April 18 (EPO), April 12 (WO)

Ahlert, T. EP 1 092 439

T cell activation

Heidelberg, Germany

Activation of antigen-specific T cells by virus- or antigen-treated dendritic cells; for stimulating immune responses.

American Cyanamid EP 1 092 775

Human CMV inhibitor screens

Stamford, Conn.

Finding non-essential genes in human cytomegalovirus genomes using _-glucuronidase as a marker; for inhibitor screens.

Amersham Pharmacia Biotech WO 01/25485

Mutation detection

Piscataway, N.J.

Methods for detecting mutations using arrayed primer extension assays.

Amgen WO 01/25445

Blood clot lysis polypeptide

Thousand Oaks, Calif.

Fibrinolytically active polypeptide, production methods; for in vivo blood clot lysis.

Angstrom Pharma WO 01/25410

uPA targeting proteins

San Diego

Urokinase plasminogen activator and uPA receptor-targeting proteins; for diagnostics and therapeutics.

Artemis Pharma EP 1 092 768

Inactivation of cellular genes

Cologne, Germany

Gene trap construct that conditionally inactivates cellular genes by mutation; for studying development.

Aventis Pharma EP 1 092 777

Self-cleaving RNA sequences

Antony, France

Self-cleaving RNA sequences from untranslated regions; for controlling protein synthesis from mRNAs.

Aventis Pharma WO 01/25278

Insulin production

Frankfurt, Germany

Modified C-peptide, encoding gene sequences; for improved production of insulin and its analogs.

Aventis Pharma WO 01/25463

Recombinant adenovirus preparation

Antony, France

Recombinant adenoviral vector preparation; for use in functional genomics assays.

Aventis Pharma WO 01/25487

Helicase modulator screens

Bridgewater, N.J.

Electrochemiluminescent assays for detecting helicase activity; for identifying modulators.

Avi Biopharma WO 01/25422

Making lineage committed cells

Corvallis, Ore.

Antisense oligomers directed at mRNAs expressed in stem cells; for increasing numbers of lineage committed cells.

BASF EP 1 092 771

Regulated transcriptional modulators

Ludwigshafen, Germany

Tetracycline-regulated transcriptional modulators; for controlling gene expression in eukaryotic cells.

Baylor Coll. Med. WO 01/25255

Zinc finger protein

Houston

Zinc finger protein, fragments, derivatives, encoding gene sequences; for gene transcription regulation.

Biosite Diagnostics WO 01/25492

Human antibody screen

San Diego

Display selection methods for screening human immunoglobulin gene libraries; for finding high affinity antibodies.

Biotransplant WO 01/25398

Inducing tolerance to myeloreduction

Charlestown, Mass.

Hematopoietic stem cells expressing new antigens; for inducing tolerance after myeloreductive therapy.

Biovet-Uco WO 01/25279

Xenotransplant acceptance

Cordoba, Spain

CD29 pig protein, encoding gene sequences, modified versions; for reducing xenoreactivity in transplants.

Boehringer Ingelheim Intl. EP 1 092 780

Recombinant CELO viruses

Ingelheim, Germany

Recombinant CELO viruses with large pieces of foreign DNA inserted; for gene therapy, vaccines, and producing protein.

Brosens, J. WO 01/25452

Cell targeting vector

London

Genetic constructs encoding a nitric oxide inducer that target specific cell types.

California, Univ. of WO 01/24821

Bone mineralization assay

San Francisco, Calif.

Use of human NELL-1 gene to identify modulators of bone mineralization.

California, Univ. of WO 01/25250

Her-2/neu associated genes

Oakland, Calif.

Differentially expressed genes associated with Her-2/neu overexpression, encoded proteins, antibodies; for cancer.

California, Univ. of WO 01/25408

Cell proliferation control

Oakland, Calif.

Dishelleved-associated kinases, encoding gene sequences; for Wnt/Wg signal pathway modulation to control cell growth.

Cambridge Drug Discovery WO 01/25477

Kinase modulator screens

Cambridge, UK

Use of reporters to screen modulators of kinases and phosphatases.

Cambridge, Univ. of WO 01/25416

Displaying T cell epitopes

Cambridge, UK

Recombinant double hybrid filamentous bacteriophage displaying cytotoxic T cell epitopes; for vaccines.

Chiron WO 01/25464

AAV vector production

Emeryville, Calif.

Simplified methods for producing replication-defective adeno-associated virus vectors; for gene therapy.

Chiron WO 01/25489

Prostate cancer gene

Emeryville, Calif.

Gene differentially expressed in prostate cancer; for developing diagnostics and therapeutics.

Chugai WO 01/24626

Blood coagulation modulators

Tokyo

Animals with cell transplants secreting human tissue factor to increase blood coagulation; for finding modulators.

Colorado State Univ. WO 01/25435

Joint disease gene therapy

Ft. Collins, Colo.

In vivo treatment of joint disease using interleukin-1 receptor antagonists encoded in an adenoviral vector.

Corixa WO 01/24820 & 25401

Mycobacterial fusion proteins

Seattle

Mycobacterial antigen fusion proteins; for tuberculosis therapy and high yield heterologous protein production.

CuraGen WO 01/25429

Hepatoma-derived growth factor

New Haven, Conn.

Hepatoma-derived growth factor-like proteins, encoding gene sequences, variants, mutants; for disease treatment.

CuraGen WO 01/25436

Endozepine-like polypeptides

New Haven, Conn.

Endozepine-like polypeptides, encoding gene sequences, variants, mutants; for diagnostics and therapeutics.

CuraGen WO 01/25437

Growth factor polypeptides

New Haven, Conn.

Growth factor polypeptides related to VEGF and PDGF, encoding gene sequences; for diagnostics and therapeutics.

Curie, Univ. Pierre & Marie EP 1 092 436

Modified tendon cells

Paris

Human tendon cell preparations; for genetic modification to restore tendons and ligaments [in French].

Dartmouth College WO 01/25400

Modulating ATP-binding proteins

Hanover, N.H.

Methods an compositions for modulating ATP-binding cassette transmembrane reporter protein expression.

Eberhard Karls Univ. WO 01/25441

Tumor-specific vector

Tubingen, Germany

Tumor-specific vector with heterologous therapeutic genes driven by telomerase catalytic subunit/cycline A promoters.

Eli Lilly WO 01/25428

Leptin homolog

Indianapolis

Human leptin homolog, encoding gene sequences; for treating obesity.

Emalfarb, M.A. WO 01/25468

Drug target screens

Jupiter, Fla.

High-throughput screening of expressed DNA libraries in filamentous fungi; for identifying drug targets.

Exiqon WO 01/25478

Mismatched DNA assay

Vedbaek, Denmark

Increasing the specificity of oxy-LNA oligonucleotides; for discriminating between matched and mismatched nucleic acids.

Florida State Univ. WO 01/25421

Cystic fibrosis drug screen

Tallahassee, Fla.

Materials and methods for detecting the interaction of CFTR polypeptides; for screening cystic fibrosis drugs.

Fraunhofer Res. Inst. EP 1 092 769

Peptide tags for purification

Munich, Germany

Polypeptide tags fused to proteins of interest; for detection and purification of proteins [in German].

Fuso Pharma EP 1 092 767 & 1 092 772

Neurosin and LAR phosphatase antibodies

Osaka, Japan

Monoclonal antibodies to neurosin, a serine protease, and LAR phosphatase; for neuronal diseases and thyroid cancer.

Genaissance Pharma WO 01/25194 & 25245

Drug target isogenes

New Haven, Conn.

Polymorphisms in the serotonin receptor 1B and death associated protein 6 genes; for finding drug targets.

Genentech WO 01/25433

Angiogenesis-related proteins

S. San Francisco

Proteins related to angiogenesis and neovascularization, encoding gene sequences; for diagnostics and therapeutics.

Genovo WO 01/25462

High titer vectors

Sharon Hill, Penn.

Adenoviruses having the p5 promoter of the rep gene replaced by a minimal promoter; for producing high titers of vectors.

Georgetown Univ. WO 01/25450

Tumor immuno-gene therapy

Washington, D.C.

Vector expressing a soluble costimulatory factor, encoding gene sequences; for enhancing T cell response to tumors.

Glaxo WO 01/25792

Vaccination T cell response

Greenford, UK

Methods for assessing in vivo T cell response after DNA vaccination.

Greenovation Plant Biotech WO 01/25456

Protein production in moss

Freiburg, Germany

Production of heterologous proteins in moss plants; for making therapeutics.

Human Genome Sciences WO 01/24815 & 25252

Plasminogen-like genes

Rockville, Md.

Human plasminogen-like and tissue plasminogen activator-like protease gene sequences, encoded proteins, antibodies.

Iowa, Univ. of WO 01/25465

Episomal AAV vectors

Iowa City, Iowa

Adeno-associated virus DNA segments that confer increased episomal stability and persistence.

Isis Innovation WO 01/25461

Utrophin promoter

Summertown, UK

Utrophin gene promoter; for linkage to reporter genes in order to find utrophin modulators.

Japan Sci. & Technol. WO 01/24627

Anti-allergy drug transgenics

Saitama, Japan

Transgenics expressing human hematopoietic prostaglandin D2 synthase; for testing anti-allergy drugs.

Kurokawa, K. WO 01/24628

Nephritis transgenics

Tokyo

Transgenics expressing megsin; for modeling mesangial cell proliferative nephritis.

Kyowa Hakko Kogyo WO 01/25427

Shear stress-response gene

Tokyo

Shear stress-response gene sequences, encoded protein, antibodies; for vascular disease.

Lexicon Genetics WO 01/25430

G protein coupled receptors

The Woodlands, Texas

Human G protein coupled receptors, encoding gene sequences; for developing therapeutics.

Lipoxen WO 01/24773

Oral liposomal vaccines

London

Liposome entrapped DNA encoding antigens; for oral vaccine administration that increases IgA levels.

Mass. Gen. Hosp. WO 01/25281

Na+K+-ATPase ligand antibodies

Boston

Oaubain-specific monoclonal antibodies, fragments; for diagnostics and therapeutics related to Na+K+-ATPase.

Maxygen WO 01/25277

TNF-a antagonists

Horsholm, Denmark

Single-chain oligomeric TNF-a polypeptides as antagonists to the extracellular ligand-binding domains of receptors.

Maxygen WO 01/25438

IFN-a homologs

Redwood City, Calif.

Interferon-a homologs, encoding gene sequences; for developing diagnostics and therapeutics.

Medicago WO 01/25454 & 25455

Nitrogen-controlled transcription

Ste.-Foy, Que.

Transgene transcription that is controlled by the presence of nitrogen.

Merck WO 01/25251

Modulating cell wall synthesis

Rahway, N.J.

Pseudomonas aeruginosa MraY gene, encoded protein; for modulating cell wall peptidoglycan synthesis.

Merck WO 01/25258

Potassium channel subunit

Rahway, N.J.

Human inwardly rectifying potassium channel subunit, encoding gene sequences; for finding modulators.

Merck WO 01/25423

Cytoplasmic calcium binding protein

Darmstadt, Germany

Splice variant of head trauma induced cytoplasmic calcium binding protein, encoding gene, protein production methods.

Michigan, Univ. of WO 01/25484

Viral DNA binding modulation

Ann Arbor, Mich.

Methods and reagents that modulate the binding of viral DNA to genomic host DNA; for gene therapy.

Millennium Pharma WO 01/25409

Human lipases

Cambridge, Mass.

Human lipase proteins, encoding genes, variants, fragments, derivatives; for glyceride metabolism modulators.

Millennium Pharma WO 01/25448

Adenylate cyclase

Cambridge, Mass.

Adenylate cyclase, encoding gene sequences, antibodies, fusions, antigenic peptides; for modulator screens.

Minnesota, Univ. of WO 01/25440

Steptococcus antibacterials

Minneapolis

C3 binding polypeptide of Group B Streptococcus that is implicated in adhesion and virulence, antibodies.

Molecular Sciences Inst. WO 01/25794

Protein fingerprinting

Berkeley, Calif.

Protein fingerprinting system that uses hydrodynamic focusing, atomic force microscopy, and electrophoresis.

NIH (Natl. Inst. Hlth.) EP 1 092 770

Human cancer antigen

Bethesda, Md.

Human cancer antigen from tyrosine-related proteins 1 and 2, encoding gene sequences; for cancer immunotherapy.

NIH (Natl. Inst. Hlth.) WO 01/25407

Topoisomerase 1 inhibitor assay

Bethesda, Md.

Tyrosine-DNA phosphodiesterase, encoding gene, antibodies, antisense; for finding topoisomerase 1 inhibitors.

New Jersey, Univ. Med. & Dent. WO 01/25486

RNA binding agent identification

New Brunswick, N.J.

Methods for identifying RNA binding compounds; for modulating protein production.

North Carolina, Univ. of WO 01/25253

Temperature-sensitive AAV vectors

Chapel Hill, N.C.

Temperature-sensitive adeno-associated virus Rep 68/78 proteins; for regulating vector packaging and delivery.

Ohio State Univ. WO 01/24765

HCG antibodies for cancer

Columbus, Ohio

Antigenic modification of human chorionic gonadotropin, linkage to carriers; for making antibodies to treat cancer.

Oxford Biomedica WO 01/25466

Producing retroviral vectors

Oxford, UK

Producer cell line with integrated recombinase recognition sequences; for producing retroviral vectors.

Pasteur Inst. EP 1 092 779

Inducing cell-mediated immunity

Paris

Lentiviral vectors having inserted heterologous genes; for inducing cell-mediated immune responses.

Paul Erlich Inst. WO 01/25415

Targeting T cells

Langen, Germany

Gene transfer in human lymphocytes using retroviral scFV cell targeting; for T cell diseases.

Penn State Univ. WO 01/25282

IL-13 mutants

University Park, Penn.

Interleukin-13 mutants, encoding gene sequences; for use as activity modulators.

Pfizer EP 1 092 727

G-protein receptor

Sandwich, UK

G-protein receptor, encoding gene sequences, variants, homologs, analogs, fragments, and derivatives.

Quark Biotech WO 01/25488

Enriching natural antisense

Pleasanton, Calif.

Enriching natural antisense mRNA by DNA polymerase treatment of sense-antisense hybrids.

Rockefeller Univ. WO 01/25431

Vomeronasal-like pheromone receptors

New York

Vomeronasal-like pheromone receptors, encoding gene sequences, allelic variants; for finding modulators.

Schering WO 01/25432

Histamine receptor

Kenilworth, N.J.

Histamine receptor, encoding gene sequences, antigenic fragments, production methods; for modulator assays.

Schering WO 01/25446

Serine protease

Berlin

Serine protease, encoding gene sequences, production methods; for diagnostics and therapeutics.

Schrotz-King, P., et al. WO 01/25268

Seizure-related proteins

Odense, Denmark

Human seizure-related proteins, encoding genes, antibodies; for neurological disease diagnostics and therapeutics.

SmithKline Beecham WO 01/24625

Uncoupling protein transgenics

Brentford, UK

Transgenic rodents having an inserted human uncoupling protein 3 gene; for UCP3 expression.

SmithKline Beecham WO 01/24635 & 24819

Antibacterial screens

Philadelphia

Bacterial asuE and ysxC polypeptides, encoding genes, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 01/25280

G-protein coupled receptor

Philadelphia

G-protein coupled receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.

Solvay Pharma WO 01/25269

G-protein coupled receptor

Weesp, Netherlands

Human G-protein coupled receptor, encoding gene sequences, antibodies, transgenics; for diagnostics and therapeutics.

Source Precision Medicine WO 01/25473

Calibrated gene expression

Boulder, Colo.

Using calibrated gene expression profiles to characterize a biological condition.

Spanish Sci. Invest. Counc. WO 01/25442

Tumor-associated DNA polymerase

Madrid, Spain

DNA polymerase lambda, isoforms associated with tumors; for cancer diagnostics and therapeutics.

Sumitomo Electric EP 1 092 783

Cancer chromosome modifications

Osaka, Japan

Detection of amplifications and deletions in chromosomes in various cancers; for diagnosis.

Symbicom EP 1 092 774

Lyme disease antigens

Umea, Sweden

Borrelia burgdorferi outer membrane antigen OspA and related antigenic polypeptides, encoding genes; for Lyme disease.

Tigenix WO 01/25402

Skeletal precursor cells

Bierbeek, Belgium

Isolation of skeletal precursor cells using cartilage-derived morphogenetic protein markers; for tissue repair.

Urogenesys WO 01/25434

Prostate cancer receptor

Santa Monica, Calif.

G protein-coupled receptor upregulated in prostate cancer, encoding gene sequences; for diagnostics and therapeutics.

Utah, Univ. of WO 01/24681

Long QT syndrome gene mutations

Salt Lake City

Alterations in the genes involved in long QT syndrome; for diagnosing syncope, seizures, and sudden death prevalence.

Utah, Univ. of WO 01/25256

TNF-like ligand

Salt Lake City

Tumor necrosis factor-like ligand, encoding gene sequences; for cancer diagnostics and therapeutics.

ZymoGenetics WO 01/25444

Human phosphodiesterase

Seattle

Human phosphodiesterase, encoding gene sequences; for detecting human chromosomal abnormalities.

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