September 27, October 4, 11, 18 & 25 (EP & GB), October 19 (WO)
Affymetrix EP 1 042 405
Proportional amplification
Santa Clara, Calif.
Proportional amplification of nucleic acids which increases relative amounts while preserving relative abundance.
Akzo Nobel EP 1 043 029
Campylobacter vaccines
Arnhem, Netherlands
Flagella-less Campylobacter jejuni strains, antigens; for vaccines.
Alabama, Univ. of WO 00/61597
Cell growth inhibition
Birmingham, Ala.
Inhibition of malignant and hyperplastic cell growth using G-rich oligonucleotides that bind nucleolin.
Aventis Behring EP 1 038 959
Modified Factor VIII
Marburg, Germany
Factor VIII without the B-domain and having Factor IX truncated intron I inserted, encoding gene; for therapy.
Aventis Behring EP 1 045 026
Factor XIII-defective transgenics
Marburg, Germany
Transgenics with defective Factor XIII coagulation factor; for wound healing and bleeding model systems.
Banyu Pharma EP 1 043 395
GTP-binding protein receptors
Tokyo
GTP-binding protein conjugate type receptor proteins, encoding genes; for modulator screens.
Bartenschiager, R. EP 1 043 399
Hepatitis C cell cultures
Gau-Odernheim, Germany
Hepatitis C virus cell culture system; for expressing hepatitis genes and selecting marker genes [in German].
Becton Dickinson EP 1 044 986
Shigella detection
Franklin Lakes, N.J.
Amplification primers for the detection of Shigella and enteroinvasive E. coli strains.
Becton Dickinson EP 1 045 030
Campylobacter detection
Franklin Lakes, N.J.
Amplification primers for the detection of Campylobacter jejuni and Campylobacter coli.
Becton Dickinson EP 1 045 031
Yersinia detection
Franklin Lakes, N.J.
Amplification primers for the detection of Yersinia enterocolitica.
Becton Dickinson EP 1 045 032
Salmonella detection
Franklin Lakes, N.J.
Amplification primers for the detection of Salmonella species.
Becton Dickinson EP 1 045 033 & 045 034
Shiga-like toxin producing organisms
Franklin Lakes, N.J.
Amplification primers for the detection of Shiga-like toxin producing microorganisms.
Biotech Res. Inst. EP 1 046 710
High-level gene expression
Braunschweig, Germany
Viral-based promoter-transactivator system for inducible high-level mammalian gene expression with growth control.
Blind, M., et al. EP 1 041 144
Functional intracellular targets
Munich, Germany
Identifying functional intracellular targets and nucleic acids called intramers for modifying their function.
Breonics WO 00/61166
Organ metabolic support
Schenectady, N.Y.
Methods and apparatus for perfusing and preserving metabolic function in organs and tissues without using blood.
California, Univ. of WO 00/61069
Hyperlipidemia therapy
Oakland, Calif.
Modulators that reduce the level of active apoE; for treating Type IV or IIb hyperlipidemia.
Calif. Inst. Technol. GB 2 348 426
Tissue engineering
Pasadena, Calif.
Enzyme-mediated modification of fibrin complexed with various peptides; for tissue engineering scaffolds.
CNRS (Natl. Ctr. Sci. Res.) WO 00/61067
HIV 1 vaccine
Paris
Anti-HIV 1 vaccine made from all or part of the Tat HIV 1 protein.
Chugai EP 1 043 586
TGF-_ inhibitor screen
Tokyo
Methods for screening TGF-_ inhibitors using protein binding assays.
Chugai EP 1 045 027
Telomerase activity assay
Tokyo
Gene having reverse transcriptase activity, encoding gene, antibodies; for detecting telomerase activity.
Cletterbridge Cancer Res. Trust GB 2 348 284
Comparing nucleic acid sequences
Wirral, UK
Methods for comparing nucleic acid sequences from libraries using hybridization techniques.
Daiichi Pharma EP 1 044 605
Alzheimer's model
Tokyo
Transgenics having a mutated presenilin-1 gene; for use as an Alzheimer's model system.
Devgen GB 2 349 150
C. elegans model
Ghent, Belgium
Use of a C. elegans promoter to direct expression of heterologous genes in flatworm disease model systems.
Devgen GB 2 349 217
Finding ATPase modulators
Ghent, Belgium
Use of C. elegans mutants to find modulators of sarco-endoplasmic reticulum calcium ATPase.
Diapharm EP 1 043 407
HIV-1 field isolates
St. Peter Port, UK
HIV-1 nucleotide sequences for the detection and characterization of field isolates that recombine.
European Molec. Biol. Lab EP 1 038 956
Subcellular localization genes
Heidelberg, Germany
Detection, cloning, and sequencing of genes encoding proteins that drive subcellular localization of proteins.
European Molec. Biol. Lab EP 1 041 147
Microtubule-associated protein
Heidelberg, Germany
Microtubule-associated protein; for modifying cellular mitotic processes.
Fudan Univ. EP 1 038 964
Alkaline phosphoesterase
Shanghai, China
Thermophilic alkaline phosphoesterase, encoding gene sequences, recombinant production methods.
Genlon EP 1 046 708
Antibacterial screens
Hamburg, Germany
Expression of bacterial potassium channels in eukaryotic cells; for identifying antibiotics [in German].
Genome Pharma EP 1 043 403
Antibacterial screens
Martinsried, Germany
Identification of inhibitors of bacterial gene expression and surrogate markers; for antibacterial screens.
German Res. Ctr. Health & Welfare EP 1 044 984
RNA isolation
Oberscleissheim, Germany
Methods and materials for extraction and isolation of RNA [in German].
Hitachi Chemical WO 00/61198
DNA probe arrays
Tokyo
Production of DNA probe arrays using fine particles on which the DNA can be immobilized.
Hoffmann-La Roche GB 2 348 645
Sodium/phosphate cotransporter
Basel, Switzerland
Human sodium-dependent phosphate cotransporter, encoding gene sequences, antibodies, transgenics.
ImaRx Pharma EP 1 046 394
Cell targeting
Tucson, Ariz.
Cell delivery compositions that contain a targeting ligand and a nuclear localization sequence.
Immtech Intl. WO 00/61181
Enhanced immune responses
Evanston, Ill.
Immunization by administering modified C-reactive peptide and an immunogen; for enhancing immune responses.
Imperial College Innovatiions GB 2 348 203
Soluble _-form prion protein
London
Monomeric soluble _-form of prion protein; for making antibodies and therapeutic modulator screens.
Inst. Phys. & Chem. Res. EP 1 041 160
Mutation detection
Wako, Japan
Finding mutations in base sequences by detecting labeled substances that specifically bind to mismatches.
Isis Pharma EP 1 044 987
Modified antisense oligos
Carlsbad, Calif.
Gapped 2'-modified oligonucleotides that have increased nuclease resistance; for use in antisense oligos.
Isis Pharma WO 00/61150
Fas antisense
Carlsbad, Calif.
Fas antisense oligos; for inhibiting the expression of Fas and treating Fas-related diseases.
Isis Pharma WO 00/61193
MDMX antisense
Carlsbad, Calif.
MDMX antisense oligos; for inhibiting the expression of MDMX and treating MDMX-related diseases.
Itoh, K. EP 1 041 146
Tumor antigen protein
Saga, Japan
Tumor antigen protein, encoding gene sequences, antibodies; for cancer diagnostics and therapeutics.
Japan Sci. & Technol. EP 1 043 396
Monocyte-expressed genes
Kawaguchi, Japan
Genes expressed in human monocytes and macrophages, probes, encoded proteins; for diagnostics and therapeutics.
Japan Sci. & Technol. EP 1 043 397
Immune response modulation
Kawaguchi, Japan
IkB kinase which is a serine-threonine kinase that activates transcription factor NF-kB; for modulating immune responses.
Japan Tobacco EP 1 043 335
CTGF antibodies
Tokyo
Monoclonal antibodies against connective tissue growth factor; for diagnostics and therapeutics.
Japan Tobacco EP 1 046 652
Hyperlipidemia assay
Tokyo
Antibody fusions used to quantitate denatured low-density lipids; for hyperlipidemia diagnosis.
Joslin Diabetes Ctr. WO 00/60933
VEGF-induced growth control
Boston
Differentially expressed genes from PKC conditioned cells; for vascular endothelial growth factor-induced growth.
Karolinska Innovations WO 00/61179
Kringle-modulated angiogenesis
Stockholm, Sweden
Kringle domains of plasminogen that are capable of modulating angiogenesis in vivo.
Kikkoman EP 1 041 151
Intracellular ATP assays
Chiba, Japan
Luciferase that is resistant to surfactants; for use in intracellular ATP assays.
Koninkiljke Univ. EP 1 046 651
T-cell interaction modulation
Nijmegen, Netherlands
Compounds that bind C-type lectins on dendritic cell surfaces; for modulating T-cell interactions.
Kudos Pharma GB 2 348 701
Phosphorylation modulators
Cambridge, UK
Identification of modulators that affect the interaction of phosphorylated peptides with yeast Rad53p.
Kyowa Hakko Kogyo EP 1 038 958
Human Nap1 protein
Tokyo
Human Nap1 protein, modified protein, encoding gene sequences; for suppressing apoptosis.
Leuven Res. & Develop. EP 1 045 024
Immortalized hepatocytes
Leuven, Belgium
Human immortalized hepatocytes; for treating liver failure by constructing artificial livers.
M&E Biotech EP 1 041 143
Active protein assay
Horsholm, Denmark
Finding biologically active proteins by transfecting their encoding genes into cells and detecting phenotypic changes.
Matushita Electric EP 1 043 334
Troponin modulators
Osaka, Japan
Troponin complexes; for finding modulators to affect the troponin calcium switching mechanism.
Max Planck Inst. EP 1 046 715
Modulating angiopoietin receptor
Munich, Germany
Modulating angiopoietin receptor-type tyrosine kinase using vascular endothelial protein tyrosine phosphatase.
Max Planck Inst. WO 00/61180
Epithelial cell migration modulation
Martinsried, Germany
Use of PTP LAR and its modulators to treat epithelial cell migration diseases.
McGill Univ. WO 00/60932
Releasing translation
Montreal
Transgenics with a knockout mutation in the gene encoding the translation repressor eIF-4E binding protein.
Merck WO 00/60945
Soluble endostatin
Rahway, N.J.
Soluble recombinant endostatin, methods of producing this protein in Streptomyces; for inhibiting angiogenesis.
MIRA Diagnostica EP 1 041 159
Degrading nucleic acids
Leverkusen, Germany
Methods and oligonucleotides suitable for the degradation of in vitro synthesized nucleic acids [in German].
Mogen Intl. EP 1 041 148
Hypersensitive response induction
Leiden, Netherlands
Pathogen-inducible promoter for linkage to antipathogenic protein genes; for eliciting a hypersensitive response.
Nippon Sanso EP 1 041 145
Antisense detection by NMR
Tokyo
Antisense oligonucleotides labeled with stable isotopes; for detection by nuclear magnetic resonance spectrometry.
Oklahoma Med. Res. Fdn. EP 1 041 142
Xenograft protection
Oklahoma City
Universal donor cells transfected with complement inhibitory activity gene; for preventing organ rejection.
Ono Pharma EP 1 043 333
Brain cell-expressed genes
Osaka, Japan
Human adult brain cell-expressed genes, encoded proteins, antibodies; for therapeutics.
Ophidian Pharma EP 1 041 149
Clostridium antitoxins
Madison, Wis.
Neutralizing antitoxins directed against Clostridium difficile toxins; for infection therapeutics.
Oriental Yeast EP 1 041 083
Modified TIMP protein
Tokyo
TIMP protein modified at the N-terminal a-amino group so that it no longer binds metalloproteinases.
Otsuka Pharma EP 1 038 957
Pancreas-specific gene
Tokyo
Pancreas-specific gene, encoded protein; for pancreatic cancer diagnostics and therapeutics.
Oxford Biomedica EP 1 041 152
Retroviral vectors
Oxford, UK
Replication-defective lentiviral vectors; for gene therapy of non-dividing mammalian target cells.
Panacea Pharma WO 00/61157
Autoimmunity therapy
Fairfield, Conn.
Methods for modulating the balance between Th1 and Th2 immune responses; for managing autoimmune disorders.
Park, J.G. WO 00/61595
Exonuclease-resistant antisense
Taegu, S. Korea
Covalently-closed multiple antisense oligonucleotides that are exonuclease-resistant and have increased activity.
Pennsylvania, Univ. of EP 1 046 711
Recombinant AAV vectors
Philadelphia
Recombinant adeno-associated viral vectors; for gene therapy.
Pierre Fabre Medicament EP 1 038 960
Brain-expressed protein
Boulogne, France
Brain cell surface-expressed protein, encoding gene sequences; for identifying modulators.
Pierre & Marie Curie, Univ. of EP 1 046 400
Nucleoside-sensitive cell killing
Paris
Herpes virus type-4 thymidine kinase and its encoding gene used to kill nucleoside-sensitive cells.
Sangamo Bioscience GB 2 348 424 & 2 348 425
Gene expression modulation
Richmond, Calif.
Modulating gene expression by selecting sites in gene sequences that interact with zinc finger proteins.
Schering WO 00/61171
Mammalian ligand OX2
Kenilworth, N.J.
Methods for using mammalian ligand OX2 to treat abnormal physiological conditions.
Seratech Biotech EP 1 043 394
PSA complex
Gottingen, Germany
Prostate-specific antigen complex, antibodies; for diagnostics and therapeutics [in German].
SmithKline Beecham EP 1 038 962
Streptococcus antibacterials
Philadelphia
Streptococcus pneumoniae peptidoglycan biosynthetic murF gene, encoded protein; for antibacterial screens.
SmithKline Beecham WO 00/61165
Bacterial vaccines
Philadelphia
Conserved adhesin motifs in bacterial proteins; for generating antibodies for vaccines.
SmithKline Beecham WO 00/61598
Profilin-3
Philadelphia
Rat kidney-expressed gene profilin-3, encoded protein, production methods; for diagnostics and therapeutics.
Sumitomo Chemical EP 1 038 953
Stereoselective transamination
Osaka, Japan
Stereoselective transaminase, encoding gene sequences; for stereoselective transamination.
Sumitomo Chemical EP 1 045 035
Transcription control modulation
Osaka, Japan
Cells expressing a gene encoding a ligand-responsive transcription control factor; for finding modulators.
Takara Shuzo EP 1 044 983
Antifungal agent
Kyoto, Japan
Peptide-based antibiotic for use in combatting fungal infections.
Tanuma, S. EP 1 045 028
Viral DNA cleavage
Tokyo
DNases a and _ that can selectively cleave linker sites of chromatin DNA; for developing antivirals.
Teijin EP 1 043 406
Respiratory disease prognosis
Osaka, Japan
Human airway trypsin protease gene polymorphism analysis; for respiratory disease prognosis.
Telogene EP 1 043 404
Modifying telomerase length
Fleurimont, Que.
Binding of hnRNP A1 and its shortened derivative UP1 to telomerase RNA; for modifying telomerase length.
Titan Pharma WO 00/61156
Schizophrenia therapy
Somerville, N.J.
Implantation of matrix-adhered cells that produce dopamine; for treating schizophrenia therapy side effects.
Transgene EP 1 038 987
Gene therapy delivery vehicles
Strasbourg, France
Viruses or virus-like particles having modified binding moieties; for delivery in gene therapy.
U.S. Biochemical EP 1 038 973
DNA cycle sequencing
Cleveland
Preparation of DNA by amplifying the DNA and contacting it with alkaline phosphatase; for sequencing.
Warner-Lambert EP 1 041 157
Phosphodiesterase modulators
Morris Plains, N.J.
Cells exhibiting upregulation of human phosphodiesterase 4A isozyme expression; for identifying modulators.
Washington, Univ. of EP 1 038 963
cGMP-specific phosphodiesterase
Seattle
Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase, encoding gene sequences; for screening modulators.