Company

Symbol

12/31/97*

03/31/98

06/30/98

09/30/98

12/31/98

%YTD

Aastrom Biosci

ASTM

4.375

4.5

3.75

2.125

2.875

-34

Abgenix

ABGX

8

-

-

7.125

16.25

103

Adv Magnetics

AVM

8.75

13.062

11.312

7.5

7.312

-16

Adv Poly Sys

APOS

6.625

8.625

7

5.437

5.375

-19

Adv Tissue Sci

ATIS

12.375

9.343

4.437

3.031

2.593

-79

Affymetrix

AFFX

31.125

34.812

24.062

25.75

24.375

-22

Agouron

AGPH

29.375

37.875

30.312

34.437

58.75

100

Agritope

AGTO

7

4.5

4

1.375

1.312

-81

Alexion Pharma

ALXN

12.5

12.375

10

9.25

13.375

7

Alkermes

ALKS

19.875

24.875

17.875

14.562

22.187

12

Allelix

AXB*

11.5

9

8

3.35

4.19

-64

Alliance

ALLP

7.25

7.562

4.187

3.062

3.281

-55

Alpha Beta

ABTI

2.593

2.125

2.437

1.343

0.687

-74

AltaRex

AXO*

3

2.26

1.05

0.78

0.46

-85

Alteon

ALTN

7.312

5.062

3.5

3

0.781

-89

Alza

AZA

31.812

44.812

43.25

43.375

52.25

64

Am Bio Sci

MABXA

1.906

1.75

1.156

0.406

0.75

-61

Amarillo Biosci

AMAR

5.5

3.25

2.75

2

1.25

-77

AMBI Inc.

AMBI

1.937

2.187

1.406

0.781

1.062

-45

Amgen

AMGN

54.125

60.875

65.375

75.562

104.562

93

Amylin

AMLN

5.437

2.75

3.781

3.187

0.5

-91

Anergen

ANRG

2.125

1.062

1.937

1.187

0.406

-81

Anesta

NSTA

16.375

18.625

14.437

18.625

26.625

63

Angiotech Pharma

ANP*

10

16.5

14.75

9

13

30

Aphton

APHT

10.125

12.687

16.625

11.75

12.75

26

Aquila Biopharma

AQLA

4.187

7.125

4.187

2.875

3.875

-7

Aradigm

ARDM

8.5

12.625

13.562

10

12.5

47

Ariad Pharm

ARIA

4.25

4.625

3.562

2.75

1.687

-60

Aronex Pharma

ARNX

4.25

3.562

3.937

2.625

2

-53

ArQule

ARQL

22.937

22.25

12.937

7.5

4.937

-78

Atlantic Pharma

ATLC

6.75

6.5

3.812

1.75

1.5

-78

Atrix Labs

ATRX

14.75

19

13.375

12.625

8.875

-40

Aurora Bioscience

ABSC

13.125

11.5

5.875

6

6.437

-51

AutoImmune

AIMM

3.312

2.312

2.562

1.875

2.25

-32

Avanir Pharma

AVNR

2.375

1.781

1.5

1.125

0.656

-72

Avant Immuno

AVAN

2.437

2.938

2.5

1.375

1.75

-28

Avax Technologies

AVXT

3.687

4.25

2.437

1.75

2.5

-32

AVI BioPharma

AVII

6.812

7.125

6.25

3.375

4

-41

Avigen

AVGN

2.25

2.437

3.5

2.75

7.812

247

Aviron

AVIR

27.125

23.125

31.187

15.437

25.875

-5

Axogen

AXG/U

39.75

57

63

69.25

66

66

Axys Pharma

AXPH

8.375

8.75

7.125

4.375

5.875

-30

Bio-Tech Gen

BTGC

10.75

8.5

7.093

6.625

6.937

-35

Biochem Pharma

BCHE

20.875

24.187

26.5

18.375

28.625

37

BioCryst

BCRX

7

7.5

7.812

7

7

0

Biogen

BGEN

36.375

48.187

49

65.812

83

128

Bioject

BJCT

1.281

1.5

1.812

1.562

1.343

5

Biomatrix

BXM

30

29.875

41

39

58.25

94

Biomira

BIOMF

2.125

2.5

2.25

1.531

3.093

46

Biora AB

BIORY

20.75

25

26.5

20.875

13

-37

Bioreliance

BREL

23

16.5

15.062

10.5

8

-65

Biotime

BTIM

19

14.25

6.25

9

17.375

-9

BioTransplant

BTRN

5.75

4.25

3.5

1.5

2.5

-57

Boston Life

BLSI

2.281

2.125

3.125

2.968

3.25

42

British Biotech

BBIOY

16.625

12.25

6.375

5.75

5.875

-65

Cadus Pharma

KDUS

6.375

8.312

7.75

2.812

1.937

-70

Calypte Biomed

CALY

3.875

5.187

4.031

1.75

2.875

-26

Cambridge Neuro

CNSI

1.968

2.312

0.593

0.531

0.718

-64

Cantab Pharm

CNTBY

11.75

13.573

12.125

10.125

9.625

-18

Carrington

CARN

4.312

4.437

4.812

3.25

2.125

-51

Cel-Sci

HIV

6.625

4.625

4.937

2.625

1.75

-74

Celgene

CELG

8.437

10.875

10.625

9.812

15.375

82

Cell Genesys

CEGE

8.5

6.625

8.562

3.187

6

-29

Cell Pathways

CLPA

16.5

-

-

-

22

33

Cell Therapeutics

CTIC

17

4.125

2.687

2.125

3

-82

Cellegy Pharma

CLGY

8.375

7.125

5.562

4.125

3.5

-58

Celtrix

CTRX

1.812

2.812

2.062

1

1.687

-7

Centocor

CNTO

33.25

44.625

36.25

39.625

45.125

36

Cephalon

CEPH

11.375

14

7.875

7.312

9

-21

Chiron

CHIR

17

20.937

15.687

19.875

26.187

54

Cholestech

CTEC

12.5

15

6.75

4.687

3.812

-70

Chrysalis Intl

CRLS

2.156

3

1.375

0.812

0.562

-74

CIMA Labs

CIMA

4.25

4.968

3.343

2.875

2.625

-38

CliniChem Devlp

CCHE

8.375

-

5.75

4.687

4.812

-43

ClinTrials

CCRO

7.875

7.125

4.875

4.75

3.937

-50

CoCensys

COCN

3.437

3.062

2.5

2.031

0.312

-91

Collab. Clin. Res

CCLR

5.062

4.25

4.125

2.812

4

-21

CollaGenex

CGPI

12.5

9.343

8.625

13.25

9.625

-23

Collateral Thera

CLTX

7.25

-

-

6

7

-3

Columbia Labs

COB

16.25

13.812

5.75

3.75

3.062

-81

CombiChem

CCHM

8

-

6.937

4

4.312

-46

Connetics Corp.

CNCT

3.062

5.312

3.812

3.687

5.875

92

Cor Thera

CORR

22.5

12.375

13.875

7.75

13.25

-41

Corixa

CRXA

8.937

7.375

6.875

6.125

9.25

4

Cortecs Intl

DLVRY

14.25

14.375

7.375

3.5

0.843

-94

Cortex

CORX

1.5

1.75

1.875

1.312

0.656

-56

Corvas

CVAS

3.875

5

4.125

2.062

2.812

-27

Coulter Pharma

CLTR

20.25

27.375

30.375

24.875

30

48

Creative Bio

CBMI

7.375

8.25

4.812

3

3.687

-50

Crescendo Pharma

CNDO

11.562

12.625

12.687

13.187

13.625

18

Cubist Pharma

CBST

5.812

4.5

4.75

2.437

3.812

-34

Curagen Corp.

CRGN

11.5

11.562

6.25

6

7.062

-39

CV Therapeutics

CVTX

9.375

9.5

8.625

5.75

4.75

-49

Cyanotech

CYAN

2.781

3.437

3.125

1.687

1.062

-62

Cygnus

CYGN

19.875

16.5

10.437

3.5

4.875

-75

Cypress Bio

CYPB

1.437

2.625

2.968

2.765

3

109

Cypros Pharma

CYP

4.25

3.812

4.062

2.812

3.25

-24

Cytel

CYTL

10.5

12.469

9.625

6.125

2.25

-79

Cytoclonal Pharma

CYPH

6.875

10.25

7

6.25

6.875

0

Cytogen

CYTO

1.625

2.156

0.781

0.812

0.843

-48

CytoTherapeut

CTII

4

3.375

1.25

0.937

1.468

-63

CytRx

CYTR

2.937

3.375

2.125

0.906

0.968

-67

DepoMed

DMI

4.25

12.375

10.25

8.75

7.875

85

DepoTech

DEPO

3.562

6

1.562

1.062

2.312

-35

Diacrin

DCRN

10.125

9.75

6.25

7.281

5.937

-41

Diagnostic Prod

DP

27.75

27.875

28.812

26.687

31.125

12

Dianon Systems

DIAN

9.375

9.75

9.25

6.125

9

-4

Diatide

DITI

9.125

10.75

8.75

6.875

7.25

-21

Digene

DIGE

8.625

8.875

9.75

7.25

5.562

-36

Discovery Labs

DSCO

4

4.75

4.25

2.375

2.625

-34

DNAP Holding

DNAP

4.859

4

4.187

3.625

3.5

-28

Draxis Health

DRAXF

3.062

2.906

2.562

1.812

2.859

-7

Dura Pharm

DURA

45.875

24.625

22.375

10.937

15.187

-67

Dusa Pharma

DUSA

11.5

15.5

6.812

3.562

7.375

-36

Ecogen

EECN

1.937

2.687

2.625

1.312

1.687

-13

Elan

ELN

51.187

64.625

64.312

72.062

69.937

37

Embrex

EMBX

5.312

5.75

6.187

4.562

5

-6

Emisphere

EMIS

18.625

17.875

12.062

7.875

15.625

-16

Endorex

DOR

5.5

6.187

4.25

2.375

2.062

-63

EntreMed

ENMD

11.312

12.812

33.25

24.125

21

86

Envirogen

ENVG

9

7.5

7.5

3

1.375

-85

Enzo Biochem

ENZ

14.625

15.75

13.375

7

10.312

-29

Enzon

ENZN

5.5

6.875

6.375

6.625

13.312

142

Epitope

EPTO

5

6.875

6.5

3.75

5.875

17

Epix Medical

EPIX

13

13.187

10.25

9.562

9.312

-28

Ergo Science

ERGO

15.25

15.062

3.562

3.25

1

-93

Ethical Hldgs

ETHCY

3.125

3

0.375

0.156

3.562

14

Flamel Tech

FLMLY

1.812

5.125

5

2.875

4.375

141

GalaGen

GGEN

1.875

1.625

3.062

1.812

2.156

15

GelTex

GELX

26.5

27

18.625

21.125

22.625

-15

Gene Logic

GLGC

8

7.625

7

3.937

6.968

-13

Genelabs

GNLB

2.812

4

3

2.312

2.75

-2

GeneMedicine

GMED

5.062

2.875

3.125

2.437

2.375

-53

Genentech

GNE

60.625

70.437

67.875

71.875

79.687

31

Genetronics

GEB*

3.094

3.55

3.6

4.3

5.05

63

Genome Thera

GENE

6.312

8.625

4.5

2.125

2.75

-56

Genset

GENXY

19.75

29

29.375

25.75

27.625

40

Gensia Sicor

GNSA

5.812

5

4

4.062

4.531

-22

Genta

GNTA

0.781

0.968

1.343

0.937

1.281

64

Genz Mol Oncol

GZMO

7

-

-

-

3.25

-54

Genz Tiss Repair

GENZL

6.875

8.625

6.562

3

2.25

-67

Genzyme

GENZ

27.75

32

25.562

36.125

49.75

79

Genzyme Trans

GZTC

9.625

11.562

7.75

4

5.625

-42

Geron

GERN

8.25

12.375

9.375

6.125

10.875

32

Gilead Sciences

GILD

38.25

36

32.062

21.625

41.062

7

Gliatech

GLIA

10.25

12.125

16.125

16.125

30

193

Guilford Pharm

GLFD

20.125

22

17.625

14

14.25

-29

Hemosol

HML*

2.188

1.797

2.98

2.5

2.8

28

Human Genome

HGSI

39.75

39.812

35.687

30

35.562

-11

Hycor Bio

HYBD

1.562

1.75

2

1.75

1.046

-33

Hyseq

HYSQ

9.625

12.5

10.812

5.437

5.25

-45

Icon plc

ICLRY

18

-

25.25

32.625

33.5

86

Icos

ICOS

18.312

15.25

19.125

17.75

29.75

62

ID Biomed

IDB*

3.4

5.15

6.05

4

3.07

-10

IDEC Pharm

IDPH

34.375

44.25

23.562

23.75

47

37

Idexx Labs

IDXX

15.937

18

24.875

23.875

26.906

69

Igen

IGEN

13.25

42.375

40.875

28.25

30.625

131

ILEX Oncology

ILXO

7.375

10.125

9.875

8.687

11.125

51

ImClone Sys

IMCL

8.125

8.312

12.25

8.75

9.062

12

Immucell

ICCC

2.468

1.937

2.187

1.937

1.25

-49

Immucor

BLUD

8.625

9.625

8.687

9.75

8.75

1

ImmuLogic

IMUL

1.875

1.656

1.625

1.406

1.218

-35

Immune Resp

IMNR

11.125

9.812

15

11.5

10.875

-2

Immunex

IMNX

54

67.375

66.25

55.375

125.812

133

ImmunoGen

IMGN

0.843

1.687

1.75

1.312

2.187

159

Immunomed

IMMU

3.625

5.062

4.437

3.5

4.125

14

Incyte Pharm

INCY

45

46.75

34.125

21.25

37.375

-17

Inhale Ther Sys

INHL

26

27.125

24.75

28

33

27

InKine Pharma

INKP

1.375

1.343

1.281

0.937

1.687

23

InSite Vision

ISV

3.25

3.375

3.375

1.937

1.25

-62

Integra LifeScien

IART

8.875

8.875

7

4.687

3.375

-62

Intercardia

ITRC

17.875

20.375

10

3.625

9

-50

Interferon Sci

IFSC

8.687

7.125

1.156

0.625

0.437

-95

Interneuron

IPIC

9.5

10.437

3.625

3

3.281

-65

Isis Pharm

ISIP

12.312

15.25

13.687

11.375

12.937

5

La Jolla Pharm

LJPC

4.437

3.875

3.5

2.875

4.5

1

LeukoSite

LKST

10.937

9.25

7.375

7.5

10.062

-8

Life Tech

LTEK

33.25

38.5

31.375

33.375

38.875

17

Lifecell

LIFC

4.625

5.093

6.125

3.937

4.375

-5

Lifecore Bio

LCBM

21.875

23.375

16.5

7.5

10.25

-53

Ligand

LGND

12.875

15.937

12.875

9.125

11.625

-10

Liposome Co

LIPO

4.625

5.562

5.406

5.687

15.437

234

LJL Biosystems

LJLB

7

7.062

4.875

2.5

3.125

-55

LXR Biotech

LXR

2.375

3.812

1.937

1.375

1.25

-47

Lynx Therapeutics

LYNX

16.25

10

9.375

8.125

11.5

-29

MacroChem

MCHM

9.125

11.187

7.062

6.312

8.437

-8

Magainin

MAGN

8.062

5.562

5.312

3.25

3.187

-60

Martek Bio

MATK

8.25

15.187

14.562

8.25

8

-3

Matritech

NMPS

4.875

5.125

2.062

0.906

1.656

-66

Matrix

MATX

3.437

4.625

4.375

2.875

2.625

-24

Maxim Pharma

MMP

16.375

14.625

20.5

14.812

15.375

-6

Medarex

MEDX

5.25

4.843

6.625

3.937

3.031

-42

Medical Science

MSSI

5.625

4

4.5

2

1

-82

MedImmune

MEDI

42.875

55.125

62.375

64.75

99.437

132

Megabios

MBIO

14.25

9.25

7.625

5.125

5.125

-64

Meridian Diag

KITS

10.125

12.75

12.375

7.625

6.75

-33

Metra Biosys

MTRA

3.625

2.25

2

0.718

1

-72

Microcide Pharma

MCDE

8.875

8.625

6.687

5.062

3.875

-56

Micrologix Biotec

MBI*

3.6

3.4

3.6

2.45

2.7

-25

Millennium

MLNM

19

18.625

14.125

17.375

25.875

36

Molecular Bio

MB

8.5

9.25

7.125

4.312

2.937

-65

Molecular Devices

MDCC

21.25

19.25

16.125

17.125

21.75

2

Myriad Genetics

MYGN

24.25

22.375

14.625

11.812

10

-59

NABI

NABI

3.406

3.062

3.031

2.187

2.687

-21

Nanogen

NGEN

11

-

6.562

3.656

4

-64

NaPro Biother

NPRO

2.5

2.468

1.25

1.031

1.406

-44

NeoPharm

NEO

5.25

3.812

3.625

4.125

12.125

131

Neoprobe

NEOP

6

4.562

2.75

0.937

0.718

-88

NeoRx Corp.

NERX

5.625

5.343

4.937

1.906

1.343

-76

Neose Technol

NTEC

15.25

13.625

16

11.125

14.062

-8

NeoTherapeutics

NEOT

10.5

8.875

12.5

6.437

10.5

0

Neurocrine Biosci

NBIX

7.875

8.125

7.937

5.875

6.875

-13

Neurogen

NRGN

13.5

15.375

17.75

16.5

17.5

30

NeXstar Pharm

NXTR

11.375

11.5

9.968

10.25

9.25

-19

North Am Vacc

NVX

24.937

17.5

15.5

11

8.875

-64

Northfield Labs

NFLD

9.125

10

14.75

9.5

12.375

36

Novavax

NOX

5

4.062

4

1.437

1.937

-61

Noven

NOVN

7

6.562

5.937

4.5

5.437

-22

NPS Pharm

NPSP

7.75

7.375

7.125

6.75

7.687

-1

Onyx Pharma

ONXX

7.75

7.5

6.125

7.375

7

-10

Ophidian Pharma

OPHD

4.422

-

3.25

2.062

1.75

-60

Organogenesis

ORG

21.5

27

19.625

10.437

11

-49

Ortec Int'l

ORTC

13.062

19.75

18.625

10.25

13.125

0

OSI Pharma

OSIP

6.75

6.125

5.625

2.906

3.187

-53

Osteotech

OSTE

27.25

25.875

17.75

26.5

46.5

71

Ostex Int'l

OSTX

2.625

2.5

1.5

1

0.406

-85

OXiGENE

OXGN

17.5

14.875

12.187

6.875

10.75

-39

Oxis Int'l

OXIS

2.109

2.969

3.75

3.281

2.875

36

Palatin Tech

PLTN

5.875

6.125

4.937

2.875

4.125

-30

Parexel Intl

PRXL

37

31.25

36.375

39

25

-32

PathoGenesis

PGNS

37.125

33.5

29

33.375

58

56

Pharma Prod Devlp

PPDI

15.375

23.375

22

28

30.062

96

Pharmacopeia

PCOP

16

18.75

14.25

10

9.5

-41

Pharmacyclics

PCYC

25.625

29.125

23.75

16.625

25.5

0

Pharmos

PARS

2

2.875

2.625

2.187

1.593

-20

Phoenix Intl

PHX*

10.25

12.2

11.8

8.1

17

66

Procept

PRCT

10

9.375

4.125

1

2.5

-75

ProCyte

PRCY

0.937

1.5

0.812

0.625

0.437

-53

Progenics Pharma

PGNX

14

18.562

14.875

10

12.375

-12

Protein Design

PDLI

40

39.25

24.093

24

23.25

-42

Protein Poly

PPTI

1.625

1.281

1.187

0.937

1.25

-23

Qiagen

QGENF

44.625

66.75

63

54.5

60.25

35

QLT PhotoTher

QLTIF

11.125

17.375

16.75

11.75

22.75

104

Quidel

QDEL

3.625

3.031

3.125

2.562

2.437

-33

Quintiles

QTRN

38.25

48.187

49.187

43.75

53.375

40

Regeneron

REGN

8.562

7.375

9.218

7.687

7.375

-14

Repligen

RGEN

0.781

1.187

1.531

1.312

1.281

64

Ribi Immuno

RIBI

3.687

5.75

5.062

3.062

2.312

-37

RiboGene

RBO

7

-

6.937

3.125

2.75

-61

Ribozyme Pharma

RZYM

8

5.937

4.937

5

4.375

-45

SangStat Med

SANG

40.5

31.875

31.375

21.25

21.25

-48

SciClone

SCLN

3.437

3.968

3.75

1.812

1.062

-69

Scios

SCIO

10

12.187

8.875

5.687

10.375

4

Sepracor

SEPR

40.062

42.625

41.5

65.75

87.562

119

Sequus Pharm

SEQU

7.437

10.562

11.375

9.687

20.25

172

Shaman

SHMN

4.937

5.031

3.375

1.375

1.906

-61

Sheffield

SHM

1.375

0.75

2.125

1.687

2.375

73

SIBIA Neurosci

SIBI

6.5

5.25

5.125

3.5

4.75

-27

Siga Pharma

SGPH

4.625

4.25

3.875

1.5

1.437

-69

Sonus Pharma

SNUS

33.125

24.5

12.312

7.25

6.75

-80

Stressgen Biotech

SSB*

3.094

2.9

2.61

1.52

1.64

-47

Sugen

SUGN

13.125

13.625

16.25

13

14.75

12

SunPharm

SUNP

4.5

5.375

3.25

1.875

1

-78

SuperGen

SUPG

15

13.25

10.062

9.437

9.25

-38

Synaptic Pharma

SNAP

10.875

12.75

14

14.75

15

38

Synbiotics

SBIO

3.125

3.5

3.312

2.75

2.562

-18

Synsorb Biotech

SYBBF

8.5

7.25

4.938

2.437

2.375

-72

Targeted Genet

TGEN

2.625

1.937

1.593

1.25

1.312

-50

Techniclone Int'l

TCLN

2.187

0.781

1.375

1

1.093

-50

Teva Pharm

TEVIY

47.312

42.75

35.187

37.875

40.687

-14

Texas Biotech

TXB

6.187

7.187

4.562

3.812

4.937

-20

Theratech

THRT

8

9.875

10.125

9.125

16.25

103

Transcend Thera

TSND

7.5

3.5

1.5

0.75

1.25

-83

Transgene

TRGNY

14.5

15.187

17.375

10.75

15.375

6

Transkaryotic

TKTX

35.125

32.375

25.75

24

25.375

-28

Trega Biosciences

TRGA

3.437

5.187

3.625

2.062

2.125

-38

Triangle Pharma

VIRS

14.625

15.75

14.875

13.25

13.625

-7

Trimeris

TRMS

13

7.5

7.375

5

11.75

-10

Trinity Bio

TRIBY

1.968

2.187

1.906

1.125

1.312

-33

Tripos

TRPS

14.625

13

14

7.25

7.625

-48

Unigene

UGNE

2.625

2.562

1.968

1.437

1.187

-55

Unimed Pharma

UMED

7.563

7.5

5.25

3.25

4.312

-43

UroCor

UCOR

6.187

7.218

7.125

4.375

6.375

3

US Bioscience

UBS

9.062

10.125

8.187

7.125

7.187

-21

Vertex Pharm

VRTX

33

31.937

22.5

23

29.75

-10

Vical

VICL

12

15.75

16.937

11

14.187

18

VimRx

VMRX

1.937

2.031

1.125

1.218

1.093

-44

Vion Pharma

VION

3.625

4

4.75

3.375

5

38

Viragen

VRGN

1.093

2.406

1.875

1.312

0.812

-26

ViroPharma

VPHM

17.625

21

23.25

17.75

9.312

-47

Visible Genetics

VGIN

8.562

8.875

9.875

10.937

11.375

33

Vysis

VYSI

12

11.25

10

4.125

5.375

-55

Xenova Group

XNVAY

2.25

3.125

2.125

0.75

0.562

-75

XOMA

XOMA

5.562

4.687

4.812

2.75

3.187

-43

Zonagen

ZONA

18.187

22

21.937

15.5

19.125

5


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