Published June 14 (EP); June 8 (WO); June 14 (GB)

A+ Science Invest WO 00/32623

Designed amino acid synthases

Goteborg, Sweden

Catalytic peptides having a designed helix-loop-helix motif; for synthesizing amino acids.

Acrogen WO 00/32753

Retroviral inactivation

Oakland, Calif.

Methods for heat inactivation of retroviruses, especially HIV; for abolishing infectivity.

Akzo Nobel WO 00/32755

Rabies virus vaccines

Arnhem, the Netherlands

Stable, attenuated rabies virus mutants with a substitution in the G protein gene; for making live, attenuated vaccines.

Asahi EP 1 008 650

MAPK kinase

Osaka, Japan

Mitogen activated protein kinase (MAPK) kinase activated by TNF-a and/or Fas antigen, encoding gene, antibodies.

Aventis Behring EP 1 008 653

Adenoviral vector

Marburg, Germany

Recombinant adenoviral vector with limited self-replication abilities in vivo; for gene therapy [in German].

Aventis Pharma WO 00/32768

Topoisomerase interacting proteins

Antony, France

Polypeptides that interact with human topoisomerase IIIa, encoding gene sequences; for enzyme activity modulation.

Aventis Pharma WO 00/32803

Nucleic acid delivery

Antony, France

Nucleic acid delivery agents with hydrophobic spacers chemically bound to polycations and hydrophilic moieties.

Avigen WO 00/32233

AAV vector storage

Alameda, Calif.

Use of dihydric and polyhydric alcohols to protect adeno-associated virus (AAV) vectors during frozen storage.

Barnes-Jewish Hosp. WO 00/33077

Bone formation modulation

St. Louis

Purified cell matrix plaques from initial bone formation made up of aV_3 integrin; for affecting bone formation.

Biogen WO 00/32625

HBV core antigen immunogens

Cambridge, Mass.

Hepatitis B core antigen particles with multiple immunogenic components attached via peptide ligands; for delivery.

Bioline GB 2 344 591

Chimeric DNA polymerase

London

Chimeric DNA polymerase having thermostability and exonuclease activity; for manipulating DNA.

Biomolec. Diagnostics EP 1 008 649

TGF-_2 antisense

Gottingen, Germany

Antisense oligonucleotides to TGF-_2; for preventing the immunosuppressive effects of TGF-_2.

Boston Univ. WO 00/32748

Gene network switches

Boston

Adjustable-threshold switch constructs for controlling gene expression in gene networks.

BTG Intl. GB 2 344 590

Polio vaccines

London

Poliovirus having mutations in the protease 2A gene causing reduced temperature sensitivity; for vaccines.

California, Univ. of WO 00/32231

Immune tolerance therapy

Berkeley, Calif.

Stimulation of T cells against self antigens using CTLA-4 blocking agents; for overcoming immune tolerance.

California, Univ. of WO 00/32752

Prostate cancer antigen

Oakland, Calif.

Prostate stem cell surface antigen overexpressed in prostate cancer, antibodies; for diagnostics and therapeutics.

Cell Pathways WO 00/33067

Cancer diagnosis

Horsham, Penn.

Methods for diagnosing patients that have cancers of various types.

Celltech Therapeutics WO 00/32795

Copper cleavable proteins

Slough, UK

Gene sequences encoding proteins that are specifically cleavable by copper ions, fusion proteins.

Connaught Labs WO 00/32784 & 32794

Chlamydia vaccines

Toronto

Chlamydia antigens, encoding gene sequences, gene fragments; for immunization and vaccines.

Cyanamid Iberica EP 1 008 652

Inducing immunoresponses

Madrid, Spain

Vectors based on recombinant defective viral genomes that express antigens for inducing immunoresponses.

Cytos Biotech WO 00/32227

Ordered antigen arrays

Zurich, Switzerland

Ordered and repetitive antigen arrays; for producing antigen covered particles useful as vaccines.

Dana-Farber Cancer Inst. WO 00/32215

Fat deposition control

Boston

Proteins that modulate adipocyte-associated activities, encoding genes; for controlling fat deposition.

Danisco WO 00/32797

Recombinant protein production

Copenhagen, Denmark

Transformed Thermomyces lanuginosus strains; for increased expression of recombinant proteins.

Dartmouth College WO 00/32819

Matrix metalloproteinase SNPs

Hanover, N.H.

Detection of matrix metalloproteinase-1 single nucleotide polymorphisms (SNPs); for treating related diseases.

Darwin Discovery WO 00/32773

Bone mineralization increase

Cambridge, UK

TGF-_ binding proteins; for developing therapeutics that increase bone mineralization.

Develop. Res. Inst. WO 00/32786

HIV gp120 mutants

Paris

Mutants of HIV gp120, encoding gene sequences; for HIV diagnostics and therapeutics.

Drexel Univ. WO 00/32826

Osteoporosis diagnosis

Philadelphia

Finding polymorphisms in TNF-a2 receptor gene associated with low bone density; for osteoporosis diagnosis.

Du Pont WO 00/32777

Potassium channel agonists

Wilmington, Del.

Scorpion toxins that are potassium channel agonists, encoding gene sequences, antisense, chimeric genes.

Du Pont WO 00/32790

Membrane-bound desaturases

Wilmington, Del.

Membrane-bound desaturases, encoding gene sequences, chimeric genes; for affecting spingolipid desaturation.

Duke Univ. WO 00/32039

Stem cell differentiation

Durham, N.C.

Isolated piwi family genes, encoded proteins, antibodies, transgenics; for affecting stem cell differentiation.

Eli Lilly WO 00/32772

Erythropoietic compounds

Indianapolis

Polymer derivatized non-glycosylated erythropoietic compounds that show stability and bioactivity in vivo.

Entremed WO 00/32631

Angiogenesis regulators

Rockville, Md.

Proteins and peptides that bind angiogenesis-inhibiting proteins; for finding angiogenesis regulators.

Essrich, M. WO 00/32811

Apolipoprotein E genotyping

Denzlingen, Germany

Determining apolipoprotein E genotype using PCR-based techniques to detect polymorphisms.

Exact Labs WO 00/32820

Target sequence detection

Maynard, Mass.

Detection and analysis of target sequences present in small proportions in heterogeneous samples.

Exelixis Pharma WO 00/32618

Insulin-like genes

S. San Francisco

Drosophila melanogaster insulin-like genes, encoded proteins, antibodies; for identifying insulin-like genes.

Florida, Univ. of WO 00/32801

Inflammation mediation

Gainesville, Fla.

Manganese superoxide dismutase gene regulatory elements; for inflammation mediator transcription regulation.

Genentech WO 00/32221

Angiogenesis modulators

S. San Francisco

Proteins modulating angiogenesis and cardiovascularization, encoding gene, chimeric proteins; for therapeutics.

Genentech WO 00/32624

Uncoupling protein

S. San Francisco

Human uncoupling protein 5, encoding gene, antibodies, fusions, recombinant production methods.

Genentech WO 00/32776

Transmembrane proteins

S. San Francisco

Secreted and transmembrane proteins, encoding genes, chimeric polypeptides, antibodies.

Genentech WO 00/32778

Anticancer genes

S. San Francisco

Screening methods for identifying anticancer genes and their encoded proteins, antibodies; for therapeutics.

General Biotech WO 00/32042

Cryopreserved reproductive tissue

Carmel, Ind.

Cryopreservation of ovarian and testicular tissue; for isolating oocytes and spermatozoa to produce organisms.

Glaxo WO 00/32766

Human vanilloid receptors

Greenford, UK

Human vanilloid receptors, encoding gene sequences,; for modulator screens.

Icos WO 00/32633

ACAM adhesion molecule

Bothell, Wash.

ACAM adhesion molecule, encoding gene sequences, antibodies; for modulator screens.

Immuno-Designed Molecules WO 00/32764

Cell delivery oligomers

Paris

Positively charged histidylated oligolysine conjugates; for transferring oligonucleotides and proteins into cells.

Immusol WO 00/32765

Restenosis gene therapy

San Diego

Ribozymes and ribozyme delivery systems for the treatment and prevention of restenosis by gene therapy.

Introgen Therapeutics WO 00/32754

Adenoviral vector production

Austin, Texas

Adenoviral vector production and purification methods that result in improved yields.

Isis Pharma WO 00/32816

Apoptosis antisense

Carlsbad, Calif.

Antisense modulation of cellular inhibitor of apoptosis-1 expression; for modulating apoptosis.

Isis Pharma WO 00/32817

G-alpha-16 antisense

Carlsbad, Calif.

Antisense modulation of G-alpha-16 expression; for treating disease associated with expression of this protein.

Isis Pharma WO 00/32818

Apoptosis antisense

Carlsbad, Calif.

Antisense modulation of cellular inhibitor of apoptosis-2 expression; for modulating apoptosis.

Itoh, K, et al. WO 00/32770

Tumor antigen

Saga, Japan

Tumor antigen, encoding gene sequences, antigenic peptides; for cancer diagnostics and therapeutics.

Ixsys WO 00/32635

Humanized tumor antibodies

San Diego

Tumor-specific human monoclonal antibodies, functional fragments, encoding genes; for cancer therapeutics.

Juppner, H., et al. WO 00/32771 & 32775

PTH receptors

Cambridge, Mass.

Parathyroid hormone (PTH) receptors from zebrafish, encoding gene sequences; for identifying modulators.

Kreatech Biotech WO 00/32814

Interstrand crosslink generation

Amsterdam, Netherlands

Generation of interstrand crosslinks in nucleic acids at specific locations; for making probes and treating cancer.

Lab Molec. Biophotonics EP 1 008 658

Solid phase hybridization

Hamakita, Japan

Oligonucleotide probes having a linked fluorochrome that are attached to a solid phase; for detecting hybridization.

Leeds, Univ. of WO 00/32787

Degeneration therapy

Leeds, UK

E3 ubiquitin ligase, encoding gene sequences, antibodies; for treating degenerative disorders.

Leeds, Univ. of WO 00/32802

HIV vaccine

Leeds, UK

Herpesvirus saimiri vector having an HIV envelope protein; for delivery to T cells as a vaccine.

Leptin, M. WO 00/32779

Insulin-like genes

Cologne, Germany

Drosophila melanogaster insulin-like genes, encoded proteins; for identifying insulin-like genes.

Lockheed Martin Energy Res. WO 00/33065

Drug delivery biosensor

Oak Ridge, Tenn.

Bioluminescent bioreporter integrated circuit devices; for controlling drug delivery systems.

Ludwig Inst. Cancer Res. WO 00/32769

Tumor rejection antigens

New York

Tumor rejection antigens that can complex with major histocompatibility molecules; for therapeutics.

Maryland, Univ. of WO 00/32047

Antigen delivery plasmids

Baltimore

Stabilization of plasmids encoding foreign antigens; for more effective antigen delivery.

Mass. Gen. Hosp. WO 00/33068

Impaired glucose tolerance

Boston

Genes and methods for screening therapeutics for impaired glucose tolerance.

Max Planck Res. Inst. WO 00/32767

Soluble Fc receptors

Munich, Germany

Recombinant soluble Fc receptors, encoding gene sequences; for production in prokaryotes to purify antibodies.

Millennium Pharma WO 00/32746

Netrin-like gene

Cambridge, Mass.

Netrin- and ependymin-like gene sequences, encoded proteins, antibodies, transgenics; for therapeutics.

Millennium Pharma WO 00/32774

G-protein coupled receptor

Cambridge, Mass.

G-protein coupled receptor, encoding gene sequences; for identifying modulators and therapeutics.

Minnesota, Univ. of WO 00/32626

T cell epitopes

Minneapolis

Isolated and purified T cell epitopes and variants; for immunizing against infectious pathogens.

Minnesota, Univ. of WO 00/32750

Tranfected endothelial cells

Minneapolis

Expansion of peripheral blood endothelial cells; for transfection and use in biocompatible medical devices.

Neurotech WO 00/32751

Neurotransmitter storage

Orsay, France

Mammalian non-neuronal cells modified to store and release neurotransmitters; for neuromuscular disorders.

Novo Nordisk WO 00/32758

Lipolytic enzyme variants

Bagsvaerd, Denmark

Lipolytic enzyme variants, encoding gene sequences; for tailoring substrate specificity.

Noxxon Pharma WO 00/32809

Solid surface cloning

Berlin

Cloning an copying genetic material on solid surfaces using attached materials.

Nycomed Pharma WO 00/32812

Separating nucleic acids

Oslo, Norway

Methods for separating nucleic acid populations and tagging them; for nucleic acid isolation and diagnostic PCR.

Oklahoma Med. Res. Fdn. WO 00/32759

Hexapeptide plasminogen activator

Oklahoma City

Hexapeptide that is a human plasminogen activator; for insertion into plasminogen or plasmin sequences.

Ono Pharma WO 00/32628

RelA binding inhibitor

Osaka, Japan

Human RelA binding inhibitor, encoding gene, antibodies; for diagnosing and treating NFkappaB-related diseases.

Oxford BioMedica GB 2 344 592

Retroviral vectors

Oxford, UK

Retroviral vectors having functional splice sites for inserting genes; for foreign gene expression.

Perkin-Elmer WO 00/32824

Determining repeat lengths

Foster City, Calif.

Length determination of nucleic acid repeat sequences by discontinuous primer extension methods.

Pfizer WO 00/32175

Restoring p53 conformation

Groton, Conn.

Pharmaceutical agents that can restore normal conformation to p53; for treating cancer.

Phagetech WO 00/32825

Antibacterial agents

Montreal

Identifying bacteriophage-encoded targets for the development of antibacterial agents.

Phylos WO 00/32823

Molecular evolution fusions

Lexington, Mass.

Methods for covalently tagging proteins with their encoding DNA sequences; for molecular evolution.

Princeton Univ. WO 00/32152

Regulating bacterial pathogenesis

Princeton, N.J.

Purified extracellular bacterial autoinducer-2 signaling molecule; for regulating bacterial pathogenesis.

Protein Design Labs WO 00/32634

Humanized interferon antibodies

Fremont, Calif.

Humanized antibodies to gamma-interferon; for treating autoimmune disease.

Ratner, P.L. WO 00/32815

Targeted gene delivery

Columbia, S.C.

Nucleic acids coupled to a site-specific chromosome-binding polypeptide; for targeted gene delivery.

Ribogene WO 00/32619

Bacterial antibiotics assay

Hayward, Calif.

Assays to detect new antibiotics that inhibit bacterial ribosome assembly and ribosomal protein synthesis.

Roche Diagnostics WO 00/32762

Purifying nucleic acids

Mannheim, Germany

Magnetic particles for purifying nucleic acids; for increased yields.

Rome Univ. WO 00/32785

Silencing gene

Rome

Neurospora crassa silencing gene having a recQ helicase domain; for expression in transgenics.

Searle WO 00/32630

Eosinophil-specific proteins

Chicago

Genes encoding eosinophil-specific proteins; for finding asthma therapeutics.

Shiozawa, S. EP 1 008 648

Arthritis genes

Kobe, Japan

Rheumatoid arthritis-associated gene; for diagnosis, prognosis, and therapy.

Stichting Labs WO 00/32629

Antiviral peptides

Utrecht, Netherlands

Oligomers of antiviral peptides having separated charged and uncharged amino acid domains.

Sunol Molecular WO 00/32821

Large-scale protein production

Miramar, Fla.

Making recombinant cells with enhanced heterologous protein expression; for large-scale protein production.

Takara Shuzo WO 00/32763

Synthesizing cDNAs

Kyoto, Japan

Synthesizing cDNAs using reverse transcription methods in the presence of an enzyme with 3'-5' exonuclease activity.

Takeda Chemical WO 00/32627

Metabolism modulators

Osaka, Japan

G protein-coupled receptor ligand; for finding modulators that control digestive and metabolic function.

Yeda Res. & Develop. WO 00/32228

Intranasal flu vaccine

Rehovot, Israel

Human synthetic peptide-based influenza vaccine having hemagglutinin and HLA binding epitopes.

Yissum Develop. WO 00/32804

Gene therapy by parasites

Jerusalem

Transfected eukaryotic diploid multicellular parasites; for host infection to deliver therapeutics.

Yissum Develop. WO 00/32813

Oligonucleotide detection

Jerusalem

Detection of oligonucleotides in samples using sensors to measure hybridization reactions.

- Compiled by Chester Bisbee

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