December 7 (WO)

Active Biotech WO 00/73336

Salmonella vaccines

Lund, Sweden

Fimbrial proteins that are specific for Salmonella enterica subspecies 1; for diagnostics and vaccines.

Agron. Res. Ctr. WO 00/73462

Attenuated pathogenic E. coli strains

Brussells, Belgium

Attenuated mutant enteropathogenic E. coli strains having functional deletions in intimins; for diagnosis.

Ajinomoto WO 00/73465

AIDS therapeutic

Tokyo

Peptides that bind to HLA-A11 antigens and induce HIV-specific cytotoxic T lymphocytes; for treating AIDS.

Alton Ochsner Med. Fdn. WO 00/73507

Autoimmunity-associated retrovirus

New Orleans

Identification of retroviral gene sequences associated with primary biliary cirrhosis and autoimmune disorders.

Angeletti Molec. Biol. Res. Inst. WO 00/73466

Hepatitis C modulator screens

Pomezia, Italy

GBV having hepatitis C virus sequences that are infective in tamarins; for in vivo assays for hepatitis C modulators.

Arizona State Univ. WO 00/73487

Recombinant vaccinia viruses

Tempe, Ariz.

Recombinant vaccinia viruses with part of the E3L gene removed; for enhanced effectiveness and reduced virulence.

Aventis Pharma WO 00/73508

Identifying organisms

Bridgewater, N.J.

Isolation of high molecular weight DNA from various natural samples; for organism identification.

Baylor Coll. Med. WO 00/73764

Deafness therapeutics

Houston

Atonal-associated gene sequences, encoded protein, transgenics; for deafness diagnostics and therapeutics.

Biogen WO 00/73337

Hedgehog protein conjugates

Cambridge, Mass.

Hedgehog proteins linked to polyalkylene polymers; for enhanced bioavailability.

Biotransplant WO 00/73512

Xenotransplant retroviruses

Charlestown, Mass.

Miniature swine endogenous retrovirus, encoded proteins, antibodies; for infection diagnosis in xenotransplants.

Boehringer Ingelheim WO 00/73438

Tumor-associated antigen

Ingelheim, Germany

Tumor-associated antigen, immunogenic peptides, encoding gene sequences; for cancer immunotherapy.

Chiron WO 00/73482

Treating lysosomal storage diseases

Emeryville, Calif.

Recombinant gene delivery vehicles for treating lysosomal storage diseases of the eye and brain.

Chugai WO 00/73423

Virus-producing cells

Tokyo

Virus-producing cells having a structural gene regulated by the EF1 a promoter; for producing high titer viruses.

Chugai Res. Inst. Molec. Med. WO 00/73442

Cytokine gene

Ibaraki, Japan

Cytokine gene that encodes a human ISF protein homolog; for immune system disease therapeutics.

Cincinnati, Univ. of WO 00/73416

Reproductive antisense

Cincinnati, Ohio

Antisense oligonucleotides to estrogen-related intracellular targets; for reproductive control and cancer therapy.

Corixa WO 00/73338

Breast cancer diagnostics

Seattle

Mammaglobin epitopes, antibodies; for breast cancer diagnostics and therapeutics.

Cornell Univ. WO 00/73432

Enhancing immunity

Ithaca, N.Y.

Modifying dendritic cells to up-regulate dendritic cell expansion; for activation and immunity enhancement.

Digital Gene Technol. WO 00/73324

Gastrointestinal inflammation genes

La Jolla, Calif.

Gene expression patterns associated with gastrointestinal inflammation, encoded proteins.

European Molec. Biol. Lab. WO 00/73460

Stabilized cytokines

Heidelberg, Germany

Cytokines having secondary structure stabilized by removal of solvent-exposed hydrophobic residues.

Genentech WO 00/73345

Inhibiting angiogenesis

S. San Francisco

Polypeptides and other antagonists that inhibit angiogenesis and cardiovascularization, encoding genes, antibodies.

Genentech WO 00/73348

Cancer-associated peptides

S. San Francisco

Polypeptides associated with neoplastic cell growth, encoding gene sequences, antibodies; for therapeutics.

Genentech WO 00/73449

Death receptor 4 antibodies

S. San Francisco

Death receptor 4 antibodies; for diagnostics and therapeutic development.

Genentech WO 00/73452

Immune disease proteins

S. San Francisco

Proteins for the diagnosis and treatment of immune-related diseases, encoding gene sequences.

Genentech WO 00/73454

Secreted proteins

S. San Francisco

Secreted and transmembrane proteins, encoding genes, fusions, chimeras, antibodies; for therapeutics.

Genera WO 00/73415

Transferring antigens

Milan, Italy

Cocultivation of dendritic cells with cells transfected with or expressing specific antigens; for antigen transfer.

Genovo WO 00/73480

High-titer recombinant virus

Sharon Hills, Pa.

Production of high-titer recombinant virus using a carrier vector derived from a non-mammalian virus.

Genox Res. WO 00/73435, 73439 & 73440

Allergy modulator screens

Ibaraki, Japan

T cell-expressed gene having lowered expression after pollen exposure; for screening allergy modulators.

Genzyme WO 00/73477

Adenoviral vector tolerance

Cambridge, Mass.

Inducing tolerance to adenoviral vectors by pre-administering vector-infected antigen presenting cells.

German Res. Ctr. Hlth. & Welfare WO 00/73476

Integrating vector

Neuherberg, Germany

Vector for integrating heterologous gene sequences into poxvirus genomes by homologous recombination.

Harvard Univ. WO 00/73453

T-bet proteins

Cambridge, Mass.

T-bet proteins, encoding gene sequences, antibodies, transgenics; for finding T-bet modulators.

Hitachi Software Engineering WO 00/73504

Microarray chips

Yokohama, Japan

Microarray chips having some elements used as an index system; for automatic data accumulation.

House Ear Inst. WO 00/73419

Middle ear cell lines

Los Angeles

Immortalized human middle ear epithelial cell lines transformed by human papillomaviruses; for therapy.

Human Genome Sciences WO 00/73323

ADAM polypeptides

Rockville, Md.

ADAM polypeptides, encoding gene sequences, antibodies, production methods; for diagnostics and therapeutics.

Immunex WO 00/73333

CD7 ligand

Seattle

CD7 ligand K12, encoding gene sequences; for modulator screens and therapeutic development

Immunex WO 00/73468

Kinases

Seattle

Human and mouse kinases, encoding gene sequences, fragments, antibodies; for therapeutics.

Incyte Genomics WO 00/73334

Sorting nexins

Palo Alto, Calif.

Human sorting nexins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/73443

Lipid metabolism transcription factor

Palo Alto, Calif.

Lipid metabolism transcription factor, encoding gene sequences; for diagnostics and therapeutics.

Incyte Genomics WO 00/73450

Cytoskeleton-associated proteins

Palo Alto, Calif.

Cytoskeleton-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/73509

Human therapeutic proteins

Palo Alto, Calif.

Human proteins for diagnostics and therapeutics, encoding gene sequences, antibodies, microarrays.

Innogenetics WO 00/73499

Antifungal assays

Ghent, Belgium

Yeast species nucleic acid probes directed to the internal transcribed spacer region of rDNA; for finding antifungals.

Italian Soc. Sci. Res. WO 00/73344

NGF antagonists

Rome

Monoclonal antibodies, fragments, synthetic derivatives; for use as NGF antagonists.

Korean Green Cross WO 00/73456

Leukotactin variant

Kyounggi-do, S. Korea

C6 _-chemokine leukotactin variant with enhanced biological activity; for inducing antibodies and therapeutics.

Kyokuto Pharma WO 00/73800

GAD antibody assay

Tokyo

Solid phase immunochemical assay for anti-GAD antibodies that releases a chemiluminescent marker.

Lasmezas, C.I. WO 00/73501

Prion disease therapeutics

Paris

Isolating nucleic acid molecules that interact specifically with native prions; for diagnostics and therapeutics.

Lifebank Services WO 00/73421

Amniotic cells

Bethesda, Md.

Amniotic epithelial cells obtained from placentas at delivery; for tissue regeneration and gene therapy.

Ludwig Inst. Cancer Res. WO 00/73801

Cancer-associated antigens

New York

Breast, gastric, and prostate cancer-associated antigens identified by autologous antibody screening.

Max Planck Inst. WO 00/73430

Conformation-dependent antigen vaccines

Berlin

Nucleic acid sequences that encode immunologic mimics of conformation-dependent antigens; for vaccines.

Max Planck Inst. WO 00/73502

Essential Helicobacter genes

Munich, Germany

Identifying and characterizing essential Helicobacter pylori gene, encoded proteins; for treating ulcers.

MRC (Med. Res. Counc.) WO 00/73463

Chaperone protein mutants

London

GroEL chaperone protein mutants, or their homologs, that have improved stability; for protein refolding.

Medigene WO 00/73464 & 73335

Papillomavirus L1 protein epitopes

Martinsried, Germany

Cytotoxic T-cell epitopes of the papillomavirus L1 protein; for diagnostics and therapeutics.

Merck Frosst WO 00/73437

Caspase assays

Kirkland, Que.

Fusions of two green fluorescent proteins that exhibit fluorescent energy transfer; for caspase assays.

Merck Frosst WO 00/73788

GABAB receptor modulator assay

Kirkland, Que.

Use of gabapentin for the identification of GABAB receptor modulators.

Millennium Pharma WO 00/73339

Integrin a subunit homologs

Cambridge, Mass.

Secreted proteins with homology to integrin a subunits, encoding gene sequences, antibodies; for therapeutics.

Millennium Pharma WO 00/73498

T helper cell genes

Cambridge, Mass.

Genes differentially expressed in T helper cells; for diagnosis and therapy of immune disorders.

Mt. Sinai Sch. Med. WO 00/73424

High-capacity adenovirus vectors

New York

Baculovirus-adenovirus hybrid for the rescue, production and titration of high-capacity adenovirus amplicon vectors.

NIH (Natl. Inst. Hlth.) WO 00/73346

Mesothelin antibodies

Bethesda, Md.

Anti-mesothelin antibodies, fragments, immunoconjugates; for treating mesotheliomas.

NIH (Natl. Inst. Hlth.) WO 00/73479

Vaccinia virus vector

Bethesda, Md.

Combined growth factor- and thymidine kinase-deleted vaccinia virus vector; for gene therapy.

Novo Nordisk WO 00/73433

Antimicrobial peptide screen

Bagsvaerd, Denmark

Methods for screening nucleic acid sequences for those encoding antimicrobial peptides.

Orchid Biosciences WO 00/73766

Identifying SNPs

Princeton, N.J.

Methods and compositions for finding single nucleotide polymorphisms using a 96-well format.

Pharmacia & Upjohn WO 00/73431

Ion channel ligand modulators

Kalamazoo, Mich.

Methods and agents for measuring ion channel conductances; for finding gated channel ligand modulators.

Promega WO 00/73345

Mycobacterial peptide antibodies

Madison, Wis.

Antibodies specific for mycobacterial peptides; for diagnostics and therapeutics.

Proteome Sciences WO 00/73330

Insulin resistance modulators

Cobham, U.K.

Gene expression profiles associated with insulin resistance, encoded proteins; for modulator screens.

Rockefeller Univ. WO 00/73787

Protein identification

New York

Protein identification using mass spectrometric information and database searching.

Saigene WO 00/73486

Target amplification

Redmond, Wash.

Isothermal target amplification of nucleic acids with a mutant RNA polymerase; for gene sequence detection.

St. Louis Univ. WO 00/73467

Transcription modulation

St. Louis, Mo.

SRCAP protein which is capable of co-activating CREB binding protein-mediated transcription; for use as a modulator.

Schering WO 00/73451

Mammalian receptors

Kenilworth, N.J.

Mammalian receptors, fragments, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Schering WO 00/73457

IL-10 homologs

Kenilworth, N.J.

Mammalian interleukin-10 homologs, encoding genes, antibodies; for diagnostics and therapeutics.

Scripps Res. Inst. WO 00/73341 & 73342

Transmembrane receptor mimics

La Jolla, Calif.

Polypeptides with a series of heptad repeats that mimic cytoplasmic domains of transmembrane receptors.

SJ Hightech WO 00/73436

Mycobacterial probes

Pusan, S. Korea

Oligonucleotide probes to the internal transcribing spacer region of mycobacterial strains; for diagnosis.

SmithKline Beecham WO 00/73447

RinTinTin chemokine

Philadelphia

RinTinTin chemokine, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

Stem Cell Technol. WO 00/73794

Immunoseparation of cells

Vancouver, B.C.

Separating nucleated and red blood cells using immunorosettes having bifunctional antibodies.

Sugen WO 00/73469

Protein kinases

S. San Francisco

Protein kinases, encoding gene sequences; for developing disease diagnostics and therapeutics.

Synaptic Pharma WO 00/73449

SNORF33 receptors

Paramus, N.J.

SNORF33 receptors, encoding gene sequences, antibodies, antisense; for identifying modulators.

Targeted Genetics WO 00/73481

Lowering TNF

Seattle

Recombinant adeno-associated virus vectors encoding a TNF antagonist; for lowering TNF levels in disease.

Texas, Univ. of WO 00/73340

Angiogenesis inhibition

Austin, Texas

Methods for using C-CAM1 cytoplasmic domains for inhibiting angiogenesis.

Texas, Univ. of WO 00/73488

Malaria treatment

Austin, Texas

Plasmodium chitinases, encoding gene sequences; for screening modulators to treat malaria.

Tibotec WO 00/73802

Protease activity assay

Mechelen, Belgium

Reporter molecules linked to a protease recognition site; for assaying high specificity protease activity.

U.S. Navy WO 00/73347

Plague diagnostics

Washington, D.C.

Monoclonal antibodies reactive with Fraction 1 of Yersina pestis; for immunochemical diagnostics.

Utah, Univ. of WO 00/73510

Studying development

Salt Lake City

Transposon-mediated mutagenesis in nematode worms; for inserting genes into the germline to study development.

Victoria Univ. WO 00/73329

Notch-related genes

Manchester, U.K.

Human homologs of Drosophila notch-related genes, encoded proteins, antibodies; for modulating differentiation.

Virco WO 00/73511

HIV-1 drug resistance

Mechelen, Belgium

Mutational profile of HIV-1 reverse transcriptase correlated with phenotypic drug resistance; for diagnosis.

Vlaams Inst. Biotech. WO 00/73500

Lymphoma translocation

Zwijnaarde, Belgium

Detection of a chromosome 11 to 18 translocation associated with mucosa-associated lymphoid tissue lymphoma.

Washington, Univ. of WO 00/73478

Recombinant adenoviral vectors

Seattle

Recombinant adenoviral vectors expressing chimeric fiber proteins; for cell-specific infection and gene integration.

Whitehead Inst. Biomed. Res. WO 00/73420

Making tumorigenic cells

Cambridge, Mass.

Tumorigenic human somatic cells produced by transfection with exogenous genes.

Yissum Res. & Develop. WO 00/73427 & 73343

Acetycholinesterase-derived peptides

Jerusalem

Acetycholinesterase-derived peptides derived from the C-terminus; for promoting stem cell survival.

ZymoGenetics WO 00/73444, 73446 & 73448

Adipocyte-complement related proteins

Seattle

Adipocyte-complement related proteins having collagen-like and C1q domains, encoding gene sequences, antibodies.

ZymoGenetics WO 00/73458 & 73459

Four-helix bundle cytokines

Seattle

Four-helical bundle cytokines, encoding genes; for stimulating hematopoiesis and immunotherapy.