Published June 14 (EP); June 8 (WO); June 14 (GB)
A+ Science Invest WO 00/32623
Designed amino acid synthases
Catalytic peptides having a designed helix-loop-helix motif; for synthesizing amino acids.
Acrogen WO 00/32753
Methods for heat inactivation of retroviruses, especially HIV; for abolishing infectivity.
Akzo Nobel WO 00/32755
Rabies virus vaccines
Arnhem, the Netherlands
Stable, attenuated rabies virus mutants with a substitution in the G protein gene; for making live, attenuated vaccines.
Asahi EP 1 008 650
Mitogen activated protein kinase (MAPK) kinase activated by TNF-a and/or Fas antigen, encoding gene, antibodies.
Aventis Behring EP 1 008 653
Recombinant adenoviral vector with limited self-replication abilities in vivo; for gene therapy [in German].
Aventis Pharma WO 00/32768
Topoisomerase interacting proteins
Polypeptides that interact with human topoisomerase IIIa, encoding gene sequences; for enzyme activity modulation.
Aventis Pharma WO 00/32803
Nucleic acid delivery
Nucleic acid delivery agents with hydrophobic spacers chemically bound to polycations and hydrophilic moieties.
Avigen WO 00/32233
AAV vector storage
Use of dihydric and polyhydric alcohols to protect adeno-associated virus (AAV) vectors during frozen storage.
Barnes-Jewish Hosp. WO 00/33077
Bone formation modulation
Purified cell matrix plaques from initial bone formation made up of aV_3 integrin; for affecting bone formation.
Biogen WO 00/32625
HBV core antigen immunogens
Hepatitis B core antigen particles with multiple immunogenic components attached via peptide ligands; for delivery.
Bioline GB 2 344 591
Chimeric DNA polymerase
Chimeric DNA polymerase having thermostability and exonuclease activity; for manipulating DNA.
Biomolec. Diagnostics EP 1 008 649
Antisense oligonucleotides to TGF-_2; for preventing the immunosuppressive effects of TGF-_2.
Boston Univ. WO 00/32748
Gene network switches
Adjustable-threshold switch constructs for controlling gene expression in gene networks.
BTG Intl. GB 2 344 590
Poliovirus having mutations in the protease 2A gene causing reduced temperature sensitivity; for vaccines.
California, Univ. of WO 00/32231
Immune tolerance therapy
Stimulation of T cells against self antigens using CTLA-4 blocking agents; for overcoming immune tolerance.
California, Univ. of WO 00/32752
Prostate cancer antigen
Prostate stem cell surface antigen overexpressed in prostate cancer, antibodies; for diagnostics and therapeutics.
Cell Pathways WO 00/33067
Methods for diagnosing patients that have cancers of various types.
Celltech Therapeutics WO 00/32795
Copper cleavable proteins
Gene sequences encoding proteins that are specifically cleavable by copper ions, fusion proteins.
Connaught Labs WO 00/32784 & 32794
Chlamydia antigens, encoding gene sequences, gene fragments; for immunization and vaccines.
Cyanamid Iberica EP 1 008 652
Vectors based on recombinant defective viral genomes that express antigens for inducing immunoresponses.
Cytos Biotech WO 00/32227
Ordered antigen arrays
Ordered and repetitive antigen arrays; for producing antigen covered particles useful as vaccines.
Dana-Farber Cancer Inst. WO 00/32215
Fat deposition control
Proteins that modulate adipocyte-associated activities, encoding genes; for controlling fat deposition.
Danisco WO 00/32797
Recombinant protein production
Transformed Thermomyces lanuginosus strains; for increased expression of recombinant proteins.
Dartmouth College WO 00/32819
Matrix metalloproteinase SNPs
Detection of matrix metalloproteinase-1 single nucleotide polymorphisms (SNPs); for treating related diseases.
Darwin Discovery WO 00/32773
Bone mineralization increase
TGF-_ binding proteins; for developing therapeutics that increase bone mineralization.
Develop. Res. Inst. WO 00/32786
HIV gp120 mutants
Mutants of HIV gp120, encoding gene sequences; for HIV diagnostics and therapeutics.
Drexel Univ. WO 00/32826
Finding polymorphisms in TNF-a2 receptor gene associated with low bone density; for osteoporosis diagnosis.
Du Pont WO 00/32777
Potassium channel agonists
Scorpion toxins that are potassium channel agonists, encoding gene sequences, antisense, chimeric genes.
Du Pont WO 00/32790
Membrane-bound desaturases, encoding gene sequences, chimeric genes; for affecting spingolipid desaturation.
Duke Univ. WO 00/32039
Stem cell differentiation
Isolated piwi family genes, encoded proteins, antibodies, transgenics; for affecting stem cell differentiation.
Eli Lilly WO 00/32772
Polymer derivatized non-glycosylated erythropoietic compounds that show stability and bioactivity in vivo.
Entremed WO 00/32631
Proteins and peptides that bind angiogenesis-inhibiting proteins; for finding angiogenesis regulators.
Essrich, M. WO 00/32811
Apolipoprotein E genotyping
Determining apolipoprotein E genotype using PCR-based techniques to detect polymorphisms.
Exact Labs WO 00/32820
Target sequence detection
Detection and analysis of target sequences present in small proportions in heterogeneous samples.
Exelixis Pharma WO 00/32618
S. San Francisco
Drosophila melanogaster insulin-like genes, encoded proteins, antibodies; for identifying insulin-like genes.
Florida, Univ. of WO 00/32801
Manganese superoxide dismutase gene regulatory elements; for inflammation mediator transcription regulation.
Genentech WO 00/32221
S. San Francisco
Proteins modulating angiogenesis and cardiovascularization, encoding gene, chimeric proteins; for therapeutics.
Genentech WO 00/32624
S. San Francisco
Human uncoupling protein 5, encoding gene, antibodies, fusions, recombinant production methods.
Genentech WO 00/32776
S. San Francisco
Secreted and transmembrane proteins, encoding genes, chimeric polypeptides, antibodies.
Genentech WO 00/32778
S. San Francisco
Screening methods for identifying anticancer genes and their encoded proteins, antibodies; for therapeutics.
General Biotech WO 00/32042
Cryopreserved reproductive tissue
Cryopreservation of ovarian and testicular tissue; for isolating oocytes and spermatozoa to produce organisms.
Glaxo WO 00/32766
Human vanilloid receptors
Human vanilloid receptors, encoding gene sequences,; for modulator screens.
Icos WO 00/32633
ACAM adhesion molecule
ACAM adhesion molecule, encoding gene sequences, antibodies; for modulator screens.
Immuno-Designed Molecules WO 00/32764
Cell delivery oligomers
Positively charged histidylated oligolysine conjugates; for transferring oligonucleotides and proteins into cells.
Immusol WO 00/32765
Restenosis gene therapy
Ribozymes and ribozyme delivery systems for the treatment and prevention of restenosis by gene therapy.
Introgen Therapeutics WO 00/32754
Adenoviral vector production
Adenoviral vector production and purification methods that result in improved yields.
Isis Pharma WO 00/32816
Antisense modulation of cellular inhibitor of apoptosis-1 expression; for modulating apoptosis.
Isis Pharma WO 00/32817
Antisense modulation of G-alpha-16 expression; for treating disease associated with expression of this protein.
Isis Pharma WO 00/32818
Antisense modulation of cellular inhibitor of apoptosis-2 expression; for modulating apoptosis.
Itoh, K, et al. WO 00/32770
Tumor antigen, encoding gene sequences, antigenic peptides; for cancer diagnostics and therapeutics.
Ixsys WO 00/32635
Humanized tumor antibodies
Tumor-specific human monoclonal antibodies, functional fragments, encoding genes; for cancer therapeutics.
Juppner, H., et al. WO 00/32771 & 32775
Parathyroid hormone (PTH) receptors from zebrafish, encoding gene sequences; for identifying modulators.
Kreatech Biotech WO 00/32814
Interstrand crosslink generation
Generation of interstrand crosslinks in nucleic acids at specific locations; for making probes and treating cancer.
Lab Molec. Biophotonics EP 1 008 658
Solid phase hybridization
Oligonucleotide probes having a linked fluorochrome that are attached to a solid phase; for detecting hybridization.
Leeds, Univ. of WO 00/32787
E3 ubiquitin ligase, encoding gene sequences, antibodies; for treating degenerative disorders.
Leeds, Univ. of WO 00/32802
Herpesvirus saimiri vector having an HIV envelope protein; for delivery to T cells as a vaccine.
Leptin, M. WO 00/32779
Drosophila melanogaster insulin-like genes, encoded proteins; for identifying insulin-like genes.
Lockheed Martin Energy Res. WO 00/33065
Drug delivery biosensor
Oak Ridge, Tenn.
Bioluminescent bioreporter integrated circuit devices; for controlling drug delivery systems.
Ludwig Inst. Cancer Res. WO 00/32769
Tumor rejection antigens
Tumor rejection antigens that can complex with major histocompatibility molecules; for therapeutics.
Maryland, Univ. of WO 00/32047
Antigen delivery plasmids
Stabilization of plasmids encoding foreign antigens; for more effective antigen delivery.
Mass. Gen. Hosp. WO 00/33068
Impaired glucose tolerance
Genes and methods for screening therapeutics for impaired glucose tolerance.
Max Planck Res. Inst. WO 00/32767
Soluble Fc receptors
Recombinant soluble Fc receptors, encoding gene sequences; for production in prokaryotes to purify antibodies.
Millennium Pharma WO 00/32746
Netrin- and ependymin-like gene sequences, encoded proteins, antibodies, transgenics; for therapeutics.
Millennium Pharma WO 00/32774
G-protein coupled receptor
G-protein coupled receptor, encoding gene sequences; for identifying modulators and therapeutics.
Minnesota, Univ. of WO 00/32626
T cell epitopes
Isolated and purified T cell epitopes and variants; for immunizing against infectious pathogens.
Minnesota, Univ. of WO 00/32750
Tranfected endothelial cells
Expansion of peripheral blood endothelial cells; for transfection and use in biocompatible medical devices.
Neurotech WO 00/32751
Mammalian non-neuronal cells modified to store and release neurotransmitters; for neuromuscular disorders.
Novo Nordisk WO 00/32758
Lipolytic enzyme variants
Lipolytic enzyme variants, encoding gene sequences; for tailoring substrate specificity.
Noxxon Pharma WO 00/32809
Solid surface cloning
Cloning an copying genetic material on solid surfaces using attached materials.
Nycomed Pharma WO 00/32812
Separating nucleic acids
Methods for separating nucleic acid populations and tagging them; for nucleic acid isolation and diagnostic PCR.
Oklahoma Med. Res. Fdn. WO 00/32759
Hexapeptide plasminogen activator
Hexapeptide that is a human plasminogen activator; for insertion into plasminogen or plasmin sequences.
Ono Pharma WO 00/32628
RelA binding inhibitor
Human RelA binding inhibitor, encoding gene, antibodies; for diagnosing and treating NFkappaB-related diseases.
Oxford BioMedica GB 2 344 592
Retroviral vectors having functional splice sites for inserting genes; for foreign gene expression.
Perkin-Elmer WO 00/32824
Determining repeat lengths
Foster City, Calif.
Length determination of nucleic acid repeat sequences by discontinuous primer extension methods.
Pfizer WO 00/32175
Restoring p53 conformation
Pharmaceutical agents that can restore normal conformation to p53; for treating cancer.
Phagetech WO 00/32825
Identifying bacteriophage-encoded targets for the development of antibacterial agents.
Phylos WO 00/32823
Molecular evolution fusions
Methods for covalently tagging proteins with their encoding DNA sequences; for molecular evolution.
Princeton Univ. WO 00/32152
Regulating bacterial pathogenesis
Purified extracellular bacterial autoinducer-2 signaling molecule; for regulating bacterial pathogenesis.
Protein Design Labs WO 00/32634
Humanized interferon antibodies
Humanized antibodies to gamma-interferon; for treating autoimmune disease.
Ratner, P.L. WO 00/32815
Targeted gene delivery
Nucleic acids coupled to a site-specific chromosome-binding polypeptide; for targeted gene delivery.
Ribogene WO 00/32619
Bacterial antibiotics assay
Assays to detect new antibiotics that inhibit bacterial ribosome assembly and ribosomal protein synthesis.
Roche Diagnostics WO 00/32762
Purifying nucleic acids
Magnetic particles for purifying nucleic acids; for increased yields.
Rome Univ. WO 00/32785
Neurospora crassa silencing gene having a recQ helicase domain; for expression in transgenics.
Searle WO 00/32630
Genes encoding eosinophil-specific proteins; for finding asthma therapeutics.
Shiozawa, S. EP 1 008 648
Rheumatoid arthritis-associated gene; for diagnosis, prognosis, and therapy.
Stichting Labs WO 00/32629
Oligomers of antiviral peptides having separated charged and uncharged amino acid domains.
Sunol Molecular WO 00/32821
Large-scale protein production
Making recombinant cells with enhanced heterologous protein expression; for large-scale protein production.
Takara Shuzo WO 00/32763
Synthesizing cDNAs using reverse transcription methods in the presence of an enzyme with 3'-5' exonuclease activity.
Takeda Chemical WO 00/32627
G protein-coupled receptor ligand; for finding modulators that control digestive and metabolic function.
Yeda Res. & Develop. WO 00/32228
Intranasal flu vaccine
Human synthetic peptide-based influenza vaccine having hemagglutinin and HLA binding epitopes.
Yissum Develop. WO 00/32804
Gene therapy by parasites
Transfected eukaryotic diploid multicellular parasites; for host infection to deliver therapeutics.
Yissum Develop. WO 00/32813
Detection of oligonucleotides in samples using sensors to measure hybridization reactions.
- Compiled by Chester Bisbee