I. COMPLETED MERGERS AND ACQUISITIONS

Company Acquired*
(Country; Symbol)

Acquired By Or Merged With* (Country; Symbol)

Date Announced

Date Completed

Value (M)**

Terms/Details


3-Dimensional Pharmaceuticals
Inc.
(DDDP)

Johnson & Johnson

1/16/03

3/28/03

$88

J&J acquired 3-Dimensional, paying cash for each of its 22.5M outstanding shares, for a total of about $88M

4C Biotech*
(Belgium)

Henogen SA* (Belgium)

5/12/03

5/12/03

ND

Henogen acquired 4C Biotech for an undisclosed amount

Biosearch Italia
(Italy; Nuovo Mercato:BIO)

Versicor Inc. (VERS)

7/31/02

3/3/03

$260.7

Versicor acquired Biosearch for $260.7M in a stock swap; stock of the merged company will trade on Nasdaq under the symbol “VERS“ and on the Nuovo Mercato under the symbol “VER“

Callisto
Pharmaceuticals
Inc.
(OTC BB:CLSP)
and Synergy
Pharmaceuticals
Inc.*

Webtronics Inc. (OTC BB:WBTN)

5/1/03

5/1/03

ND

Webtronics issued about 17.3M common shares in exchange for Callisto's stock, and about 4.4M shares for Synergy's stock; both are now wholly owned subsidiaries of Webtronics, which now trades under Callisto on the Over-the-Counter Bulletin Board

Chemicon
International
Inc.*

Serologicals Corp. (SERO)

2/11/03

4/8/03

$95

Serologicals acquired Chemicon and certain affiliated companies for $95M in cash, less Chemicon's outstanding debt

Chienna BV*
(subsidiary of IsoTis
SA; Switzerland)

OctoPlus BV* (the Netherlands)

2/26/03***

5/16/03

ND

OctoPlus purchased Chienna for an undisclosed amount

DNA
Sciences
Inc.*

Genaissance Pharmaceuticals Inc. (GNSC)

4/1/03

5/15/03

$1.35

Genaissance acquired DNA Sciences for about $1.3M in cash

Eos
Biotechnology
Inc.*

Protein Design Labs Inc. (PDLI)

2/4/03

4/7/03

$37.5

Protein Design Labs purchased Eos, issuing about 4.3M shares; the deal was originally valued at $37.5M

ExperTech
Associates Inc.*

Boston Healthcare Associates Inc.*

5/2/03

5/02/03

ND

Boston Healthcare acquired ExperTech for an undisclosed amount

GeneFormatics
Inc.*

Structural Bioinformatics Inc.*

1/6/03

5/19/03

ND

The companies merged, with SBI shareholders holding the majority of the new company called Cengent Therapeutics

Genomic
Instrumentation
Services Inc.*

Genomic Solutions Inc. (subsidiary of Harvard Bioscience Inc.; HBIO)

3/3/03

3/13/03

$8.3

Genomic Solutions acquired all of the assets of Genomic Instrumentation, doing business as GeneMachines, for about $8.3M in cash and the assumption of certain specified liabilities

HA North American
Sales AB
(unit of
Q-Med Group; Sweden; QMED)

Medicis Pharmaceutical Corp.
(NYSE:MRX)

3/10/03

3/10/03

$160

Medicis acquired all outstanding shares of HA North American Sales for about $160M, with $58.2M paid upon closing and the rest paid upon the achievement of certain milestones

Interfacial
Dynamics
Corp.*

Molecular Probes Inc.*

4/16/03

4/16/03

ND

Molecular Probes acquired Interfacial Dynamics for an undisclosed amount

MemRx Corp.*

Sagres Discovery Inc.*

4/2/03

4/2/03

ND

Sagres acquired MemRx for an undisclosed amount

Technical and analytical
services group of NaPro BioTherapeutics Inc. (NPRO)

ChromaDex Inc.*

4/9/03

4/9/03

ND

ChromaDex bought the technical and analytical services group of NaPro for an undisclosed amount

Oncotherapeutics
Inc.*

IBEX Technologies Inc. (Canada; TSE:IBT)

5/7/03

5/8/03

$0.73

IBEX acquired Oncotherapeutics in a deal valued at $730,986 plus milestone payments

Procyon Biopharma
Inc.
(Canada; TSE:PBP)

-

3/28/03

4/21/03

C$2.94 (US$1.99)

Procyon purchased Pharmacor for about US$1.99M in an all-stock deal; the transaction was dependent upon a concurrent C$3.25M financing for Procyon by Pharmacor's current investors

PPL Therapeutics
Inc.
(division of PPL Therapeutics plc; UK; LSE:PTH)

Regenecor Holdings Inc.*

4/10/03

4/10/03

$1

Regenecor purchased PPL's xenograft, stem cell and polyclonal antibody research division for $1M

RiboTargets
Holdings plc*

British Biotech plc (UK; BBIOY; LSE:BBG)

3/21/03

4/22/03

ND

British Biotech and RiboTargets merged, giving the combined company a market capitalization of £52M (US$81.3M); British Biotech shareholders own 50.01% and RiboTargets shareholders own 49.99%

Scios Inc.
(SCIO)

Johnson & Johnson

2/10/03

4/29/03

$2.4B

Johnson & Johnson acquired Scios for $2.4B in cash, or $45 for each outstanding share

Semaia BV*
(the Netherlands)

Hybrigenics SA* (France)

4/29/03

4/29/03

ND

Hybrigenics acquired Semaia in an all-share transaction for an undisclosed amount

Synaptic
Pharmaceutical
Corp.
(SNAP)

H. Lundbeck A/S (Denmark)

11/21/02

3/6/03

$121

The companies merged in a deal worth about $121M, or $6.50 in cash per share for Synaptic; Synaptic's shareholders approved the merger in February

TherImmune
Research Corp.*

Gene Logic Inc. (GLGC)

2/25/03

4/2/03

$52

Gene Logic acquired TherImmune, paying about $31M in cash, and issuing to TherImmune shareholders new Gene Logic common shares worth about $21M

II. PENDING MERGERS AND ACQUISITIONS

Company To
Be Acquired*
(Country; Symbol)

Acquiring Company* (Country; Symbol)

Date Announced

Expected Completion

Value (M)**

Terms/Details


Advanced
Tobacco
Products
Inc.
(OTC BB:AVTH)

IVAX Corp. (AMEX:IVX)

5/27/03

ND

ND

Companies will merge; ATP shareholders would receive the number of outstanding shares of IVAX stock determined by multiplying the number of outstanding shares of ATP stock by 54 cents and dividing the result by the average closing price of IVAX's stock

Ancile
Pharmaceuticals
Inc.*

Mera Pharmaceuticals Inc. (OTC BB:MRPI)

1/10/03

ND

ND

Mera plans to acquire Ancile by paying its shareholders with shares of Mera common stock equal to about 35% of Mera in exchange for their Ancile shares

Anosys Inc.*

Epimmune Inc. (EPMN)

2/13/03

ND

$13.5

Epimmune plans to acquire Anosys in an all stock transaction; Epimmune will issue about 8.44M shares, valuing the deal at $13.5M; Epimmune will own 65% of the new company

Antex Biologics Inc. (AMEX:ANX)

BioPort Corp.*

3/17/03

ND

$3.6

BioPort plans to acquire all of Antex's assets for between $3M and $3.6M

Bruker Daltonics
Inc. (BDAL)

Bruker AXS Inc. (BAXS)

4/7/03

ND

$103.6

Companies plan to merge, with Bruker AXS issuing one common share for 0.63 shares of Bruker Daltonics' common stock; the com- bined company will be named Bruker Biosciences Corp.

Cell Pathways
Inc.
(CLPA)

OSI Pharmaceuticals Inc. (OSIP)

2/10/03

2Q:03

$32

OSI plans to acquire Cell Pathways in an all-stock deal valued at $32M; OSI will exchange 0.0567 shares of OSI for every share of Cell Pathways

Ciro International
Inc.
(Pink Sheets: CIRR)

Advanced Bio/Chem Inc.*

3/28/03

ND

ND

Advanced Bio/Chem plans to acquire Ciro in a reverse merger

Corvas International
Inc.
(CVAS)

Dendreon Corp. (DNDN)

2/25/03

2Q:03

$72.9

Dendreon plans to acquire Corvas in a $72.9M stock transaction; each Corvas common share will be exchanged for 0.45 shares of Dendreon common stock; Dendreon would own about 68.6% of the com- bined company, with Corvas shareholders holding the rest; Dendreon expects to issue about 12.4M shares

Cureon A/S*
(Denmark)

Pantheco A/S* (Denmark)

3/12/02***

ND

ND

Cureon and Pantheco plan to merge in a stock-based transaction

Enzon
Pharmaceuticals
Inc. (ENZN)

NPS Pharmaceuticals Inc. (NPSP)

2/20/03

2Q:03

$750

NPS is offering about $750M in stock for Enzon; NPS shareholders will receive a full share of the combined entity's common stock for each NPS share owned; Enzon shareholders will receive 0.7264 shares for each Enzon share; the combine company is valued at $1.6B

Oligonucleotide operations
of Epoch Biosciences
Inc.
(EBIO)

Eurogentec SA* (Belgium)

5/28/03

2Q:03

$1.4

Eurogentec plans to buy the assets and customer base of Epoch's specialty oligonucleotide business for $1.4M in cash

GenomeVision business
of Genome
Therapeutics
Corp.
(GENE)

Agencourt Bioscience Corp.*

2/25/03

ND

ND

Agencourt will acquire the genomic sequencing service business of Genome Therapeutics for an undisclosed amount; Genome Therapeutics will receive a percentage of revenues for two years from commercial and government customers transferred to Agencourt

GenVec Inc.
(GNVC)

Diacrin Inc. (DCRN)

4/15/03

3Q:03

$40.4

The companies plan to merge with each share of Diacrin being exchanged for 1.5292 shares of GenVec in a tax-free deal; GenVec shareholders would have 45.5% of the combined entity and Diacrin holders would have 54.5%

GlycoDesign
Inc.
(Canada; TSE:GD)

Inflazyme Pharmaceuticals Ltd. (Canada; TSE:IZP)

4/9/03

2Q:03

C$12.8 (US$8.7)

Inflazyme plans to issue 22M shares to acquire the outstanding stock of GlycoDesign, making the deal worth US$8.7M

GTB
GenThera
peutika
Berlin-
Buch GmbH (subsidiary of Schering
AG; Germany)

Bavarian Nordic A/S (Denmark; CSE:BAVA)

5/13/03

ND

ND

Bavarian Nordic plans to acquire GTB GenTherapeutika for an undisclosed amount

Kiadis BV* (the Netherlands)

Biofrontera Pharmaceuticals GmbH*(Germany)

2/18/03

ND

ND

Biofrontera and Kiadis plan to merge into a single entity called Aliga Pharmaceuticals AG, which will be based in Germany with subsidiaries in Germany and the Netherlands

Oxford
GlycoSciences
plc
(UK; OGSI; LSE:OGS)

Celltech plc
(UK; NYSE:CLL)

4/11/03

ND

£101.4 (US$173)

Celltech made a bid to acquire Oxford GlycoSciences; the bid is worth US$173M

Plexus Vaccine
Inc.
(PLXS)

SIGA Technologies (SIGA)

4/1/03

ND

ND

SIGA plans to buy Plexus Vaccine for an undisclosed number of shares

PowderJect Pharmaceuticals plc (UK; LSE:PJP)

Chiron Corp. (CHIR)

5/19/03

ND

£542 (US$878)

Chiron plans to acquire PowderJect by paying cash for all of the outstanding shares, valuing the deal at $878M

Quintiles
Transnational
Corp. (QTRN)

Pharma Services Holding Inc.*

4/11/03

ND

$1.7B

Pharma Services will acquire Quintiles, paying its shareholders $14.50 per share in cash; the value is based on 118.2M shares outstanding

Salix
Pharmaceuticals
Ltd.
(SLXP)

Axcan Pharma
Inc. (Canada; AXCA)

4/10/03

2Q:03

$224.7

Axcan increased its cash tender offer for all of Salix's outstanding shares to $10.50 per share from $8.75 per share; the offer was raised in May after the board rejected the prior offer; later in May, the board rejected the revised offer

III. TERMINATED MERGERS AND ACQUISITIONS

Company To Be Acquired* (Country; Symbol)

Acquiring Company* (Country; Symbol)

Date Announced

Termination Date

Value (M)**

Terms/Details


Lavipharm
Corp.*

Zonagen Inc. (ZONA)

10/31/02

3/28/03

$9.6

Zonagen was to issue Lavipharm about 7.7M shares at the close of the proposed merger, plus it was to issue 2M shares to Lavipharm to cover $10M in debt owed by Lavipharm; the merger agreement was terminated

Oxford GlycoSciences plc (UK; OGSI; LSE:OGS)

Cambridge Antibody Technology Groupplc (UK; CATG; LSE:CAT)

1/23/03

ND

£109.6 (US$177)

Cambridge Antibody Technology planned to acquire Oxford GlycoSciences in an all-share deal initially valued at £109.6M (US$177M); the deal did not go through after CAT's share price dropped significantly

SIRTeX Medical Ltd. (Australia; ASX:SRX)

Cephalon Australia Pty. Ltd. (subsidiary of Cephalon Inc.; CEPH)

2/11/03

5/28/03

$161

Cephalon Australia planned to buy SIRTeX for A$4.85 (US$2.85) cash for each ordinary share; the acceptance period of the bid expired in May with only 88% of SIRTeX shares tendered; the bid was contingent upon at least 90% of SIRTeX shares being tendered


Notes:

# This chart is intended to include not only mergers and acquisitions of entire businesses, but also of divisions or subsidiaries of those businesses, where appropriate. It does not include acquisitions of single products or of manufacturing facilities and plants.

For those deals that are pending, and for which the acquiring company is issuing stock, the value of the transaction has been calculated based on the closing price on the day prior to the first announcement. For those deals that have been completed, and for which the acquiring company is issuing stock, the final value has been calculated based on the closing price on the date that the merger's completion was announced.

* Private companies are indicated with an asterisk.

** Conversions of non-U.S. currencies are calculated using the rate on the date the transaction closed, or for pending deals, on the date it was announced.

*** Denotes the date the item ran in BioWorld International.

ND = Not disclosed, reported and/or available.

Unless otherwise indicated, shares are traded on Nasdaq.

ASX = Australian Stock Exchange; AMEX = American Stock Exchange; CSE = Copenhagen Stock Exchange; LSE = London Stock Exchange; NYSE = New York Stock Exchange; OTC BB = Over-the-Counter Bulletin Board; TSE = Toronto Stock Exchange.