August 23 (EP), August 17 (WO), August 23 (GB)
Advanced Med. Solutions WO 00/47716
Fiber cultured cells
Fibers having at least one open-topped channel on the mouth of which eukaryotic cells can be cultured.
Amgen WO 00/47740
Thousand Oaks, Calif.
Tumor necrosis factor (TNF)-related proteins, encoding genes, antibodies, fragments, fusions, modulators.
Amgen WO 00/47741
Thousand Oaks, Calif.
Glycosylated leptin compositions, encoding gene sequences, production methods; for treating obesity and diabetes.
AstraZeneca WO 00/47766
Detection of variant nucleotides in a target sequence using multiplex amplification; for genotyping polymorphisms.
AstraZeneca WO 00/47767
Predetermined sequence oligo arrays having the same melting temperature placed on solid surfaces at distinct locations.
Bio Merieux EP 1 029 917 & WO 00/47745
Viral infection diagnostics
Marcy l'Etoile, France
MSRV-1 retrovirus LTR region fragment, encoded proteins, antibodies; for viral infection diagnostics.
Bioinside WO 00/47764
Detecting GMO DNA
Qualitative and quantitative fluorescence-coupled PCR for detecting DNA from genetically modified organisms (GMOs).
Biotix WO 00/47732
Single-stranded DNA isolation
Electromagnetic radiation-induced dissociation of double-stranded DNA; for isolating single-stranded DNA.
Catalyst Biomedica WO 00/47769 & 47770
Genomic regions having sequences that affect susceptibility to osteoarthritis on chromosomes 4 and 6.
CNRS (Natl. Ctr. Sci. Res.) WO 00/47738
Human and mouse potassium transport proteins; for identifying anesthetics.
Chicago, Univ. of WO 00/47713
Genes encoding light and heavy variable regions of a 5HT antibody; for inducing programmed cell death.
Chisso WO 00/47753
Cyclic plasmid DNA isolated from a Streptomyces genus; for use in making expression vectors.
Dade Behring WO 00/47739
Auto-antigens found in patients having endometriosis, encoding genes; for diagnostics.
Develop. Res. Inst. WO 00/47216
Immunogenic compositions having targeting and therapeutic moieties; for treating mammalian infections.
Du Pont WO 00/47748 & 47755
Modifying UDP-glucose levels
Genes encoding UDP-glucose pyrophosphorylase and UDP-galactose 4-epimerase; for modifying UDP-glucose levels.
Duke Univ. EP 1 029 915
G protein coupled receptor expression
Expression of mammalian G protein coupled receptors in yeast strains that cannot express their endogenous receptors.
Eberhard Karls Univ. WO 00/47217
Chemical agent protection
Modified fragment of a Bowman-Birk protease inhibitor; for protecting cells against chemical agents.
Elan Pharma WO 00/47618
S. San Francisco
_-secretase active variants and forms; for use in assays to identify potential Alzheimer's disease therapeutics.
Entremed WO 00/47729
Deglycosylated kringle 1-5 region fragments of plasminogen; for treating angiogenesis-related diseases.
Gen-Probe WO 00/47777
Labelled detection probes
San Diego, Calif.
Detection probes having labels susceptible to chemical or enzymatic alteration; for use in amplification reactions.
Genentech EP 1 029 870
S. San Francisco
Hybrid immunoglobulins useful as cell surface adhesion molecules and ligands; for diagnostics and therapeutics.
GeneSense Technol. WO 00/47733
Antitumor antisense sequences directed against R1 and R2 components of ribonucleotide reductase.
Genetics Inst. WO 00/47625
Humanized immunoglobulins reactive with B7; for treatment of autoimmunity, transplant rejection, and inflammation.
Genetics Inst. WO 00/47763
cPLA2 crystal structure
Crystalline cPLA2, for developing model structures to identify modulators.
Genset WO 00/47771
Arachidonic acid metabolism alleles
Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism.
Genset WO 00/47772
LSR gene polymorphisms
Polymorphic LSR genomic sequences, encoded proteins, antibodies; for genotyping.
Genzyme WO 00/47229
Antigenic peptide concatamers
Concatamers of antigenic peptides to MHC molecules, encoding gene sequences; for modulating immune responses.
Glaxo WO 00/47723
Diacylglycerol kinase modulators
Human diacylglycerol kinase, encoding gene sequences, antibodies; for screening modulators.
Grummt, F. WO 00/47237
Cells for drug delivery
Encapsulated cells containing amplified expression vectors encoding therapeutics; for drug delivery.
Hammerschreid, J. GB 2 346 884
Wound healing factors
Obtaining regulatory factors from wound granulation and epithelialization tissue.
Hanmi Pharma WO 00/47717
Embryonic germ cells
Kyunggi-do, S. Korea
Pluripotent embryonic germ cells from birds; for establishing cell lines and making transgenic birds.
Harvard Univ. WO 00/47734
Inhibition of the formation of atherosclerotic lesions by reducing AFA binding protein activity.
Human Genome Sciences WO 00/47602
33 secreted proteins
33 human secreted proteins, encoding gene sequences, antibodies, production methods; for therapeutics.
Interleukin Genetics WO 00/47619
San Antonio, Texas
Methods for detecting an interleukin (IL)-2B mutation associated with the development of inflammatory diseases.
Iowa, Univ. of WO 00/47752
Macular degeneration mutations
Iowa City, Iowa
Identification of genetic mutations associated with macular degeneration; for diagnostics and therapeutics.
Isis Innovation WO 00/47768
Modulating TNF- expression
DNA binding proteins that specifically bind target sequences in the TNF- promoter; for expression modulation.
JCR Pharma EP 1 029 914
GH-regulated growth marker
Growth hormone (GH)-regulated growth marker gene, encoded protein; for diagnostics and therapeutics.
Kao EP 1 029 920
Thermostable alkaline protease that is tolerant of fatty acids and stable to various surfactants.
Krebs Res. Ctr. WO 00/47722
Chimeric virus-like particles from papillomaviruses, fusion proteins, encoding genes; for vaccines.
Kyowa Hakko Kogyo EP 1 029 918
HIV T cell receptor
Killer T cell receptor that recognizes HIV, encoding gene sequences, transgenics; for developing therapeutics.
Kyowa Hakko Kogyo WO 00/47606
Vascular endothelium inhibition
Peptides that inhibit the migration of vascular endothelial cells; for treating inflammatory diseases.
Kyowa Hakko Kogyo WO 00/47730
N-acetylglucosamine 2-epimerase, encoding gene sequences, recombinant production methods.
Lexicon Genetics WO 00/47617
The Woodlands, Texas
Human uncoupling proteins, encoding gene sequences; for metabolic diagnostics and therapeutics.
Marie Curie Cancer Care WO 00/47765
Melanoma cell marker
Microphthalmia-associated transcription factor, encoding gene, detection of variants in melanoma cells.
Mass. Gen. Hosp. WO 00/47775
Selection of proteins using RNA-protein fusion production methods involving a high salt post-translational step.
McGill Univ. WO 00/47735
Nuclear receptor knockouts
Transgenics with germ cells having a knockout mutation in an orphan nuclear receptor.
Medigene WO 00/47757
Producing AAV vectors
Production recombinant adeno-associated viruses (AAV) using helper constructs; for inserting GM-CSF genes into tumors.
Medvet Science WO 00/47620
Cytokine-binding domain; for use in identifying modulators of cytokine action.
Merck GB 2 346 882
Human vanilloid receptor-like receptor, encoding gene sequences, antisense; for diagnostics and therapeutics.
Merial WO 00/47756
Replication-deficient pig adenovirus with inserted heterologous sequences; for making vaccines and vectors.
Microbiol. Res. Auth. WO 00/47725
Anti-cancer drug conversion
Nitroreductase enzymes, encoding gene sequences; for catalytic conversion of anti-cancer alkylating agents.
Molecular Toxicol. WO 00/47761
Santa Fe, N.M.
High-throughput toxicological testing using microwell plates with cultured cells and organisms.
Montreal, Univ. of WO 00/47750
PCR-based methods for identifying metalloproteases of the neprilysin family, identified proteins, production methods.
NIH (Natl. Inst. Hlth.) WO 00/47627
Drug metabolism phenotypes
Antibodies to and other binding agents for cytochromes; for screening drug metabolism capabilities.
New England Biolabs WO 00/47751
Intein-mediated ligation of expressed proteins, modified inteins, encoding gene sequences.
Nexstar Pharma WO 00/47774
Nucleic acid binding assay
Using aptamers in high-throughput screening assays; for determining specific nucleic acid binding to targets.
Nissui Pharma WO 00/47609
Cyclic dodecapeptides that can neutralize cellular HIV receptors; for AIDS treatment.
Oklahoma Med. Res. Fdn. WO 00/47611
Targeting mucosal surfaces
Oklahoma City, Okla.
Polymeric immunoglobulin receptor that binds to IgA and transports it to mucosal epithelium; for targeting.
Ono Pharma EP 1 029 916
Lysophosphatidic acid receptor
Human lysophosphatidic acid receptor, encoding gene sequences; for modulator screens.
Ontogeny WO 00/47720 & 47721
Cellular diabetes therapy
Insulin-positive pancreatic progenitor cells isolated for culturing and subsequent diabetes therapy.
Osteogenetics WO 00/47736
Polypeptide variants having increased heparin-binding capacity, encoding genes; for stimulating osteogenesis.
Oxford Biomedica WO 00/47622
Type 1 repeat peptide
Non-naturally occurring type 1 repeat peptide, methods for expressing this peptide.
Panacea Pharma WO 00/47610
Less immunogenic peptides
Polypeptide variants that retain activity but are less immunogenic, encoding genes; for reducing immune responses.
Pharmacal Biotech WO 00/47175
Oral bacteria therapeutics
Westlake Village, Calif.
Fusion protein with enzyme and anchoring moieties; for attachment near bacterial colonies in the oral cavity.
Pharmacopeia WO 00/47778
Episomal apoptosis modulators
Methods for the maintenance and selection of episomes in transfected cells; for expressing apoptosis modulators.
Powderject Vaccines WO 00/47227
Recombinant nucleic acid sequences encoding at least two Mycobacterium tuberculosis antigens; for vaccines.
Protease WO 00/47626
Protein C inhibitor action assay
Monoclonal antibodies for use in assays that monitor systems involving protein C inhibitor action.
Rhein Biotech Res. Inst. WO 00/47749
Protein production in yeast
Heat-inducible promoters; for use in yeast strains to produce heterologous proteins.
Rockefeller Univ. WO 00/47744
Immunoprotective epitope of an Erysipelothrix antigen; for an infection protecting vaccine.
St. Jude Children's Hosp. WO 00/47760
ATM kinase inhibitors
Identifying the consensus sequence that is phosphorylated by ATM kinase; for finding target proteins and inhibitors.
Salk Inst. WO 00/47718
Cells for dystrophic retinas
La Jolla, Calif.
Transplantation of adult hippocampus-derived progenitor cells into dystrophic retinas.
Schepens Eye Res. Inst. WO 00/47238
Dystrophic neural cell repair
Integration of transplanted neural progenitor cells into neural tissue of immature and mature dystrophic patients.
Shanghai Second Med. Univ. WO 00/47616
Human gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/47737
Haemophilus influenzae outer membrane proteins, encoding genes, production methods; for antibacterial screens.
SmithKline Beecham WO 00/47743
Neisseria meningitidis serogroup B antigen, encoding gene sequences; for diagnostics and therapeutics.
Stanford Univ. WO 00/47724
Palo Alto, Calif.
Type 1 polyketide synthase modules that can be alternatively linked; for synthesizing new antibacterial polyketides.
Stem Cells WO 00/47762
Neural stem cells
Enriched neural stem and progenitor cell populations, identification methods using cell surface markers.
Strathmann WO 00/47223
Mixtures of viral protein molecule variants, encoding gene sequences; for making wide-spectrum HIV vaccines.
Sumitomo Electric WO 00/47731
DNA helicase protein, encoding gene sequences, antisense, antibodies; for diagnostics and therapeutics.
Texas, Univ. of EP 1 029 921
Serpin-resistant chymotrypsin superfamily proteases, including tPA mutants, encoding genes; for therapeutics.
3M Innovative Properties WO 00/47719
Dendritic cell maturation
St. Paul, Minn.
Inducing maturation of dendritic cells by stimulation with an imidazoquinoline that causes immune responses.
Toronto, Univ. of WO 00/47615
Nerve growth stimulation
Stimulating nerve growth using neural plakophilin-related Armadillo protein, modulator assays.
Urocor WO 00/47773
Prostate cancer diagnostics
Oklahoma City, Okla.
Prostate-specific gene, encoded protein, probes; for diagnostics and therapeutics.
Wang, J., et al. WO/47613
Treponema infection assay
Modified Treponema pallidum outer membrane protein, encoding gene sequences; for diagnostic immunoassays.
Xencor WO 00/47612
Receptor ligand screens
Non-naturally occurring cell surface receptor analogs, encoding genes; for screening ligand analogs.
Yoon, J.H., et al. WO 00/47607
Intracellular signaling modulation
Kyunggi-do, S. Korea
Synthetic peptides with SH2/SH3 motifs critical in protein-protein interactions; for affecting intracellular signaling.
ZymoGenetics WO 00/47776
Insulin family homolog
Insulin family homolog localized to chromosome 1, encoding gene; for identifying polymorphisms and treating diabetes.