Published Feb. 10 and 17 (EPO); Feb. 11 (WO); Feb. 17 (GB)

Abiogen PharmaWO 99/06066
Plaque antibodies
Rome, Italy
Catalytic monoclonal antibodies having protease activity; for lysing plaques and aggregates.

Abiogen PharmaWO 99/06536
Corticosteroid prodrug conversion
Rome, Italy
Catalytic monoclonal antibodies for in vivo transformation of corticosteroid prodrugs.

Amersham Pharmacia BiotechWO 99/06538
DNA polymerase mutants
Piscataway, N.J.
Thermococcus barosii DNA polymerase mutants with reduced exonuclease activity; for better nucleotide incorporation.

AmgenWO 99/06064
Hearing loss treatment
Thousand Oaks, Calif.
Methods for treating cochlear hair cell degeneration using neurturin; for sensorineural hearing loss.

AsymptoteGB 2 328 209
Colored reporter protein
Cambridge, U.K.
Vectors having a reporter gene encoding a protein that develops color; for rapid assays.

Baylor Coll. Med.WO 99/06034
Neural degeneration therapeutic
Houston, Texas
Antagonists of the product of the COUP-TFI gene; for treating neural and bone degeneration.

BionovaWO 99/06837
Complexed HBV antigens
San Francisco
Hepatitis B virus (HBV) antigens complexed with albumin or unprocessed RNA virus proteins; for increased antigenicity.

Boehringer MannheimEPO 896 965
G-protein antagonists
Mannheim, Germany
Phosphoducin inhibitors of G-protein beta/gamma subunits; for designing antagonists.

Boehringer MannheimWO 99/06072
Cyclized prodrugs
Indianapolis, Ind.
Cyclized prodrugs that are covalently cross-linked; for cleavage and use as therapeutics.

Boehringer MannheimWO 99/06537
Activating cross-linked enzymes
Indianapolis, Ind.
Covalently cross-linked enzyme subunits or fragments; for cleavage and activation by analyte binding.

Burnham, Inst.WO 99/06588
Mitochondria-dependent apoptosis
La Jolla, Calif.
Cell-free system for identifying compounds modulating apoptosis dependent on mitochondria.

California, Univ. ofWO 99/06060
Neural tissue transplants
Oakland, Calif.
Treating neural progenitor cells with epidermal growth factor; for growing progeny cells for transplant.

California, Univ. ofWO 99/06830
G-protein modulators
Oakland, Calif.
Methods for affecting G-protein coupled receptors; for modulators screens.

CalydonWO 99/06576
Glandular kallikrein enhancer
Sunnyvale, Calif.
Human glandular kallikrein enhancer sequence; for prostate-selective gene therapy and subsequent cytotoxicity.

CDC (Ctr. Dis. Control)WO 99/06596
Yeast infection diagnosis
Atlanta, Ga.
Nucleic acid probes for detecting Candida species; for detection and diagnosis of yeast infections.

ChironWO 99/06562
AAV vector readministration
Emeryville, Calif.
Gene therapy using adeno-associated virus (AAV) vectors and host immunosuppression; for repeated administration.

Chong Kun DangWO 99/06531
Fungal mevalonic acid
Seoul, S. Korea
Aspergillus fungi genus showing resistance to cerulenin and L-methionine analogs; for preparing mevalonic acid.

CorningWO 99/06425
Immobilized hybridization assays
Corning, N.Y.
Oxidized styrenic polymers for immobilizing aminated DNA; for hybridization assays.

Dana-Farber Cancer Inst.WO 99/06069
Herpesvirus vaccines
Boston, Mass.
Replication-defective herpesvirus mutants; for vaccines and treating immune system diseases.

Dorssers, L.C.J.WO 99/06831
Breast cancer probes
Rotterdam, Netherlands
Methods for measuring genes and encoded proteins associated with estrogen-independent breast cancers.

Emory Univ.WO 99/06563
Bone mineralization therapy
Atlanta, Ga.
Bone mineralization protein, encoding gene sequences; for transfecting osteogenic precursor cells for therapy.

Food Ind. Res. & Develop. Inst.EPO 897 006
Amino acid oxidase
Hsinchu, Taiwan
Rhodosporidium D-amino acid oxidase, encoding gene sequences; for amino acid conversion.

Fuchsbauer, H.-L.WO 99/06446
Acyl/amine donor generation
Muhital-Traisa, Germany
Transglutaminase-catalyzed coupling of proteins to solid supports; for generating acyl and amine donors.

Genetic SystemsWO 99/06599
Synthetic HIV antigens
Redmond, Wash.
Synthetic antigens that are immunoreactive with HIV; for detection of HIV antibodies and exposure determination.

GensetWO 99/06439
Endoderm ESTs
5' expressed sequence tags (ESTs) from endoderm tissue; for diagnostics, gene therapy, and chromosome mapping.

GensetWO 99/06548-06554
Secreted protein ESTs
5' expressed sequence tags (ESTs) of secreted proteins from testes, prostate, neurons, and muscles.

Glasgow, Univ. ofWO 99/06542
Phage library screen
Glasgow, U.K.
Phage library screen for expressed heterologous proteins after subtracting background cell protein binding.

Hawaii BiotechWO 99/06068
Dengue virus vaccine
Aiea, Hawaii
Truncated flaviviral envelope proteins; for making diagnostics and vaccines against dengue viruses.

Henkel Res. Inst.WO 99/06573
Dusseldorf, Germany
Bacillus alkalophilus ß-glucanase; for glucanolysis in neutral to alkaline conditions.

Hoffmann-La RocheEPO 897 010
Modified phytases
Basel, Switzerland
Modified phytases, encoding gene sequences, production methods.

Human Genome SciencesWO 99/06423
83 secreted proteins
Rockville, Md.
83 human secreted proteins, encoding gene sequences, production methods; for diagnosis and therapy.

Ice BiotechWO 99/06565
Antifreeze proteins
Waterloo, Ont.
Winter rye antifreeze proteins, encoding gene sequences; for preventing ice crystal formation in biological materials.

Immune ResponseWO 99/06544
Immunomodulatory cytokines
Carlsbad, Calif.
Membrane attachment domain-bound cytokine compositions; for modulating immune responses.

Incyte PharmaWO 99/06558
Longevity-assurance proteins
Palo Alto, Calif.
Human longevity-assurance protein homologs, encoding gene sequences, antibodies, modulators; for diagnostics.

Incyte PharmaWO 99/06560
Annexin binding protein
Palo Alto, Calif.
Annexin binding protein, encoding gene sequences, antibodies, modulators; for diagnostics.

Incyte PharmaWO 99/06572
Synaptojanin isoform
Palo Alto, Calif.
Human synaptojanin isoform, encoding gene sequences, antibodies, modulators; for therapeutics.

Inst. Phys. & Chem. Res.WO 99/06591
DNA mutation detection
Saitama, Japan
Method of detecting DNA mutations on a solid support using proteins that bind to base pair mismatches.

Japan Sci. & Technol.EPO 897 005
Polyester synthesis
Kawaguchi, Japan
Polyester synthase, derivatives, encoding gene sequences, vector, host cells.

Japanese Fdn. Cancer Inst.EPO 896 055
Apoptosis-inducing protein
Apoptosis-inducing protein kinase, encoding gene; for treating cancer.

Johns Hopkins Univ.WO 99/06443-06445, 06556 & 06559
Growth differentiation factors
Baltimore, Md.
Growth differentiation factors, encoding gene sequences; for diagnostics and therapeutics.

Korea Inst. Sci. & Technol.WO 99/06532
Bacterial succinic acid
Seoul, S. Korea
E. coli pta ldhA double mutant strain made by recombinant engineering techniques; for making succinic acid.

Koszinowski, U.H.WO 99/06582
Viral genome mutagenesis
Munich, Germany
Recombinant vectors having infectious viral genome sequences, production methods; for mutagenesis.

Krebs Res. Inst.WO 99/06577
HPOL epitope fusion
Leverkusen, Germany
Expression vector encoding an HPOL epitope fusion protein, antibodies; for expressing and detecting the complex.

Lampert, F.EPO 897 001
GTPase polypeptide
Glessen, Germany
Polypeptide having a GTPase activity, encoding gene sequences; for diagnostics and therapy.

Lubitz, W.WO 99/06567
Bacterial production system
Vienna, Austria
Secretion of carrier-bound proteins into periplasmic and extracellular spaces of bacteria; for protein production.

Maine Med. Ctr.WO 99/06594
Genetic testing controls
Portland, Me.
Stable, encapsulated reference nucleic acid; for controls in diagnostic and genetic testing assays.

Massachusetts, Univ. ofWO 99/06533 & 06534
Bird transgenics
Amherst, Mass.
Bird primordial germ cells, methods of long-term culture and production of stem cells; for producing bird transgenics.

Mass. Gen. Hosp.WO 99/06535
G-protein modulators
Boston, Mass.
Renal cells tranfected with parathyroid hormone; for detecting G-protein coupled receptor modulators.

Mass. Inst. Technol.WO 99/06543
Life span extension
Cambridge, Mass.
Identification of agents inhibiting DNA circle replication, mWRN, encoding gene sequences; for extending life spans.

Max Planck Inst.WO 99/06545
Amyloid formation inhibitors
Berlin, Germany
Methods for detecting and monitoring amyloid-like fibril formation, identification of inhibitors.

Metra BiosystemsWO 99/06840
Collagen fragment antibodies
Mountain View, Calif.
Antibodies specific for type I collagen peptide fragments; for assaying fragment presence in biological fluids.

Millennium BiotherapeuticsWO 99/06426-06428
Tango family proteins
Cambridge, Mass.
Tango-related family proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Missouri, Univ. ofWO 99/06571
Cytokinin oxidase
Columbus, Mo.
Cytokinin oxidase, variants and fragments, encoding gene sequences; for therapeutics.

MitotixWO 99/06540
Cyclin complex inhibitors
Cambridge, Mass.
Inhibitors of cyclin-dependent kinase/cyclin complexes; for controlling cell growth and differentiation.

MorphosysWO 99/06587
Multimeric protein library
Martinsreid, Germany
Method for screening phage display libraries for genes encoding multimeric protein complexes.

MycogenWO 99/06568
Bacterial crystal protein toxins
San Diego, Calif.
Bacillus thuringiensis Cry6 toxins, truncated and hybrid variants; for controlling pests.

NIH (Natl. Inst. Hlth.)WO 99/06561
CCR8 chemokine receptor
Bethesda, Md.
CCR8 chemokine receptor, encoding gene sequences; for HIV diagnostics and therapeutics.

NestleEPO 897 003
Proteolytic enzyme production
Vevey, Switzerland
Enhanced expression of proteolytic enzymes in koji mold; for enzyme production and purification.

NestleEPO 897 012
Proteolysis peptidase
Vevey, Switzerland
Prolyl-dipeptidyl peptidase from Aspergillus oryzae, encoding gene sequences; for proteolysis.

New York Med. Coll.WO 99/06592
Halogenated DNA detection
Valhalla, N.Y.
Immunocytochemical detection and isolation of nucleic acids using halogenated labels.

OncormedWO 99/06598
Functional allele profiles
Gaithersburg, Md.
Profiling functional allele profiles using gene frequencies; for pharmacogenetic prediction of drug effectiveness.

Paris Hosp. Public AssistanceWO 99/06547
Cystic fibrosis treatment
Glutathione carrier peptide derived from the CFTR protein, encoding gene sequences; for treating cystic fibrosis.

Pittsburgh, Univ. ofWO 99/06583
HSV vector targeting
Pittsburgh, Penn.
Herpes simplex virus (HSV) vector with a non-native ligand in its envelope; for targeting HSV vectors.

PolyprobeWO 99/06595
Dendrimeric nucleic acids
Philadelphia, Penn.
Nucleic acids having a dendrimeric network of interconnected monomers; for maximal self-assembly/structural integrity.

ScheringWO 99/06557
Myeloid development modulators
Kenilworth, N.J.
Mammalian cell membrane proteins, encoding gene sequences, antibodies; for modulating myeloid cell development.

ShionogiEPO 896 999
Arthritis therapy
Osaka, Japan
Human T cell clone specific for synovial cell antigens expressed during rheumatoid arthritis; for therapy.

SmithKline BeechamEPO 897 002
JNK-binding domains
Brentford, U.K.
Polypeptides having a JNK-binding domain, encoding gene sequences; for diagnostics and therapeutics.

SmithKline BeechamEPO 897 004
Streptococcus antibacterials
Philadelphia, Penn.
Streptococcus pneumoniae histidyl tRNA synthetase peptides, encoding gene sequences; for antibacterial screens.

SmithKline BeechamEPO 897 007
Antibacterial screen
Philadelphia, Penn.
mraY polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline BeechamEPO 897 008
Antibacterial screen
Philadelphia, Penn.
His5 polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline BeechamEPO 897 009
Cancer therapeutics
Brentford, U.K.
HKABY60 polypeptides, encoding gene sequences, production methods; for treating cancer and immune disorders.

SmithKline BeechamEPO 897 011
Antibacterial screen
Philadelphia, Penn.
Arginine deiminase polypeptides, encoding gene sequences, production methods; for antibacterial screens.

SmithKline BeechamEPO 897 114
TNF receptor modulators
Philadelphia, Penn.
Tumor necrosis factor (TNF) receptor-related polypeptides; for identifying antagonists and agonists.

SmithKline BeechamWO 99/06063 & 06442
EPO primary response gene
Philadelphia, Penn.
Erythropoietin (EPO) primary response gene sequences, encoded polypeptides: for diagnosis and therapy.

SmithKline BeechamWO 99/06546
Opioid-regulated protein
Baranzate di Bollate, Italy
Human ortholog of NGD5 protein which is regulated by opioid treatment, encoding gene sequences; for diagnostics.

Stichting Inst.WO 99/06569
Cytotoxic ribonuclease fragment
Lelystad, Netherlands
Peptide fragment from ribonuclease; for immunosuppression and lymphocyte apoptosis.

Sumitomo ElectricWO 99/06541
Leukemia diagnostic
Osaka, Japan
Antibodies to human pre-B cell receptors but not the cell itself; for diagnosing childhood leukemia.

Texas, Univ. ofWO 99/06059
SOD in diabetes
Austin, Texas
Methods for using superoxide dismutase (SOD) to protect pancreatic islet cell tissue.

Tulane Univ.WO 99/06061
New Orleans, La.
Detection and creation of immunodominant T cell epitopes in antigens; for inhibiting immune responses.

UnileverWO 99/06570
Non-selectable marker plasmids
Recombinant plasmid with non-selectable marker, replication without selection pressure; for genetic modification.

VirologicWO 99/06597
Screening antivirals
S. San Francisco
Infection of cells with hepatitis C virus or cytomegalovirus; for screening antiviral compounds.

YakuhinWO 99/06555
Matrix metalloprotease
Toyama, Japan
Human matrix metalloprotease, encoding gene sequences, antibodies, production methods; for therapeutics.

Yissum Res. & Develop.WO 99/06586
Carotenoid production
Jerusalem, Israel
Paracoccus bacterial species that produces and secretes carotenoids; for their production.

ZenecaWO 99/06539
Bipolar affective disorder
Bipolar affective disorder proteins, encoding genes, polymorphic variants; for identifying modulators.