Published Feb. 10 and 17 (EPO); Feb. 11 (WO); Feb. 17 (GB)
Abiogen PharmaWO 99/06066
Catalytic monoclonal antibodies having protease activity; for lysing plaques and aggregates.
Abiogen PharmaWO 99/06536
Corticosteroid prodrug conversion
Catalytic monoclonal antibodies for in vivo transformation of corticosteroid prodrugs.
Amersham Pharmacia BiotechWO 99/06538
DNA polymerase mutants
Thermococcus barosii DNA polymerase mutants with reduced exonuclease activity; for better nucleotide incorporation.
Hearing loss treatment
Thousand Oaks, Calif.
Methods for treating cochlear hair cell degeneration using neurturin; for sensorineural hearing loss.
AsymptoteGB 2 328 209
Colored reporter protein
Vectors having a reporter gene encoding a protein that develops color; for rapid assays.
Baylor Coll. Med.WO 99/06034
Neural degeneration therapeutic
Antagonists of the product of the COUP-TFI gene; for treating neural and bone degeneration.
Complexed HBV antigens
Hepatitis B virus (HBV) antigens complexed with albumin or unprocessed RNA virus proteins; for increased antigenicity.
Boehringer MannheimEPO 896 965
Phosphoducin inhibitors of G-protein beta/gamma subunits; for designing antagonists.
Boehringer MannheimWO 99/06072
Cyclized prodrugs that are covalently cross-linked; for cleavage and use as therapeutics.
Boehringer MannheimWO 99/06537
Activating cross-linked enzymes
Covalently cross-linked enzyme subunits or fragments; for cleavage and activation by analyte binding.
Burnham, Inst.WO 99/06588
La Jolla, Calif.
Cell-free system for identifying compounds modulating apoptosis dependent on mitochondria.
California, Univ. ofWO 99/06060
Neural tissue transplants
Treating neural progenitor cells with epidermal growth factor; for growing progeny cells for transplant.
California, Univ. ofWO 99/06830
Methods for affecting G-protein coupled receptors; for modulators screens.
Glandular kallikrein enhancer
Human glandular kallikrein enhancer sequence; for prostate-selective gene therapy and subsequent cytotoxicity.
CDC (Ctr. Dis. Control)WO 99/06596
Yeast infection diagnosis
Nucleic acid probes for detecting Candida species; for detection and diagnosis of yeast infections.
AAV vector readministration
Gene therapy using adeno-associated virus (AAV) vectors and host immunosuppression; for repeated administration.
Chong Kun DangWO 99/06531
Fungal mevalonic acid
Seoul, S. Korea
Aspergillus fungi genus showing resistance to cerulenin and L-methionine analogs; for preparing mevalonic acid.
Immobilized hybridization assays
Oxidized styrenic polymers for immobilizing aminated DNA; for hybridization assays.
Dana-Farber Cancer Inst.WO 99/06069
Replication-defective herpesvirus mutants; for vaccines and treating immune system diseases.
Dorssers, L.C.J.WO 99/06831
Breast cancer probes
Methods for measuring genes and encoded proteins associated with estrogen-independent breast cancers.
Emory Univ.WO 99/06563
Bone mineralization therapy
Bone mineralization protein, encoding gene sequences; for transfecting osteogenic precursor cells for therapy.
Food Ind. Res. & Develop. Inst.EPO 897 006
Amino acid oxidase
Rhodosporidium D-amino acid oxidase, encoding gene sequences; for amino acid conversion.
Fuchsbauer, H.-L.WO 99/06446
Acyl/amine donor generation
Transglutaminase-catalyzed coupling of proteins to solid supports; for generating acyl and amine donors.
Genetic SystemsWO 99/06599
Synthetic HIV antigens
Synthetic antigens that are immunoreactive with HIV; for detection of HIV antibodies and exposure determination.
5' expressed sequence tags (ESTs) from endoderm tissue; for diagnostics, gene therapy, and chromosome mapping.
Secreted protein ESTs
5' expressed sequence tags (ESTs) of secreted proteins from testes, prostate, neurons, and muscles.
Glasgow, Univ. ofWO 99/06542
Phage library screen
Phage library screen for expressed heterologous proteins after subtracting background cell protein binding.
Hawaii BiotechWO 99/06068
Dengue virus vaccine
Truncated flaviviral envelope proteins; for making diagnostics and vaccines against dengue viruses.
Henkel Res. Inst.WO 99/06573
Bacillus alkalophilus ß-glucanase; for glucanolysis in neutral to alkaline conditions.
Hoffmann-La RocheEPO 897 010
Modified phytases, encoding gene sequences, production methods.
Human Genome SciencesWO 99/06423
83 secreted proteins
83 human secreted proteins, encoding gene sequences, production methods; for diagnosis and therapy.
Ice BiotechWO 99/06565
Winter rye antifreeze proteins, encoding gene sequences; for preventing ice crystal formation in biological materials.
Immune ResponseWO 99/06544
Membrane attachment domain-bound cytokine compositions; for modulating immune responses.
Incyte PharmaWO 99/06558
Palo Alto, Calif.
Human longevity-assurance protein homologs, encoding gene sequences, antibodies, modulators; for diagnostics.
Incyte PharmaWO 99/06560
Annexin binding protein
Palo Alto, Calif.
Annexin binding protein, encoding gene sequences, antibodies, modulators; for diagnostics.
Incyte PharmaWO 99/06572
Palo Alto, Calif.
Human synaptojanin isoform, encoding gene sequences, antibodies, modulators; for therapeutics.
Inst. Phys. & Chem. Res.WO 99/06591
DNA mutation detection
Method of detecting DNA mutations on a solid support using proteins that bind to base pair mismatches.
Japan Sci. & Technol.EPO 897 005
Polyester synthase, derivatives, encoding gene sequences, vector, host cells.
Japanese Fdn. Cancer Inst.EPO 896 055
Apoptosis-inducing protein kinase, encoding gene; for treating cancer.
Johns Hopkins Univ.WO 99/06443-06445, 06556 & 06559
Growth differentiation factors
Growth differentiation factors, encoding gene sequences; for diagnostics and therapeutics.
Korea Inst. Sci. & Technol.WO 99/06532
Bacterial succinic acid
Seoul, S. Korea
E. coli pta ldhA double mutant strain made by recombinant engineering techniques; for making succinic acid.
Koszinowski, U.H.WO 99/06582
Viral genome mutagenesis
Recombinant vectors having infectious viral genome sequences, production methods; for mutagenesis.
Krebs Res. Inst.WO 99/06577
HPOL epitope fusion
Expression vector encoding an HPOL epitope fusion protein, antibodies; for expressing and detecting the complex.
Lampert, F.EPO 897 001
Polypeptide having a GTPase activity, encoding gene sequences; for diagnostics and therapy.
Lubitz, W.WO 99/06567
Bacterial production system
Secretion of carrier-bound proteins into periplasmic and extracellular spaces of bacteria; for protein production.
Maine Med. Ctr.WO 99/06594
Genetic testing controls
Stable, encapsulated reference nucleic acid; for controls in diagnostic and genetic testing assays.
Massachusetts, Univ. ofWO 99/06533 & 06534
Bird primordial germ cells, methods of long-term culture and production of stem cells; for producing bird transgenics.
Mass. Gen. Hosp.WO 99/06535
Renal cells tranfected with parathyroid hormone; for detecting G-protein coupled receptor modulators.
Mass. Inst. Technol.WO 99/06543
Life span extension
Identification of agents inhibiting DNA circle replication, mWRN, encoding gene sequences; for extending life spans.
Max Planck Inst.WO 99/06545
Amyloid formation inhibitors
Methods for detecting and monitoring amyloid-like fibril formation, identification of inhibitors.
Metra BiosystemsWO 99/06840
Collagen fragment antibodies
Mountain View, Calif.
Antibodies specific for type I collagen peptide fragments; for assaying fragment presence in biological fluids.
Millennium BiotherapeuticsWO 99/06426-06428
Tango family proteins
Tango-related family proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Missouri, Univ. ofWO 99/06571
Cytokinin oxidase, variants and fragments, encoding gene sequences; for therapeutics.
Cyclin complex inhibitors
Inhibitors of cyclin-dependent kinase/cyclin complexes; for controlling cell growth and differentiation.
Multimeric protein library
Method for screening phage display libraries for genes encoding multimeric protein complexes.
Bacterial crystal protein toxins
San Diego, Calif.
Bacillus thuringiensis Cry6 toxins, truncated and hybrid variants; for controlling pests.
NIH (Natl. Inst. Hlth.)WO 99/06561
CCR8 chemokine receptor
CCR8 chemokine receptor, encoding gene sequences; for HIV diagnostics and therapeutics.
NestleEPO 897 003
Proteolytic enzyme production
Enhanced expression of proteolytic enzymes in koji mold; for enzyme production and purification.
NestleEPO 897 012
Prolyl-dipeptidyl peptidase from Aspergillus oryzae, encoding gene sequences; for proteolysis.
New York Med. Coll.WO 99/06592
Halogenated DNA detection
Immunocytochemical detection and isolation of nucleic acids using halogenated labels.
Functional allele profiles
Profiling functional allele profiles using gene frequencies; for pharmacogenetic prediction of drug effectiveness.
Paris Hosp. Public AssistanceWO 99/06547
Cystic fibrosis treatment
Glutathione carrier peptide derived from the CFTR protein, encoding gene sequences; for treating cystic fibrosis.
Pittsburgh, Univ. ofWO 99/06583
HSV vector targeting
Herpes simplex virus (HSV) vector with a non-native ligand in its envelope; for targeting HSV vectors.
Dendrimeric nucleic acids
Nucleic acids having a dendrimeric network of interconnected monomers; for maximal self-assembly/structural integrity.
Myeloid development modulators
Mammalian cell membrane proteins, encoding gene sequences, antibodies; for modulating myeloid cell development.
ShionogiEPO 896 999
Human T cell clone specific for synovial cell antigens expressed during rheumatoid arthritis; for therapy.
SmithKline BeechamEPO 897 002
Polypeptides having a JNK-binding domain, encoding gene sequences; for diagnostics and therapeutics.
SmithKline BeechamEPO 897 004
Streptococcus pneumoniae histidyl tRNA synthetase peptides, encoding gene sequences; for antibacterial screens.
SmithKline BeechamEPO 897 007
mraY polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline BeechamEPO 897 008
His5 polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline BeechamEPO 897 009
HKABY60 polypeptides, encoding gene sequences, production methods; for treating cancer and immune disorders.
SmithKline BeechamEPO 897 011
Arginine deiminase polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline BeechamEPO 897 114
TNF receptor modulators
Tumor necrosis factor (TNF) receptor-related polypeptides; for identifying antagonists and agonists.
SmithKline BeechamWO 99/06063 & 06442
EPO primary response gene
Erythropoietin (EPO) primary response gene sequences, encoded polypeptides: for diagnosis and therapy.
SmithKline BeechamWO 99/06546
Baranzate di Bollate, Italy
Human ortholog of NGD5 protein which is regulated by opioid treatment, encoding gene sequences; for diagnostics.
Stichting Inst.WO 99/06569
Cytotoxic ribonuclease fragment
Peptide fragment from ribonuclease; for immunosuppression and lymphocyte apoptosis.
Sumitomo ElectricWO 99/06541
Antibodies to human pre-B cell receptors but not the cell itself; for diagnosing childhood leukemia.
Texas, Univ. ofWO 99/06059
SOD in diabetes
Methods for using superoxide dismutase (SOD) to protect pancreatic islet cell tissue.
Tulane Univ.WO 99/06061
New Orleans, La.
Detection and creation of immunodominant T cell epitopes in antigens; for inhibiting immune responses.
Non-selectable marker plasmids
Recombinant plasmid with non-selectable marker, replication without selection pressure; for genetic modification.
S. San Francisco
Infection of cells with hepatitis C virus or cytomegalovirus; for screening antiviral compounds.
Human matrix metalloprotease, encoding gene sequences, antibodies, production methods; for therapeutics.
Yissum Res. & Develop.WO 99/06586
Paracoccus bacterial species that produces and secretes carotenoids; for their production.
Bipolar affective disorder
Bipolar affective disorder proteins, encoding genes, polymorphic variants; for identifying modulators.