Published November 3 (EPO); October 28 (WO); November 3 (GB)
Abbott Labs WO 99/54355
Purifying recombinant proteins
Abbott Park, Ill.
Extraction and purification of recombinant proteins from cells using water-miscible organic solvents.
Affymetrix WO 99/54509
Array non-specific binding
Santa Clara, Calif.
Reduction of non-specific binding to nucleic acid probe arrays using surface and oligonucleotide modification.
Ajinomoto WO 99/54360
Antithrombotic factors
Tokyo
Assays for antithrombotic factors using immobilized chimeric von Willebrand factor fragments.
Alabama, Univ. of WO 99/53940
Pneumococcal vaccines
Birmingham, Ala.
Antigenic epitope regions of pneumococcal surface protein C, encoding gene sequences; for diagnostics and therapeutics.
Alberta, Univ. of WO 99/54493
Glaucoma diagnosis
Edmonton, Alberta
Mutations in the FREAC3 gene, for identifying modulators and early diagnosis of glaucoma.
Angiogenix WO 99/53943
Angiogenic factors
Palo Alto, Calif.
Angiogenic factors such as pleitrophin and midkine protein, encoding gene sequences; for therapeutics.
Arch Development WO 99/53949
Metastatic melanoma vaccine
Chicago
Vaccine adjuvants for inducing the production of cytotoxic T cells directed against metastatic melanoma.
Astra WO 99/54443
Bile salt-stimulated lipase
Sodertalje, Sweden
Human bile salt-stimulated lipase, encoding gene sequences; for expression in transgenic sheep for therapeutics.
Bioage Pharma WO 99/54506
Oligo libraries for targets
San Diego, Calif.
Preparing oligonucleotide libraries and isolating specific aptamers; for affinity purification of targets.
Bioresearch Ireland WO 99/54501
Identifying mutations
Dublin, Ireland
Generation of extendible upstream DNA fragments resulting from cleavage at an abasic site; for finding mutations.
Boehringer Ingelheim EPO 953 639
Fibroblast activator antibodies
Ingelheim, Germany
Fibroblast activator protein a antibodies, framework modifications; for diagnostics and therapeutics.
Boston Univ. WO 99/53743
Modulating apoptosis
Boston
Genes related to apoptosis, encoded proteins; for modulating apoptosis.
California, Univ. of WO 99/54484
Modified IgA
Oakland, Calif.
Modified immunoglobulin (Ig) A molecules, encoding genes; for treating and preventing infectious diseases.
California, Univ. of WO 99/54733
Lung injury detection
Oakland, Calif.
Monoclonal antibodies specific for human type I and II alveolar cells; for detecting lung injury.
Cambridge Univ. Tech. Serv. WO 99/53946
Enhanced immune response
Cambridge, UK
Modified antigens having incorporated alkyl aldehyde groups; for enhancing the immune response.
Cantab Pharma EPO 953 648
Non-infectious viral vaccines
Cambridge, UK
Viral vaccines having defects in genes essential for production of infectious viruses.
CDC (Ctr. Disease Control) WO 99/54508
Histoplasma detection
Atlanta
Oligonucleotide probes for detecting Histoplasma capsulatum bacteria using PCR methodology.
Children's Hosp. WO 99/54491
Muscular dystrophy gene therapy
Cincinnati
Mouse a and _ myosin heavy chain promoters; for transgenics and gene therapy for muscular dystrophy.
Chiron WO 99/53960
Enhanced genetic immunization
Emeryville, Calif.
Enhancing immune responses to DNA immunogens using chemokines or encoding gene sequences.
Chiron WO 99/54457
Streptococcal vaccines
Siena, Italy
Anti-idiotypic antibodies that immunologically mimic group B streptococcal carbohydrates; for vaccines.
Chugai Res. Inst. Molec. Med. WO 99/54357
Cytokine homolog
Ibaraki, Japan
Cytokine homolog, encoding gene sequences; for supporting the growth of myeloid cells.
Clontech Labs WO 99/54348
Degrading GFP
Palo Alto, Calif.
Rapidly degrading green fluorescent protein (GFP) made by fusion with the C-terminal end of ornithine decarboxylase.
Clontech Labs WO 99/54732
Enhanced GFP
Palo Alto, Calif.
Enhanced green fluorescent protein (GFP) made by fusion with IkappaB, encoding gene sequences.
Columbia Univ. WO 99/54485
Metastases inhibition
New York
Soluble receptor for advanced glycation end products; for inhibiting tumor invasion and metastases.
Cornell Univ. WO 99/54479
Antimicrobial assays
Ithaca, N.Y.
Alkyl hydroperoxide reductase; for resistance to reactive nitrogen antimicrobial intermediates; for inhibitors.
David, S., et al. WO 99/53945
Axon regeneration
Baie d'Urfe, Que.
Neuron growth inhibitory molecules, derivatives; for generating antibodies that promote axon regeneration.
Dorken, B., et al. WO 99/54440
B cell cancers
Berlin
Single-chain, multifunctional peptides having CD19 and CD3 antigen moieties, encoding genes; for B cell cancers.
Eisai EPO 953 647
Gene therapy vectors
Tokyo
Preparing high titer retrovirus vectors with recombinant genes using a recombinase; for gene therapy.
Emory Univ. WO 99/54442
Modifying regulatory proteins
Atlanta
Protein phosphatase methylesterase, encoding gene sequences; for controlling regulatory protein carboxymethylation.
Exelixis Pharma WO 99/54436
Insulin function study
S. San Francisco
Caenorabditis elegans insulin-like genes, encoded proteins, analogs, fragments, antibodies; for studying function.
Genentech WO 99/54467
SH2 domain-containing peptides
S. San Francisco
SH2 domain-containing peptides, gene sequences, probes, modulators; for cancer diagnostics and therapeutics.
Genentech WO 99/54510
Gene expression analysis
S. San Francisco
Quantitative analysis of gene expression using PCR assays; for determining the effect of treatments on expression.
Genset WO 99/54500
Biallelic genome markers
Paris
Biallelic markers from the human genome; for constructing a high density disequilibrium map.
Genvec WO 99/54441
Adenovirus purification
Rockville, Md.
Efficient purification of adenovirus using anion exchange chromatography and salt gradients.
Glaxo WO 99/54462, 54470, 54473 & 54474
Broad spectrum antibiotics
Greenford, UK
Bacterial polypeptides necessary for growth, encoding gene sequences; for identifying broad spectrum antibiotics.
Gropep WO 99/54359
Matrix binding factor
Adelaide, Australia
Recombinant polypeptide bioactive factor that binds cellular matrix, encoding genes; for surgical implants.
Grunenthal WO 99/54454
Mycobacterial antibiotics
Aachen, Germany
Mycobacterium strains having the siderophor iron absorption system inactivated; for identifying siderophor antibiotics.
Gustave-Roussy Inst. WO 99/54464
hsp70 cancer vaccines
Villejuif, France
Mutated peptides from heat shock protein (hsp) 70, encoding gene sequences; for cancer vaccines.
Hamburg Univ. Hormone Inst. WO 99/54347
_-amyloid binding protein
Hamburg, Germany
Alzheimer's-associated _-amyloid binding protein, encoding gene sequence, antibodies; for disease models.
Heska WO 99/54349
Dermatophagoides diagnostics
Ft. Collins, Colo.
Dermatophagoides proteins, encoding gene sequences; for diagnostics and therapeutics.
Hoechst Marion Roussel WO 99/54456
Integrin expression inhibition
Frankfurt, Germany
Antisense oligonucleotides and their derivatives for the inhibition of integrin av subunit expression.
Huang, F, et al. WO 99/54466
Colon cancer antigens
Elmhurst, N.Y.
Colon cancer-associated antigens, encoding gene sequences, variants, antibodies; for diagnostics and therapeutics.
Incyte Pharma WO 99/54469
B cell growth factor
Palo Alto, Calif.
Human B cell growth factor-related protein, encoding gene, antibodies, modulators; for diagnostics and therapeutics.
Inex Pharma WO 99/54444
Combination cancer therapy
Burnaby, B.C.
Combination cancer therapy using therapeutic gene sequences and radiation treatment.
Inex Pharma WO 99/54445
Combination cancer therapy
Burnaby, B.C.
Combination cancer therapy using therapeutic gene sequences and conventional chemotherapy drugs.
Innogenetics EPO 953 650
HLA allele typing
Ghent, Belgium
HLA allele typing using probes for specific exons; for diagnostics.
Isis Pharma WO 99/54341
Enhanced ICAM-1 modulation
Carlsbad, Calif.
Enhanced antisense detection and modulation of intracellular adhesion molecule (ICAM)-1.
Joslin Diabetes Ctr. WO 99/54507
Frataxin gene polymorphism
Boston
Intermediate GAA repeat length polymorphism in the frataxin gene; for disease diagnosis.
Konin-Kluke Acad. WO 99/53959
Nerve injury treatment
Amsterdam
Viral vectors having nerve growth influencing molecule genes; for treating injured nerves.
Krebs Res. Ctr. WO 99/54449
Dyskeratosis diagnosis
Heidelberg, Germany
Dyskerine, encoding gene sequences, antibodies; for the diagnosis and therapy of dyskeratosis congenita.
Krone, W., et al. WO 99/54352
Activated SREBP-1/2
Cologne, Germany
Phosphorylated or activated SREBP-1 and SREBP-2; for therapeutics.
Lexigen Pharma WO 99/53958
Enhanced immune response
Lexington, Mass.
Enhancing cytocidal immune responses against preselected cell types using antibody-cytokine fusion proteins.
Livercell EPO 953 633
Normal cultured liver cells
East Sebago, Maine
Production of normal, differentiated liver cells using specified medium and additives.
Loma Linda Univ. WO 99/54452
Edible autoimmunity vaccines
Loma Linda, Calif.
Transgenic plants expressing the CTB autoantigen, gene optimized for plant expression; for edible vaccines.
Ludwig Inst. Cancer Res. WO 99/54738
Cancer antigens
New York
Cancer associated antigens, encoding gene sequences; for inducing antibodies against cancer.
Lumigen WO 99/54503
Chemiluminescent DNA detection
Southfield, Mich.
Detection of labeled DNA with horseradish peroxidase (HRP) and inhibitors of HRP chemiluminescence; for fingerprinting.
Madrid, Univ. of WO 99/53944
Endotoxic shock therapy
Madrid, Spain
Vasoactive intestinal peptide and the peptide activator of hypophyseal adenyl cyclase used for endotoxic shock therapy.
Maryland, Univ. of WO 99/53931
More antigenic tumors
Baltimore
Mammary tumor cells having increased antigenicity due to co-expression of MHC class II antigens; for metastasis therapy.
Maryland, Univ. of WO 99/54504
Antigen epitope modulators
Baltimore
Antibodies to functional antigenic epitopes; for use in rational design of modulators and vaccine antigens.
Mass. Inst. Technol. WO 99/54476
Cephalosporin production
Cambridge, Mass.
Expandase enzymes that can convert penicillin substrates, other than penicillin N, into cephalosporins.
Max Planck Inst. WO 99/54463
Potassium channel
Berlin
Human potassium ion channel, encoding gene sequences; for neurological diagnostics and therapeutics.
Meiji EPO 953 644
Recombinant protein production
Tokyo
Expression vectors based on the cellulase gene from Humicola insolens; for recombinant protein production.
Merck WO 99/53757
Autoantigens
Rahway, N.J.
Autoantigens, fragments; for diagnosis and therapy of autoimmune disease.
Metagen WO 99/54353
Normal uterus genes
Berlin
Human gene sequences from normal uterus tissue, encoded proteins; for diagnostics and therapeutics.
Metagen WO 99/54446
Normal pancreas genes
Berlin
Human gene sequences from normal pancreas tissue, encoded proteins; for diagnostics and therapeutics.
Metagen WO 99/54447
Bladder tumor genes
Berlin
Human gene sequences from bladder tumor tissue, encoded proteins; for diagnostics and therapeutics.
Metagen WO 99/54448
Uterus myoma genes
Berlin
Human gene sequences from uterus myoma tissue, encoded proteins; for diagnostics and therapeutics.
Metagen WO 99/54460
Normal bladder genes
Berlin
Human gene sequences from normal bladder tissue, encoded proteins; for diagnostics and therapeutics.
Metagen WO 99/54461
Endometrial tumor genes
Berlin
Human gene sequences from endometrial tumor tissue, encoded proteins; for diagnostics and therapeutics.
Metrohealth System WO 99/54505
Enhancing potassium channel expression
Cleveland
Potassium channel associated protein, encoding gene sequences; for enhancing potassium channel expression.
Michigan, Univ. of WO 99/53961
Efficient gene transfer
Ann Arbor, Mich.
Nucleic acids bound to polycationic peptides; for making condensates for efficient gene transfer.
Millennium Biotherapeutics WO 99/54343
T139-related proteins
Cambridge, Mass.
T139-related protein family members, encoding gene sequences; for diagnostics and therapeutics.
Millennium Biotherapeutics WO 99/54437
T125-related proteins
Cambridge, Mass.
T125-related protein family members, encoding gene sequences; for diagnostics and therapeutics.
NIH (Natl. Inst. Hlth.) WO 99/53954
Pancreatic islet transplants
Bethesda, Md.
T cell reductions using immunotoxins; for immune tolerance induction to allogeneic pancreatic islet cell transplants.
Nestle WO 99/54435
Immortalized skin cells
Vevey, Switzerland
Immortalized cell lines derived from normal human skin tissues; for constructing artificial skin.
Nippon Zeon EPO 953 642
Laryngotracheitis vaccine
Tokyo
Antigenic protein from infectious laryngotracheitis virus, encoding gene sequence; for vaccines.
Novalon Pharma WO 99/54728
Receptor modulator assay
Durham, N.C.
Predicting potential modulator activity using panels of molecules that modify receptor conformation.
Oregon State Univ. WO 99/53948
Chlamydia vaccines
Corvallis, Ore.
Infection-specific Chlamydia proteins associated with the vegetative reticulate body form; for vaccines.
Ortho-Clinical Diagnostics EPO 953 635
Tissue nucleic acid extraction
Rochester, N.Y.
Rapid and effective methods for extracting nucleic acids from tissue samples and paraffin-embedded sections.
Ortho-McNeil Pharma WO 99/54450
HCP modulator assay
Raritan, N.J.
Hematopoietic cell phosphatase (HCP), encoding gene, production methods; for identifying modulators.
Oxford BioMedica GB 2 336 844
HIV therapeutics
Oxford, UK
Altered HIV p16 and p17 proteins, fragments; encoding gene sequences; for therapeutics.
Pasteur Inst. WO 99/54487
Unique mycobacterial genes
Paris
Isolating gene sequences present in one mycobacterial strain but not another using bacterial artificial chromosomes.
Pfizer EPO 953 641
Neospora vaccines
Groton, Conn.
Neospora caninum proteins, encoding gene sequences; for preparing modified strains and vaccines.
Promega WO 99/54340
Endotoxin reduction
Madison, Wis.
Reduction of endotoxin contamination in nucleic acid preparations from bacteria using silica-based materials.
Quadrant Holdings WO 99/54358
Melanocortin receptor ligands
Ruddington, UK
Melanocortin receptor ligands; for affecting behavior or metabolism.
Queen's Univ. WO 99/54356
Epidermal growth factor fragments
Belfast, UK
Peptide fragments of mouse epidermal growth factor; for targeting laminin receptors and promoting wound healing.
Queensland, Univ. of WO 99/54350
Modified conotoxin peptides
St. Lucia, Australia
Isolated, synthetic, or recombinant omega conotoxins peptides having modified residues.
Rhone Poulenc Agro EPO 953 649
Transfecting nucleic acids
Lyon, France
Nitrogen-substituted silicone; for compacting nucleic acids for cellular transfection [in French].
Ribozyme Pharma WO 99/54459
Gene expression modification
Boulder, Colo.
Ribozymes having combinations of chemical modifications; for modulating gene expression.
Rigel Pharma WO 99/54494
Cell cycle modulation
S. San Francisco
Multiparameter fluorescent activated cell sorting; for screening cell cycle regulation modulators.
Science Res. Lab WO 99/54439
Cell purging
Somerville, Mass.
Lysing cell subpopulations based on nuclear to cytoplasmic ratios using osmotic pressure; for cell purging.
Shionogi WO 99/53947
Varying T cell balance
Osaka, Japan
Various antigens for changing the Th1/Th2 balance of T cells towards Th2; for autoimmune disease and allergy.
SmithKline Beecham EPO 953 636
Cytokine signal regulators
Brentford, UK
Cytokine signal regulators, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham EPO 953 637
Acetylcholine receptor
Brentford, UK
Acetylcholine receptor, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 99/54351
Edg family protein
Philadelphia
Edg family protein, encoding gene sequences, production methods; for diagnostics and therapeutics.
Sumitomo Chemical EPO 953 643
Raffinose production
Osaka, Japan
Raffinose synthase genes, encoded enzymes; for producing raffinose from sucrose.
Synthelabo EPO 953 638
Human cation channel
Le Plessis Robinson, France
Human vanilloid receptor-like cation channel, encoding gene sequences; for diagnostics and therapeutics.
Takara Shuzo WO 99/54455
Efficient DNA synthesis
Kyoto, Japan
DNA synthesis using acidic substances and cationic complexes; for higher efficiency synthesis.
Texas, Univ. of WO 99/54482
Apoptosis control
Austin, Texas
DNA fragmentation factor, encoding gene sequences, antibodies; for controlling apoptosis.
Thomas Jefferson Univ. WO 99/54345
CD8 antagonists
Philadelphia
CD8 antagonists; for inhibiting CD8-induced T cell activation.
Transgene WO 99/54481
Suicide gene therapy
Strasbourg, France
Mutated uracil phosphoribosyl transferase, encoding gene sequences; for suicide gene therapy.
U.S. Environ. Protection Agency WO 99/54354
Male fertility control
Washington
A fertility-associated protein from sperm; for evaluating and affecting male fertility.
Umana, P., et al. WO 99/54342
Enhanced cellular cytotoxicity
Zurich, Switzerland
Engineering of glycosylation patterns in antibodies; for enhanced antibody-dependent cellular cytotoxicity.
Vanderbilt Univ. WO 99/54451
Insulin production
Nashville, Tenn.
Neuroendocrine cells having a gene encoding a non-glucose insulin secretogogue receptor; for insulin production.
Vermont, Univ. of WO 99/53953
Regulating cell growth
Burlington, Vt.
Manipulation of mitochondrial metabolism and the expression of cell surface immune proteins; for regulating cell growth.
Warner-Lambert WO 99/54465
Insulin resistance therapy
Morris Plains, N.J.
Syntaxin interacting protein, encoding gene, antibodies; for insulin resistance diagnostics and therapeutics.
Whitehead Inst. Biomed. Res. WO 99/54458
Nucleic acid-protein conjugates
Cambridge, Mass.
Engineered mRNAs having linked ribozymes, polypeptide-nucleic acid tag conjugates.
Zeneca WO 99/54498
Allelic imbalance
London
Iterative annealing of alleles and removal of mismatched heteroduplexes; for measuring allelic imbalance.
Zootechnol. Consortium WO 99/53751
Nuclear transfer methods
Cremona, Italy
Use of lymphocytes as sources of nuclei for nuclear transfer into oocyte; for making transgenics.
Zymogenetics WO 99/54468
Thymopoietin homologs
Seattle
Soluble protein with homology to emerin and thymopoietins, encoding gene sequences; for diagnostics and therapeutics.
- Compiled by Chester A. Bisbee