Published October 14 (EPO); October 8 (WO); October 14 (GB)
Abbott Labs WO 98/44133, 44159, & 44160
Gastrointestinal tract genes
Abbott Park, Ill.
Genes expressed in the gastrointestinal tract, encoded proteins, antibodies, modulators; for diagnosis.
Apotech WO 98/44104
Death effector domains
DNA sequences with death effector domains, expression vectors having these domains; for isolation.
Barnes-Jewish Hosp. WO 98/44091
Neutrophil elastase, encoding gene sequences; for making transgenics deficient in elastase expression.
British Columbia, Univ. of WO 98/44141
Insect cell expression system
Insect cell expression vectors based on baculoviruses that have inserted heterologous and selectable marker genes.
California, Univ. of WO 98/44107 & 44108
Glucocorticoid-induced protein of trabecular meshwork cells, encoding gene sequences; for diagnosing glaucoma.
California, Univ. of WO 98/44147
Eucaryote screening method
Transfer of procaryotic proteins to eucaryotic cells by protoplast fusion; for screening binding molecules.
Chugai Res. Inst. Molec. Med. WO 98/43998
Osteoblast growth inhibitor
Membrane-secreted proteins from osteoblast-like cell lines; for suppression of cell growth.
CSIRO (Comm. Sci. Indus. Res. Org.) WO 98/44001
High avidity Ig-like proteins
High avidity, polyvalent and polyspecific peptides made of immunoglobulin (Ig)-like domains.
Cytoclonal Pharma WO 98/44096
Mycobacterial recombinant vaccines
Recombinant mycobacterial vectors containing inserted genes; for making immunogenic vaccines.
Daewoong Pharma WO 98/44130
Sungnam, S. Korea
Chimeric proteins with cholera toxin and Helicobacter pylori antigenic domains, encoding gene sequences; for vaccines.
Duphar Intl. EPO 970 508
Isolation of influenza virus surface antigens in cell culture systems; for developing vaccines.
Fuji Yakuhin EPO 870 826
Tumor matrix metalloproteinase
Cell surface matrix metalloproteinase that is diagnostic for cancer, encoding gene sequences, monoclonal antibodies.
Garvin, A.M. WO 98/44154
Expression analysis improvement
Inhibition of protein synthesis during the isolation of mRNA from cells; for improving expression analysis assays.
Gemini Res. WO 98/44150
IL-1 receptor antagonist alleles
Polymorphisms of the interleukin (IL)-1 receptor antagonist gene; for diagnosing osteoporosis susceptibility.
Genetics Inst. WO 98/44113
Secreted proteins, encoding gene sequences; for developing therapeutics.
Genzyme WO 98/43994
Gene therapy vehicles
Cationic amphiphiles that facilitate the transport of biologically active molecules into cells; for gene therapy.
Genzyme WO 98/44143
Polymer-modified viruses; for longer blood half-life and targeted delivery to tumors.
Glaxo WO 98/44151 & 44152
Localized parallel sequencing
Iterative amplification of nucleic acids using primers immobilized to a surface; for parallel sequencing.
Green Cross WO 98/44146
Recombinant protein production
Production of foreign proteins using media having fatty acids and surfactants; for less degradation and higher yields.
Hoechst WO 98/44135
Antifungal screen using yeast genes or their sequence and functional homologs.
Human Genome Sciences WO 98/44109
Cytostatin II growth modulatory peptides, encoding gene sequences, modulators; for diagnostics and therapeutics.
Human Genome Sciences WO 98/44111
Thymus receptor tyrosine kinase receptors
Thymus receptor tyrosine kinase receptors, encoding gene sequences, production methods; for therapeutics.
Human Genome Sciences WO 98/44112
Cardiac/pancreatic muscle-derived growth factor, encoding gene sequences, production methods; for therapeutics.
Human Genome Sciences WO 98/44118
Human chemokine beta-6
Human chemokine beta-6, encoding gene sequences, production methods, agonist polypeptides; for immunotherapy.
Incyte Pharma WO 98/44110
TGF-beta receptor-associated protein
Palo Alto, Calif.
Transforming growth factor (TGF)-beta receptor-associated protein, encoding gene, modulators; for therapeutics.
Incyte Pharma WO 98/44114
Regulators of G-proteins
Palo Alto, Calif.
Regulators of G-protein signalling, encoding gene sequences, expression vectors, antibodies, modulators; for therapeutics.
Incyte Pharma WO 98/44115
Palo Alto, Calif.
Reticulocalbin-like calcium-binding protein, encoding gene sequences, antibodies, modulators; for therapeutics.
Incyte Pharma WO 98/44124
Mitochondrial adenylate kinase
Palo Alto, Calif.
Human mitochondrial adenylate kinase, encoding gene sequences, antisense, antibodies, modulators.
Incyte Pharma WO 98/44128
Palo Alto, Calif.
Human serine carboxypeptidase, encoding gene sequences, antibodies, modulators; for therapeutics.
Inst. Environ. Sci. & Res. WO 98/44153
Listeria infection detection
Christchurch, New Zealand
Probes to the 16S and 23S rRNA genes of Listeria; for detection and diagnosis of bacterial infection.
INSERM (Natl. Inst. Hlth. Med. Res.) WO 98/44099
Protein interaction detection
One conditional promoter used to detect one or more proteins interacting directly or indirectly with other proteins.
Jackson Labs WO 98/43666
Atherosclerosis antioxidant protein
Bar Harbor, Me.
Antioxidant protein associated with atherosclerotic disease in mice, human homolog, encoding gene sequences.
Japan Science & Technol. EPO 870 842
Specific adaptor tagging of DNA fragments before amplification; for quantitative competitive PCR.
Johns Hopkins Univ. WO 98/43679
Gonadal germ cells
Primordial germ cells isolated from the gonadal ridge of human embryos; for use in transgenic technology.
Joslin Diabetes Ctr. WO 98/44088
Treating proliferative disorders
Method of modulating nm23 activity by modulating Rad activity; for treating proliferative disorders.
Krebs Res. Inst. WO 98/44103
Protein that inhibits apoptosis, encoding gene sequences, antibodies.
Kureha Chemical WO 98/44116
Recombinant trehalose phosphorylase; industrial scale preparation of trehalose.
Kyowa Hakko Kogyo EPO 870 841
Complex carbohydrate production
Production of sugar nucleotides and complex carbohydrates from microorganism culture broths.
Life Technologies WO 98/44156
Nucleic acid ladders
Nucleic acid ladders; for estimating size and mass during separations.
Life Technologies WO 98/44161
Compositions and methods for simplified reverse transcriptase (RT)-PCR amplification reactions.
L'Oreal WO 98/44105
Epidermis-specific polypeptides involved in horny layer cell cohesion; for making cosmetics.
Manchester, Univ. of WO 98/44149
DNA damage screen
Regulatory element sequences that are activated by DNA damaging agents and is also linked to a reporter gene.
Mass. Gen. Hosp. WO 98/44142
Muscle stem cell isolation
Isolation of muscle stem cells using Bcl-2 expression as a marker; for identifying modulators and gene therapy.
Mass. Inst. Technol. EPO 870 837
Manipulation of enzyme genes for the synthesis of polyhydroxybutyrate and polyhydroxyalkanoate esters.
Megan Health WO 98/44120
Attenuated bacterial strains
Salmonella typhimurium poxR gene, attenuated bacterial strains with mutated poxR gene; for vaccines.
NIH (Natl. Inst. Hlth.) WO 98/44098
HIV fusion factor
Human fusion accessory factor associated with HIV (STRL33), cell lines coexpressing STRL33 and CD4; for HIV research.
NIH (Natl. Inst. Hlth.) WO 98/44123
O-linked N-acetylglucosamine transferase
O-linked N-acetylglucosamine transferase (OGT), encoding gene sequences; for diagnosis of OGT pathology.
New York, St. Univ. of WO 98/44101
Breast cancer antisense
Antisense oligos for mitogen-activated protein kinases; for breast cancer therapy.
New York Univ. WO 98/44132
Chimeric envelope proteins
Chimeric viral envelope proteins with the immunoglobulin G binding domain of protein A; for gene therapy
Nicod, P. WO 98/44106
Apoptosis transcription factor
Transcription factor islet-brain 1 (IB1), encoding gene; for regulating insulin expression, apoptosis, and neural disease.
November Inst. Molec. Med. WO 98/44122
Hepatitis A mutants
Methods for constructing and producing non-infectious, recombinant hepatitis A viruses.
Oncormed WO 98/44157
Genetic variation assay
Allele-specific hybridization, sequence variation assay, and direct sequencing; for identifying genetic variations.
Otsuka Pharma EPO 870 509
Sugar-chain recognizing immunoglobulin M (IgM) antibody; for HIV infection treatment.
Pasteur Inst. WO 98/44094
Helicobacter alphatic amidase polypeptides, encoding gene sequences; for diagnostics and therapeutics.
Pasteur Merieux WO 98/43478 & 43479
Helicobacter polypeptides, encoding gene sequences; for making vaccines to treat ulcers.
Pharma-Zentrale WO 98/44134
Plasmids and DNA sequences derived from a variety of bacterial strains.
Queensland Inst. Med. Res. WO 98/44129
Gene sequences encoding a targeting molecule and an antigen; for inducing immune responses.
Rican GB 2 324 093
Helicobacter pylori bacterioferritin, encoding gene; for immunoreactivity in H. pylori-negative individuals.
Santen Pharma WO 98/43997
Water channel protein
Polypeptide having water channel activity, encoding gene sequences.
Scientific Generics WO 98/44100
Dissociation of double-stranded DNA or protein-ligand complexes using electrical voltage.
Seikagaku WO 98/43995
Targeted HIV therapeutics
HIV reverse transcriptase and/or protease inhibitors bound to CD4 receptor targeting proteins; for therapeutics.
SmithKline Beecham EPO 870 825
Human protein kinase polypeptides, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham EPO 870 827
TNF-related receptor TR6
Tumor necrosis factor (TNF)-related receptor TR6 peptides, encoding gene sequences; for diagnostics and therapeutics.
SmithKline Beecham EPO 870 829
Staphylococcus aureus cell division gene sequences, encoded polypeptides, production methods; for antibacterial screens.
SmithKline Beecham EPO 870 831
Histidine kinase polypeptides, encoding gene sequences, production methods; for antibacterial screens.
Stanford Univ. WO 98/44350
Palo Alto, Calif.
Protein-protein interactions detected by binding beta-galactosidase mutants whose proximity allows enzyme activity.
Statens Serum Inst. WO 98/44119
Mycobacterium tuberculosis antigenic proteins, encoding gene sequences; for therapeutics and skin test diagnostics.
Takara Shuzo EPO 870 832
DNA polymerase for PCR
DNA polymerase, a polymerase-constituting protein, encoding gene sequences; for PCR reactions.
Takara Shuzo EPO 870 833
Hyperthermostable proteases, encoding gene sequences, production methods.
Takara Shuzo EPO 870 839
Gene therapy retroviruses
Retroviral vector transfection in the presence of targeting domains; for increased efficiency of gene therapy.
Takeda Chemical WO 98/44346
Aberrant gene products
Agents capable of interacting with aberrant proteins; for developing therapeutics.
Thomas Jefferson Univ. WO 98/43669
Chimeric viral proteins
Chimeric viral proteins, encoding gene sequences; for therapeutics.
Thrombosis & Coagulation WO 98/44000
Blood coagulation muteins
Variants of the blood coagulation proteins A and C, encoding gene sequences; for diagnostics and therapeutics.
Tonen EPO 870 830
Hepatitis C antigen
Chimeric hepatitis C virus antigen containing core protein epitope regions; for detection and diagnosis.
Transgene WO 98/44121
Adenoviral fiber mutein
Adenoviruses with a mutation in the fiber protein that acts as a cell receptor, encoding gene sequences.
Univ. Technol. WO 98/44092
Heart disease transgenics
Transgenics that are models for heart failure and disease, gene therapy methods.
Univ. Technol. Intl. WO 98/44102
Apoptosis modulating oligos
Oligonucleotides derived from the ING1 gene, expressed proteins and derivatives; for modulating apoptosis.
Vlaams Inst. Biotechnol. WO 98/44095
Skin hyperproliferation model
Transgenic animals with keratin genes controlled by a herpes thymidine kinase promoter; for studying hyperproliferation.
Walter Reed Army Inst. Res. WO 98/44131
Transfection of therapeutic genes into attenuated bacteria and subsequent lysis; for disease treatment.
Washington Univ. WO 98/43999
Glycoprotein hormone modulators
Glycosylated or unglcosylated alpha-subunit of glycoprotein hormones linked as a dimer; for producing modulators.
Yale Univ. WO 98/43993
New Haven, Conn.
Nucleic acid molecules having hammerhead structure and catalytic activity, synthesis methods.
Zymogenetics WO 98/44117
Human chemokine ZSIG-35
Human chemokine ZSIG-35, encoding gene sequences, ligands; for regulating inflammatory disease.