February 14 (EP), February 8 (WO)
Affymetrix WO 01/09369
Gene expression monitoring
Santa Clara, Calif.
Single-phase amplification of nucleic acids using probe arrays; for gene expression monitoring.
American Home Products WO 01/09309
Attenuated mumps virus
Recombinant production of attenuated nonsegmented, negative-sense, single-stranded RNA virus by mumps virus rescue.
Avigen WO 01/09360
Restenosis gene therapy
Adeno-associated virus vector encoding a therapeutic protein that prevents smooth muscle cell growth in grafts.
Aviron WO 01/08703
Attenuated RSV vectors
Mountain View, Calif.
Recombinant respiratory syncytial virus vectors having engineered accessory gene deletions that cause attenuation.
Baylor Coll. Med. WO 01/09351
Targeted transgene integration
Vectors without antibiotic resistance markers; for selectable targeted chromosomal integration of transgenes.
Berlex Labs WO 01/09310
Signal sequence cDNA libraries
Generation of 5'-enriched cDNA libraries that allows selection of cDNAs that encode signal sequences.
Bioergonomics WO 01/09608
Binding pair detection
St. Paul, Minn.
Simultaneous immunological detection of both members of a binding pair using antibodies and flow cytometry.
Canadian Natl. Res. Counc. WO 01/09298
Expression of a highly antigenic surface antigen in cancer cells expressing modified a2-8 polysialic acid residues.
Carl Zeiss WO 01/09591
Methods for optical excitation of fluorophore-marked DNA and RNA; for fluorescent in situ hybridization (FISH).
Catholic Univ. EP 1 076 091
Treating heart ischemia
Modulators of endogenous caveolin-1 binding; for treating heart ischemia and peripheral vascular diseases.
CNRS (Natl. Ctr. Sci. Res.) WO 01/09194
MHC immune diagnostics
Soluble recombinant protein dimers with MHC class I/II a and _ chains; for immune diagnostics and therapeutics.
Cytocell WO 01/09376 & 09377
Amplifying nucleic acids
Detection and amplification of nucleic acids in vitro using single-stranded probes and an RNA polymerase blocker.
Dade Behring WO 01/09190
Antibodies to immunosuppressants
IgG monoclonal antibodies to the immunosuppressive drug tacrolimus; for drug concentration immunoassays.
Dana-Farber Cancer Inst. WO 01/09308
Inducible cancer transgenics
Cancer-susceptible transgenics having an oncogene operably linked to an inducible promoter; for studying cancer.
Epidauros WO 01/09183
MDR-1 gene SNPs
Human multidrug resistance-1 gene polymorphisms; for diagnostics and modulator screens.
Epigenomics WO 01/09374
Methods for characterizing nucleic acids using solid supports to form arrays.
Epoch Pharma WO 01/09385
Nucleic acid detection
Attachment of oligonucleotides to solid supports using Schiff base-type linkages; for nucleic acid detection.
Erasmus Univ. EP 1 075 841
Staphylococcus pneumoniae protein and fragments, encoding gene sequences; for vaccines.
European Molec. Biol. Lab WO 01/09615
Predicting potential protein-protein interactions by finding for genes encoding multi-domain proteins.
Genaissance Pharma WO 01/09161
Drug development SNPs
New Haven, Conn.
Solute carrier family 6-neurotransmitter transporter, serotonin member, 4 gene SNPs; for drug development.
Genentech WO 01/09327
Retinal neuron protection
S. San Francisco
Use of PRO polypeptides to delay or prevent injury or death of retinal neurons.
Genome Therapeutics WO 01/09367
Drug design using SNPs
Methods for determining the section of a gene that has the least number of polymorphisms; for drug design.
Genzyme WO 01/09384
Gene alteration analysis
Rapid detection and identification of multiple genetic alterations using serial analysis.
Helix Res. Inst. WO 01/09315
Smooth muscle differentiation gene
Gene participating in the maintenance of smooth muscle cell differentiation, encoded protein; for therapeutics.
Helix Res. Inst. WO 01/09316 & 09345
Protein kinase gene
Protein kinase and protein phosphatase genes, encoded proteins; for developing therapeutics.
Helix Res. Inst. WO 01/09317
Stomach cancer gene
Stomach cancer-associated gene, encoded protein; for developing therapeutics.
Helix Res. Inst. WO 01/09318
Liver cancer gene
Liver cancer-associated gene, encoded protein; for developing therapeutics.
Helix Res. Inst. WO 01/09319
Fetal heart gene
Gene expressed in human fetal heart muscle, encoded protein; for developing therapeutics.
Helix Res. Inst. WO 01/09320
ADP-ribosylation factor-like protein gene
Gene encoding ADP-ribosylation factor-like protein, encoded protein; for developing therapeutics.
Helix Res. Inst. WO 01/09321
Brain tumor-associated gene
TSP1-like protein showing lowered expression in brain tumors, encoded protein; for developing therapeutics.
Helix Res. Inst. WO 01/09322 & 09323
GTP-binding protein coupled receptors
GTP-binding protein coupled receptors, encoding genes; for developing cancer and Alzheimer's therapeutics.
Helix Res. Inst. WO 01/09346
Adenylate kinase 3-like protein gene
Gene encoding an adenylate kinase 3-like protein, encoded protein; for modulating cell morphology.
Helix Res. Inst. WO 01/09349
Serine protease-like protein gene
Gene encoding a serine protease-like protein, encoded protein; for developing Alzheimer's therapeutics.
Human Genome Sciences WO 01/08634
Human serine proteases, encoding gene sequences, antibodies,
production methods; for diagnostics and therapeutics.
Human Genome Sciences WO 01/08635
Calcium channel proteins
Human calcium channel transport proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Incyte Genomics WO 01/09178
Palo Alto, Calif.
Human chaperone proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 01/09314
ABCA transporter modulator screen
ABCA transporter gene-containing vectors inserted into eukaryotic cells; for screening modulators.
Isis Innovation WO 01/09291
Attenuated influenza vaccine
Negative-sense single-stranded influenza virus attenuated by replacing poly U tracks with poly A tracks; for attenuation.
Isis Pharma WO 01/09379
Mitochondrial PEPCK antisense
Antisense oligos for modulating the mitochondrial expression of PEPCK.
Japan Soc. Promotion Science EP 1 076 065
Inhibiting HIV syncytium formation
Human protein that inhibits syncytium formation by fusion of the HIV envelope glycoprotein; for therapeutics.
Johns Hopkins Univ. WO 01/09386
Digital gene analysis
Exponential analog data from PCR-based amplification is transformed into linear digital signals; for gene analysis.
Kim, H.T., et al. WO 01/09378
Microwell DNA detection
Seoul, S. Korea
Methods for detecting nucleic acids in samples using microwell plates with various DNA probes.
Medarex WO 01/09187
Human HER2/neu antibodies
Human monoclonal antibodies to HER2/neu, fragments, hybridomas, transgenics; for therapeutics.
Medarex WO 01/09192
Human PSA antibodies
Human monoclonal antibodies to prostate-specific membrane antigen, fragments, hybridomas, transgenics; for therapy.
Merck WO 01/09155
Cloning of Streptomyces avermitilis genes; for glycosylation of avermectin aglycone antibiotics.
Merck WO 01/09313
G-protein coupled receptor
G-protein coupled receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Millennium Pharma WO 01/09162
Human CD9 homologs
Secreted proteins having homology to human CD9 antigen, encoding gene sequences; for diagnostics and therapeutics.
Millennium Pharma WO 01/09185
Transmembrane transport proteins, encoding gene sequences, antisense, transgenics, antibodies; for therapeutics.
Millennium Pharma WO 01/09328
G protein-coupled receptor of the secretin family, encoding gene sequences, antibodies, transgenics; for therapeutics.
Millennium Pharma WO 01/09383
Bone-related disorder therapeutics
Methods and compositions for diagnosis, prevention, and treatment of bone-related disorders.
Mirus WO 01/08710
Gene delivery complexes
Nucleic acids modified with polyanions while retaining their ability to be expressed; for gene delivery.
NIH (Natl. Inst. Hlth.) WO 01/09325
Human p53 mutations
Human p53 mutations, yeast genetic system for identifying functional p53 mutations; for developing therapeutics.
Netherlands Org. Tech. Develop. WO 01/09352
Recombinant protein production
Transformation of fungi with selectable marker genes; for use in heterologous protein production.
Nexstar Pharma WO 01/09156
TGF_2 nucleic acid ligands
High affinity nucleic acid ligands to TGF_2, including RNA ligands that inhibit receptor interaction.
Nexstar Pharma WO 01/09157
VEGF nucleic acid ligands
High affinity nucleic acid ligands to VEGF, including RNA ligands that inhibit receptor interaction.
Nexstar Pharma WO 01/09159
Integrin nucleic acid ligands
Nucleic acid ligands to hepatocyte growth factor/scatter factor, its c-met receptor, and integrins.
Nexstar Pharma WO 01/09160
CD40 ligand ligands
Nucleic acid ligands to CD40 ligand isolated using SELEX methods; for developing therapeutics.
Nexstar Pharma WO 01/09380
Transcription-free SELEX that assembles nucleic acid ligands from synthetic nucleic acids by annealing.
Nexstar Pharma WO 01/09390
Nucleic acid ligands to tenascin-C isolated using SELEX methods; for developing therapeutics.
Northeastern Univ. WO 01/09387
Isolation of hematopoietic genes from icefish by PCR-based representational difference analysis; for therapeutics.
Ohio State Univ. WO 01/08636
HER-2 immunoresponse enhancers
Proteins and chimeras for enhancing immune reactivity to HER-2 proteins; for breast cancer therapy.
Pasteur Inst. WO 01/09344
Streptogramin A inactivation
Detection of vatD gene which encoded an acetyltransferase that inactivates streptogramin A.
Ramot Univ. WO 01/09311
Cancer growth inhibition
Tel Aviv, Israel
ADNF III antisense oligonucleotides for inhibiting the growth of cancer cells.
Rockefeller Univ. WO 01/09164
DNA replication proteins of Gram positive bacteria; for screening chemical inhibitors with antibiotic activity.
Rockefeller Univ. WO 01/09326
Modified Stat proteins
Modified Stat proteins that are constitutively active; for cell transfection and transgenic production to study cancer.
Schering WO 01/09176
Mammalian cytokines, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Sequitur WO 01/09312
Modified antisense oligomers
Antisense oligomers having a silicon-based 2' hydroxy protecting group; for improved activity and delivery.
Sheffield, Univ. of WO 01/09343
Exonuclease variants lacking 5' to 3' exonuclease activity but retain endonuclease activity; for genotyping.
Signature Bioscience WO 01/09381
Nucleic acid analysis
Analysis of nucleic acids using the unique dielectric properties of different hybridization complexes.
Signature Bioscience WO 01/09606
Protein binding analysis
Analysis of protein binding events using a system that detects the dielectric properties of the binding complex.
SmithKline Beecham WO 01/08486 & 09167
Bacterial coaA and kdtB proteins, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 01/09166
G-protein coupled receptor
Octoray, a G-protein coupled receptor, encoding gene, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 01/09172, 09179 & 09329-09339
Moraxella cattarrhalis antigens
Moraxella cattarrhalis antigens, encoding genes, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 01/09350
Bacterial bleb vaccine
Gram negative bacteria bleb vaccine in which protective antigen expression on the blebs is upregulated.
Solvay Pharma WO 01/09184
CNS G-protein coupled receptor
Human G-protein coupled receptor, encoding gene sequences, transgenics; for treating psychiatric and CNS disorders.
Somalogic WO 01/09158
Nucleic acid ligand production
Methods for producing nucleic acid ligands that modulate cell stimuli using conditional SELEX.
Stratagene WO 01/09347
Enhancing polymerase reactions
La Jolla, Calif.
Archael replication accessory factors, encoding gene sequences; for enhancing polymerase reactions.
Texas, Univ. of WO 01/09292
Protease active against sentrin-modified proteins in vivo, encoding gene sequences; for diagnostics and therapeutics.
Texas A&M Univ. WO 01/09382
Bacteriophage protein antibiotics
College Stn., Texas
Polypeptide antibiotics developed from bacteriophage proteins that cause bacterial lysis.
Univ. College WO 01/09307, 09342 & 09375
Nitric oxide synthase modulators
Nitric oxide synthase structural gene linked to cell-specific promoters; for cell delivery and modulator screens.
Vical WO 01/09303
Flt-3 ligand gene vaccine enhancer
Flt-3 ligand-encoding gene sequences used in combination with antigen or cytokine genes as a vaccine enhancer.
Welfide WO 01/09324
Brain type PGT gene
Human brain type PGT gene, encoded protein; for developing therapeutics.
Whitehead Inst. Biomed. Res. WO 01/09177
Affinity fluorescent proteins
Modified green fluorescent protein having a heterologous ligand-activated protein binding site.
Wisconsin, Univ. of WO 01/09363
Modified Tn5 transposase proteins that prefer inside, rather than outside, ends of genes; for end-specific transposition.
Wistar Inst. WO 01/09150
Mitotic checkpoint gene
Mitotic checkpoint gene, encoded protein; for screening drugs that affect cancer cell division.
Yale Univ. WO 01/09154
Staphylococcus antibiotic design
New Haven, Conn.
Crystal structure of Staphylococcus aureus isoleucyl-tRNA synthetase; for designing antibiotics.
Yissum Res. & Develop. WO 01/09361
Recombinant herpes simplex virus-1 genomes having mutations; for vaccines.
Zeneca WO 01/09174 & 09175
Antimicrobial peptides derived from plant defensins, derivatives, and mutants.
ZymoGenetics WO 01/09293
Adhesion protease peptides
Mammalian adhesion protease peptides of the disintegrin protease family, encoding gene, variants, antibodies.