April 25 (EPO), April 19 (WO)

Amrad WO 01/27157

NR6-cytokine complex

Richmond, Australia

Biologically active complex of NR6 and cardiotropin-like cytokine; for identifying modulators.

Arkansas, Univ. of WO 01/27257

Tumor antigen-derived gene

Little Rock, Ark

Tumor antigen-derived gene that encodes an extracellular serine protease, encoded protein; for tumor therapeutics.

Boehringer Ingelheim Intl. EP 1 094 317

Bone disorder treatment

Ingelheim, Germany

Identifying modulators of Fra-1 expression; for treating diseases of bone metabolism.

Boehringer Ingelheim Intl. WO 01/27302

CELO virus for vaccines

Ingelheim, Germany

Recombinant replication-defective CELO virus, CELO virus DNA; for gene therapy, vaccines, and protein production.

Bremen Univ. WO 01/27265

Thyroid cancer-associated genes

Bremen, Germany

Nucleic acid sequences associated with thyroid hyperplasia and cancer, encoded zinc finger protein.

California, Univ. of WO 01/27256

Prostate-targeted gene expression

Los Angeles, Calif.

Chimeric transcriptional regulatory elements; for increasing prostate-targeted gene expression.

Cambridge Antibody Technol. WO 01/27279

Adipocyte antibodies

Royston, UK

Human anti-adipocyte antibodies; for identifying antigens and developing diagnostics and therapeutics.

CDD Holdings WO 01/27292

Growth factor ligand screen

Cambridge, UK

Cysteine knot growth factors displayed on viral particles; for screening drugs that will bind these growth factors.

Chiron WO 01/27269

Neuroblastoma cell gene

Siena, Italy

Vimentin-associated protein found in neuroblastoma cells, encoding gene, antibodies; for diagnostics and therapeutics.

Chugai Res. Inst. Molec. Med. WO 01/27270

Early hematopoiesis gene

Ibaraki, Japan

Gene involved in early hematopoiesis, encoded protein; for developing blood disease therapeutics.

Corixa WO 01/27276

Breast tumor proteins

Seattle

Breast tumor proteins, fragments, encoding gene sequences; for diagnostics and therapeutics.

CuraGen WO 01/27156

IL-2 like protein

New Haven, Conn.

Interleukin-2 like protein, encoding gene sequences, variants, fragments, antibodies; for therapeutics.

CuraGen WO 01/27277

MBSPX proteins

New Haven, Conn.

MBSPX proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.

CuraGen WO 01/27290

Carboxypeptidase-like protein

New Haven, Conn.

Aortic carboxypeptidase-like protein, encoding gene sequences; for developing diagnostics and therapeutics.

Dendreon WO 01/27245

Isolating dendritic cells

Seattle

Isolation and characterization of dendritic cells isolated from human peripheral blood mononuclear cells.

DNAVec Res. EP 1 094 115

Nerve cell gene therapy

Ibaraki, Japan

Negative strand RNA virus vector for transferring genes into nerve cells during gene therapy.

Eli Lilly EP 1 094 118

Recombinant protein production

Indianapolis

Conversion of precursor proteins using a Dictyostelium dipeptydlaminopeptidase; for recombinant protein production.

Elitra Pharma WO 01/27322

Chitobiase reporter

San Diego

Reporter gene constructs encoding the cytoplasmic form of chitobiase; for use as a reporter enzyme.

Epigenomics WO 01/27317

Measuring methylation patterns

Berlin

Detecting 5-position methylation changes in genes and single nucleotide polymorphisms; for genome analysis.

Finnish Immunotech WO 01/27249

DNA methyltransferase

Tampere, Finland

DNA methyltransferase gene, encoded protein; for diagnosing and treating hereditary diseases and cancer.

Genzyme Transgenics WO 01/26455

Transgenic multivalent polypeptides

Framingham, Mass.

Transgenic expression of multivalent binding polypeptides for use in purifying target molecules.

Georgia, Univ. of WO 01/27258

High yield protein expression

Athens, Ga.

Increasing pyruvate carboxylase activity in protein expression systems; for high yields.

Hamilton, Brook, Smith & Reynolds WO 0127272

Oculomedin in glaucoma

Lexington, Mass.

Oculomedin, encoding gene sequences; for diagnosing and developing therapeutics for glaucoma.

Hammers, H.-J. EP 1 094 316

Detecting replicating cells

McLean, Va.

Detecting replicating cells by incorporating halogenated pyrimidines into them and measuring them with antibodies.

Hyseq WO 01/27278

Immunoglobulin superfamily protein

Sunnyvale, Calif.

Immunoglobulin superfamily protein, encoding gene sequences; for developing diagnostics and therapeutics.

Icos WO 01/27288

Cell cycle checkpoint proteins

Bothell, Wash.

Atr-2 cell cycle checkpoint polypeptides, encoding gene sequences; for identifying modulators.

Immunex WO 01/27299

Recombinant protein expression vector

Seattle

Vectors having an internal polyadenylation signal inserted between the therapeutic protein gene and the reporter gene.

Isis Innovation WO 01/27152

Altering protein aggregation

Summertown, UK

Methods for producing proteins having altered aggregation properties by analyzing their amino acid sequences.

Isis Innovation WO 01/27267

Immunoregulatory therapeutics

Summertown, UK

Genes differentially expressed in specific T cells, encoded proteins; for developing immunoregulatory therapeutics.

Japan Sci. & Technol. WO 01/27271

C-type lectin

Saitama, Japan

C-type lectin, encoding gene sequences; for activating macrophages and regulating the immune system.

Japanese Agency of Ind. Sci. & Technol. WO 01/27263

Aptamers for HIV therapeutics

Tokyo

Aptamers that bind and modulate the activity of Tat protein; for developing HIV therapeutics.

Johns Hopkins Univ. WO 01/27324

Genetic defect diagnosis

Baltimore

Conversion of diploid cells to haploid ones using somatic cell fusion; for unambiguous genetic defect diagnosis.

Kim, J.W. WO 01/27149

Cervical cancer proto-oncogene

Seoul, S. Korea

Human cervical cancer 1 proto-oncogene, encoded protein, fragments, antisense; for diagnostics and therapeutics.

Kosan Biosciences WO 01/27284

Megalomicin antibacterials

Hayward, Calif.

Recombinant nucleic acid sequences encoding megalomicin polyketide synthase; for developing antibacterials.

Krebs Res. Ctr. WO 01/27255

T cell lymphoma genes

Heidelberg, Germany

Cutaneous T cell lymphoma-associated genes, encoded proteins; for cancer diagnosis and therapeutics.

Krebs Res. Ctr. WO 01/27295

Bacteria expressing tumor antigens

Heidelberg, Germany

Recombinant attenuated Listeria strains expressing human tumor antigens; for cancer immunotherapy.

Kyowa Hakko Kogyo WO 01/27286

Ubiquinone 10 production

Tokyo

Methods for producing ubiquinone 10 in microorganisms having lowered geranylgeranyl transferase activity.

Lausanne, Univ. of WO 01/27268

JNK signal pathway modulation

Lausanne, Switzerland

Cell permeable peptide inhibitors that bind to JNK proteins; for inhibiting the JNK-mediated signal transduction pathway.

Leadd EP 1 094 110

Apoptosis inducer

Leiden, Netherlands

Apoptosis-inducing proteinaceous substance; for effects when p53 is non-functional and Bcl-2 is overexpressed.

Ledbetter, J.A., et al. WO 01/26608

AIDS DNA vaccines

Shoreline, Wash.

DNA vaccines encoding an HIV-1 antigen linked to a domain that binds CD40; for AIDS therapy.

Lexicon Genetics WO 01/27273

Galanin family proteins

The Woodlands, Texas

Human galanin family proteins, encoding gene sequences; for developing diagnostics and therapeutics.

Lexicon Genetics WO 01/27274

Human LDL receptor family proteins

The Woodlands, Texas

Human LDL receptor family proteins, encoding gene sequences; for developing diagnostics and therapeutics.

Lexicon Genetics WO 01/27275

G protein coupled receptor family proteins

The Woodlands, Texas

Human G protein coupled membrane receptor family proteins, encoding genes; for developing diagnostics and therapeutics.

Maryland, Univ. Biotech Inst. WO 01/27294

Viral infection inhibition

Baltimore

Virus coat protein-virus receptor chimeras; for inhibiting viral infection.

Massachusetts, Univ. of WO 01/26454

Nuclear transplantation

Amherst, Mass.

Synchronizing somatic cells in G1; for nuclear transfer using mitotic doublet cells.

Maxygen EP 1 094 108

Antibodies by mutagenesis

Redwood City, Calif.

DNA mutagenesis by random fragmentation and reassembly of sequences encoding antibody chains; for antibody production.

Medeva Europe WO 01/27281

Designing immunogens

Leatherhead, UK

Designing immunogens by modifying amino acid sequences and measuring T helper cell responses.

Merck WO 01/27246

Potassium channel subunit

Rahway, N.J.

Human potassium channel subunit, encoding gene sequences; for identifying modulators.

Miguel Hernandez Univ. WO 01/27266

Differentiation-associated genes

Elche, Spain

Identifying genes expressed in differentiated cells using transcription factor complex assays.

Mochida Pharma EP 1 094 077

Thrombomodulin-like peptide

Tokyo

Sugar chain-bonded thrombomodulin-like peptide; for blood coagulation diagnostics and therapeutics.

NIH (Natl. Inst. Hlth.) WO 01/27334

Hypertension genotyping

Bethesda, Md.

Methods and compositions for correlating CCR5 expression with essential hypertension.

Necker Inst. WO 01/27250

Immunoglobulin gene mutation assay

Paris

Mutase active DNA polymerase, encoded protein; for finding mutations in immunoglobulin genes.

Neutec Pharma WO 01/27280

Burkholderia antimicrobials

Manchester, UK

Antimicrobial compositions which affect Burkholderia cepacia, diagnostic tests.

NGK Insulators EP 1 094 119, 1 094 120 & 1 094 318

DNA chip production

Nagoya, Japan

Methods for making DNA chips using a poly-L-lysine layer and PCR-amplified DNA.

Nihon Univ. WO 01/27264

Platelet growth factor ribozymes

Tokyo

Ribozymes targeted to a growth factor originating in human platelets.

North Carolina, Univ. of WO 01/27303

Hemophilia gene therapy

Chapel Hill, N.C.

Adeno-associated virus vectors encoding Factor VIII; for treating hemophilia.

Ortho-McNeil Pharma WO 01/26453

ABC transporter transgenics

Raritan, N.J.

ATP-binding cassette transporter modified transgenic mice, cell lines; for identifying modulators.

Pantheco WO 01/27261 & 27262

Antimicrobial-targeted genes

Copenhagen, Denmark

Conjugates of cationic peptides and peptide nucleic acids; for finding genes to target with antimicrobials.

Pasteur Inst. WO 01/27291

HIV T cell response

Paris

Design of polyepitopic constructs for the induction of HLA-A2.1 restricted HIV-1 specific cytotoxic T cell responses.

Pasteur Inst. WO 01/27300 & 27304

HIV immunotherapy vectors

Paris

Lentiviral vectors encoding transgenes that induce cytotoxic T cell responses triplex DNA; for HIV immunotherapy.

Pennsylvania, Univ. of WO 01/27243

Neuropsychiatric disorder gene

Philadelphia

Gene sequences associated with neuropsychiatric disorders, encoded protein; for diagnostics and therapeutics.

PE Applied Biosystems WO 01/27326

SNP identification

Foster City, Calif.

Template-dependent ligation with protein nucleic acid-DNA chimeric probes; for identifying SNPs.

Protogene Labs WO 01/27327

Sequence variation detection

Menlo Park, Calif.

Performing large numbers of amplification reactions using array assemblies; for detecting sequence variation.

Quip Technol. WO 01/27318

Reverse transcriptase assay

Glasgow, UK

Detection of reverse transcriptase activity from endogenous pig retroviruses in biological samples.

Res. & Develop. Inst. WO 01/27287

Telomerase reverse transcriptase genes

Bozeman, Mont.

Telomerase reverse transcriptase genes, encoded proteins; for developing therapeutics.

Rockefeller Univ. WO 01/27301

Expressing viral antigens

New York

Rapid generation of baculovirus-based expression vectors to express therapeutic viral antigens in silkworm larvae.

Schwarzmann, F. WO 01/27254

Autoimmunity therapy

Regensburg, Germany

Gene transfer vectors that encode targeting and apoptosis-inducing genes; for treating autoimmunity.

Shanghai Bio Door Gene Technol. WO 01/27148

Glutamine-rich factor

Shanghai, China

Homo-glutamine-rich factor 56, encoding gene, recombinant production methods, antibodies; for therapeutics.

Shanghai Bio Door Gene Technol. WO 01/27151

Zinc finger protein

Shanghai, China

Human zinc finger Kruppel family member, encoding gene, production methods, antibodies; for therapeutics.

Shanghai Bio Door Gene Technol. WO 01/27283

Reverse transcriptase-like protein

Shanghai, China

Human reverse transcriptase-like protein, encoding gene, production methods, modulators; for treating viral cancers.

Shanghai Bio Door Gene Technol. WO 01/27285

DPB methyltransferase

Shanghai, China

Human DPB methyltransferase, encoding gene, modulators; for developing immunological disease therapeutics.

Shionogi WO 01/27310

Adrenomedulin precursor production

Osaka, Japan

Production of large amounts of adrenomedulin precursor using a fused protein that can be subsequently cleaved.

Sigma-Aldrich WO 01/27293

Purifying recombinant proteins

Highland, Ill.

Purification of recombinant proteins fused to multiple epitopes by using affinity chromatography.

Singapore National Univ. WO 01/27289

Factor C endotoxin sensing

Singapore

Recombinant fragments of Factor C; for use as endotoxin biosensors and developing antimicrobial therapeutics.

SmithKline Beecham WO 01/27153

Seven transmembrane receptor

Philadelphia

Mouse seven transmembrane receptor, encoding gene sequences, recombinant production methods; for modulator screens.

SmithKline Beecham WO 01/27155

FGF-10a variants

Philadelphia

Human fibroblast growth factor-10a variants, encoding gene sequences, recombinant production methods; for diagnostics.

Takara Shuzo EP 1 094 114

Gene transfer complex

Kyoto, Japan

Retroviral gene transfer using DNA immobilized on a carrier and bound to a cell-targeting antibody.

Tanuma, S. EP 1 094 080

DNase antibodies

Tokyo

Anti-DNase gamma antibodies, both polyclonal and monoclonal; for diagnostics and therapeutics.

Texas, Univ. of WO 01/27329

Expression analysis

Austin, Texas

Combinatorial oligonucleotide PCR; for rapid, global expression analysis.

Texas, Univ. of WO 01/27330

CCR2/5 genotyping

Austin, Texas

Genotype assay for the CCR2 and CCR5 genes; for diagnosing susceptibility to accelerated progression of HIV-1 disease.

Toagosei WO 01/27259

Artificial promoter screen

Tokyo

Methods for screening candidate DNA sequences for artificial promoters.

Tosoh EP 1 094 081

IL-6/IL-6 receptor fusion

Yamaguchi, Japan

Fused protein in which interleukin-6 is directly bonded to the IL-6 receptor; for immunotherapeutics.

Toyo Ink WO 01/27316

Luminescence test system

Tokyo

Expression from luminescence genes used as reporters; for developing assays.

Transgenomic WO 01/27331

DNA sequencing chromatography

San Jose, Calif.

Detection of nucleic acid heteroduplex molecules by anion-exchange chromatography; for DNA sequencing.

Tularik WO 01/27333

Cancer gene detection

S. San Francisco

Characterizing tumor biopsies for SODD gene copy number; for diagnosing cancer.

Vanderbilt Univ. WO 01/27323

Drug-induced cardiac arrhythmia SNPs

Nashville, Tenn.

Detecting human cardiac potassium channel SNPs; for screening susceptibility to drug-induced cardiac arrhythmia.

Wakenyaku WO 01/27260

Cell-free protein synthesis

Kyoto, Japan

Methods of making mRNAs having a high translational template activity; for cell-free protein synthesis.

Yeda Res. & Develop. WO 01/26678

Apoptosis-neutralizing DAP-kinase fragments

Rehovot, Israel

Short segments of DAP-kinase that protect cells from the apoptosis-neutralizing function of the intact molecules.

Yeda Res. & Develop. WO 01/27319

Leptin assay

Rehovot, Israel

Methods for determining the presence of leptin in biological samples.

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