November 2 (EP), October 26 (WO)
Abbott Labs WO 00/63379
P2X3 receptor
Abbott Park, Ill.
P2X3 receptor, encoding gene sequences; for accelerating resensitization of the desensitized receptor.
Actinova WO 00/63383
IgA purification
Cambridge, U.K.
Immunoglobulin A binding protein, encoding gene sequences; for IgA purification.
Affymetrix WO 00/63442
Gene probe arrays
Santa Clara, Calif.
Gene probe arrays for samples containing fluorescently tagged ligands; for improved detection dynamic range.
American Home Products WO 00/63364
Gene expression inhibition
Madison, N.J.
Inhibition of gene function using double-stranded RNA fragments homologous to the target genes.
Amersham Pharmacia Biotech WO 00/63691
Mutation detection
Tokyo
Methods for detecting and modifying mismatches and mutations in nucleic acid sequences using the MutM protein.
Amgen WO 00/63253
AGP-1 fragment fusion
Thousand Oaks, Calif.
Fc antibody fragments fused to the N-terminal region of AGP-1; for diagnostics and therapeutics.
Anticancer WO 00/63420
Folate assays
San Diego
Methods for analyzing folate and hydrogen peroxide in biological samples; for cancer diagnostics.
AstraZeneca WO 00/63404
Intron-assisted gene expression
Sodertalje, Sweden
Use of intron IV of the human NPY receptor for increased expression of recombinant proteins in cells.
Aventis Behring EP 1 048 735 & 1 048 736
Factor IX gene therapy
Marburg, Germany
Promoter sequences that allow hematopoietic cell-specific expression of Factor IX.
Bayer WO 00/63429
Telomerase mRNA assay
Leverkusen, Germany
Automatable rapid assays for detecting cancers based on telomerase mRNA detection.
Beth Israel Deaconess Hosp. WO 00/63357
CNTF activity modulation
Boston
Methods and agents for altering cytokine inhibitors; for modulating ciliary neurotrophic factor activity.
Bios Group WO 00/63421
Shape-directed modulator assays
Santa Fe, N.M.
Automated methods for modulator selection using extended target protein shapes.
Boston Med. Ctr. WO 00/63386
Lyme disease therapeutics
Boston
Borrelia burgdorferi toxins and antitoxins; for Lyme disease diagnostics and therapeutics.
California, Univ. of WO 00/62804
Bacterial cell wall sortase
Oakland, Calif.
Identification of the bacterial cell wall sortase gene, encoded protein; for antibacterial screens.
California, Univ. of WO 00/63418
Protein transport assays
Oakland, Calif.
Assays for detecting protein transport across cell membranes using fluorescent labels.
Celltech Therapeutics WO 00/63360
Combinatorial gene construction
Slough, U.K.
Combinatorial methods for assembling blocks of nucleic acid sequences; for producing new sequences.
Celltech Therapeutics WO 00/63372-63374
Synthetic signalling molecules
Slough, U.K.
Synthetic signalling molecules derived from transmembrane immunoglobulin tyrosine receptor-based activation motifs.
Centeon Pharma EP 1 048 726
Modified Factor VIII cDNA
Marburg, Germany
Factor VIII cDNA with a deleted B domain and having inserted truncated Factor IX intron I sequences; for gene therapy.
Ceptyr WO 00/63393
Cell growth modulation
Bothell, Wash.
Dual-specificity MAP kinase phosphatase-8, variants, antibodies; for modulating cell growth.
Columbia Univ. WO 00/63687
Gene discovery
New York
Discovery of unknown genes using networks of structural and functional relationships among known genes and proteins.
CuraGen WO 00/63435
Liver toxin assay
New Haven, Conn.
Identification of liver toxins using gene expression patterns influenced by troglitazone.
CuraGen WO 00/63438
Thyroid carcinoma classification
New Haven, Conn.
Classifying thyroid carcinomas using differential gene expression; for diagnosis and therapy.
Cytokinetics WO 00/63353
Human kinesins
S. San Francisco
Human kinesins, encoding genes, bacterial production methods; for making unglycosylated versions.
Devgen WO 00/63424-63427
Therapeutic screens
Ghent, Belgium
High-throughput screening of therapeutics using C. elegans nematode worms by adding compounds to food sources.
Duke Univ. WO 00/63416
Mitochondrial metabolism
Durham, N.C.
Fatty acids labelled at specific sites; for tracing mitochondrial metabolism.
Eberhard Karls Univ. WO 00/63363
Tumor cell vaccines
Tubingen, Germany
Peptide from the MUC-1 antigen, modified fragments; for triggering immune responses to tumor cells.
Eiken Kagaku EP 1 048 727
Bipolar disorder gene
Tokyo
Transmembrane protein having homology to calcium channels, encoding gene; for diagnosing bipolar disorder.
French Armaments Ministry WO 00/63428
Microorganism detection
Armees, Frances
Methods for detecting microorganisms by measuring leakage current induced by applied electric field.
Genentech WO 00/63380
VEGF variants
S. San Francisco
Vascular endothelial cell growth factor variants that have modified affinity for the KDR or Flt-1 receptor.
Genetics Inst. WO 00/63692
Secreted proteins
Cambridge, Mass.
Secreted proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
Genome Technologies WO 00/63439
Shot-gun sequencing
Madison, Wis.
Shot-gun sequencing and PCR amplification without gene cloning.
Genset WO 00/63375
Kinesin-like protein gene
Paris
Gene sequences encoding a kinesin-like protein, encoded protein, antibodies, biallelic markers; for diagnostics.
Genzyme WO 00/63406
Vector-induced immunoresponse
Cambridge, Mass.
Adenoviral vectors with genes encoding immunomodulatory molecules; for reducing vector antigenic response.
Georgia, Univ. of WO 00/63394
Proteinase inhibitor modulators
Athens, Ga.
Human a1-proteinase inhibitor that has amidolytic activity for cleavage of serpin and denatured proteins.
Hitachi Software Engineering EP 1 048 723
Biochips
Yokohama, Japan
Biochips made with a glass substrate and spotted biopolymers; for gene expression assays.
Hoffmann-La Roche EP 1 048 732
Recombinant protein production
Basel, Switzerland
Process for producing naturally folded and secreted therapeutic proteins in prokaryotes [in German].
Hoffmann-La Roche WO 00/63395 & 63405
Cancer gene therapy
Basel, Switzerland
Gene sequences encoding CD40/CD40 ligand chimeras, encoded proteins; for localized cancer gene therapy.
Hormos Medical WO 00/63430
Diabetic retinopathy diagnosis
Turku, Finland
Use of polymorphisms in the prepro neuropeptide Y gene for diagnosing diabetic retinopathy.
Human Genome Sciences WO 00/63230
49 secreted proteins
Rockville, Md.
49 human secreted protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Icagen WO 00/63349
Cation channel modulators
Durham, N.C.
Human HAC3, encoding gene, antibodies; for screening modulators of hyperpolarization-activated cation channels.
Illinois Inst. Technol. WO 00/63422
Biological warfare agent assay
Chicago
Detection of biological warfare bacterial agents using phosphorescence detection of spore-specific molecules.
Illumina WO 00/63437
Genotyping methods
San Diego
Detection of nucleic acid sequence reactions on microsphere arrays; for genotyping and SNP detection.
Introgene WO 00/63403
Protein production system
Leiden, Netherlands
Methods for the production of recombinant proteins in human cell lines.
Joslin Diabetes Ctr. WO 00/63436
Tissue remodeling therapeutics
Boston
Genes preferentially expressed in healing or remodeling tissue; for diagnostics and therapeutics.
Kyowa Hakko Kogyo WO 00/63392
Lung cancer-associated gene
Tokyo
Tyrosine phosphatase encoded by a gene on chromosome 3p21 whose deletion is associated with lung cancer.
Mass. Inst. Technol. WO 00/63409
Endosome delivery
Cambridge, Mass.
Biocompatible endosomolytic agents; for delivery of therapeutics to endosomes.
Mass. Inst. Technol. WO 00/63410
Site-specific recombination
Cambridge, Mass.
Site-specific recombination using inverted lox sequences and recombinase genes; for making defined transgenics.
MRC (Med. Res. Counc.) WO 00/63245
Malaria vaccines
London
Non-naturally occurring variant of the C-terminal fragment of Plasmodium merozoite surface protein-1; for vaccines.
Michigan, Univ. of WO 00/63396
Enhanced myoblast migration
Ann Arbor, Mich.
Cytokines for enhancing myoblast migration and invasion during gene therapy.
Mitokor WO 00/63441
Alzheimer's SNPs
San Diego
Single nucleotide polymorphisms in mitochondrial genes that segregate with Alzheimer's disease.
Nair, P.P. WO 00/63358
Colorectal cancer diagnostics
Ellicott City, Md.
Isolation of exfoliated fecal colonocytes; for detecting colorectal cancer and gastrointestinal pathology.
NIH (Natl. Inst. Hlth.) WO 00/63440
Virus detection
Bethesda, Md.
Incompetent viral particles that contain primer binding sites homologous to wild type genomes; for detection.
New York Blood Ctr. WO 00/63700
Metalloproteinase antibodies
New York
Monoclonal antibodies reactive with fibrinogen degradation products generated by matrix metalloproteinases.
Novartis WO 00/63369
Vascular gene therapy
Basel, Switzerland
Transfection of vascular cells with soluble FasR or FGF receptor-1 gene sequences; for gene therapy.
Novo Nordisk WO 00/63346
Protein production system
Bagsvaerd, Denmark
Bacillus strains having suppressed expression of the yjbH gene; for recombinant protein production.
Ohio State Univ. WO 00/62604
Transgenic gene expression
Columbus, Ohio
Transgenics having inserted genes and promoters that allow expression of these genes; for breeding for expression.
Ortho-McNeil Pharma WO 00/63415
Vanilloid receptor
Raritan, N.J.
Human vanilloid receptor VR1, encoding gene sequences; for identifying modulators.
Osiris Therapeutics WO 00/63382
Hematopoietic stem cell genes
Baltimore
Hematopoietic stem cell expressed genes, encoded proteins; for diagnostics and therapeutics.
Pangene WO 00/63365
Locked nucleic acid hybrids
Mountain View, Calif.
Nucleic acid hybrids having locked structure; for cloning and labelling endogenous gene sequences.
Pasteur Inst. WO 00/63242
Lyssavirus vaccines
Paris
Chimeric lyssavirus genes and encoded proteins; for supplying multiple antigens for vaccination.
Pasteur Inst. WO 00/63402
Muscle cell gene expression
Paris
Vector sequences regulating the expression of heterologous genes in muscle cells; for gene expression.
Pasteur Inst. WO 00/63444
Hepatitis C virus detection
Paris
Direct detection of hepatitis C virus in serum samples using hybridomas producing core protein antibodies.
Pharmacia & Upjohn WO 00/63243
Factor VIII interaction
Stockholm, Sweden
Derivatives of the B or Z domain from Staphylococcal protein A; for interaction with human Factor VIII.
Pharmacia & Upjohn WO 00/63352
Serine/threonine kinase signalling
Milan, Italy
Human homologs of the protein-serine/threonine kinase fused, encoding gene sequences; for signal transduction.
Powderject Vaccines WO 00/63385
Nucleic acid immunization
Madison, Wis.
Recombinant nucleic acid sequences encoding peptides that mimic target antigens; for immunization.
Rabkin, S.W., et al. WO 00/63384
Streptokinase fragments
Vancouver, B.C.
Streptokinase fragments and analogs, encoding gene sequences; for inhibiting cell death.
Samsung Fine Chemicals WO 00/63431
Congenital adrenal hyperplasia screen
Ulsen, S. Korea
Use of polymorphisms in the 21-hydroxylase gene for diagnosing congenital adrenal hyperplasia.
Scios WO 00/63381
Cardiac kinase
Sunnyvale, Calif.
Mammalian protein having kinase activity, encoding gene, antibodies; for treating cardiac disease.
Sequitur WO 00/63366
Antisense oligomers
Natick, Mass.
Antisense oligomers having enhanced uptake and reduced sensitivity to nucleases.
Sloan-Kettering Inst. WO 00/63433
Antifungal assay
New York
Yeast strains used to identify agents that target mRNA cap formation; for finding antifungal agents.
SmithKline Beecham WO 00/63226
IL-1 homolog
Philadelphia
Interleukin-1 homolog IL-1H4, encoding gene sequences; for diagnostics and therapeutics.
SmithKline Beecham WO 00/63227
Metalloproteinase-5 variant
Philadelphia
Splicing variant of human membrane-type matrix metalloproteinase-5, encoding gene; for therapeutics.
SmithKline Beecham WO 00/63390
P101 protein splice variant
Brentford, U.K.
Splice variant of P101 protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Stichting Labs EP 1 048 728
Trypanosomosis therapeutics
Wageningen, Netherlands
Isolation of factors from medium containing trypanosomes that inhibit their growth; for treating trypanosomosis.
Transgene EP 1 048 724
Myoblast cell lines
Strasbourg, France
Human myoblast cell lines derived from primary muscle cells and immortalized using non-retroviral gene sequences.
Transgene EP 1 048 725
Mammalian cell lines
Strasbourg, France
Mammalian cell lines derived from primary cells and immortalized using non-retroviral gene sequences.
Univ. College WO 00/63359
Heterologous gene expression
London
Gene sequences containing sequences encoding heterologous introns; for transfecting cells.
Utah, Univ. of WO 00/63434
Cardiac arrhythmia genes
Salt Lake City, Utah
MinK-related genes, encoded potassium channel proteins; for diagnosing cardiac arrhythmias.
Virtual Arrays WO 00/63419
Combinatorial chemistry methods
San Jose, Calif.
Multiplexed detection and quantification of analytes by reacting them with probes attached to specific carriers.
Warner-Lambert WO 00/63367
Sodium channel modulators
Morris Plains, N.J.
Family of _ subunit proteins from a voltage-gated sodium channel, encoding genes; for modulators screens.
Warner-Lambert WO 00/63370
Neuronal regeneration
Morris Plains, N.J.
Truncated CART proteins, encoding gene sequences; for promoting neuronal regeneration.
Yale Univ. WO 00/62605
Cardiovascular gene therapy
New Haven, Conn.
Variant and mutant nitric oxide synthases having alterations in the Akt-dependent phosphorylation site, encoding genes.
Zetesis WO 00/63368
Cancer-associated protein
Milan, Italy
Recombinant protein UK114, encoding gene sequences; for cancer diagnostics and therapeutics.
Zymetx WO 00/63423
Influenza diagnostics
Oklahoma City
Chemiluminescent methods for detecting the presence of influenza virus; for diagnostics.
ZymoGenetics WO 00/63376 & 63377
Complement-related protein
Seattle
Adipocyte complement-related protein homolog with collagen-like and C1q domains, encoding gene, antibodies.
ZymoGenetics WO 00/63378
Metabolism regulating proteins
Seattle
Human secreted proteins that regulate metabolism and differentiation, encoding genes; for therapeutics.