April 4 (EPO), March 29 (WO)
Aberdeen Univ. WO 01/21800
Monoclonal antibodies that neutralize viral hemorrhagic septicemia virus; for viral therapy.
Affina Immunotech. WO 01/21660
Peptides for combating the autoantibodies responsible for dilative cardiomyopathy.
Al-Mahmood, S. WO 01/21831
Isolating mRNA from endothelial cells growing in cell culture; for identifying angiogenesis regulating genes.
Alabama, Univ. of WO 01/21216
Cell-targeted gene therapy
Capsid-modified recombinant adenoviral vector having an introduced single-chain antibody for cell targeting.
Amgen WO 01/21812
MAP kinase phosphatases
Thousand Oaks, Calif.
Phosphatases that activate MAP kinase pathways, encoding genes, antibodies; for diagnostics and therapeutics.
An-Go-Gen WO 01/21184
Fibroblasts that express angiogenic factors; for injection into pulmonary circulation to locally treat vasculature.
Antigen Express WO 01/21193
Enhancing MHC antigen presentation
Hybrid polypeptides that enhance MHC Class II antigen presentation; for immune response modulation.
AstraZeneca WO 01/21833
Cystic fibrosis gene alleles
Detection of specific alleles of the human CFTR gene; for diagnosing cystic fibrosis.
Aventis Pasteur WO 01/21802-21806 & 21810
Chlamydia antigens, encoding gene sequences; for developing diagnostics and therapeutics.
Aventis Pharma WO 01/20977
Animals that show amyloid plaques and mitochondrial dysfunctions; for modeling Alzheimer's.
Aventis Pharma WO 01/21662
Signal sequences used for the production of leu-hirudin via secretion by E. coli; for hemostasis therapeutics.
Barnes Jewish Hosp. WO 01/21762
Decreasing cholesterol uptake
Administration of agents that inhibit MDR1; for decreasing cholesterol uptake.
Boehringer Ingelheim Intl. WO 01/22092
Bone disorder therapeutic assay
Assays for agents that upregulate osteoblast Fra-1 gene expression; for identifying bone disorder therapeutics.
Brocker, T. WO 01/21199
Dedritic cell DNA vaccination
Highly efficient dendritic cell-targeted DNA vaccination using a promoter active in antigen-presenting cells.
California, Univ. of WO 01/21191
CRF inhibition of cell growth
Inhibition of abnormal cell growth with corticotropin-releasing factor analogs having D-amino acid moieties.
Cambridge, Univ. of EP 1 088 889
Displaying CTL epitopes
Double hybrid filamentous bacteriophage engineered to display a cytotoxic T cell epitope; for vaccines.
Canbas WO 01/21771
Cell cycle arrest inhibition
Inhibition of Chk1/2 kinases; for inhibiting G2 cell cycle arrest and sensitizing cells to DNA damaging agents.
Cedars-Sinai Med. Ctr. WO 01/21649
Estrogen modulator screens
Genes encoding vitamin D response element binding proteins, encoded proteins; for screening estrogen modulators.
Cell Science Therapeutics WO 01/21766
Non-hematopoietic stem cells
Methods for isolating non-hematopoietic lineage cells from hematopoietic progenitor cells.
Chugai Res. Inst. Molec. Med. EP 1 088 831
Hemopoietin receptors, modified versions, encoding gene sequences, production methods; for therapeutics.
Chugai Res. Inst. Molec. Med. WO 01/21792
OATP transporter-related proteins
OATP transporter-related proteins, encoding genes, single nucleotide polymorphisms; for assessing drug therapy.
Cognetix WO 01/21648
Conotoxins for ischemia
Salt Lake City
Use of kappa-conotoxin PVIIA analogs and derivatives to activate ATPase-sensitive potassium channels; for ischemia.
Corixa WO 01/21192
Treating hematologic malignancies
Detecting and treating hematologic and virus-associated malignancies using Her2/neu genes and encoded proteins.
Corixa WO 01/21653
Ovarian tumor antigen
Ovarian tumor antigen, variants, immunogenic fragments, encoding gene sequences; for diagnostics and therapeutics.
Eberhard Karls Univ. WO 01/21789
Ribozymes that target cyclin E or E2F1 mRNAs; for inhibiting smooth muscle cell growth and consequent restenosis.
Epimmune WO 01/21189
Hepatitis immune response
Inducing cellular immune responses to hepatitis C virus using viral peptides and encoding nucleic acid sequences.
Forsyth Dental Infirmary WO 01/21797
Osteoclast G-protein regulator
G-protein regulator expressed in osteoclasts, encoding gene sequences; for developing diagnostics and therapeutics.
Fox Chase Cancer Ctr. WO 01/21798
ABCA transporter 2
Human ABCA transporter 2, encoding gene sequences; for developing diagnostics and therapeutics.
Friz Biochem WO 01/21635
Detecting DNA hybridization
Methods for electrochemically detecting sequence-specific nucleic acid-oligomer hybridization events.
Genaissance Pharma WO 01/21639
IL-1_ gene SNPs
New Haven, Conn.
Polymorphisms in the interleukin-1_ gene; for defining drug targets.
Gene Logic WO 01/21840
Methods for using specific gene sequence probes to index populations.
Genetics Inst. WO 01/21796
GL50 proteins, encoding gene sequences, antisense, transgenics, fusions, antigenic peptides, antibodies.
Genset WO 01/21647
Methods for screening for compounds that modulate the LSR-leptin interaction; for treating obesity-related diseases.
Genzyme WO 01/21824
Pseudoadenoviral vector production
Helper vectors and cell lines for the production of pseudoadenoviral vectors; for gene therapy.
Glaxo WO 01/21791
Stargazin-like polypeptide, encoding gene, variants; for modulating voltage-gated calcium channel activity.
Hitachi Software Engineering EP 1 089 211
Gene expression pattern display
Methods and apparatus for displaying gene expression patterns; for cluster analysis.
Human Genome Sciences WO 01/21658
32 secreted proteins
32 human secreted proteins, encoding genes, antibodies, production methods; for diagnostics and therapeutics.
Imgenex WO 01/21136
Cancer therapeutic development
Antibodies that bind transcription factors; for finding modulators that affect these factors in cancer cells.
Incyte Genomics EP 1 088 890
Recombinant BPI proteins
Palo Alto, Calif.
Recombinant BPI proteins and complexes that have endotoxin neutralizing activity but no bacteriocidal activity.
Incyte Genomics WO 01/21836
Palo Alto, Calif.
Gene sequences for diagnostics and therapeutics, encoded proteins, fragments, oligo probes, gene chips.
Isis Innovation WO 01/21201
Boosting CD8+ cell responses
Use of replication-deficient adenoviral vectors to boost CD8+ cell immune responses to antigens.
Isis Innovation WO 01/21655
Bacterial virulence gene
Virulence gene from enteric bacteria, encoded protein; for developing antibacterials.
Isis Innovation WO 01/21816
IgE expression modulation
Modulation of immunoglobulin E cell surface expression; for modulating allergic reactions.
Isis Innovation WO 01/21832
Diagnosis of inflammatory bowel disease by looking for a 32 base pair deletion in the chemokine receptor CCR5 gene.
Japan Sci. & Technol. WO 01/21788
Mast cell transduction proteins
Mast cell-specific transducing molecules, encoding gene sequences, antibodies; for developing allergy drugs.
Johns Hopkins Univ. WO 01/21652
Correcting protein misfolding
Use of a cell-free system to identify agents that correct defective protein folding.
Karolinska Inst. WO 01/21659
Bone marrow protein
Bone marrow protein, encoding gene sequences; for bone disease diagnostics and therapeutics.
Keio Univ. WO 01/21786
Cell death modulation
Methods for screening for proteins that have an effect in diseases associated with cell death.
Keio Univ. WO 01/21787
Neuronal cell death inhibition
Protein that inhibits neuronal cell death associated with Alzheimer's disease, encoding gene sequences.
Kennedy Inst. Rheumatology WO 01/21202
Inhibiting NF-kappaB mediated T cell-induced release of pro-inflammatory cytokines from monocytes; for arthritis.
Kennedy Inst. Rheumatology WO 01/21823
Cytokine controlled vector genes
Adenoviral vectors containing cytokine gene promoters linked to a reporter gene; for studying their cellular expression.
Kennedy Inst. Rheumatology WO 01/21834
Comparison of reporter gene activity linked to distinct promoters in adenoviral vectors; for polymorphism assays.
Leeds, Univ. of WO 01/21780
Targeted transgene removal
Removing transgenes with flanking regions of bacteriophage lambda attachment P regions using homologous recombination.
Lexicon Genetics WO 01/21651
Protease inhibitor-like proteins
The Woodlands, Texas
Human protease inhibitor-like proteins, encoding gene sequences; for diagnostics and therapeutics.
Lexicon Genetics WO 01/21773
Endothelin converting enzyme-like proteins
The Woodlands, Texas
Human endothelin converting enzyme-like proteins, encoding genes; for diagnostics and therapeutics.
Linden Technol. WO 01/20998
Finding drug candidates
Relational databases containing gene expression profiles from various phenotypes; for identifying drug candidates.
Ludwig Inst. Cancer Res. WO 01/21794
Smad-associating proteins, encoding genes, fragments, functional variants, antibodies; for therapeutics.
Manitoba, Univ. of WO 01/21811
Chlamydia DNA vaccines
Chlamydia serine-threonine kinase, encoding gene sequences; for DNA immunization against infection.
Mass. Gen. Hosp. WO 01/21837
Potentiating antisense activity by linking antisense to protein-coding gene sequences such as a recombinase gene.
Max Planck Inst. EP 1 088 898
Use of modulators of Rab and Rho GTPases to affect cell cytoskeleton-membrane interactions; for treating cancer.
Mayo Fdn. WO 01/20989
Cancer gene therapy
Recombinant paramyxoviruses specific for cancers that encode cancer therapeutics; for gene therapy.
McGill Univ. WO 01/21769
Cystic fibrosis therapy
Three-dimensional structure and crystals of a class I endoplasmic reticulum a1,2-mannosidase; for cystic fibrosis.
Medeva EP 1 088 830
Hepatitis B vaccines
Immunogenic hepatitis B virus antigen particles; for making vaccines.
Medgene Bioscience WO 01/21214
Cerebrovascular gene therapy
Transferring hepatocyte growth factor and VEGF genes into the subarachnoidal space to treat cerebrovascular disorders.
Merck EP 1 088 888
Immunoglobulin Fc fusion
Fusion of a signal sequence to an immunoglobulin Fc region that is linked by a target protein; for therapeutics.
Merck WO 01/21814
Heparanase-2, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
Millennium Pharma WO 01/21631
Secreted and transmembrane proteins, encoding genes, antibodies; for cancer and immune system therapeutics.
Millennium Pharma WO 01/21641
Immune disorder-related genes
Genes differentially expressed in TH1 and TH2 cells; for diagnosing and treating immune system disorders.
Miyasaka, N. WO 01/21793
Use of inhibitors of cyclin-dependent kinases in articular tissues to treat rheumatoid arthritis.
Morphogen Pharma WO 01/21767
Pluripotent embryonic stem cells
Pluripotent embryonic-like stem cells, isolation methods; for producing lineage-committed cells.
Motorola WO 01/21838
Parallel SNP genotyping
Three-dimensional microarray system for parallel genotyping of single nucleotide polymorphisms.
Netherlands Tech. Develop. Org. WO 01/21200
Recombinant modified Lactobacillus bacteria strains that express antigens; for oral vaccines.
NIH (Natl. Inst. Hlth.) WO 01/21188
Finding serum amyloid ligands
Assay for identifying serum amyloid ligands using the interaction of this protein with the PPRL 1 receptor.
NIH (Natl. Inst. Hlth.) WO 01/21656
Mutated anthrax toxin protective antigen proteins that target cells having cell surface metalloproteinases.
NIH (Natl. Inst. Hlth.) WO 01/21807
Hepatitis C vaccines
Hepatitis C virus envelope protein E2 lacking its hypervariable region, chimeras; for vaccines.
New York, State Univ. of WO 01/21636
E. coli vaccines
Cytoplasmic protein from an extraintestinal isolate of E. coli; for developing vaccines.
Novo Nordisk WO 01/21661
Bivalent serine protease inhibitor of the Factor VIIa/Xa complex; for treating thrombotic surgical complications.
Pennsylvania, Univ. of WO 01/21640
Sulfatase family, encoding genes; for modifying cell growth and preventing lymphocyte recruitment to inflamed tissue.
Pharmacia & Upjohn WO 01/21839
Pathogen gene expression profiles
Analysis of data generated from microarrays; for developing gene expression profiles of pathogens.
Philadelphia Hlth. & Education WO 01/21828
Cancer marker protein
PCAM-1 cancer marker protein, encoding gene sequences, antibodies; for developing diagnostics and therapeutics.
Pierre Fabre Medicament WO 01/21203
Outer membrane protein A of an enterobacterium associated with an RSV immunogenic peptide; for intranasal vaccines.
Plumley, K.M. EP 1 088 557
In vivo production of antibodies to modified p53; for cancer vaccines.
Prodigene WO 01/21270
Therapeutic proteins from plants
College Stn., Texas
Recovery of recombinant therapeutic proteins from plant tissue; for therapeutic protein production.
Reneuron WO 01/21790
Conditional cell immortalization
Cells having a conditionally-inducible oncogene and a telomerase complex subunit gene; for immortalization.
Rigel Pharma WO 01/21654, 21663, 21784, 21799 & 21815
Cell cycle-related proteins
S. San Francisco
Syk kinase, PCNA, and TRAF4-associated cell cycle proteins, encoding genes, antibodies; for cell cycle control.
Robarts Res. Inst. WO 01/21204
Using M3 polypeptide formulations to treat a variety of inflammatory and autoimmune disorders.
Rome Univ. WO 01/21765
Tumor cell killing
Methods for protecting growing normal cells while eradicating tumor cells having an inactive p53 pathway.
Shionogi WO 01/21775
Secretory phospholipase A2
Human secretory phospholipase A2, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 01/21764
PCRA helicase of Staphylococcus aureus, encoding gene, recombinant production methods; for antibacterial screens.
Stanford Univ. WO 01/21829
Soluble adenylyl cyclase
Palo Alto, Calif.
Human soluble adenylyl cyclase, encoding gene sequences; for identifying agents for use as male contraceptives.
Suntory WO 01/21205
Coupling factor 6 inhibitor
Inhibitor of coupling factor 6, which is a subunit of a proton-translocating ATPase inhibitor; for therapeutics.
TGT Labs WO 01/21761
Fibrotic disease therapy
Recombinant adenoviral vectors expressing therapeutic proteins that treat various fibrotic diseases.
Vlaams Biotech Inst. EP 1 088 892 & WO 01/21817
Genetically modified pseudovirions
Genetically modified pseudovirions, bacteriophages, or phagemids that enter cells via an artificial receptor.
Whitehead Inst. Biomed. Res. WO 01/21795
Fatty acid transport proteins
Fatty acid transport proteins, encoding gene sequences; for developing diagnostics and therapeutics.
York, Univ. of WO 01/21645
Crystals of an E2 N-terminal module dimmer protein having vital viral transcription residues; for antivirals.