March 21 (EPO), March 15 (WO)
Advanced Cell Technol. WO 01/18193
Methods for generating immune-compatible cells and tissues using nuclear transfer techniques; for transplantation.
Advanced Cell Technol. WO 01/18236
Extending cell life span
Methods for repairing tandemly repeated DNA sequences and extending cell life span using nuclear transfer technology.
Amgen WO 01/18172
Thousand Oaks, Calif.
Fibroblast growth factor-like polypeptides, encoding gene sequences, antibodies, production methods; for therapeutics.
Amgen WO 01/18203
OPG fusion proteins
Thousand Oaks, Calif.
OPG fusion protein compositions having an immunoglobulin Fc region moiety.
Beth Israel Deaconess Med. Ctr. WO 01/18036
Finding transcriptional activators
Using molecular diversity to find minimal, co-activator domain-specific synthetic transcriptional activators.
Brigham & Women's Hosp. WO 01/17544
Urokinase receptor binding peptides
Peptides that bind to the urokinase receptor; for impairing integrin function in inflammation and cancer.
British Columbia, Univ. of WO 01/18240
Measurement of polymorphisms in the interferon gamma genes; for diagnosing autoimmunity.
California, Univ. of WO 01/17508
Methods for cationic delivery of taxanes to angiogenic blood vessels.
California, Univ. of WO 01/18019
Epithelial cancer therapeutics
Epithelial protein whose expression is lost in neoplasms, encoding gene sequences; for cancer therapeutics.
California, Univ. of WO 01/18020
Mechanosensory transduction channel
Eukaryotic mechanosensory transduction channel, encoding gene sequences; for developing sensation therapeutics.
California, Univ. of WO 01/18050
Taste transduction receptors
Family of taste transduction G-protein coupled receptors, encoding gene sequences, antibodies; for modulator screens.
California, Univ. of WO 01/18251
Electronic detection of polynucleotide molecules using methods for translocating through nanopores.
Cambridge Univ. Tech. Services WO 01/18057
Drosophila developmental-related genes, encoded proteins; for linking mutations to phenotype changes.
Canji WO 01/17537
Reducing pre-existing immune responses by selective elimination of antiviral antibodies from serum.
CNRS (Natl. Ctr. Sci. Res.) WO 01/18198
Spastic paraplegia gene
Cloning and characterization of the SPG4 gene encoding spastin; for studying familial spastic paraplegia.
Chugai WO 01/18200
Fruit fly TSG gene homolog, encoded protein; for developing hematopoietic function modulators.
Corixa WO 01/18046
Ovarian cancer therapeutics
Ovarian tumor expressed proteins, encoding gene sequences, antibodies; for cancer diagnostics and therapeutics.
CuraGen WO 01/18204
B7 family genes
New Haven, Conn.
Human B cell activation antigen B7 family genes, encoded proteins, variants, antibodies; for therapeutics.
CuraGen WO 01/18208
New Haven, Conn.
Interferon-induced gene sequences, encoded proteins, variants, fusions, fragments, antibodies; for therapeutics.
CuraGen WO 01/18209
New Haven, Conn.
Fibroblast growth factor polypeptide, encoding gene sequences, variants, fusions, fragments, antibodies.
Decode Genetics WO 01/18245
Detecting gene alterations
Detection of alterations in genes by long range PCR using human mobile sequence elements.
DNAVec Res. WO 01/18223
Paramyxoviruses having modified transcription initiation sequences; for making vaccines.
Eli Lilly WO 01/18041, 18055 & 18202
Fas-FasL interaction modulation
Protease-resistant FLINT complexes/analogs with reduced aggregation; for Fas-FasL interaction-related diseases.
Exact Labs WO 01/18252
Nucleic acid integrity
Methods for detecting the integrity of nucleic acids in patient samples; for disease detection.
Florida, Univ. of WO 01/18222
Chromosomal gene integration
Vector constructs with in vivo excisable selection markers; for chromosomal integration of heterologous gene sequences.
Genaissance Pharma WO 01/18232
Uncoupling protein 3 gene SNPs
New Haven, Conn.
17 single nucleotide polymorphisms in the uncoupling protein 3 gene; for designing therapeutics.
Genena WO 01/18056
Cancer gene therapy
Tel Mond, Israel
Gene construct having extracellular matrix, transmembrane, and virus coat binding moieties; for cancer gene therapy.
Genentech WO 01/18210
S. San Francisco
Fibroblast growth factor-19, encoding gene sequences, fusions, antibodies; for treating obesity.
Genetrol Biotherapeutics WO 01/18185
High level cytokine production
Methods for enhancing cytokine production in cell culture while avoiding apoptosis induction.
Genzyme WO 01/18224
Cystic fibrosis gene therapy
Adenoviral vectors for persistent expression of the cystic fibrosis transmembrane conductance gene in airway epithelia.
Glasgow, Univ. of WO 01/18547
Identifying essential genes
Identification of essential genes whose lack of expression leads to lethal or semi-lethal phenotypes.
Glaxo WO 01/18039
IFN-a production modulation
Use of interferon regulatory factor 7 and its functional analogs to modulate interferon-a production.
Helix Res. Inst. EP 1 085 024
Nuclear transport proteins
Isolation of gene sequences encoding proteins having nuclear transport activity, encoded proteins.
Henry Ford Hlth. System WO 01/17533
Inhibitor of vascular superoxide anion, vector expressing superoxide anion; for treating atherosclerosis.
Human Genome Sciences WO 01/17532
Human neuropeptide receptor, encoding gene sequences, production methods; for diagnostics and therapeutics.
Human Genome Sciences WO 01/18014
29 human cancer-associated proteins, encoding genes, antibodies; for identifying modulators to treat cancer.
Human Genome Sciences WO 01/18021
B7-like gene sequences
B7-like gene sequences, encoded proteins, antibodies; for developing diagnostics and therapeutics.
Human Genome Sciences WO 01/18022
52 secreted proteins
52 human secreted proteins, encoding gene sequences, antibodies, production methods; for therapeutics.
Human Genome Sciences WO 01/18049
Steroid hormone receptors
Steroid hormone receptors, encoding genes, antibodies; for developing diagnostics and therapeutics.
Human Genome Sciences WO 01/18176
Immunoglobulin superfamily genes
Immunoglobulin superfamily gene sequences, encoded proteins, antibodies, production methods; for therapeutics.
Immunex WO 01/18044
Multiple drug resistance therapy
Use of semaphorin and its gene sequences to affect cellular efflux pumps; for treating multiple drug resistance.
Imperial Coll. Innovation WO 01/18038
Treating clostridial toxin poisoning
Use of soluble N-ethylmaleimide-sensitive fusion proteins to treat clostridial toxin poisoning.
Incyte Genomics EP 1 085 468
Displaying sequence data
Palo Alto, Calif.
Methods, media, and systems for graphically displaying biomolecular sequence data.
Incyte Genomics WO 01/18042
Palo Alto, Calif.
Apoptosis proteins, encoding gene sequences, antibodies, modulators; for developing therapeutics.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 01/18053
MHC class I antigen analogs
Recombinant protein analogs of MHC class I antigens having alterations in the zone of interaction with CD8 receptors.
Introgene WO 01/18048
Smooth muscle cell promoter
Smooth muscle cell promoter; for linkage to heterologous genes in an adenoviral vector for gene therapy.
Isis Pharma WO 01/18023 & 18024
Antisense modulation of expression
Antisense modulation of P13 kinase P110_ and X-linked inhibitor of apoptosis expression; for therapeutics.
Kyowa Hakko Kogyo EP 1 085 090
IgA nephropathy gene
Immunoglobulin A nephropathy-associated gene sequences, encoded protein; for diagnostics and therapeutics.
Lexicon Genetics WO 01/18206 & 18207
The Woodlands, Texas
Human G-protein coupled 7-transmembrane receptor, encoding gene sequences; for therapeutics.
Lifebeam Technol. WO 01/18247
Analyzing polynucleotide molecules by detecting their quenching effects on a fluorescent reporter.
Mass. Gen. Hosp. WO 01/17343
Evaluating agents affecting skin
Non-transgenic mice having a reporter gene coupled to a skin metabolism promoter; for evaluating skin agents.
Max Planck Inst. WO 01/18215
Producing serine proteases
Methods for producing active serine proteases and inactive variants in prokaryotic host cells.
Max Planck Inst. WO 01/18546
Paired helical filament nucleation
Determining the minimal tau peptide that is necessary for nucleation of paired helical filaments.
McGill Univ. WO 01/18544
Trinucleotide repeat disease assay
Detecting protein accumulation in intranuclear inclusions; for diagnosing trinucleotide repeat diseases.
MRC (Med. Res. Counc.) WO 01/18244
Detecting binding events
Hybrid sigma54 RNAP proteins genetic selection system; for detecting DNA:protein and protein:protein binding events.
Merck WO 01/18018
Pseudomonas aeruginosa MurF protein, encoding gene sequences; for identification of modulators.
Millennium Pharma WO 01/18016
Genes encoding proteins having therapeutic action, encoded proteins, antibodies; for modulator screens.
Millennium Pharma WO 01/18216
Calpain protease, encoding gene sequences, fusions, antibodies; for developing diagnostics and therapeutics.
Millennium Predictive Med. WO 01/18542
Ovarian cancer markers
Markers that correlate with the presence of ovarian cancer; for diagnosis and treatment.
NIH (Natl. Inst. Hlth.) WO 01/18254
Breast cancer gene
Identification of RAD51 gene mutants; for diagnosing a predisposition to breast cancer.
NIH (Natl. Inst. Hlth.) WO 01/18550
Adrenomedullin binding proteins
Identification and isolation of adrenomedullin binding proteins; for treating cancer and diabetes.
Neurogenetics WO 01/18549
Increasing life span
Agents that activate C. elegans DAF-16 gene and its human homologs; for increasing stress resistance and life span.
New York Univ. EP 1 085 093
UV-damaged skin genes
Genes associated with UV-mediated skin damage, encoded proteins; for developing diagnostics and therapeutics.
Novopharm Biotech WO 01/18058
VH fragment library
Enhanced phage display library of human VH fragments, production methods; for developing therapeutics.
Pennsylvania, Univ. of WO 01/18173
Neuropilin-1 deletion mutant
Neuropilin-1 having a deletion in one of its extracellular domains; for modulating secreted semaphorin action.
Pfizer EP 1 085 089 & 1 085 092
Human phosphodiesterases, including cyclic nucleotide phosphodiesterases, encoding gene sequences.
Princeton Univ. WO 01/18246
Nucleic acid sequencing
Sequencing nucleic acids by electronic detection of differentially labelled single nucleotides.
Prolifia WO 01/18043
Promoting neurite outgrowth
Extracellular administration of Mts 1 protein; for promoting neurite outgrowth from neuronal cells.
Psiron WO 01/18541
Measuring cell-mediated immune response to _2GPI; for diagnosing autoimmune disease.
Queensland Inst. Med. Res. WO 01/18047
T cell stimulatory protein
Dendritic cell membrane protein FIRE that is preferentially expressed in dendritic cells that stimulate T cells.
Ramot Univ. WO 01/18169
Tel Aviv, Israel
Presentation of antigens or antibodies on a display vehicle; for vaccination against plaque-forming diseases.
Ramot Univ. WO 01/18197
Tel Aviv, Israel
Screening molecules and DNA for gene-specific lethality; for modulating gene function and eliminating cells and tissues.
RIKEN EP 1 085 323
Apoptosis modulator screens
Apoptosis-related protein that binds NADE, encoding gene sequences; for modulator screens.
Salk Inst. Biol. Studies WO 01/17514
Gene expression modulation
La Jolla, Calif.
Modulating gene expression by using agents that affect histone acetylation.
Schering WO 01/17558
Administration of CCR6 or MIP-3a alone or in combination with other therapeutic agents; for immunomodulation.
Schering WO 01/18051
Mammalian cytokines, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Shanghai Inst. Biotech. WO 01/18052
Monomeric insulin analogs
Monomeric analogs of human insulin having specific amino acid residue substitutions in the B chain.
Sheriff, A. EP 1 085 085
Process for reducing immune system reactions using antigen-presenting cells and CD40 receptors [in German].
Sloan-Kettering Inst. Cancer Res. WO 01/18045
Histone deacetylation agents
Crystal structure of histone deacetylase and its inhibitors; for developing therapeutics.
SmithKline Beecham WO 01/17550 & 17551
Multi-antigen viral vaccines
Compositions having more than one viral antigen; for inducing antiviral responses.
SmithKline Beecham WO 01/18054
Monkey GPR14 polypeptides
Monkey GPR14 polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 01/18228
Human sbgFGF-10a polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 01/18249
Staphylococcus aureus kdtB polypeptides, encoding nucleic acid sequences; for antibacterial screens.
SmithKline Beecham WO 01/18253
Inserting gene sequences
Gene manipulation using homologous recombination methods; for inserting polynucleotide sequences.
Teikoku Hormone EP 1 085 088
Fibrin degradation assays
Monoclonal antibodies that do not react with fibrin degradation products; for developing assays.
Texas, Univ. of WO 01/17552
Kaposi's sarcoma therapeutics
Kaposi's sarcoma-associated herpes virus KS-SM gene product; for developing diagnostics and therapeutics.
Transgene WO 01/18035
Cytotoxic T cell activation
MUC-1 derived proteins that activate the cytotoxic T cell response, encoding gene sequences.
University Hlth. Network WO 01/18037
Death domain protein
p53-induced protein with a death domain that can promote apoptosis, encoding gene sequences; for therapeutics.
Veso WO 01/18212
Mycobacterial antigenic polypeptides, antibodies; for infection diagnostics and therapeutics.
Whitehead Inst. Biomed. Res. WO 01/18250
Allele-specific primers for finding single nucleotide polymorphisms in genes.
Xenogen WO 01/18225
Making transgenics that have a non-essential gene replaced with a reporter gene.
Yale Univ. WO 01/18234
Solid phase phage display
New Haven, Conn.
Isolation of specific proteins using phage display technology, bound ligands, and affinity chromatography.
Yeda Res. & Develop. WO 01/18040
Use of leptin and VEGF to inhibit endothelial cell proliferation; for angiogenesis modulation.
Zink, D. WO 01/18189
Expressing exogenous genes
Integration of transfected gene sequences into the active compartment of nuclei; for expressing exogenous genes.
ZymoGenetics WO 01/18205
Secreted polypeptides, encoding gene sequences; for developing diagnostics and therapeutics.