPO)

6/21

$6

$12.125

$34.5

+102%

Argonaut Technologies Inc. (AGNT) (Lead, IPO)

7/24

$15

$17.375

$79.35

+16%

Discovery Partners International Inc. (DPII) (IPO)

7/27

$18

$20.875

$103.5

+16%

Genaissance Pharmaceuticals Inc. (GNSC) (IPO)

8/2

$13

$22.312

$89.7

+72%

Versicor Inc. (VERS) (IPO)

8/3

$11

$11.687

$58.2

+6%

Telik Inc. (TELK) (IPO)

8/16

$7

$10.187

$40.25

+46%

U.S. Bancorp Piper Jaffray

Antigenics LLC (AGEN) (Lead, IPO)

2/3

$18

$16.875

$72.5

-6%

Celgene Corp. (CELG)

2/10

$33.67

$74

$348.45

+120% (Split adjusted)4

OraPharma Inc. (OPHM) (IPO)

3/9

$18

$11.375

$82.8

-37%

Neose Technologies Inc. (NTEC)

3/16

$32

$41

$73.6

+28%

Aclara Biosciences Inc. (ACLA) (IPO)

3/20

$21

$39

$217.4

+86%

Angiotech Pharmaceuticals Inc. (Canada; ANPI)2

3/22

$53.50

$45.25

$93.6

-15.4%

Allos Therapeutics Inc. (ALTH) (IPO)

3/28

$18

$11.75

$90

-35%

Aviron (AVIR)

4/4

$22.50

$45

$51.75

+100%

Deltagen Inc. (DGEN) (IPO)

8/3

$15

$28.875

$120.4

+93%

Inspire Pharmaceuticals Inc. (ISPH) (IPO)

8/3

$12

$17.50

$75.9

+46%

3-Dimensional Pharmaceuticals Inc. (DDDP) (IPO)

8/4

$15

$38.875

$86.25

+159%

Esperion Therapeutics Inc. (ESPR) (IPO)

8/10

$9

$16.062

$62.1

+78%

Compugen Ltd. (Israel; CGEN)

8/14

$10

$15.75

$57.5

+58%

Westport Resources Investment Services Inc.

Entropin Inc. (OTC BB:ETOP)

3/21

$7.25

$8.625

$16.2

+19%

William Blair & Co.

Sangamo Biosciences- Inc. (SGMO) (IPO)

4/6

$15

$49.25

$52.5

+228%

Large Scale Biology Corp. (LSBC) (IPO)

8/10

$17

$30.906

$97.75

+82%

Wit SoundView

Pharsight Corp. (PHST) (IPO)

8/9

$10

$9.625

$30

-4%

Notes:

* The financings in this chart are for U.S. public offerings only. The data were compiled primarily from BioWorld Financial Watch's monthly financing charts covering the period from Jan. 1 to Aug. 31, 2000. Those charts were published on Feb. 21, March 6, April 10, May 15, June 5, July 10, Aug. 7 and Sept. 11. The gross proceeds totals listed reflect shares sold by selling stockholders, in addition to financing raised for the companies.

** All prices in U.S. dollars. Offering price per share is adjusted to reflect any post-offering splits.

1 EntreMed's public offering was part of a shelf registration filed 1/14/00.

2 The U.S. underwriters for Angiotech's offering are included in this chart. The underwriting syndicate also included Loewen, Ondaatje, McCutcheon Ltd. and Yorkton Securities Inc. in Canada.

3 The U.S. underwriters for Keryx's offering are included in this chart. WestLB Panmure Ltd. led the offering outside the U.S.

4 Celgene shares split 3-for-1 on 4/17/00.

5 Abgenix shares split 2-for-1 on 4/7/00 and 2-for-1 on 7/10/00.

6 Genome Therapeutics' offering was part of a shelf registration. Tuker Anthony acted as placement agent.

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