December 7 (WO)
Active Biotech WO 00/73336
Salmonella vaccines
Lund, Sweden
Fimbrial proteins that are specific for Salmonella enterica subspecies 1; for diagnostics and vaccines.
Agron. Res. Ctr. WO 00/73462
Attenuated pathogenic E. coli strains
Brussells, Belgium
Attenuated mutant enteropathogenic E. coli strains having functional deletions in intimins; for diagnosis.
Ajinomoto WO 00/73465
AIDS therapeutic
Tokyo
Peptides that bind to HLA-A11 antigens and induce HIV-specific cytotoxic T lymphocytes; for treating AIDS.
Alton Ochsner Med. Fdn. WO 00/73507
Autoimmunity-associated retrovirus
New Orleans
Identification of retroviral gene sequences associated with primary biliary cirrhosis and autoimmune disorders.
Angeletti Molec. Biol. Res. Inst. WO 00/73466
Hepatitis C modulator screens
Pomezia, Italy
GBV having hepatitis C virus sequences that are infective in tamarins; for in vivo assays for hepatitis C modulators.
Arizona State Univ. WO 00/73487
Recombinant vaccinia viruses
Tempe, Ariz.
Recombinant vaccinia viruses with part of the E3L gene removed; for enhanced effectiveness and reduced virulence.
Aventis Pharma WO 00/73508
Identifying organisms
Bridgewater, N.J.
Isolation of high molecular weight DNA from various natural samples; for organism identification.
Baylor Coll. Med. WO 00/73764
Deafness therapeutics
Houston
Atonal-associated gene sequences, encoded protein, transgenics; for deafness diagnostics and therapeutics.
Biogen WO 00/73337
Hedgehog protein conjugates
Cambridge, Mass.
Hedgehog proteins linked to polyalkylene polymers; for enhanced bioavailability.
Biotransplant WO 00/73512
Xenotransplant retroviruses
Charlestown, Mass.
Miniature swine endogenous retrovirus, encoded proteins, antibodies; for infection diagnosis in xenotransplants.
Boehringer Ingelheim WO 00/73438
Tumor-associated antigen
Ingelheim, Germany
Tumor-associated antigen, immunogenic peptides, encoding gene sequences; for cancer immunotherapy.
Chiron WO 00/73482
Treating lysosomal storage diseases
Emeryville, Calif.
Recombinant gene delivery vehicles for treating lysosomal storage diseases of the eye and brain.
Chugai WO 00/73423
Virus-producing cells
Tokyo
Virus-producing cells having a structural gene regulated by the EF1 a promoter; for producing high titer viruses.
Chugai Res. Inst. Molec. Med. WO 00/73442
Cytokine gene
Ibaraki, Japan
Cytokine gene that encodes a human ISF protein homolog; for immune system disease therapeutics.
Cincinnati, Univ. of WO 00/73416
Reproductive antisense
Cincinnati, Ohio
Antisense oligonucleotides to estrogen-related intracellular targets; for reproductive control and cancer therapy.
Corixa WO 00/73338
Breast cancer diagnostics
Seattle
Mammaglobin epitopes, antibodies; for breast cancer diagnostics and therapeutics.
Cornell Univ. WO 00/73432
Enhancing immunity
Ithaca, N.Y.
Modifying dendritic cells to up-regulate dendritic cell expansion; for activation and immunity enhancement.
Digital Gene Technol. WO 00/73324
Gastrointestinal inflammation genes
La Jolla, Calif.
Gene expression patterns associated with gastrointestinal inflammation, encoded proteins.
European Molec. Biol. Lab. WO 00/73460
Stabilized cytokines
Heidelberg, Germany
Cytokines having secondary structure stabilized by removal of solvent-exposed hydrophobic residues.
Genentech WO 00/73345
Inhibiting angiogenesis
S. San Francisco
Polypeptides and other antagonists that inhibit angiogenesis and cardiovascularization, encoding genes, antibodies.
Genentech WO 00/73348
Cancer-associated peptides
S. San Francisco
Polypeptides associated with neoplastic cell growth, encoding gene sequences, antibodies; for therapeutics.
Genentech WO 00/73449
Death receptor 4 antibodies
S. San Francisco
Death receptor 4 antibodies; for diagnostics and therapeutic development.
Genentech WO 00/73452
Immune disease proteins
S. San Francisco
Proteins for the diagnosis and treatment of immune-related diseases, encoding gene sequences.
Genentech WO 00/73454
Secreted proteins
S. San Francisco
Secreted and transmembrane proteins, encoding genes, fusions, chimeras, antibodies; for therapeutics.
Genera WO 00/73415
Transferring antigens
Milan, Italy
Cocultivation of dendritic cells with cells transfected with or expressing specific antigens; for antigen transfer.
Genovo WO 00/73480
High-titer recombinant virus
Sharon Hills, Pa.
Production of high-titer recombinant virus using a carrier vector derived from a non-mammalian virus.
Genox Res. WO 00/73435, 73439 & 73440
Allergy modulator screens
Ibaraki, Japan
T cell-expressed gene having lowered expression after pollen exposure; for screening allergy modulators.
Genzyme WO 00/73477
Adenoviral vector tolerance
Cambridge, Mass.
Inducing tolerance to adenoviral vectors by pre-administering vector-infected antigen presenting cells.
German Res. Ctr. Hlth. & Welfare WO 00/73476
Integrating vector
Neuherberg, Germany
Vector for integrating heterologous gene sequences into poxvirus genomes by homologous recombination.
Harvard Univ. WO 00/73453
T-bet proteins
Cambridge, Mass.
T-bet proteins, encoding gene sequences, antibodies, transgenics; for finding T-bet modulators.
Hitachi Software Engineering WO 00/73504
Microarray chips
Yokohama, Japan
Microarray chips having some elements used as an index system; for automatic data accumulation.
House Ear Inst. WO 00/73419
Middle ear cell lines
Los Angeles
Immortalized human middle ear epithelial cell lines transformed by human papillomaviruses; for therapy.
Human Genome Sciences WO 00/73323
ADAM polypeptides
Rockville, Md.
ADAM polypeptides, encoding gene sequences, antibodies, production methods; for diagnostics and therapeutics.
Immunex WO 00/73333
CD7 ligand
Seattle
CD7 ligand K12, encoding gene sequences; for modulator screens and therapeutic development
Immunex WO 00/73468
Kinases
Seattle
Human and mouse kinases, encoding gene sequences, fragments, antibodies; for therapeutics.
Incyte Genomics WO 00/73334
Sorting nexins
Palo Alto, Calif.
Human sorting nexins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/73443
Lipid metabolism transcription factor
Palo Alto, Calif.
Lipid metabolism transcription factor, encoding gene sequences; for diagnostics and therapeutics.
Incyte Genomics WO 00/73450
Cytoskeleton-associated proteins
Palo Alto, Calif.
Cytoskeleton-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/73509
Human therapeutic proteins
Palo Alto, Calif.
Human proteins for diagnostics and therapeutics, encoding gene sequences, antibodies, microarrays.
Innogenetics WO 00/73499
Antifungal assays
Ghent, Belgium
Yeast species nucleic acid probes directed to the internal transcribed spacer region of rDNA; for finding antifungals.
Italian Soc. Sci. Res. WO 00/73344
NGF antagonists
Rome
Monoclonal antibodies, fragments, synthetic derivatives; for use as NGF antagonists.
Korean Green Cross WO 00/73456
Leukotactin variant
Kyounggi-do, S. Korea
C6 _-chemokine leukotactin variant with enhanced biological activity; for inducing antibodies and therapeutics.
Kyokuto Pharma WO 00/73800
GAD antibody assay
Tokyo
Solid phase immunochemical assay for anti-GAD antibodies that releases a chemiluminescent marker.
Lasmezas, C.I. WO 00/73501
Prion disease therapeutics
Paris
Isolating nucleic acid molecules that interact specifically with native prions; for diagnostics and therapeutics.
Lifebank Services WO 00/73421
Amniotic cells
Bethesda, Md.
Amniotic epithelial cells obtained from placentas at delivery; for tissue regeneration and gene therapy.
Ludwig Inst. Cancer Res. WO 00/73801
Cancer-associated antigens
New York
Breast, gastric, and prostate cancer-associated antigens identified by autologous antibody screening.
Max Planck Inst. WO 00/73430
Conformation-dependent antigen vaccines
Berlin
Nucleic acid sequences that encode immunologic mimics of conformation-dependent antigens; for vaccines.
Max Planck Inst. WO 00/73502
Essential Helicobacter genes
Munich, Germany
Identifying and characterizing essential Helicobacter pylori gene, encoded proteins; for treating ulcers.
MRC (Med. Res. Counc.) WO 00/73463
Chaperone protein mutants
London
GroEL chaperone protein mutants, or their homologs, that have improved stability; for protein refolding.
Medigene WO 00/73464 & 73335
Papillomavirus L1 protein epitopes
Martinsried, Germany
Cytotoxic T-cell epitopes of the papillomavirus L1 protein; for diagnostics and therapeutics.
Merck Frosst WO 00/73437
Caspase assays
Kirkland, Que.
Fusions of two green fluorescent proteins that exhibit fluorescent energy transfer; for caspase assays.
Merck Frosst WO 00/73788
GABAB receptor modulator assay
Kirkland, Que.
Use of gabapentin for the identification of GABAB receptor modulators.
Millennium Pharma WO 00/73339
Integrin a subunit homologs
Cambridge, Mass.
Secreted proteins with homology to integrin a subunits, encoding gene sequences, antibodies; for therapeutics.
Millennium Pharma WO 00/73498
T helper cell genes
Cambridge, Mass.
Genes differentially expressed in T helper cells; for diagnosis and therapy of immune disorders.
Mt. Sinai Sch. Med. WO 00/73424
High-capacity adenovirus vectors
New York
Baculovirus-adenovirus hybrid for the rescue, production and titration of high-capacity adenovirus amplicon vectors.
NIH (Natl. Inst. Hlth.) WO 00/73346
Mesothelin antibodies
Bethesda, Md.
Anti-mesothelin antibodies, fragments, immunoconjugates; for treating mesotheliomas.
NIH (Natl. Inst. Hlth.) WO 00/73479
Vaccinia virus vector
Bethesda, Md.
Combined growth factor- and thymidine kinase-deleted vaccinia virus vector; for gene therapy.
Novo Nordisk WO 00/73433
Antimicrobial peptide screen
Bagsvaerd, Denmark
Methods for screening nucleic acid sequences for those encoding antimicrobial peptides.
Orchid Biosciences WO 00/73766
Identifying SNPs
Princeton, N.J.
Methods and compositions for finding single nucleotide polymorphisms using a 96-well format.
Pharmacia & Upjohn WO 00/73431
Ion channel ligand modulators
Kalamazoo, Mich.
Methods and agents for measuring ion channel conductances; for finding gated channel ligand modulators.
Promega WO 00/73345
Mycobacterial peptide antibodies
Madison, Wis.
Antibodies specific for mycobacterial peptides; for diagnostics and therapeutics.
Proteome Sciences WO 00/73330
Insulin resistance modulators
Cobham, U.K.
Gene expression profiles associated with insulin resistance, encoded proteins; for modulator screens.
Rockefeller Univ. WO 00/73787
Protein identification
New York
Protein identification using mass spectrometric information and database searching.
Saigene WO 00/73486
Target amplification
Redmond, Wash.
Isothermal target amplification of nucleic acids with a mutant RNA polymerase; for gene sequence detection.
St. Louis Univ. WO 00/73467
Transcription modulation
St. Louis, Mo.
SRCAP protein which is capable of co-activating CREB binding protein-mediated transcription; for use as a modulator.
Schering WO 00/73451
Mammalian receptors
Kenilworth, N.J.
Mammalian receptors, fragments, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Schering WO 00/73457
IL-10 homologs
Kenilworth, N.J.
Mammalian interleukin-10 homologs, encoding genes, antibodies; for diagnostics and therapeutics.
Scripps Res. Inst. WO 00/73341 & 73342
Transmembrane receptor mimics
La Jolla, Calif.
Polypeptides with a series of heptad repeats that mimic cytoplasmic domains of transmembrane receptors.
SJ Hightech WO 00/73436
Mycobacterial probes
Pusan, S. Korea
Oligonucleotide probes to the internal transcribing spacer region of mycobacterial strains; for diagnosis.
SmithKline Beecham WO 00/73447
RinTinTin chemokine
Philadelphia
RinTinTin chemokine, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
Stem Cell Technol. WO 00/73794
Immunoseparation of cells
Vancouver, B.C.
Separating nucleated and red blood cells using immunorosettes having bifunctional antibodies.
Sugen WO 00/73469
Protein kinases
S. San Francisco
Protein kinases, encoding gene sequences; for developing disease diagnostics and therapeutics.
Synaptic Pharma WO 00/73449
SNORF33 receptors
Paramus, N.J.
SNORF33 receptors, encoding gene sequences, antibodies, antisense; for identifying modulators.
Targeted Genetics WO 00/73481
Lowering TNF
Seattle
Recombinant adeno-associated virus vectors encoding a TNF antagonist; for lowering TNF levels in disease.
Texas, Univ. of WO 00/73340
Angiogenesis inhibition
Austin, Texas
Methods for using C-CAM1 cytoplasmic domains for inhibiting angiogenesis.
Texas, Univ. of WO 00/73488
Malaria treatment
Austin, Texas
Plasmodium chitinases, encoding gene sequences; for screening modulators to treat malaria.
Tibotec WO 00/73802
Protease activity assay
Mechelen, Belgium
Reporter molecules linked to a protease recognition site; for assaying high specificity protease activity.
U.S. Navy WO 00/73347
Plague diagnostics
Washington, D.C.
Monoclonal antibodies reactive with Fraction 1 of Yersina pestis; for immunochemical diagnostics.
Utah, Univ. of WO 00/73510
Studying development
Salt Lake City
Transposon-mediated mutagenesis in nematode worms; for inserting genes into the germline to study development.
Victoria Univ. WO 00/73329
Notch-related genes
Manchester, U.K.
Human homologs of Drosophila notch-related genes, encoded proteins, antibodies; for modulating differentiation.
Virco WO 00/73511
HIV-1 drug resistance
Mechelen, Belgium
Mutational profile of HIV-1 reverse transcriptase correlated with phenotypic drug resistance; for diagnosis.
Vlaams Inst. Biotech. WO 00/73500
Lymphoma translocation
Zwijnaarde, Belgium
Detection of a chromosome 11 to 18 translocation associated with mucosa-associated lymphoid tissue lymphoma.
Washington, Univ. of WO 00/73478
Recombinant adenoviral vectors
Seattle
Recombinant adenoviral vectors expressing chimeric fiber proteins; for cell-specific infection and gene integration.
Whitehead Inst. Biomed. Res. WO 00/73420
Making tumorigenic cells
Cambridge, Mass.
Tumorigenic human somatic cells produced by transfection with exogenous genes.
Yissum Res. & Develop. WO 00/73427 & 73343
Acetycholinesterase-derived peptides
Jerusalem
Acetycholinesterase-derived peptides derived from the C-terminus; for promoting stem cell survival.
ZymoGenetics WO 00/73444, 73446 & 73448
Adipocyte-complement related proteins
Seattle
Adipocyte-complement related proteins having collagen-like and C1q domains, encoding gene sequences, antibodies.
ZymoGenetics WO 00/73458 & 73459
Four-helix bundle cytokines
Seattle
Four-helical bundle cytokines, encoding genes; for stimulating hematopoiesis and immunotherapy.