April 25 (EPO), April 19 (WO)
Amrad WO 01/27157
Biologically active complex of NR6 and cardiotropin-like cytokine; for identifying modulators.
Arkansas, Univ. of WO 01/27257
Tumor antigen-derived gene
Little Rock, Ark
Tumor antigen-derived gene that encodes an extracellular serine protease, encoded protein; for tumor therapeutics.
Boehringer Ingelheim Intl. EP 1 094 317
Bone disorder treatment
Identifying modulators of Fra-1 expression; for treating diseases of bone metabolism.
Boehringer Ingelheim Intl. WO 01/27302
CELO virus for vaccines
Recombinant replication-defective CELO virus, CELO virus DNA; for gene therapy, vaccines, and protein production.
Bremen Univ. WO 01/27265
Thyroid cancer-associated genes
Nucleic acid sequences associated with thyroid hyperplasia and cancer, encoded zinc finger protein.
California, Univ. of WO 01/27256
Prostate-targeted gene expression
Los Angeles, Calif.
Chimeric transcriptional regulatory elements; for increasing prostate-targeted gene expression.
Cambridge Antibody Technol. WO 01/27279
Human anti-adipocyte antibodies; for identifying antigens and developing diagnostics and therapeutics.
CDD Holdings WO 01/27292
Growth factor ligand screen
Cysteine knot growth factors displayed on viral particles; for screening drugs that will bind these growth factors.
Chiron WO 01/27269
Neuroblastoma cell gene
Vimentin-associated protein found in neuroblastoma cells, encoding gene, antibodies; for diagnostics and therapeutics.
Chugai Res. Inst. Molec. Med. WO 01/27270
Early hematopoiesis gene
Gene involved in early hematopoiesis, encoded protein; for developing blood disease therapeutics.
Corixa WO 01/27276
Breast tumor proteins
Breast tumor proteins, fragments, encoding gene sequences; for diagnostics and therapeutics.
CuraGen WO 01/27156
IL-2 like protein
New Haven, Conn.
Interleukin-2 like protein, encoding gene sequences, variants, fragments, antibodies; for therapeutics.
CuraGen WO 01/27277
New Haven, Conn.
MBSPX proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
CuraGen WO 01/27290
New Haven, Conn.
Aortic carboxypeptidase-like protein, encoding gene sequences; for developing diagnostics and therapeutics.
Dendreon WO 01/27245
Isolating dendritic cells
Isolation and characterization of dendritic cells isolated from human peripheral blood mononuclear cells.
DNAVec Res. EP 1 094 115
Nerve cell gene therapy
Negative strand RNA virus vector for transferring genes into nerve cells during gene therapy.
Eli Lilly EP 1 094 118
Recombinant protein production
Conversion of precursor proteins using a Dictyostelium dipeptydlaminopeptidase; for recombinant protein production.
Elitra Pharma WO 01/27322
Reporter gene constructs encoding the cytoplasmic form of chitobiase; for use as a reporter enzyme.
Epigenomics WO 01/27317
Measuring methylation patterns
Detecting 5-position methylation changes in genes and single nucleotide polymorphisms; for genome analysis.
Finnish Immunotech WO 01/27249
DNA methyltransferase gene, encoded protein; for diagnosing and treating hereditary diseases and cancer.
Genzyme Transgenics WO 01/26455
Transgenic multivalent polypeptides
Transgenic expression of multivalent binding polypeptides for use in purifying target molecules.
Georgia, Univ. of WO 01/27258
High yield protein expression
Increasing pyruvate carboxylase activity in protein expression systems; for high yields.
Hamilton, Brook, Smith & Reynolds WO 0127272
Oculomedin in glaucoma
Oculomedin, encoding gene sequences; for diagnosing and developing therapeutics for glaucoma.
Hammers, H.-J. EP 1 094 316
Detecting replicating cells
Detecting replicating cells by incorporating halogenated pyrimidines into them and measuring them with antibodies.
Hyseq WO 01/27278
Immunoglobulin superfamily protein
Immunoglobulin superfamily protein, encoding gene sequences; for developing diagnostics and therapeutics.
Icos WO 01/27288
Cell cycle checkpoint proteins
Atr-2 cell cycle checkpoint polypeptides, encoding gene sequences; for identifying modulators.
Immunex WO 01/27299
Recombinant protein expression vector
Vectors having an internal polyadenylation signal inserted between the therapeutic protein gene and the reporter gene.
Isis Innovation WO 01/27152
Altering protein aggregation
Methods for producing proteins having altered aggregation properties by analyzing their amino acid sequences.
Isis Innovation WO 01/27267
Genes differentially expressed in specific T cells, encoded proteins; for developing immunoregulatory therapeutics.
Japan Sci. & Technol. WO 01/27271
C-type lectin, encoding gene sequences; for activating macrophages and regulating the immune system.
Japanese Agency of Ind. Sci. & Technol. WO 01/27263
Aptamers for HIV therapeutics
Aptamers that bind and modulate the activity of Tat protein; for developing HIV therapeutics.
Johns Hopkins Univ. WO 01/27324
Genetic defect diagnosis
Conversion of diploid cells to haploid ones using somatic cell fusion; for unambiguous genetic defect diagnosis.
Kim, J.W. WO 01/27149
Cervical cancer proto-oncogene
Seoul, S. Korea
Human cervical cancer 1 proto-oncogene, encoded protein, fragments, antisense; for diagnostics and therapeutics.
Kosan Biosciences WO 01/27284
Recombinant nucleic acid sequences encoding megalomicin polyketide synthase; for developing antibacterials.
Krebs Res. Ctr. WO 01/27255
T cell lymphoma genes
Cutaneous T cell lymphoma-associated genes, encoded proteins; for cancer diagnosis and therapeutics.
Krebs Res. Ctr. WO 01/27295
Bacteria expressing tumor antigens
Recombinant attenuated Listeria strains expressing human tumor antigens; for cancer immunotherapy.
Kyowa Hakko Kogyo WO 01/27286
Ubiquinone 10 production
Methods for producing ubiquinone 10 in microorganisms having lowered geranylgeranyl transferase activity.
Lausanne, Univ. of WO 01/27268
JNK signal pathway modulation
Cell permeable peptide inhibitors that bind to JNK proteins; for inhibiting the JNK-mediated signal transduction pathway.
Leadd EP 1 094 110
Apoptosis-inducing proteinaceous substance; for effects when p53 is non-functional and Bcl-2 is overexpressed.
Ledbetter, J.A., et al. WO 01/26608
AIDS DNA vaccines
DNA vaccines encoding an HIV-1 antigen linked to a domain that binds CD40; for AIDS therapy.
Lexicon Genetics WO 01/27273
Galanin family proteins
The Woodlands, Texas
Human galanin family proteins, encoding gene sequences; for developing diagnostics and therapeutics.
Lexicon Genetics WO 01/27274
Human LDL receptor family proteins
The Woodlands, Texas
Human LDL receptor family proteins, encoding gene sequences; for developing diagnostics and therapeutics.
Lexicon Genetics WO 01/27275
G protein coupled receptor family proteins
The Woodlands, Texas
Human G protein coupled membrane receptor family proteins, encoding genes; for developing diagnostics and therapeutics.
Maryland, Univ. Biotech Inst. WO 01/27294
Viral infection inhibition
Virus coat protein-virus receptor chimeras; for inhibiting viral infection.
Massachusetts, Univ. of WO 01/26454
Synchronizing somatic cells in G1; for nuclear transfer using mitotic doublet cells.
Maxygen EP 1 094 108
Antibodies by mutagenesis
Redwood City, Calif.
DNA mutagenesis by random fragmentation and reassembly of sequences encoding antibody chains; for antibody production.
Medeva Europe WO 01/27281
Designing immunogens by modifying amino acid sequences and measuring T helper cell responses.
Merck WO 01/27246
Potassium channel subunit
Human potassium channel subunit, encoding gene sequences; for identifying modulators.
Miguel Hernandez Univ. WO 01/27266
Identifying genes expressed in differentiated cells using transcription factor complex assays.
Mochida Pharma EP 1 094 077
Sugar chain-bonded thrombomodulin-like peptide; for blood coagulation diagnostics and therapeutics.
NIH (Natl. Inst. Hlth.) WO 01/27334
Methods and compositions for correlating CCR5 expression with essential hypertension.
Necker Inst. WO 01/27250
Immunoglobulin gene mutation assay
Mutase active DNA polymerase, encoded protein; for finding mutations in immunoglobulin genes.
Neutec Pharma WO 01/27280
Antimicrobial compositions which affect Burkholderia cepacia, diagnostic tests.
NGK Insulators EP 1 094 119, 1 094 120 & 1 094 318
DNA chip production
Methods for making DNA chips using a poly-L-lysine layer and PCR-amplified DNA.
Nihon Univ. WO 01/27264
Platelet growth factor ribozymes
Ribozymes targeted to a growth factor originating in human platelets.
North Carolina, Univ. of WO 01/27303
Hemophilia gene therapy
Chapel Hill, N.C.
Adeno-associated virus vectors encoding Factor VIII; for treating hemophilia.
Ortho-McNeil Pharma WO 01/26453
ABC transporter transgenics
ATP-binding cassette transporter modified transgenic mice, cell lines; for identifying modulators.
Pantheco WO 01/27261 & 27262
Conjugates of cationic peptides and peptide nucleic acids; for finding genes to target with antimicrobials.
Pasteur Inst. WO 01/27291
HIV T cell response
Design of polyepitopic constructs for the induction of HLA-A2.1 restricted HIV-1 specific cytotoxic T cell responses.
Pasteur Inst. WO 01/27300 & 27304
HIV immunotherapy vectors
Lentiviral vectors encoding transgenes that induce cytotoxic T cell responses triplex DNA; for HIV immunotherapy.
Pennsylvania, Univ. of WO 01/27243
Neuropsychiatric disorder gene
Gene sequences associated with neuropsychiatric disorders, encoded protein; for diagnostics and therapeutics.
PE Applied Biosystems WO 01/27326
Foster City, Calif.
Template-dependent ligation with protein nucleic acid-DNA chimeric probes; for identifying SNPs.
Protogene Labs WO 01/27327
Sequence variation detection
Menlo Park, Calif.
Performing large numbers of amplification reactions using array assemblies; for detecting sequence variation.
Quip Technol. WO 01/27318
Reverse transcriptase assay
Detection of reverse transcriptase activity from endogenous pig retroviruses in biological samples.
Res. & Develop. Inst. WO 01/27287
Telomerase reverse transcriptase genes
Telomerase reverse transcriptase genes, encoded proteins; for developing therapeutics.
Rockefeller Univ. WO 01/27301
Expressing viral antigens
Rapid generation of baculovirus-based expression vectors to express therapeutic viral antigens in silkworm larvae.
Schwarzmann, F. WO 01/27254
Gene transfer vectors that encode targeting and apoptosis-inducing genes; for treating autoimmunity.
Shanghai Bio Door Gene Technol. WO 01/27148
Homo-glutamine-rich factor 56, encoding gene, recombinant production methods, antibodies; for therapeutics.
Shanghai Bio Door Gene Technol. WO 01/27151
Zinc finger protein
Human zinc finger Kruppel family member, encoding gene, production methods, antibodies; for therapeutics.
Shanghai Bio Door Gene Technol. WO 01/27283
Reverse transcriptase-like protein
Human reverse transcriptase-like protein, encoding gene, production methods, modulators; for treating viral cancers.
Shanghai Bio Door Gene Technol. WO 01/27285
Human DPB methyltransferase, encoding gene, modulators; for developing immunological disease therapeutics.
Shionogi WO 01/27310
Adrenomedulin precursor production
Production of large amounts of adrenomedulin precursor using a fused protein that can be subsequently cleaved.
Sigma-Aldrich WO 01/27293
Purifying recombinant proteins
Purification of recombinant proteins fused to multiple epitopes by using affinity chromatography.
Singapore National Univ. WO 01/27289
Factor C endotoxin sensing
Recombinant fragments of Factor C; for use as endotoxin biosensors and developing antimicrobial therapeutics.
SmithKline Beecham WO 01/27153
Seven transmembrane receptor
Mouse seven transmembrane receptor, encoding gene sequences, recombinant production methods; for modulator screens.
SmithKline Beecham WO 01/27155
Human fibroblast growth factor-10a variants, encoding gene sequences, recombinant production methods; for diagnostics.
Takara Shuzo EP 1 094 114
Gene transfer complex
Retroviral gene transfer using DNA immobilized on a carrier and bound to a cell-targeting antibody.
Tanuma, S. EP 1 094 080
Anti-DNase gamma antibodies, both polyclonal and monoclonal; for diagnostics and therapeutics.
Texas, Univ. of WO 01/27329
Combinatorial oligonucleotide PCR; for rapid, global expression analysis.
Texas, Univ. of WO 01/27330
Genotype assay for the CCR2 and CCR5 genes; for diagnosing susceptibility to accelerated progression of HIV-1 disease.
Toagosei WO 01/27259
Artificial promoter screen
Methods for screening candidate DNA sequences for artificial promoters.
Tosoh EP 1 094 081
IL-6/IL-6 receptor fusion
Fused protein in which interleukin-6 is directly bonded to the IL-6 receptor; for immunotherapeutics.
Toyo Ink WO 01/27316
Luminescence test system
Expression from luminescence genes used as reporters; for developing assays.
Transgenomic WO 01/27331
DNA sequencing chromatography
San Jose, Calif.
Detection of nucleic acid heteroduplex molecules by anion-exchange chromatography; for DNA sequencing.
Tularik WO 01/27333
Cancer gene detection
S. San Francisco
Characterizing tumor biopsies for SODD gene copy number; for diagnosing cancer.
Vanderbilt Univ. WO 01/27323
Drug-induced cardiac arrhythmia SNPs
Detecting human cardiac potassium channel SNPs; for screening susceptibility to drug-induced cardiac arrhythmia.
Wakenyaku WO 01/27260
Cell-free protein synthesis
Methods of making mRNAs having a high translational template activity; for cell-free protein synthesis.
Yeda Res. & Develop. WO 01/26678
Apoptosis-neutralizing DAP-kinase fragments
Short segments of DAP-kinase that protect cells from the apoptosis-neutralizing function of the intact molecules.
Yeda Res. & Develop. WO 01/27319
Methods for determining the presence of leptin in biological samples.