November 2 (EP), October 26 (WO)

Abbott Labs WO 00/63379

P2X3 receptor

Abbott Park, Ill.

P2X3 receptor, encoding gene sequences; for accelerating resensitization of the desensitized receptor.

Actinova WO 00/63383

IgA purification

Cambridge, U.K.

Immunoglobulin A binding protein, encoding gene sequences; for IgA purification.

Affymetrix WO 00/63442

Gene probe arrays

Santa Clara, Calif.

Gene probe arrays for samples containing fluorescently tagged ligands; for improved detection dynamic range.

American Home Products WO 00/63364

Gene expression inhibition

Madison, N.J.

Inhibition of gene function using double-stranded RNA fragments homologous to the target genes.

Amersham Pharmacia Biotech WO 00/63691

Mutation detection


Methods for detecting and modifying mismatches and mutations in nucleic acid sequences using the MutM protein.

Amgen WO 00/63253

AGP-1 fragment fusion

Thousand Oaks, Calif.

Fc antibody fragments fused to the N-terminal region of AGP-1; for diagnostics and therapeutics.

Anticancer WO 00/63420

Folate assays

San Diego

Methods for analyzing folate and hydrogen peroxide in biological samples; for cancer diagnostics.

AstraZeneca WO 00/63404

Intron-assisted gene expression

Sodertalje, Sweden

Use of intron IV of the human NPY receptor for increased expression of recombinant proteins in cells.

Aventis Behring EP 1 048 735 & 1 048 736

Factor IX gene therapy

Marburg, Germany

Promoter sequences that allow hematopoietic cell-specific expression of Factor IX.

Bayer WO 00/63429

Telomerase mRNA assay

Leverkusen, Germany

Automatable rapid assays for detecting cancers based on telomerase mRNA detection.

Beth Israel Deaconess Hosp. WO 00/63357

CNTF activity modulation


Methods and agents for altering cytokine inhibitors; for modulating ciliary neurotrophic factor activity.

Bios Group WO 00/63421

Shape-directed modulator assays

Santa Fe, N.M.

Automated methods for modulator selection using extended target protein shapes.

Boston Med. Ctr. WO 00/63386

Lyme disease therapeutics


Borrelia burgdorferi toxins and antitoxins; for Lyme disease diagnostics and therapeutics.

California, Univ. of WO 00/62804

Bacterial cell wall sortase

Oakland, Calif.

Identification of the bacterial cell wall sortase gene, encoded protein; for antibacterial screens.

California, Univ. of WO 00/63418

Protein transport assays

Oakland, Calif.

Assays for detecting protein transport across cell membranes using fluorescent labels.

Celltech Therapeutics WO 00/63360

Combinatorial gene construction

Slough, U.K.

Combinatorial methods for assembling blocks of nucleic acid sequences; for producing new sequences.

Celltech Therapeutics WO 00/63372-63374

Synthetic signalling molecules

Slough, U.K.

Synthetic signalling molecules derived from transmembrane immunoglobulin tyrosine receptor-based activation motifs.

Centeon Pharma EP 1 048 726

Modified Factor VIII cDNA

Marburg, Germany

Factor VIII cDNA with a deleted B domain and having inserted truncated Factor IX intron I sequences; for gene therapy.

Ceptyr WO 00/63393

Cell growth modulation

Bothell, Wash.

Dual-specificity MAP kinase phosphatase-8, variants, antibodies; for modulating cell growth.

Columbia Univ. WO 00/63687

Gene discovery

New York

Discovery of unknown genes using networks of structural and functional relationships among known genes and proteins.

CuraGen WO 00/63435

Liver toxin assay

New Haven, Conn.

Identification of liver toxins using gene expression patterns influenced by troglitazone.

CuraGen WO 00/63438

Thyroid carcinoma classification

New Haven, Conn.

Classifying thyroid carcinomas using differential gene expression; for diagnosis and therapy.

Cytokinetics WO 00/63353

Human kinesins

S. San Francisco

Human kinesins, encoding genes, bacterial production methods; for making unglycosylated versions.

Devgen WO 00/63424-63427

Therapeutic screens

Ghent, Belgium

High-throughput screening of therapeutics using C. elegans nematode worms by adding compounds to food sources.

Duke Univ. WO 00/63416

Mitochondrial metabolism

Durham, N.C.

Fatty acids labelled at specific sites; for tracing mitochondrial metabolism.

Eberhard Karls Univ. WO 00/63363

Tumor cell vaccines

Tubingen, Germany

Peptide from the MUC-1 antigen, modified fragments; for triggering immune responses to tumor cells.

Eiken Kagaku EP 1 048 727

Bipolar disorder gene


Transmembrane protein having homology to calcium channels, encoding gene; for diagnosing bipolar disorder.

French Armaments Ministry WO 00/63428

Microorganism detection

Armees, Frances

Methods for detecting microorganisms by measuring leakage current induced by applied electric field.

Genentech WO 00/63380

VEGF variants

S. San Francisco

Vascular endothelial cell growth factor variants that have modified affinity for the KDR or Flt-1 receptor.

Genetics Inst. WO 00/63692

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.

Genome Technologies WO 00/63439

Shot-gun sequencing

Madison, Wis.

Shot-gun sequencing and PCR amplification without gene cloning.

Genset WO 00/63375

Kinesin-like protein gene


Gene sequences encoding a kinesin-like protein, encoded protein, antibodies, biallelic markers; for diagnostics.

Genzyme WO 00/63406

Vector-induced immunoresponse

Cambridge, Mass.

Adenoviral vectors with genes encoding immunomodulatory molecules; for reducing vector antigenic response.

Georgia, Univ. of WO 00/63394

Proteinase inhibitor modulators

Athens, Ga.

Human a1-proteinase inhibitor that has amidolytic activity for cleavage of serpin and denatured proteins.

Hitachi Software Engineering EP 1 048 723


Yokohama, Japan

Biochips made with a glass substrate and spotted biopolymers; for gene expression assays.

Hoffmann-La Roche EP 1 048 732

Recombinant protein production

Basel, Switzerland

Process for producing naturally folded and secreted therapeutic proteins in prokaryotes [in German].

Hoffmann-La Roche WO 00/63395 & 63405

Cancer gene therapy

Basel, Switzerland

Gene sequences encoding CD40/CD40 ligand chimeras, encoded proteins; for localized cancer gene therapy.

Hormos Medical WO 00/63430

Diabetic retinopathy diagnosis

Turku, Finland

Use of polymorphisms in the prepro neuropeptide Y gene for diagnosing diabetic retinopathy.

Human Genome Sciences WO 00/63230

49 secreted proteins

Rockville, Md.

49 human secreted protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.

Icagen WO 00/63349

Cation channel modulators

Durham, N.C.

Human HAC3, encoding gene, antibodies; for screening modulators of hyperpolarization-activated cation channels.

Illinois Inst. Technol. WO 00/63422

Biological warfare agent assay


Detection of biological warfare bacterial agents using phosphorescence detection of spore-specific molecules.

Illumina WO 00/63437

Genotyping methods

San Diego

Detection of nucleic acid sequence reactions on microsphere arrays; for genotyping and SNP detection.

Introgene WO 00/63403

Protein production system

Leiden, Netherlands

Methods for the production of recombinant proteins in human cell lines.

Joslin Diabetes Ctr. WO 00/63436

Tissue remodeling therapeutics


Genes preferentially expressed in healing or remodeling tissue; for diagnostics and therapeutics.

Kyowa Hakko Kogyo WO 00/63392

Lung cancer-associated gene


Tyrosine phosphatase encoded by a gene on chromosome 3p21 whose deletion is associated with lung cancer.

Mass. Inst. Technol. WO 00/63409

Endosome delivery

Cambridge, Mass.

Biocompatible endosomolytic agents; for delivery of therapeutics to endosomes.

Mass. Inst. Technol. WO 00/63410

Site-specific recombination

Cambridge, Mass.

Site-specific recombination using inverted lox sequences and recombinase genes; for making defined transgenics.

MRC (Med. Res. Counc.) WO 00/63245

Malaria vaccines


Non-naturally occurring variant of the C-terminal fragment of Plasmodium merozoite surface protein-1; for vaccines.

Michigan, Univ. of WO 00/63396

Enhanced myoblast migration

Ann Arbor, Mich.

Cytokines for enhancing myoblast migration and invasion during gene therapy.

Mitokor WO 00/63441

Alzheimer's SNPs

San Diego

Single nucleotide polymorphisms in mitochondrial genes that segregate with Alzheimer's disease.

Nair, P.P. WO 00/63358

Colorectal cancer diagnostics

Ellicott City, Md.

Isolation of exfoliated fecal colonocytes; for detecting colorectal cancer and gastrointestinal pathology.

NIH (Natl. Inst. Hlth.) WO 00/63440

Virus detection

Bethesda, Md.

Incompetent viral particles that contain primer binding sites homologous to wild type genomes; for detection.

New York Blood Ctr. WO 00/63700

Metalloproteinase antibodies

New York

Monoclonal antibodies reactive with fibrinogen degradation products generated by matrix metalloproteinases.

Novartis WO 00/63369

Vascular gene therapy

Basel, Switzerland

Transfection of vascular cells with soluble FasR or FGF receptor-1 gene sequences; for gene therapy.

Novo Nordisk WO 00/63346

Protein production system

Bagsvaerd, Denmark

Bacillus strains having suppressed expression of the yjbH gene; for recombinant protein production.

Ohio State Univ. WO 00/62604

Transgenic gene expression

Columbus, Ohio

Transgenics having inserted genes and promoters that allow expression of these genes; for breeding for expression.

Ortho-McNeil Pharma WO 00/63415

Vanilloid receptor

Raritan, N.J.

Human vanilloid receptor VR1, encoding gene sequences; for identifying modulators.

Osiris Therapeutics WO 00/63382

Hematopoietic stem cell genes


Hematopoietic stem cell expressed genes, encoded proteins; for diagnostics and therapeutics.

Pangene WO 00/63365

Locked nucleic acid hybrids

Mountain View, Calif.

Nucleic acid hybrids having locked structure; for cloning and labelling endogenous gene sequences.

Pasteur Inst. WO 00/63242

Lyssavirus vaccines


Chimeric lyssavirus genes and encoded proteins; for supplying multiple antigens for vaccination.

Pasteur Inst. WO 00/63402

Muscle cell gene expression


Vector sequences regulating the expression of heterologous genes in muscle cells; for gene expression.

Pasteur Inst. WO 00/63444

Hepatitis C virus detection


Direct detection of hepatitis C virus in serum samples using hybridomas producing core protein antibodies.

Pharmacia & Upjohn WO 00/63243

Factor VIII interaction

Stockholm, Sweden

Derivatives of the B or Z domain from Staphylococcal protein A; for interaction with human Factor VIII.

Pharmacia & Upjohn WO 00/63352

Serine/threonine kinase signalling

Milan, Italy

Human homologs of the protein-serine/threonine kinase fused, encoding gene sequences; for signal transduction.

Powderject Vaccines WO 00/63385

Nucleic acid immunization

Madison, Wis.

Recombinant nucleic acid sequences encoding peptides that mimic target antigens; for immunization.

Rabkin, S.W., et al. WO 00/63384

Streptokinase fragments

Vancouver, B.C.

Streptokinase fragments and analogs, encoding gene sequences; for inhibiting cell death.

Samsung Fine Chemicals WO 00/63431

Congenital adrenal hyperplasia screen

Ulsen, S. Korea

Use of polymorphisms in the 21-hydroxylase gene for diagnosing congenital adrenal hyperplasia.

Scios WO 00/63381

Cardiac kinase

Sunnyvale, Calif.

Mammalian protein having kinase activity, encoding gene, antibodies; for treating cardiac disease.

Sequitur WO 00/63366

Antisense oligomers

Natick, Mass.

Antisense oligomers having enhanced uptake and reduced sensitivity to nucleases.

Sloan-Kettering Inst. WO 00/63433

Antifungal assay

New York

Yeast strains used to identify agents that target mRNA cap formation; for finding antifungal agents.

SmithKline Beecham WO 00/63226

IL-1 homolog


Interleukin-1 homolog IL-1H4, encoding gene sequences; for diagnostics and therapeutics.

SmithKline Beecham WO 00/63227

Metalloproteinase-5 variant


Splicing variant of human membrane-type matrix metalloproteinase-5, encoding gene; for therapeutics.

SmithKline Beecham WO 00/63390

P101 protein splice variant

Brentford, U.K.

Splice variant of P101 protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.

Stichting Labs EP 1 048 728

Trypanosomosis therapeutics

Wageningen, Netherlands

Isolation of factors from medium containing trypanosomes that inhibit their growth; for treating trypanosomosis.

Transgene EP 1 048 724

Myoblast cell lines

Strasbourg, France

Human myoblast cell lines derived from primary muscle cells and immortalized using non-retroviral gene sequences.

Transgene EP 1 048 725

Mammalian cell lines

Strasbourg, France

Mammalian cell lines derived from primary cells and immortalized using non-retroviral gene sequences.

Univ. College WO 00/63359

Heterologous gene expression


Gene sequences containing sequences encoding heterologous introns; for transfecting cells.

Utah, Univ. of WO 00/63434

Cardiac arrhythmia genes

Salt Lake City, Utah

MinK-related genes, encoded potassium channel proteins; for diagnosing cardiac arrhythmias.

Virtual Arrays WO 00/63419

Combinatorial chemistry methods

San Jose, Calif.

Multiplexed detection and quantification of analytes by reacting them with probes attached to specific carriers.

Warner-Lambert WO 00/63367

Sodium channel modulators

Morris Plains, N.J.

Family of _ subunit proteins from a voltage-gated sodium channel, encoding genes; for modulators screens.

Warner-Lambert WO 00/63370

Neuronal regeneration

Morris Plains, N.J.

Truncated CART proteins, encoding gene sequences; for promoting neuronal regeneration.

Yale Univ. WO 00/62605

Cardiovascular gene therapy

New Haven, Conn.

Variant and mutant nitric oxide synthases having alterations in the Akt-dependent phosphorylation site, encoding genes.

Zetesis WO 00/63368

Cancer-associated protein

Milan, Italy

Recombinant protein UK114, encoding gene sequences; for cancer diagnostics and therapeutics.

Zymetx WO 00/63423

Influenza diagnostics

Oklahoma City

Chemiluminescent methods for detecting the presence of influenza virus; for diagnostics.

ZymoGenetics WO 00/63376 & 63377

Complement-related protein


Adipocyte complement-related protein homolog with collagen-like and C1q domains, encoding gene, antibodies.

ZymoGenetics WO 00/63378

Metabolism regulating proteins


Human secreted proteins that regulate metabolism and differentiation, encoding genes; for therapeutics.