February 14 (EP), February 8 (WO)

Affymetrix WO 01/09369

Gene expression monitoring

Santa Clara, Calif.

Single-phase amplification of nucleic acids using probe arrays; for gene expression monitoring.

American Home Products WO 01/09309

Attenuated mumps virus

Madison, N.J.

Recombinant production of attenuated nonsegmented, negative-sense, single-stranded RNA virus by mumps virus rescue.

Avigen WO 01/09360

Restenosis gene therapy

Alameda, Calif.

Adeno-associated virus vector encoding a therapeutic protein that prevents smooth muscle cell growth in grafts.

Aviron WO 01/08703

Attenuated RSV vectors

Mountain View, Calif.

Recombinant respiratory syncytial virus vectors having engineered accessory gene deletions that cause attenuation.

Baylor Coll. Med. WO 01/09351

Targeted transgene integration


Vectors without antibiotic resistance markers; for selectable targeted chromosomal integration of transgenes.

Berlex Labs WO 01/09310

Signal sequence cDNA libraries

Richmond, Calif.

Generation of 5'-enriched cDNA libraries that allows selection of cDNAs that encode signal sequences.

Bioergonomics WO 01/09608

Binding pair detection

St. Paul, Minn.

Simultaneous immunological detection of both members of a binding pair using antibodies and flow cytometry.

Canadian Natl. Res. Counc. WO 01/09298

Cancer vaccines


Expression of a highly antigenic surface antigen in cancer cells expressing modified a2-8 polysialic acid residues.

Carl Zeiss WO 01/09591

FISH methods

Jena, Germany

Methods for optical excitation of fluorophore-marked DNA and RNA; for fluorescent in situ hybridization (FISH).

Catholic Univ. EP 1 076 091

Treating heart ischemia

Louvain, Belgium

Modulators of endogenous caveolin-1 binding; for treating heart ischemia and peripheral vascular diseases.

CNRS (Natl. Ctr. Sci. Res.) WO 01/09194

MHC immune diagnostics


Soluble recombinant protein dimers with MHC class I/II a and _ chains; for immune diagnostics and therapeutics.

Cytocell WO 01/09376 & 09377

Amplifying nucleic acids

Banbury, UK

Detection and amplification of nucleic acids in vitro using single-stranded probes and an RNA polymerase blocker.

Dade Behring WO 01/09190

Antibodies to immunosuppressants

Deerfield, Ill.

IgG monoclonal antibodies to the immunosuppressive drug tacrolimus; for drug concentration immunoassays.

Dana-Farber Cancer Inst. WO 01/09308

Inducible cancer transgenics


Cancer-susceptible transgenics having an oncogene operably linked to an inducible promoter; for studying cancer.

Epidauros WO 01/09183

MDR-1 gene SNPs

Bernried, Germany

Human multidrug resistance-1 gene polymorphisms; for diagnostics and modulator screens.

Epigenomics WO 01/09374

Gene arrays


Methods for characterizing nucleic acids using solid supports to form arrays.

Epoch Pharma WO 01/09385

Nucleic acid detection

Redmond, Wash.

Attachment of oligonucleotides to solid supports using Schiff base-type linkages; for nucleic acid detection.

Erasmus Univ. EP 1 075 841

Pneumococal vaccines

Rotterdam, Netherlands

Staphylococcus pneumoniae protein and fragments, encoding gene sequences; for vaccines.

European Molec. Biol. Lab WO 01/09615

Protein-protein interactions

Heidelberg, Germany

Predicting potential protein-protein interactions by finding for genes encoding multi-domain proteins.

Genaissance Pharma WO 01/09161

Drug development SNPs

New Haven, Conn.

Solute carrier family 6-neurotransmitter transporter, serotonin member, 4 gene SNPs; for drug development.

Genentech WO 01/09327

Retinal neuron protection

S. San Francisco

Use of PRO polypeptides to delay or prevent injury or death of retinal neurons.

Genome Therapeutics WO 01/09367

Drug design using SNPs

Waltham, Mass.

Methods for determining the section of a gene that has the least number of polymorphisms; for drug design.

Genzyme WO 01/09384

Gene alteration analysis

Framingham, Mass.

Rapid detection and identification of multiple genetic alterations using serial analysis.

Helix Res. Inst. WO 01/09315

Smooth muscle differentiation gene

Chiba, Japan

Gene participating in the maintenance of smooth muscle cell differentiation, encoded protein; for therapeutics.

Helix Res. Inst. WO 01/09316 & 09345

Protein kinase gene

Chiba, Japan

Protein kinase and protein phosphatase genes, encoded proteins; for developing therapeutics.

Helix Res. Inst. WO 01/09317

Stomach cancer gene

Chiba, Japan

Stomach cancer-associated gene, encoded protein; for developing therapeutics.

Helix Res. Inst. WO 01/09318

Liver cancer gene

Chiba, Japan

Liver cancer-associated gene, encoded protein; for developing therapeutics.

Helix Res. Inst. WO 01/09319

Fetal heart gene

Chiba, Japan

Gene expressed in human fetal heart muscle, encoded protein; for developing therapeutics.

Helix Res. Inst. WO 01/09320

ADP-ribosylation factor-like protein gene

Chiba, Japan

Gene encoding ADP-ribosylation factor-like protein, encoded protein; for developing therapeutics.

Helix Res. Inst. WO 01/09321

Brain tumor-associated gene

Chiba, Japan

TSP1-like protein showing lowered expression in brain tumors, encoded protein; for developing therapeutics.

Helix Res. Inst. WO 01/09322 & 09323

GTP-binding protein coupled receptors

Chiba, Japan

GTP-binding protein coupled receptors, encoding genes; for developing cancer and Alzheimer's therapeutics.

Helix Res. Inst. WO 01/09346

Adenylate kinase 3-like protein gene

Chiba, Japan

Gene encoding an adenylate kinase 3-like protein, encoded protein; for modulating cell morphology.

Helix Res. Inst. WO 01/09349

Serine protease-like protein gene

Chiba, Japan

Gene encoding a serine protease-like protein, encoded protein; for developing Alzheimer's therapeutics.

Human Genome Sciences WO 01/08634

Serine proteases

Rockville, Md.

Human serine proteases, encoding gene sequences, antibodies,

production methods; for diagnostics and therapeutics.

Human Genome Sciences WO 01/08635

Calcium channel proteins

Rockville, Md.

Human calcium channel transport proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Incyte Genomics WO 01/09178

Chaperone proteins

Palo Alto, Calif.

Human chaperone proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

INSERM (Natl. Inst. Hlth. & Med. Res.) WO 01/09314

ABCA transporter modulator screen


ABCA transporter gene-containing vectors inserted into eukaryotic cells; for screening modulators.

Isis Innovation WO 01/09291

Attenuated influenza vaccine

Summertown, N.J.

Negative-sense single-stranded influenza virus attenuated by replacing poly U tracks with poly A tracks; for attenuation.

Isis Pharma WO 01/09379

Mitochondrial PEPCK antisense

Carlsbad, Calif.

Antisense oligos for modulating the mitochondrial expression of PEPCK.

Japan Soc. Promotion Science EP 1 076 065

Inhibiting HIV syncytium formation


Human protein that inhibits syncytium formation by fusion of the HIV envelope glycoprotein; for therapeutics.

Johns Hopkins Univ. WO 01/09386

Digital gene analysis


Exponential analog data from PCR-based amplification is transformed into linear digital signals; for gene analysis.

Kim, H.T., et al. WO 01/09378

Microwell DNA detection

Seoul, S. Korea

Methods for detecting nucleic acids in samples using microwell plates with various DNA probes.

Medarex WO 01/09187

Human HER2/neu antibodies

Annandale, N.J.

Human monoclonal antibodies to HER2/neu, fragments, hybridomas, transgenics; for therapeutics.

Medarex WO 01/09192

Human PSA antibodies

Annandale, N.J.

Human monoclonal antibodies to prostate-specific membrane antigen, fragments, hybridomas, transgenics; for therapy.

Merck WO 01/09155

Avermectin antibiotics

Rahway, N.J.

Cloning of Streptomyces avermitilis genes; for glycosylation of avermectin aglycone antibiotics.

Merck WO 01/09313

G-protein coupled receptor

Darmstadt, Germany

G-protein coupled receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.

Millennium Pharma WO 01/09162

Human CD9 homologs

Cambridge, Mass.

Secreted proteins having homology to human CD9 antigen, encoding gene sequences; for diagnostics and therapeutics.

Millennium Pharma WO 01/09185

Transport proteins

Cambridge, Mass.

Transmembrane transport proteins, encoding gene sequences, antisense, transgenics, antibodies; for therapeutics.

Millennium Pharma WO 01/09328

Secretin-like receptor

Cambridge, Mass.

G protein-coupled receptor of the secretin family, encoding gene sequences, antibodies, transgenics; for therapeutics.

Millennium Pharma WO 01/09383

Bone-related disorder therapeutics

Cambridge, Mass.

Methods and compositions for diagnosis, prevention, and treatment of bone-related disorders.

Mirus WO 01/08710

Gene delivery complexes

Madison, Wis.

Nucleic acids modified with polyanions while retaining their ability to be expressed; for gene delivery.

NIH (Natl. Inst. Hlth.) WO 01/09325

Human p53 mutations

Bethesda, Md.

Human p53 mutations, yeast genetic system for identifying functional p53 mutations; for developing therapeutics.

Netherlands Org. Tech. Develop. WO 01/09352

Recombinant protein production

Delft, Netherlands

Transformation of fungi with selectable marker genes; for use in heterologous protein production.

Nexstar Pharma WO 01/09156

TGF_2 nucleic acid ligands

Boulder, Colo.

High affinity nucleic acid ligands to TGF_2, including RNA ligands that inhibit receptor interaction.

Nexstar Pharma WO 01/09157

VEGF nucleic acid ligands

Boulder, Colo.

High affinity nucleic acid ligands to VEGF, including RNA ligands that inhibit receptor interaction.

Nexstar Pharma WO 01/09159

Integrin nucleic acid ligands

Boulder, Colo.

Nucleic acid ligands to hepatocyte growth factor/scatter factor, its c-met receptor, and integrins.

Nexstar Pharma WO 01/09160

CD40 ligand ligands

Boulder, Colo.

Nucleic acid ligands to CD40 ligand isolated using SELEX methods; for developing therapeutics.

Nexstar Pharma WO 01/09380

Transcription-free SELEX

Boulder, Colo.

Transcription-free SELEX that assembles nucleic acid ligands from synthetic nucleic acids by annealing.

Nexstar Pharma WO 01/09390

Tenascin-C ligands

Boulder, Colo.

Nucleic acid ligands to tenascin-C isolated using SELEX methods; for developing therapeutics.

Northeastern Univ. WO 01/09387

Hematopoietic genes


Isolation of hematopoietic genes from icefish by PCR-based representational difference analysis; for therapeutics.

Ohio State Univ. WO 01/08636

HER-2 immunoresponse enhancers

Columbus, Ohio

Proteins and chimeras for enhancing immune reactivity to HER-2 proteins; for breast cancer therapy.

Pasteur Inst. WO 01/09344

Streptogramin A inactivation


Detection of vatD gene which encoded an acetyltransferase that inactivates streptogramin A.

Ramot Univ. WO 01/09311

Cancer growth inhibition

Tel Aviv, Israel

ADNF III antisense oligonucleotides for inhibiting the growth of cancer cells.

Rockefeller Univ. WO 01/09164

Antibiotic screens

New York

DNA replication proteins of Gram positive bacteria; for screening chemical inhibitors with antibiotic activity.

Rockefeller Univ. WO 01/09326

Modified Stat proteins

New York

Modified Stat proteins that are constitutively active; for cell transfection and transgenic production to study cancer.

Schering WO 01/09176

Mammalian cytokines

Kenilworth, N.J.

Mammalian cytokines, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Sequitur WO 01/09312

Modified antisense oligomers

Natick, Mass.

Antisense oligomers having a silicon-based 2' hydroxy protecting group; for improved activity and delivery.

Sheffield, Univ. of WO 01/09343

Genotyping exonucleases

Sheffield, UK

Exonuclease variants lacking 5' to 3' exonuclease activity but retain endonuclease activity; for genotyping.

Signature Bioscience WO 01/09381

Nucleic acid analysis

Hayward, Calif.

Analysis of nucleic acids using the unique dielectric properties of different hybridization complexes.

Signature Bioscience WO 01/09606

Protein binding analysis

Burlingame, Calif.

Analysis of protein binding events using a system that detects the dielectric properties of the binding complex.

SmithKline Beecham WO 01/08486 & 09167

Antibacterial screens


Bacterial coaA and kdtB proteins, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 01/09166

G-protein coupled receptor


Octoray, a G-protein coupled receptor, encoding gene, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 01/09172, 09179 & 09329-09339

Moraxella cattarrhalis antigens


Moraxella cattarrhalis antigens, encoding genes, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 01/09350

Bacterial bleb vaccine


Gram negative bacteria bleb vaccine in which protective antigen expression on the blebs is upregulated.

Solvay Pharma WO 01/09184

CNS G-protein coupled receptor

Weesp, Netherlands

Human G-protein coupled receptor, encoding gene sequences, transgenics; for treating psychiatric and CNS disorders.

Somalogic WO 01/09158

Nucleic acid ligand production

Boulder, Colo.

Methods for producing nucleic acid ligands that modulate cell stimuli using conditional SELEX.

Stratagene WO 01/09347

Enhancing polymerase reactions

La Jolla, Calif.

Archael replication accessory factors, encoding gene sequences; for enhancing polymerase reactions.

Texas, Univ. of WO 01/09292

Sentrin-specific protease

Austin, Texas

Protease active against sentrin-modified proteins in vivo, encoding gene sequences; for diagnostics and therapeutics.

Texas A&M Univ. WO 01/09382

Bacteriophage protein antibiotics

College Stn., Texas

Polypeptide antibiotics developed from bacteriophage proteins that cause bacterial lysis.

Univ. College WO 01/09307, 09342 & 09375

Nitric oxide synthase modulators


Nitric oxide synthase structural gene linked to cell-specific promoters; for cell delivery and modulator screens.

Vical WO 01/09303

Flt-3 ligand gene vaccine enhancer

San Diego

Flt-3 ligand-encoding gene sequences used in combination with antigen or cytokine genes as a vaccine enhancer.

Welfide WO 01/09324

Brain type PGT gene

Osaka, Japan

Chiba, Japan

Human brain type PGT gene, encoded protein; for developing therapeutics.

Whitehead Inst. Biomed. Res. WO 01/09177

Affinity fluorescent proteins

Cambridge, Mass.

Modified green fluorescent protein having a heterologous ligand-activated protein binding site.

Wisconsin, Univ. of WO 01/09363

Modified transposases

Madison, Wis.

Modified Tn5 transposase proteins that prefer inside, rather than outside, ends of genes; for end-specific transposition.

Wistar Inst. WO 01/09150

Mitotic checkpoint gene


Mitotic checkpoint gene, encoded protein; for screening drugs that affect cancer cell division.

Yale Univ. WO 01/09154

Staphylococcus antibiotic design

New Haven, Conn.

Crystal structure of Staphylococcus aureus isoleucyl-tRNA synthetase; for designing antibiotics.

Yissum Res. & Develop. WO 01/09361

RSV vaccines

Jerusalem, Israel

Recombinant herpes simplex virus-1 genomes having mutations; for vaccines.

Zeneca WO 01/09174 & 09175

Antimicrobial peptides


Antimicrobial peptides derived from plant defensins, derivatives, and mutants.

ZymoGenetics WO 01/09293

Adhesion protease peptides


Mammalian adhesion protease peptides of the disintegrin protease family, encoding gene, variants, antibodies.

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