Published Sept. 30 (EPO); Sept. 24 (WO)
Affymetrix WO 98/41657
Iterative resequencing
Santa Clara, Calif.
Iterative resequencing using a variable array of probes; for detecting allelic or homologous gene variants.
Alabama, Univ. of WO 98/41618
Targeting adenovirus vectors
Birmingham, Ala.
Recombinant adenovirus vectors having binding proteins included in their coats; for targeting specific cells.
Angletti Molec. Biol. Res. Inst. WO 98/41625
CNTF variants
Pomezia, Italy
Variants of ciliary neurotrophic factor (CNTF) with enhanced receptor selectivity; for treating neuronal diseases.
Arkansas, Univ. of WO 98/41656
Ovarian cancer probes
Little Rock, Ark.
Probes for specific protease genes that are over-expressed in ovarian cancer; for PCR diagnostics.
Ascendia WO 98/41617
Pancreatic beta-cells
Sollentuna, Sweden
Isolation and culture of pancreatic beta-cells; for the production and therapeutic use of insulin.
BASF WO 98/41232
Enhancing corticosteroid effects
Ludwigshafen, Germany
Combination therapy with corticosteroids and agents that antagonize targets regulating gamma-interferon production.
Bayer EPO 867 514
Enhanced protein production
Pittsburgh.
Vector with intron sequences placed between the promoter and the coding sequences; for enhanced protein production.
British Technol. Grp. WO 98/41619
Attenuated polio vaccine
London
Attenuated polioviruses with specific nucleic acid substitutions in their genomes; for vaccines.
Burian, J., et al. WO 98/41636
Creating high-copy vectors
Vancouver, B.C.
Replication genes and products from small cryptic plasmids; for making controlled-replication, high-copy vectors.
Children's Hosp. WO 98/41240
Hemophilia gene therapy
Philadelphia
Adeno-associated virus vector having the Factor IX gene; for gene therapy to treat hemophilia.
Chugai EPO 867 448
Immunosuppression
Tokyo
Phosphorylation inhibiting IkappaB-alpha peptide; for immunosuppression or use as an anti-inflammatory agent.
Dana-Farber WO 98/41614
Infertility transgenics
Boston
Transgenics with mutations in the endogenous TIAR gene alleles; for identifying infertility agents.
Gel Tech Group WO 98/41616
Alcohol consumption therapy
Miami Beach, Fla.
Production of mammalian alcohol dehydrogenase in plants; for edible therapy to prevent effects of alcohol consumption.
GeneSense WO 98/41231
Cancer growth control
Winnipeg, Man.
Elevated expression or concentration of ribonucleotide reductase R1; for suppressing cancer cell growth.
Genetics Inst. WO 98/41539
Secreted protein genes
Cambridge, Mass.
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Harris, W., et al. WO 98/41871
Recombinant antibody immunoassays
Carnoustic, U.K.
Substitution of recombinant antibodies fragments for intact antibodies or Fab fragments in immunoassays.
Hoechst Marion Roussel EPO 867 114
Transfected sperm for transgenics
Tokyo
Insertion of exogenous DNA into sperm cells; for fertilization or artificial insemination to produce transgenics.
HSC Res. & Develop. WO 98/41651
Chromatin preparation method
Toronto
Methods for isolating and preparing chromatin; for gene mapping and other assays.
Human Genome Sciences WO 98/41629
Death domain containing receptor 5
Rockville, Md.
Death domain containing receptor 5, encoding gene sequences, vectors, host cells, antibodies, production methods.
Idec Pharma WO 98/41645
Homologous recombination vectors
San Diego
Vectors for site-specific integration of genes into cells by homologous recombination.
Incyte Pharma WO 98/41630
Histone-like protein
Palo Alto, Calif.
Human histone-like protein, encoding gene sequences, vectors, antibodies, modulators.
Incyte Pharma WO 98/41632
Human tumor suppressor
Palo Alto, Calif.
Human tumor suppressor, encoding gene sequences, vectors, antibodies, modulators, production method.
Incyte Pharma WO 98/41633
Pancreatitis-associated protein
Palo Alto, Calif.
Human pancreatitis-associated protein, encoding gene sequences, vectors, antibodies, modulators, production method.
Incyte Pharma WO 98/41634
Growth and differentiation protein
Palo Alto, Calif.
Human growth and differentiation protein, encoding gene sequences, vectors, antibodies, modulators, production method.
Incyte Pharma WO 98/41635
Tumorigenesis-associated protein
Palo Alto, Calif.
Human tumorigenesis-associated protein, encoding gene sequences, vectors, antibodies, modulators, production method.
Incyte Pharma WO 98/41637
ATP synthase subunit
Palo Alto, Calif.
Human ATP synthase subunit d protein, encoding gene sequences, vectors, antibodies, modu-lators, production method.
Incyte Pharma WO 98/41538
Cytokine/steroid receptor protein
Palo Alto, Calif.
Human cytokine/steroid receptor protein, encoding gene sequences, vectors, antibodies, modulators.
Incyte Pharma WO 98/41639
Serine-threonine protein kinase
Palo Alto, Calif.
Human serine-threonine protein kinase, encoding gene sequences, vectors, antisense, antibodies, modulators.
Intelligene WO 98/41654
In vitro oligo evolution
Jerusalem
In vitro evolution of oligonucleotides in which undesired oligos are removed by using a unique random tag sequence.
Introgene WO 98/41644
Bone marrow therapy
Leiden, Netherlands
In vitro modification of bone marrow cells by transfection with recombinant retroviruses; for therapy.
Johns Hopkins Univ. WO 98/41631
Colon transcription factor
Baltimore
Colon epithelium transcription factor, encoding gene; for use in developing cancer therapies.
Kanegafuchi Kagaku EPO 867 449
Cell adhesion proteins
Osaka, Japan
Cell adhesion protein, analogs; for inhibiting immunological reactions and making cells that cause immunosuppression.
Krebs Res. Inst. WO 98/41652
Chromosome 7 changes
Heidelberg, Germany
DNA probes for detecting changes in chromosome 7, encoded proteins, antibodies.
La Jolla Cancer Res. Fdn. EPO 867 511
Recombinant alkaline phosphatase
La Jolla, Calif.
Recombinant calf intestinal alkaline phosphatase; for incorporation into assays for determining ligand concentrations.
Lab Molec. Biophotonics EPO 867 506
Solid phase DNA detection
Hamakita, Japan
Solid phase attached split DNA targets that hybridize and are detected in the presence of complementary DNA samples.
LXR Biotechnol. WO 98/41626
Bak binding protein
Richmond, Calif.
Bak binding protein, encoding gene sequences, antibodies, modulators; for influencing Bak function.
MRC (Med. Res. Counc.) WO 98/41638
Phosphoinositide-dependent protein kinase
London
Phosphoinositide-dependent protein kinase, encoding gene sequences; for screening new drugs.
MRC (Med. Res. Counc.) WO 98/41873
Cell cycle regulators
London
Identification of cell cycle regulators disrupting a herpes peptide interaction with proliferating cell nuclear antigen.
NIH (Natl. Inst. Hlth.) WO 98/41641
B cell cancer therapy
Bethesda, Md.
Immunoconjugates of CD22 antibodies and Pseudomonas exotoxin; for inhibiting cancerous B cell growth.
North Carolina St. Univ. WO 98/41082
Photosensitizer resistance genes
Raleigh, N.C.
Photosensitizer resistance genes, encoded proteins; for transforming cells and organisms.
Novo Nordisk WO 98/41622 & 41623
DNA shuffling library
Bagsvaerd, Denmark
Shuffling gene segments encoding a range of homologous peptide segments; for making new recombinant proteins.
Novo Nordisk WO 98/41640 & 41653
Respiratory-deficient cells
Bagsvaerd, Denmark
Production of recombinant proteins and disruption of genes in respiratory-deficient cells.
Osaka Univ. Microbial Dis. Res. Fdn. EPO 867 510
Retroviral processing vector
Osaka, Japan
Plasmids having both the ability to express retroviral genes and to process their protein products after translation.
Otten, G.R. WO 98/41613
Lymphocyte targeting chimeras
Foster City, Calif.
Chimeric proteins with targeting and signalling domains, encoded proteins; for affecting lymphocytes.
Pharmacia & Upjohn WO 98/41872
Discriminating cytokine receptor antibodies
Stockholm, Sweden
Antibodies that discriminate between activated and inactive cytokine receptor conformations; for modulator screens.
Pittsburgh, Univ. of WO 98/41620
Heart disease transgenics
Pittsburgh
Transgenic mice with a TNF-alpha gene controlled by a cardiac-specific regulatory element; for treating heart disease.
SmithKline Beecham EPO 867 507
Streptococcus antibacterials
Philadelphia
LicB polypeptides from Streptococcus pneumoniae, encoding gene sequences, production methods; for antibacterials.
SmithKline Beecham EPO 867 508
Olfactory 7-transmembrane receptor
Philadelphia
Olfactory receptor of the 7-transmembrane receptor family, encoding gene sequences; for diagnostics and therapeutics.
SmithKline Beecham EPO 867 509
Tumor necrosis-related receptor
Philadelphia
Tumor necrosis-related receptor, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham EPO 867 513
ICE apoptosis protease-10
Philadelphia.
Interleukin-1-beta converting enzyme (ICE) apoptosis protease-10, encoding gene sequences; for diagnosis and therapy.
SmithKline Beecham WO 98/41233 & 41234
Antibacterial screen
Philadelphia
Gene sequences for ratA and ratB polypeptides, encoded proteins; for screening antibacterials.
T Cell Sciences EPO 867 189 & 867 451
T cell receptor antibodies
Needham, Mass.
Monoclonal antibodies that recognize defined regions of the T cell receptor; for diagnosis and therapy.
Tanaka, T. EPO 867 505
Ligand-bound protein gene cloning
Mie, Japan
Plate to membrane transfer of cell colonies and use of a ligand to detect an expressed protein; for gene cloning.
Variagenics WO 98/41648
Allele-specific drugs
Cambridge, Mass.
Identification of allele-specific drugs; for treating cancer cells that have lost heterozygosity at defined alleles.
Wisconsin, Univ. of WO 98/41615
Transgenic production method
Madison, Wis.
Gene introduction into unfertilized eggs via retroviruses; for more efficient production of non-chimeric transgenics.
Yale Univ. WO 98/41090
Apoptosis modulation
New Haven, Conn.
Agents that modulate the phosphorylation of proteins in the receptor/PTK-STAT pathway; for controlling apoptosis.
Yeda Res. & Devlop. WO 98/41624
TNF/NGF receptor modulators
Rehovot, Israel
Modulators of the function of receptors of the tumor necrosis factor (TNF)/nerve growth factor (NGF) family.
Zymogenetics WO 98/41627
Cement gland protein homologs
Seattle
Secreted polypeptides with homologies to Xenopus cement gland proteins, encoding gene sequences, antibodies.
Zymogenetics WO 98/41628
Secreted salivary polypeptides
Seattle
Secreted salivary polypeptides, encoding gene sequences, antibodies, binding proteins; for affecting adhesion.