Published October 14 (EPO); October 8 (WO); October 14 (GB)

Abbott Labs WO 98/44133, 44159, & 44160

Gastrointestinal tract genes

Abbott Park, Ill.

Genes expressed in the gastrointestinal tract, encoded proteins, antibodies, modulators; for diagnosis.

Apotech WO 98/44104

Death effector domains

Genf, Switzerland

DNA sequences with death effector domains, expression vectors having these domains; for isolation.

Barnes-Jewish Hosp. WO 98/44091

Neutrophil elastase

St. Louis

Neutrophil elastase, encoding gene sequences; for making transgenics deficient in elastase expression.

British Columbia, Univ. of WO 98/44141

Insect cell expression system

Vancouver, B.C.

Insect cell expression vectors based on baculoviruses that have inserted heterologous and selectable marker genes.

California, Univ. of WO 98/44107 & 44108

Glaucoma diagnosis

Alameda, Calif.

Glucocorticoid-induced protein of trabecular meshwork cells, encoding gene sequences; for diagnosing glaucoma.

California, Univ. of WO 98/44147

Eucaryote screening method

Oakland, Calif.

Transfer of procaryotic proteins to eucaryotic cells by protoplast fusion; for screening binding molecules.

Chugai Res. Inst. Molec. Med. WO 98/43998

Osteoblast growth inhibitor

Ibaraki, Japan

Membrane-secreted proteins from osteoblast-like cell lines; for suppression of cell growth.

CSIRO (Comm. Sci. Indus. Res. Org.) WO 98/44001

High avidity Ig-like proteins

Campbell, Australia

High avidity, polyvalent and polyspecific peptides made of immunoglobulin (Ig)-like domains.

Cytoclonal Pharma WO 98/44096

Mycobacterial recombinant vaccines

Dallas, Texas

Recombinant mycobacterial vectors containing inserted genes; for making immunogenic vaccines.

Daewoong Pharma WO 98/44130

Ulcer vaccine

Sungnam, S. Korea

Chimeric proteins with cholera toxin and Helicobacter pylori antigenic domains, encoding gene sequences; for vaccines.

Duphar Intl. EPO 970 508

Influenza vaccines

Weesp, Netherlands

Isolation of influenza virus surface antigens in cell culture systems; for developing vaccines.

Fuji Yakuhin EPO 870 826

Tumor matrix metalloproteinase

Toyama, Japan

Cell surface matrix metalloproteinase that is diagnostic for cancer, encoding gene sequences, monoclonal antibodies.

Garvin, A.M. WO 98/44154

Expression analysis improvement

Durmenach, France

Inhibition of protein synthesis during the isolation of mRNA from cells; for improving expression analysis assays.

Gemini Res. WO 98/44150

IL-1 receptor antagonist alleles


Polymorphisms of the interleukin (IL)-1 receptor antagonist gene; for diagnosing osteoporosis susceptibility.

Genetics Inst. WO 98/44113

Secreted proteins

Cambridge, Mass.

Secreted proteins, encoding gene sequences; for developing therapeutics.

Genzyme WO 98/43994

Gene therapy vehicles

Framingham, Mass.

Cationic amphiphiles that facilitate the transport of biologically active molecules into cells; for gene therapy.

Genzyme WO 98/44143

Polymer-modified viruses

Framingham, Mass.

Polymer-modified viruses; for longer blood half-life and targeted delivery to tumors.

Glaxo WO 98/44151 & 44152

Localized parallel sequencing

Greenford, U.K.

Iterative amplification of nucleic acids using primers immobilized to a surface; for parallel sequencing.

Green Cross WO 98/44146

Recombinant protein production

Osaka, Japan

Production of foreign proteins using media having fatty acids and surfactants; for less degradation and higher yields.

Hoechst WO 98/44135

Antifungal screen

Frankfurt, Germany

Antifungal screen using yeast genes or their sequence and functional homologs.

Human Genome Sciences WO 98/44109

Cytostatin II

Rockville, Md.

Cytostatin II growth modulatory peptides, encoding gene sequences, modulators; for diagnostics and therapeutics.

Human Genome Sciences WO 98/44111

Thymus receptor tyrosine kinase receptors

Rockville, Md.

Thymus receptor tyrosine kinase receptors, encoding gene sequences, production methods; for therapeutics.

Human Genome Sciences WO 98/44112

Cardiac/pancreatic protein

Rockville, Md.

Cardiac/pancreatic muscle-derived growth factor, encoding gene sequences, production methods; for therapeutics.

Human Genome Sciences WO 98/44118

Human chemokine beta-6

Rockville, Md.

Human chemokine beta-6, encoding gene sequences, production methods, agonist polypeptides; for immunotherapy.

Incyte Pharma WO 98/44110

TGF-beta receptor-associated protein

Palo Alto, Calif.

Transforming growth factor (TGF)-beta receptor-associated protein, encoding gene, modulators; for therapeutics.

Incyte Pharma WO 98/44114

Regulators of G-proteins

Palo Alto, Calif.

Regulators of G-protein signalling, encoding gene sequences, expression vectors, antibodies, modulators; for therapeutics.

Incyte Pharma WO 98/44115

Calcium-binding protein

Palo Alto, Calif.

Reticulocalbin-like calcium-binding protein, encoding gene sequences, antibodies, modulators; for therapeutics.

Incyte Pharma WO 98/44124

Mitochondrial adenylate kinase

Palo Alto, Calif.

Human mitochondrial adenylate kinase, encoding gene sequences, antisense, antibodies, modulators.

Incyte Pharma WO 98/44128

Serine carboxypeptidase

Palo Alto, Calif.

Human serine carboxypeptidase, encoding gene sequences, antibodies, modulators; for therapeutics.

Inst. Environ. Sci. & Res. WO 98/44153

Listeria infection detection

Christchurch, New Zealand

Probes to the 16S and 23S rRNA genes of Listeria; for detection and diagnosis of bacterial infection.

INSERM (Natl. Inst. Hlth. Med. Res.) WO 98/44099

Protein interaction detection


One conditional promoter used to detect one or more proteins interacting directly or indirectly with other proteins.

Jackson Labs WO 98/43666

Atherosclerosis antioxidant protein

Bar Harbor, Me.

Antioxidant protein associated with atherosclerotic disease in mice, human homolog, encoding gene sequences.

Japan Science & Technol. EPO 870 842

Competitive PCR

Kawaguchi, Japan

Specific adaptor tagging of DNA fragments before amplification; for quantitative competitive PCR.

Johns Hopkins Univ. WO 98/43679

Gonadal germ cells


Primordial germ cells isolated from the gonadal ridge of human embryos; for use in transgenic technology.

Joslin Diabetes Ctr. WO 98/44088

Treating proliferative disorders


Method of modulating nm23 activity by modulating Rad activity; for treating proliferative disorders.

Krebs Res. Inst. WO 98/44103

Apoptosis-inhibiting protein

Heidelberg, Germany

Protein that inhibits apoptosis, encoding gene sequences, antibodies.

Kureha Chemical WO 98/44116

Trehalose preparation


Recombinant trehalose phosphorylase; industrial scale preparation of trehalose.

Kyowa Hakko Kogyo EPO 870 841

Complex carbohydrate production


Production of sugar nucleotides and complex carbohydrates from microorganism culture broths.

Life Technologies WO 98/44156

Nucleic acid ladders

Rockville, Md.

Nucleic acid ladders; for estimating size and mass during separations.

Life Technologies WO 98/44161

Simplified RT-PCR

Rockville, Md.

Compositions and methods for simplified reverse transcriptase (RT)-PCR amplification reactions.

L'Oreal WO 98/44105

Skin cosmetics


Epidermis-specific polypeptides involved in horny layer cell cohesion; for making cosmetics.

Manchester, Univ. of WO 98/44149

DNA damage screen

Manchester, U.K.

Regulatory element sequences that are activated by DNA damaging agents and is also linked to a reporter gene.

Mass. Gen. Hosp. WO 98/44142

Muscle stem cell isolation


Isolation of muscle stem cells using Bcl-2 expression as a marker; for identifying modulators and gene therapy.

Mass. Inst. Technol. EPO 870 837

Polyester biopolymers

Cambridge, Mass.

Manipulation of enzyme genes for the synthesis of polyhydroxybutyrate and polyhydroxyalkanoate esters.

Megan Health WO 98/44120

Attenuated bacterial strains

St. Louis

Salmonella typhimurium poxR gene, attenuated bacterial strains with mutated poxR gene; for vaccines.

NIH (Natl. Inst. Hlth.) WO 98/44098

HIV fusion factor

Bethesda, Md.

Human fusion accessory factor associated with HIV (STRL33), cell lines coexpressing STRL33 and CD4; for HIV research.

NIH (Natl. Inst. Hlth.) WO 98/44123

O-linked N-acetylglucosamine transferase

Bethesda, Md.

O-linked N-acetylglucosamine transferase (OGT), encoding gene sequences; for diagnosis of OGT pathology.

New York, St. Univ. of WO 98/44101

Breast cancer antisense

Albany, N.Y.

Antisense oligos for mitogen-activated protein kinases; for breast cancer therapy.

New York Univ. WO 98/44132

Chimeric envelope proteins

New York

Chimeric viral envelope proteins with the immunoglobulin G binding domain of protein A; for gene therapy

Nicod, P. WO 98/44106

Apoptosis transcription factor

Pully, Switzerland

Transcription factor islet-brain 1 (IB1), encoding gene; for regulating insulin expression, apoptosis, and neural disease.

November Inst. Molec. Med. WO 98/44122

Hepatitis A mutants

Erlangen, Germany

Methods for constructing and producing non-infectious, recombinant hepatitis A viruses.

Oncormed WO 98/44157

Genetic variation assay

Gaithersburg, Md.

Allele-specific hybridization, sequence variation assay, and direct sequencing; for identifying genetic variations.

Otsuka Pharma EPO 870 509

HIV antibodies


Sugar-chain recognizing immunoglobulin M (IgM) antibody; for HIV infection treatment.

Pasteur Inst. WO 98/44094

Ulcer therapeutics


Helicobacter alphatic amidase polypeptides, encoding gene sequences; for diagnostics and therapeutics.

Pasteur Merieux WO 98/43478 & 43479

Ulcer vaccines

Lyon, France

Helicobacter polypeptides, encoding gene sequences; for making vaccines to treat ulcers.

Pharma-Zentrale WO 98/44134

Bacterial plasmids

Herdecke, Germany

Plasmids and DNA sequences derived from a variety of bacterial strains.

Queensland Inst. Med. Res. WO 98/44129

Targeted antigens

Herston, Australia

Gene sequences encoding a targeting molecule and an antigen; for inducing immune responses.

Rican GB 2 324 093

Ulcer vaccine

Dublin, Ireland

Helicobacter pylori bacterioferritin, encoding gene; for immunoreactivity in H. pylori-negative individuals.

Santen Pharma WO 98/43997

Water channel protein

Osaka, Japan

Polypeptide having water channel activity, encoding gene sequences.

Scientific Generics WO 98/44100

Electrical-mediated dissociation

Cambridge, U.K.

Dissociation of double-stranded DNA or protein-ligand complexes using electrical voltage.

Seikagaku WO 98/43995

Targeted HIV therapeutics


HIV reverse transcriptase and/or protease inhibitors bound to CD4 receptor targeting proteins; for therapeutics.

SmithKline Beecham EPO 870 825

Protein kinases

Philadelphia, Penn.

Human protein kinase polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham EPO 870 827

TNF-related receptor TR6


Tumor necrosis factor (TNF)-related receptor TR6 peptides, encoding gene sequences; for diagnostics and therapeutics.

SmithKline Beecham EPO 870 829

Staphylococcus antibacterials


Staphylococcus aureus cell division gene sequences, encoded polypeptides, production methods; for antibacterial screens.

SmithKline Beecham EPO 870 831

Antibacterial screens


Histidine kinase polypeptides, encoding gene sequences, production methods; for antibacterial screens.

Stanford Univ. WO 98/44350

Protein-protein interactions

Palo Alto, Calif.

Protein-protein interactions detected by binding beta-galactosidase mutants whose proximity allows enzyme activity.

Statens Serum Inst. WO 98/44119

Mycobacterium antigens

Copenhagen, Denmark

Mycobacterium tuberculosis antigenic proteins, encoding gene sequences; for therapeutics and skin test diagnostics.

Takara Shuzo EPO 870 832

DNA polymerase for PCR

Kyoto, Japan

DNA polymerase, a polymerase-constituting protein, encoding gene sequences; for PCR reactions.

Takara Shuzo EPO 870 833

Hyperthermostable proteases

Kyoto, Japan

Hyperthermostable proteases, encoding gene sequences, production methods.

Takara Shuzo EPO 870 839

Gene therapy retroviruses

Kyoto, Japan

Retroviral vector transfection in the presence of targeting domains; for increased efficiency of gene therapy.

Takeda Chemical WO 98/44346

Aberrant gene products

Osaka, Japan

Agents capable of interacting with aberrant proteins; for developing therapeutics.

Thomas Jefferson Univ. WO 98/43669

Chimeric viral proteins


Chimeric viral proteins, encoding gene sequences; for therapeutics.

Thrombosis & Coagulation WO 98/44000

Blood coagulation muteins

Malmo, Sweden

Variants of the blood coagulation proteins A and C, encoding gene sequences; for diagnostics and therapeutics.

Tonen EPO 870 830

Hepatitis C antigen


Chimeric hepatitis C virus antigen containing core protein epitope regions; for detection and diagnosis.

Transgene WO 98/44121

Adenoviral fiber mutein

Strasbourg, France

Adenoviruses with a mutation in the fiber protein that acts as a cell receptor, encoding gene sequences.

Univ. Technol. WO 98/44092

Heart disease transgenics

Boulder, Colo.

Transgenics that are models for heart failure and disease, gene therapy methods.

Univ. Technol. Intl. WO 98/44102

Apoptosis modulating oligos

Calgary, Alberta

Oligonucleotides derived from the ING1 gene, expressed proteins and derivatives; for modulating apoptosis.

Vlaams Inst. Biotechnol. WO 98/44095

Skin hyperproliferation model

Zwijnaarde, Belgium

Transgenic animals with keratin genes controlled by a herpes thymidine kinase promoter; for studying hyperproliferation.

Walter Reed Army Inst. Res. WO 98/44131

Therapeutic bacteria

Washington, D.C.

Transfection of therapeutic genes into attenuated bacteria and subsequent lysis; for disease treatment.

Washington Univ. WO 98/43999

Glycoprotein hormone modulators

St. Louis

Glycosylated or unglcosylated alpha-subunit of glycoprotein hormones linked as a dimer; for producing modulators.

Yale Univ. WO 98/43993

Hammerhead ribozymes

New Haven, Conn.

Nucleic acid molecules having hammerhead structure and catalytic activity, synthesis methods.

Zymogenetics WO 98/44117

Human chemokine ZSIG-35


Human chemokine ZSIG-35, encoding gene sequences, ligands; for regulating inflammatory disease.