August 23 (EP), August 17 (WO), August 23 (GB)

Advanced Med. Solutions WO 00/47716

Fiber cultured cells

Winsford, UK

Fibers having at least one open-topped channel on the mouth of which eukaryotic cells can be cultured.

Amgen WO 00/47740

TNF-related proteins

Thousand Oaks, Calif.

Tumor necrosis factor (TNF)-related proteins, encoding genes, antibodies, fragments, fusions, modulators.

Amgen WO 00/47741

Glycosylated leptin

Thousand Oaks, Calif.

Glycosylated leptin compositions, encoding gene sequences, production methods; for treating obesity and diabetes.

AstraZeneca WO 00/47766

Polymorphism identification

London

Detection of variant nucleotides in a target sequence using multiplex amplification; for genotyping polymorphisms.

AstraZeneca WO 00/47767

Oligonucleotide arrays

London

Predetermined sequence oligo arrays having the same melting temperature placed on solid surfaces at distinct locations.

Bio Merieux EP 1 029 917 & WO 00/47745

Viral infection diagnostics

Marcy l'Etoile, France

MSRV-1 retrovirus LTR region fragment, encoded proteins, antibodies; for viral infection diagnostics.

Bioinside WO 00/47764

Detecting GMO DNA

Teltow, Germany

Qualitative and quantitative fluorescence-coupled PCR for detecting DNA from genetically modified organisms (GMOs).

Biotix WO 00/47732

Single-stranded DNA isolation

Luckenwalde, Germany

Electromagnetic radiation-induced dissociation of double-stranded DNA; for isolating single-stranded DNA.

Catalyst Biomedica WO 00/47769 & 47770

Osteoarthritis susceptibility

London

Genomic regions having sequences that affect susceptibility to osteoarthritis on chromosomes 4 and 6.

CNRS (Natl. Ctr. Sci. Res.) WO 00/47738

Identifying anesthetics

Paris

Human and mouse potassium transport proteins; for identifying anesthetics.

Chicago, Univ. of WO 00/47713

Inducing apoptosis

Chicago

Genes encoding light and heavy variable regions of a 5HT antibody; for inducing programmed cell death.

Chisso WO 00/47753

Streptomyces plasmid

Osaka, Japan

Cyclic plasmid DNA isolated from a Streptomyces genus; for use in making expression vectors.

Dade Behring WO 00/47739

Endometriosis auto-antigens

Deerfield, Ill.

Auto-antigens found in patients having endometriosis, encoding genes; for diagnostics.

Develop. Res. Inst. WO 00/47216

Infection therapeutics

Paris

Immunogenic compositions having targeting and therapeutic moieties; for treating mammalian infections.

Du Pont WO 00/47748 & 47755

Modifying UDP-glucose levels

Wilmington, Del.

Genes encoding UDP-glucose pyrophosphorylase and UDP-galactose 4-epimerase; for modifying UDP-glucose levels.

Duke Univ. EP 1 029 915

G protein coupled receptor expression

Durham, N.C.

Expression of mammalian G protein coupled receptors in yeast strains that cannot express their endogenous receptors.

Eberhard Karls Univ. WO 00/47217

Chemical agent protection

Tubingen, Germany

Modified fragment of a Bowman-Birk protease inhibitor; for protecting cells against chemical agents.

Elan Pharma WO 00/47618

_-secretase modulators

S. San Francisco

_-secretase active variants and forms; for use in assays to identify potential Alzheimer's disease therapeutics.

Entremed WO 00/47729

Treating angiogenesis

Rockville, Md.

Deglycosylated kringle 1-5 region fragments of plasminogen; for treating angiogenesis-related diseases.

Gen-Probe WO 00/47777

Labelled detection probes

San Diego, Calif.

Detection probes having labels susceptible to chemical or enzymatic alteration; for use in amplification reactions.

Genentech EP 1 029 870

Hybrid immunoglobulins

S. San Francisco

Hybrid immunoglobulins useful as cell surface adhesion molecules and ligands; for diagnostics and therapeutics.

GeneSense Technol. WO 00/47733

Antitumor antisense

Toronto, Ont.

Antitumor antisense sequences directed against R1 and R2 components of ribonucleotide reductase.

Genetics Inst. WO 00/47625

Anti-inflammatory antibodies

Cambridge, Mass.

Humanized immunoglobulins reactive with B7; for treatment of autoimmunity, transplant rejection, and inflammation.

Genetics Inst. WO 00/47763

cPLA2 crystal structure

Cambridge, Mass.

Crystalline cPLA2, for developing model structures to identify modulators.

Genset WO 00/47771

Arachidonic acid metabolism alleles

Paris

Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism.

Genset WO 00/47772

LSR gene polymorphisms

Paris

Polymorphic LSR genomic sequences, encoded proteins, antibodies; for genotyping.

Genzyme WO 00/47229

Antigenic peptide concatamers

Framingham, Mass.

Concatamers of antigenic peptides to MHC molecules, encoding gene sequences; for modulating immune responses.

Glaxo WO 00/47723

Diacylglycerol kinase modulators

Greenford, UK

Human diacylglycerol kinase, encoding gene sequences, antibodies; for screening modulators.

Grummt, F. WO 00/47237

Cells for drug delivery

Wurzburg, Germany

Encapsulated cells containing amplified expression vectors encoding therapeutics; for drug delivery.

Hammerschreid, J. GB 2 346 884

Wound healing factors

Grunwald, Germany

Obtaining regulatory factors from wound granulation and epithelialization tissue.

Hanmi Pharma WO 00/47717

Embryonic germ cells

Kyunggi-do, S. Korea

Pluripotent embryonic germ cells from birds; for establishing cell lines and making transgenic birds.

Harvard Univ. WO 00/47734

Inhibiting atherosclerosis

Cambridge, Mass.

Inhibition of the formation of atherosclerotic lesions by reducing AFA binding protein activity.

Human Genome Sciences WO 00/47602

33 secreted proteins

Rockville, Md.

33 human secreted proteins, encoding gene sequences, antibodies, production methods; for therapeutics.

Interleukin Genetics WO 00/47619

IL-2B mutation

San Antonio, Texas

Methods for detecting an interleukin (IL)-2B mutation associated with the development of inflammatory diseases.

Iowa, Univ. of WO 00/47752

Macular degeneration mutations

Iowa City, Iowa

Identification of genetic mutations associated with macular degeneration; for diagnostics and therapeutics.

Isis Innovation WO 00/47768

Modulating TNF- expression

Oxford, UK

DNA binding proteins that specifically bind target sequences in the TNF- promoter; for expression modulation.

JCR Pharma EP 1 029 914

GH-regulated growth marker

Hyogo, Japan

Growth hormone (GH)-regulated growth marker gene, encoded protein; for diagnostics and therapeutics.

Kao EP 1 029 920

Alkaline protease

Tokyo

Thermostable alkaline protease that is tolerant of fatty acids and stable to various surfactants.

Krebs Res. Ctr. WO 00/47722

Papillomavirus vaccines

Heidelberg, Germany

Chimeric virus-like particles from papillomaviruses, fusion proteins, encoding genes; for vaccines.

Kyowa Hakko Kogyo EP 1 029 918

HIV T cell receptor

Tokyo

Killer T cell receptor that recognizes HIV, encoding gene sequences, transgenics; for developing therapeutics.

Kyowa Hakko Kogyo WO 00/47606

Vascular endothelium inhibition

Tokyo

Peptides that inhibit the migration of vascular endothelial cells; for treating inflammatory diseases.

Kyowa Hakko Kogyo WO 00/47730

N-acetylglucosamine 2-epimerase

Tokyo

N-acetylglucosamine 2-epimerase, encoding gene sequences, recombinant production methods.

Lexicon Genetics WO 00/47617

Uncoupling proteins

The Woodlands, Texas

Human uncoupling proteins, encoding gene sequences; for metabolic diagnostics and therapeutics.

Marie Curie Cancer Care WO 00/47765

Melanoma cell marker

London

Microphthalmia-associated transcription factor, encoding gene, detection of variants in melanoma cells.

Mass. Gen. Hosp. WO 00/47775

RNA-protein fusions

Boston

Selection of proteins using RNA-protein fusion production methods involving a high salt post-translational step.

McGill Univ. WO 00/47735

Nuclear receptor knockouts

Montreal, Que.

Transgenics with germ cells having a knockout mutation in an orphan nuclear receptor.

Medigene WO 00/47757

Producing AAV vectors

Planegg, Germany

Production recombinant adeno-associated viruses (AAV) using helper constructs; for inserting GM-CSF genes into tumors.

Medvet Science WO 00/47620

Cytokine-binding domain

Adelaide, Australia

Cytokine-binding domain; for use in identifying modulators of cytokine action.

Merck GB 2 346 882

Vanilloid-like receptor

Hoddesdon, UK

Human vanilloid receptor-like receptor, encoding gene sequences, antisense; for diagnostics and therapeutics.

Merial WO 00/47756

Adenovirus-based vaccines

Lyon, France

Replication-deficient pig adenovirus with inserted heterologous sequences; for making vaccines and vectors.

Microbiol. Res. Auth. WO 00/47725

Anti-cancer drug conversion

Salisbury, UK

Nitroreductase enzymes, encoding gene sequences; for catalytic conversion of anti-cancer alkylating agents.

Molecular Toxicol. WO 00/47761

Toxicological testing

Santa Fe, N.M.

High-throughput toxicological testing using microwell plates with cultured cells and organisms.

Montreal, Univ. of WO 00/47750

Neprilysin metalloproteases

Montreal, Que.

PCR-based methods for identifying metalloproteases of the neprilysin family, identified proteins, production methods.

NIH (Natl. Inst. Hlth.) WO 00/47627

Drug metabolism phenotypes

Bethesda, Md.

Antibodies to and other binding agents for cytochromes; for screening drug metabolism capabilities.

New England Biolabs WO 00/47751

Intein-mediated ligation

Beverly, Mass.

Intein-mediated ligation of expressed proteins, modified inteins, encoding gene sequences.

Nexstar Pharma WO 00/47774

Nucleic acid binding assay

Boulder, Colo.

Using aptamers in high-throughput screening assays; for determining specific nucleic acid binding to targets.

Nissui Pharma WO 00/47609

AIDS vaccines

Tokyo

Cyclic dodecapeptides that can neutralize cellular HIV receptors; for AIDS treatment.

Oklahoma Med. Res. Fdn. WO 00/47611

Targeting mucosal surfaces

Oklahoma City, Okla.

Polymeric immunoglobulin receptor that binds to IgA and transports it to mucosal epithelium; for targeting.

Ono Pharma EP 1 029 916

Lysophosphatidic acid receptor

Osaka, Japan

Human lysophosphatidic acid receptor, encoding gene sequences; for modulator screens.

Ontogeny WO 00/47720 & 47721

Cellular diabetes therapy

Cambridge, Mass.

Insulin-positive pancreatic progenitor cells isolated for culturing and subsequent diabetes therapy.

Osteogenetics WO 00/47736

Stimulating osteogenesis

Wurzburg, Germany

Polypeptide variants having increased heparin-binding capacity, encoding genes; for stimulating osteogenesis.

Oxford Biomedica WO 00/47622

Type 1 repeat peptide

Oxford, UK

Non-naturally occurring type 1 repeat peptide, methods for expressing this peptide.

Panacea Pharma WO 00/47610

Less immunogenic peptides

Southport, Conn.

Polypeptide variants that retain activity but are less immunogenic, encoding genes; for reducing immune responses.

Pharmacal Biotech WO 00/47175

Oral bacteria therapeutics

Westlake Village, Calif.

Fusion protein with enzyme and anchoring moieties; for attachment near bacterial colonies in the oral cavity.

Pharmacopeia WO 00/47778

Episomal apoptosis modulators

Cranbury, N.J.

Methods for the maintenance and selection of episomes in transfected cells; for expressing apoptosis modulators.

Powderject Vaccines WO 00/47227

Mycobacterial vaccines

Madison, Wis.

Recombinant nucleic acid sequences encoding at least two Mycobacterium tuberculosis antigens; for vaccines.

Protease WO 00/47626

Protein C inhibitor action assay

Maimo, Sweden

Monoclonal antibodies for use in assays that monitor systems involving protein C inhibitor action.

Rhein Biotech Res. Inst. WO 00/47749

Protein production in yeast

Dusseldorf, Germany

Heat-inducible promoters; for use in yeast strains to produce heterologous proteins.

Rockefeller Univ. WO 00/47744

Erysipelothrix antigen

New York

Immunoprotective epitope of an Erysipelothrix antigen; for an infection protecting vaccine.

St. Jude Children's Hosp. WO 00/47760

ATM kinase inhibitors

Memphis, Tenn.

Identifying the consensus sequence that is phosphorylated by ATM kinase; for finding target proteins and inhibitors.

Salk Inst. WO 00/47718

Cells for dystrophic retinas

La Jolla, Calif.

Transplantation of adult hippocampus-derived progenitor cells into dystrophic retinas.

Schepens Eye Res. Inst. WO 00/47238

Dystrophic neural cell repair

Boston

Integration of transplanted neural progenitor cells into neural tissue of immature and mature dystrophic patients.

Shanghai Second Med. Univ. WO 00/47616

Human gene

Shanghai, China

Human gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 00/47737

Antibacterial screens

Rixensart, Belgium

Haemophilus influenzae outer membrane proteins, encoding genes, production methods; for antibacterial screens.

SmithKline Beecham WO 00/47743

Meningitis diagnostics

Rixensart, Belgium

Neisseria meningitidis serogroup B antigen, encoding gene sequences; for diagnostics and therapeutics.

Stanford Univ. WO 00/47724

Antibacterial polyketides

Palo Alto, Calif.

Type 1 polyketide synthase modules that can be alternatively linked; for synthesizing new antibacterial polyketides.

Stem Cells WO 00/47762

Neural stem cells

Sunnyvale, Calif.

Enriched neural stem and progenitor cell populations, identification methods using cell surface markers.

Strathmann WO 00/47223

HIV vaccines

Hamburg, Germany

Mixtures of viral protein molecule variants, encoding gene sequences; for making wide-spectrum HIV vaccines.

Sumitomo Electric WO 00/47731

DNA helicase

Osaka, Japan

DNA helicase protein, encoding gene sequences, antisense, antibodies; for diagnostics and therapeutics.

Texas, Univ. of EP 1 029 921

tPA mutants

Austin, Texas

Serpin-resistant chymotrypsin superfamily proteases, including tPA mutants, encoding genes; for therapeutics.

3M Innovative Properties WO 00/47719

Dendritic cell maturation

St. Paul, Minn.

Inducing maturation of dendritic cells by stimulation with an imidazoquinoline that causes immune responses.

Toronto, Univ. of WO 00/47615

Nerve growth stimulation

Toronto, Ont.

Stimulating nerve growth using neural plakophilin-related Armadillo protein, modulator assays.

Urocor WO 00/47773

Prostate cancer diagnostics

Oklahoma City, Okla.

Prostate-specific gene, encoded protein, probes; for diagnostics and therapeutics.

Wang, J., et al. WO/47613

Treponema infection assay

Beijing

Modified Treponema pallidum outer membrane protein, encoding gene sequences; for diagnostic immunoassays.

Xencor WO 00/47612

Receptor ligand screens

Pasadena, Calif.

Non-naturally occurring cell surface receptor analogs, encoding genes; for screening ligand analogs.

Yoon, J.H., et al. WO 00/47607

Intracellular signaling modulation

Kyunggi-do, S. Korea

Synthetic peptides with SH2/SH3 motifs critical in protein-protein interactions; for affecting intracellular signaling.

ZymoGenetics WO 00/47776

Insulin family homolog

Seattle, Wash.

Insulin family homolog localized to chromosome 1, encoding gene; for identifying polymorphisms and treating diabetes.

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