March 21 (EPO), March 15 (WO)

Advanced Cell Technol. WO 01/18193

Immune-compatible cells

Worcester, Mass.

Methods for generating immune-compatible cells and tissues using nuclear transfer techniques; for transplantation.

Advanced Cell Technol. WO 01/18236

Extending cell life span

Worcester, Mass.

Methods for repairing tandemly repeated DNA sequences and extending cell life span using nuclear transfer technology.

Amgen WO 01/18172

FGF-like polypeptides

Thousand Oaks, Calif.

Fibroblast growth factor-like polypeptides, encoding gene sequences, antibodies, production methods; for therapeutics.

Amgen WO 01/18203

OPG fusion proteins

Thousand Oaks, Calif.

OPG fusion protein compositions having an immunoglobulin Fc region moiety.

Beth Israel Deaconess Med. Ctr. WO 01/18036

Finding transcriptional activators

Brookline, Mass.

Using molecular diversity to find minimal, co-activator domain-specific synthetic transcriptional activators.

Brigham & Women's Hosp. WO 01/17544

Urokinase receptor binding peptides

Boston

Peptides that bind to the urokinase receptor; for impairing integrin function in inflammation and cancer.

British Columbia, Univ. of WO 01/18240

Autoimmunity SNPs

Vancouver, B.C.

Measurement of polymorphisms in the interferon gamma genes; for diagnosing autoimmunity.

California, Univ. of WO 01/17508

Taxane delivery

Oakland, Calif.

Methods for cationic delivery of taxanes to angiogenic blood vessels.

California, Univ. of WO 01/18019

Epithelial cancer therapeutics

Oakland, Calif.

Epithelial protein whose expression is lost in neoplasms, encoding gene sequences; for cancer therapeutics.

California, Univ. of WO 01/18020

Mechanosensory transduction channel

Oakland, Calif.

Eukaryotic mechanosensory transduction channel, encoding gene sequences; for developing sensation therapeutics.

California, Univ. of WO 01/18050

Taste transduction receptors

Oakland, Calif.

Family of taste transduction G-protein coupled receptors, encoding gene sequences, antibodies; for modulator screens.

California, Univ. of WO 01/18251

Polynucleotide detection

Oakland, Calif.

Electronic detection of polynucleotide molecules using methods for translocating through nanopores.

Cambridge Univ. Tech. Services WO 01/18057

Developmental genes

Cambridge, UK

Drosophila developmental-related genes, encoded proteins; for linking mutations to phenotype changes.

Canji WO 01/17537

Reducing immunoresponses

San Diego

Reducing pre-existing immune responses by selective elimination of antiviral antibodies from serum.

CNRS (Natl. Ctr. Sci. Res.) WO 01/18198

Spastic paraplegia gene

Paris

Cloning and characterization of the SPG4 gene encoding spastin; for studying familial spastic paraplegia.

Chugai WO 01/18200

Hematopoiesis modulation

Tokyo

Fruit fly TSG gene homolog, encoded protein; for developing hematopoietic function modulators.

Corixa WO 01/18046

Ovarian cancer therapeutics

Seattle

Ovarian tumor expressed proteins, encoding gene sequences, antibodies; for cancer diagnostics and therapeutics.

CuraGen WO 01/18204

B7 family genes

New Haven, Conn.

Human B cell activation antigen B7 family genes, encoded proteins, variants, antibodies; for therapeutics.

CuraGen WO 01/18208

Interferon-induced genes

New Haven, Conn.

Interferon-induced gene sequences, encoded proteins, variants, fusions, fragments, antibodies; for therapeutics.

CuraGen WO 01/18209

FGF polypeptide

New Haven, Conn.

Fibroblast growth factor polypeptide, encoding gene sequences, variants, fusions, fragments, antibodies.

Decode Genetics WO 01/18245

Detecting gene alterations

Reykjavik, Iceland

Detection of alterations in genes by long range PCR using human mobile sequence elements.

DNAVec Res. WO 01/18223

Paramyxovirus vaccines

Ibaraki, Japan

Paramyxoviruses having modified transcription initiation sequences; for making vaccines.

Eli Lilly WO 01/18041, 18055 & 18202

Fas-FasL interaction modulation

Indianapolis

Protease-resistant FLINT complexes/analogs with reduced aggregation; for Fas-FasL interaction-related diseases.

Exact Labs WO 01/18252

Nucleic acid integrity

Maynard, Mass.

Methods for detecting the integrity of nucleic acids in patient samples; for disease detection.

Florida, Univ. of WO 01/18222

Chromosomal gene integration

Gainesville, Fla.

Vector constructs with in vivo excisable selection markers; for chromosomal integration of heterologous gene sequences.

Genaissance Pharma WO 01/18232

Uncoupling protein 3 gene SNPs

New Haven, Conn.

17 single nucleotide polymorphisms in the uncoupling protein 3 gene; for designing therapeutics.

Genena WO 01/18056

Cancer gene therapy

Tel Mond, Israel

Gene construct having extracellular matrix, transmembrane, and virus coat binding moieties; for cancer gene therapy.

Genentech WO 01/18210

FGF-19

S. San Francisco

Fibroblast growth factor-19, encoding gene sequences, fusions, antibodies; for treating obesity.

Genetrol Biotherapeutics WO 01/18185

High level cytokine production

Oakland, Calif.

Methods for enhancing cytokine production in cell culture while avoiding apoptosis induction.

Genzyme WO 01/18224

Cystic fibrosis gene therapy

Cambridge, Mass.

Adenoviral vectors for persistent expression of the cystic fibrosis transmembrane conductance gene in airway epithelia.

Glasgow, Univ. of WO 01/18547

Identifying essential genes

Glasgow, UK

Identification of essential genes whose lack of expression leads to lethal or semi-lethal phenotypes.

Glaxo WO 01/18039

IFN-a production modulation

Greenford, UK

Use of interferon regulatory factor 7 and its functional analogs to modulate interferon-a production.

Helix Res. Inst. EP 1 085 024

Nuclear transport proteins

Chiba, Japan

Isolation of gene sequences encoding proteins having nuclear transport activity, encoded proteins.

Henry Ford Hlth. System WO 01/17533

Atherosclerosis therapy

Detroit

Inhibitor of vascular superoxide anion, vector expressing superoxide anion; for treating atherosclerosis.

Human Genome Sciences WO 01/17532

Neuropeptide receptor

Rockville, Md.

Human neuropeptide receptor, encoding gene sequences, production methods; for diagnostics and therapeutics.

Human Genome Sciences WO 01/18014

Cancer-associated proteins

Rockville, Md.

29 human cancer-associated proteins, encoding genes, antibodies; for identifying modulators to treat cancer.

Human Genome Sciences WO 01/18021

B7-like gene sequences

Rockville, Md.

B7-like gene sequences, encoded proteins, antibodies; for developing diagnostics and therapeutics.

Human Genome Sciences WO 01/18022

52 secreted proteins

Rockville, Md.

52 human secreted proteins, encoding gene sequences, antibodies, production methods; for therapeutics.

Human Genome Sciences WO 01/18049

Steroid hormone receptors

Rockville, Md.

Steroid hormone receptors, encoding genes, antibodies; for developing diagnostics and therapeutics.

Human Genome Sciences WO 01/18176

Immunoglobulin superfamily genes

Rockville, Md.

Immunoglobulin superfamily gene sequences, encoded proteins, antibodies, production methods; for therapeutics.

Immunex WO 01/18044

Multiple drug resistance therapy

Seattle

Use of semaphorin and its gene sequences to affect cellular efflux pumps; for treating multiple drug resistance.

Imperial Coll. Innovation WO 01/18038

Treating clostridial toxin poisoning

London

Use of soluble N-ethylmaleimide-sensitive fusion proteins to treat clostridial toxin poisoning.

Incyte Genomics EP 1 085 468

Displaying sequence data

Palo Alto, Calif.

Methods, media, and systems for graphically displaying biomolecular sequence data.

Incyte Genomics WO 01/18042

Apoptosis proteins

Palo Alto, Calif.

Apoptosis proteins, encoding gene sequences, antibodies, modulators; for developing therapeutics.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 01/18053

MHC class I antigen analogs

Paris

Recombinant protein analogs of MHC class I antigens having alterations in the zone of interaction with CD8 receptors.

Introgene WO 01/18048

Smooth muscle cell promoter

Leiden, Netherlands

Smooth muscle cell promoter; for linkage to heterologous genes in an adenoviral vector for gene therapy.

Isis Pharma WO 01/18023 & 18024

Antisense modulation of expression

Carlsbad, Calif.

Antisense modulation of P13 kinase P110_ and X-linked inhibitor of apoptosis expression; for therapeutics.

Kyowa Hakko Kogyo EP 1 085 090

IgA nephropathy gene

Tokyo

Immunoglobulin A nephropathy-associated gene sequences, encoded protein; for diagnostics and therapeutics.

Lexicon Genetics WO 01/18206 & 18207

7-transmembrane receptor

The Woodlands, Texas

Human G-protein coupled 7-transmembrane receptor, encoding gene sequences; for therapeutics.

Lifebeam Technol. WO 01/18247

Analyzing polynucleotides

Braintree, Mass.

Analyzing polynucleotide molecules by detecting their quenching effects on a fluorescent reporter.

Mass. Gen. Hosp. WO 01/17343

Evaluating agents affecting skin

Boston

Non-transgenic mice having a reporter gene coupled to a skin metabolism promoter; for evaluating skin agents.

Max Planck Inst. WO 01/18215

Producing serine proteases

Munich, Germany

Methods for producing active serine proteases and inactive variants in prokaryotic host cells.

Max Planck Inst. WO 01/18546

Paired helical filament nucleation

Berlin

Determining the minimal tau peptide that is necessary for nucleation of paired helical filaments.

McGill Univ. WO 01/18544

Trinucleotide repeat disease assay

Montreal

Detecting protein accumulation in intranuclear inclusions; for diagnosing trinucleotide repeat diseases.

MRC (Med. Res. Counc.) WO 01/18244

Detecting binding events

London

Hybrid sigma54 RNAP proteins genetic selection system; for detecting DNA:protein and protein:protein binding events.

Merck WO 01/18018

Pseudomonas antibacterials

Rahway, N.J.

Pseudomonas aeruginosa MurF protein, encoding gene sequences; for identification of modulators.

Millennium Pharma WO 01/18016

Therapeutic proteins

Cambridge, Mass.

Genes encoding proteins having therapeutic action, encoded proteins, antibodies; for modulator screens.

Millennium Pharma WO 01/18216

Calpain protease

Cambridge, Mass.

Calpain protease, encoding gene sequences, fusions, antibodies; for developing diagnostics and therapeutics.

Millennium Predictive Med. WO 01/18542

Ovarian cancer markers

Cambridge, Mass.

Markers that correlate with the presence of ovarian cancer; for diagnosis and treatment.

NIH (Natl. Inst. Hlth.) WO 01/18254

Breast cancer gene

Bethesda, Md.

Identification of RAD51 gene mutants; for diagnosing a predisposition to breast cancer.

NIH (Natl. Inst. Hlth.) WO 01/18550

Adrenomedullin binding proteins

Bethesda, Md.

Identification and isolation of adrenomedullin binding proteins; for treating cancer and diabetes.

Neurogenetics WO 01/18549

Increasing life span

San Diego

Agents that activate C. elegans DAF-16 gene and its human homologs; for increasing stress resistance and life span.

New York Univ. EP 1 085 093

UV-damaged skin genes

New York

Genes associated with UV-mediated skin damage, encoded proteins; for developing diagnostics and therapeutics.

Novopharm Biotech WO 01/18058

VH fragment library

Toronto

Enhanced phage display library of human VH fragments, production methods; for developing therapeutics.

Pennsylvania, Univ. of WO 01/18173

Neuropilin-1 deletion mutant

Philadelphia

Neuropilin-1 having a deletion in one of its extracellular domains; for modulating secreted semaphorin action.

Pfizer EP 1 085 089 & 1 085 092

Phosphodiesterases

Sandwich, UK

Human phosphodiesterases, including cyclic nucleotide phosphodiesterases, encoding gene sequences.

Princeton Univ. WO 01/18246

Nucleic acid sequencing

Princeton, N.J.

Sequencing nucleic acids by electronic detection of differentially labelled single nucleotides.

Prolifia WO 01/18043

Promoting neurite outgrowth

Tucson, Ariz.

Extracellular administration of Mts 1 protein; for promoting neurite outgrowth from neuronal cells.

Psiron WO 01/18541

Diagnosing autoimmunity

Sydney, Australia

Measuring cell-mediated immune response to _2GPI; for diagnosing autoimmune disease.

Queensland Inst. Med. Res. WO 01/18047

T cell stimulatory protein

Herston, Australia

Dendritic cell membrane protein FIRE that is preferentially expressed in dendritic cells that stimulate T cells.

Ramot Univ. WO 01/18169

Plaque vaccines

Tel Aviv, Israel

Presentation of antigens or antibodies on a display vehicle; for vaccination against plaque-forming diseases.

Ramot Univ. WO 01/18197

Gene-specific lethality

Tel Aviv, Israel

Screening molecules and DNA for gene-specific lethality; for modulating gene function and eliminating cells and tissues.

RIKEN EP 1 085 323

Apoptosis modulator screens

Wako, Japan

Apoptosis-related protein that binds NADE, encoding gene sequences; for modulator screens.

Salk Inst. Biol. Studies WO 01/17514

Gene expression modulation

La Jolla, Calif.

Modulating gene expression by using agents that affect histone acetylation.

Schering WO 01/17558

CCR6/MIP-3a therapeutics

Kenilworth, N.J.

Administration of CCR6 or MIP-3a alone or in combination with other therapeutic agents; for immunomodulation.

Schering WO 01/18051

Mammalian cytokines

Kenilworth, N.J.

Mammalian cytokines, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Shanghai Inst. Biotech. WO 01/18052

Monomeric insulin analogs

Shanghai, China

Monomeric analogs of human insulin having specific amino acid residue substitutions in the B chain.

Sheriff, A. EP 1 085 085

Reducing immunoresponse

Berlin

Process for reducing immune system reactions using antigen-presenting cells and CD40 receptors [in German].

Sloan-Kettering Inst. Cancer Res. WO 01/18045

Histone deacetylation agents

New York

Crystal structure of histone deacetylase and its inhibitors; for developing therapeutics.

SmithKline Beecham WO 01/17550 & 17551

Multi-antigen viral vaccines

Rixensart, Belgium

Compositions having more than one viral antigen; for inducing antiviral responses.

SmithKline Beecham WO 01/18054

Monkey GPR14 polypeptides

Philadelphia

Monkey GPR14 polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 01/18228

Human sbgFGF-10a

Philadelphia

Human sbgFGF-10a polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 01/18249

Staphylococcus antibacterials

Philadelphia

Staphylococcus aureus kdtB polypeptides, encoding nucleic acid sequences; for antibacterial screens.

SmithKline Beecham WO 01/18253

Inserting gene sequences

Philadelphia

Gene manipulation using homologous recombination methods; for inserting polynucleotide sequences.

Teikoku Hormone EP 1 085 088

Fibrin degradation assays

Tokyo

Monoclonal antibodies that do not react with fibrin degradation products; for developing assays.

Texas, Univ. of WO 01/17552

Kaposi's sarcoma therapeutics

Austin, Texas

Kaposi's sarcoma-associated herpes virus KS-SM gene product; for developing diagnostics and therapeutics.

Transgene WO 01/18035

Cytotoxic T cell activation

Strasbourg, France

MUC-1 derived proteins that activate the cytotoxic T cell response, encoding gene sequences.

University Hlth. Network WO 01/18037

Death domain protein

Toronto

p53-induced protein with a death domain that can promote apoptosis, encoding gene sequences; for therapeutics.

Veso WO 01/18212

Mycobacterial antigens

Oslo, Norway

Mycobacterial antigenic polypeptides, antibodies; for infection diagnostics and therapeutics.

Whitehead Inst. Biomed. Res. WO 01/18250

Finding SNPs

Cambridge, Mass.

Allele-specific primers for finding single nucleotide polymorphisms in genes.

Xenogen WO 01/18225

Reporter transgenics

Alameda, Calif.

Making transgenics that have a non-essential gene replaced with a reporter gene.

Yale Univ. WO 01/18234

Solid phase phage display

New Haven, Conn.

Isolation of specific proteins using phage display technology, bound ligands, and affinity chromatography.

Yeda Res. & Develop. WO 01/18040

Angiogenesis modulation

Rehovot, Israel

Use of leptin and VEGF to inhibit endothelial cell proliferation; for angiogenesis modulation.

Zink, D. WO 01/18189

Expressing exogenous genes

Weilheim, Germany

Integration of transfected gene sequences into the active compartment of nuclei; for expressing exogenous genes.

ZymoGenetics WO 01/18205

Secreted polypeptides

Seattle

Secreted polypeptides, encoding gene sequences; for developing diagnostics and therapeutics.

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