Published Sept. 30 (EPO); Sept. 24 (WO)

Affymetrix WO 98/41657

Iterative resequencing

Santa Clara, Calif.

Iterative resequencing using a variable array of probes; for detecting allelic or homologous gene variants.

Alabama, Univ. of WO 98/41618

Targeting adenovirus vectors

Birmingham, Ala.

Recombinant adenovirus vectors having binding proteins included in their coats; for targeting specific cells.

Angletti Molec. Biol. Res. Inst. WO 98/41625

CNTF variants

Pomezia, Italy

Variants of ciliary neurotrophic factor (CNTF) with enhanced receptor selectivity; for treating neuronal diseases.

Arkansas, Univ. of WO 98/41656

Ovarian cancer probes

Little Rock, Ark.

Probes for specific protease genes that are over-expressed in ovarian cancer; for PCR diagnostics.

Ascendia WO 98/41617

Pancreatic beta-cells

Sollentuna, Sweden

Isolation and culture of pancreatic beta-cells; for the production and therapeutic use of insulin.

BASF WO 98/41232

Enhancing corticosteroid effects

Ludwigshafen, Germany

Combination therapy with corticosteroids and agents that antagonize targets regulating gamma-interferon production.

Bayer EPO 867 514

Enhanced protein production


Vector with intron sequences placed between the promoter and the coding sequences; for enhanced protein production.

British Technol. Grp. WO 98/41619

Attenuated polio vaccine


Attenuated polioviruses with specific nucleic acid substitutions in their genomes; for vaccines.

Burian, J., et al. WO 98/41636

Creating high-copy vectors

Vancouver, B.C.

Replication genes and products from small cryptic plasmids; for making controlled-replication, high-copy vectors.

Children's Hosp. WO 98/41240

Hemophilia gene therapy


Adeno-associated virus vector having the Factor IX gene; for gene therapy to treat hemophilia.

Chugai EPO 867 448



Phosphorylation inhibiting IkappaB-alpha peptide; for immunosuppression or use as an anti-inflammatory agent.

Dana-Farber WO 98/41614

Infertility transgenics


Transgenics with mutations in the endogenous TIAR gene alleles; for identifying infertility agents.

Gel Tech Group WO 98/41616

Alcohol consumption therapy

Miami Beach, Fla.

Production of mammalian alcohol dehydrogenase in plants; for edible therapy to prevent effects of alcohol consumption.

GeneSense WO 98/41231

Cancer growth control

Winnipeg, Man.

Elevated expression or concentration of ribonucleotide reductase R1; for suppressing cancer cell growth.

Genetics Inst. WO 98/41539

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

Harris, W., et al. WO 98/41871

Recombinant antibody immunoassays

Carnoustic, U.K.

Substitution of recombinant antibodies fragments for intact antibodies or Fab fragments in immunoassays.

Hoechst Marion Roussel EPO 867 114

Transfected sperm for transgenics


Insertion of exogenous DNA into sperm cells; for fertilization or artificial insemination to produce transgenics.

HSC Res. & Develop. WO 98/41651

Chromatin preparation method


Methods for isolating and preparing chromatin; for gene mapping and other assays.

Human Genome Sciences WO 98/41629

Death domain containing receptor 5

Rockville, Md.

Death domain containing receptor 5, encoding gene sequences, vectors, host cells, antibodies, production methods.

Idec Pharma WO 98/41645

Homologous recombination vectors

San Diego

Vectors for site-specific integration of genes into cells by homologous recombination.

Incyte Pharma WO 98/41630

Histone-like protein

Palo Alto, Calif.

Human histone-like protein, encoding gene sequences, vectors, antibodies, modulators.

Incyte Pharma WO 98/41632

Human tumor suppressor

Palo Alto, Calif.

Human tumor suppressor, encoding gene sequences, vectors, antibodies, modulators, production method.

Incyte Pharma WO 98/41633

Pancreatitis-associated protein

Palo Alto, Calif.

Human pancreatitis-associated protein, encoding gene sequences, vectors, antibodies, modulators, production method.

Incyte Pharma WO 98/41634

Growth and differentiation protein

Palo Alto, Calif.

Human growth and differentiation protein, encoding gene sequences, vectors, antibodies, modulators, production method.

Incyte Pharma WO 98/41635

Tumorigenesis-associated protein

Palo Alto, Calif.

Human tumorigenesis-associated protein, encoding gene sequences, vectors, antibodies, modulators, production method.

Incyte Pharma WO 98/41637

ATP synthase subunit

Palo Alto, Calif.

Human ATP synthase subunit d protein, encoding gene sequences, vectors, antibodies, modu-lators, production method.

Incyte Pharma WO 98/41538

Cytokine/steroid receptor protein

Palo Alto, Calif.

Human cytokine/steroid receptor protein, encoding gene sequences, vectors, antibodies, modulators.

Incyte Pharma WO 98/41639

Serine-threonine protein kinase

Palo Alto, Calif.

Human serine-threonine protein kinase, encoding gene sequences, vectors, antisense, antibodies, modulators.

Intelligene WO 98/41654

In vitro oligo evolution


In vitro evolution of oligonucleotides in which undesired oligos are removed by using a unique random tag sequence.

Introgene WO 98/41644

Bone marrow therapy

Leiden, Netherlands

In vitro modification of bone marrow cells by transfection with recombinant retroviruses; for therapy.

Johns Hopkins Univ. WO 98/41631

Colon transcription factor


Colon epithelium transcription factor, encoding gene; for use in developing cancer therapies.

Kanegafuchi Kagaku EPO 867 449

Cell adhesion proteins

Osaka, Japan

Cell adhesion protein, analogs; for inhibiting immunological reactions and making cells that cause immunosuppression.

Krebs Res. Inst. WO 98/41652

Chromosome 7 changes

Heidelberg, Germany

DNA probes for detecting changes in chromosome 7, encoded proteins, antibodies.

La Jolla Cancer Res. Fdn. EPO 867 511

Recombinant alkaline phosphatase

La Jolla, Calif.

Recombinant calf intestinal alkaline phosphatase; for incorporation into assays for determining ligand concentrations.

Lab Molec. Biophotonics EPO 867 506

Solid phase DNA detection

Hamakita, Japan

Solid phase attached split DNA targets that hybridize and are detected in the presence of complementary DNA samples.

LXR Biotechnol. WO 98/41626

Bak binding protein

Richmond, Calif.

Bak binding protein, encoding gene sequences, antibodies, modulators; for influencing Bak function.

MRC (Med. Res. Counc.) WO 98/41638

Phosphoinositide-dependent protein kinase


Phosphoinositide-dependent protein kinase, encoding gene sequences; for screening new drugs.

MRC (Med. Res. Counc.) WO 98/41873

Cell cycle regulators


Identification of cell cycle regulators disrupting a herpes peptide interaction with proliferating cell nuclear antigen.

NIH (Natl. Inst. Hlth.) WO 98/41641

B cell cancer therapy

Bethesda, Md.

Immunoconjugates of CD22 antibodies and Pseudomonas exotoxin; for inhibiting cancerous B cell growth.

North Carolina St. Univ. WO 98/41082

Photosensitizer resistance genes

Raleigh, N.C.

Photosensitizer resistance genes, encoded proteins; for transforming cells and organisms.

Novo Nordisk WO 98/41622 & 41623

DNA shuffling library

Bagsvaerd, Denmark

Shuffling gene segments encoding a range of homologous peptide segments; for making new recombinant proteins.

Novo Nordisk WO 98/41640 & 41653

Respiratory-deficient cells

Bagsvaerd, Denmark

Production of recombinant proteins and disruption of genes in respiratory-deficient cells.

Osaka Univ. Microbial Dis. Res. Fdn. EPO 867 510

Retroviral processing vector

Osaka, Japan

Plasmids having both the ability to express retroviral genes and to process their protein products after translation.

Otten, G.R. WO 98/41613

Lymphocyte targeting chimeras

Foster City, Calif.

Chimeric proteins with targeting and signalling domains, encoded proteins; for affecting lymphocytes.

Pharmacia & Upjohn WO 98/41872

Discriminating cytokine receptor antibodies

Stockholm, Sweden

Antibodies that discriminate between activated and inactive cytokine receptor conformations; for modulator screens.

Pittsburgh, Univ. of WO 98/41620

Heart disease transgenics


Transgenic mice with a TNF-alpha gene controlled by a cardiac-specific regulatory element; for treating heart disease.

SmithKline Beecham EPO 867 507

Streptococcus antibacterials


LicB polypeptides from Streptococcus pneumoniae, encoding gene sequences, production methods; for antibacterials.

SmithKline Beecham EPO 867 508

Olfactory 7-transmembrane receptor


Olfactory receptor of the 7-transmembrane receptor family, encoding gene sequences; for diagnostics and therapeutics.

SmithKline Beecham EPO 867 509

Tumor necrosis-related receptor


Tumor necrosis-related receptor, encoding gene sequences, production methods; for diagnostics and therapeutics.

SmithKline Beecham EPO 867 513

ICE apoptosis protease-10


Interleukin-1-beta converting enzyme (ICE) apoptosis protease-10, encoding gene sequences; for diagnosis and therapy.

SmithKline Beecham WO 98/41233 & 41234

Antibacterial screen


Gene sequences for ratA and ratB polypeptides, encoded proteins; for screening antibacterials.

T Cell Sciences EPO 867 189 & 867 451

T cell receptor antibodies

Needham, Mass.

Monoclonal antibodies that recognize defined regions of the T cell receptor; for diagnosis and therapy.

Tanaka, T. EPO 867 505

Ligand-bound protein gene cloning

Mie, Japan

Plate to membrane transfer of cell colonies and use of a ligand to detect an expressed protein; for gene cloning.

Variagenics WO 98/41648

Allele-specific drugs

Cambridge, Mass.

Identification of allele-specific drugs; for treating cancer cells that have lost heterozygosity at defined alleles.

Wisconsin, Univ. of WO 98/41615

Transgenic production method

Madison, Wis.

Gene introduction into unfertilized eggs via retroviruses; for more efficient production of non-chimeric transgenics.

Yale Univ. WO 98/41090

Apoptosis modulation

New Haven, Conn.

Agents that modulate the phosphorylation of proteins in the receptor/PTK-STAT pathway; for controlling apoptosis.

Yeda Res. & Devlop. WO 98/41624

TNF/NGF receptor modulators

Rehovot, Israel

Modulators of the function of receptors of the tumor necrosis factor (TNF)/nerve growth factor (NGF) family.

Zymogenetics WO 98/41627

Cement gland protein homologs


Secreted polypeptides with homologies to Xenopus cement gland proteins, encoding gene sequences, antibodies.

Zymogenetics WO 98/41628

Secreted salivary polypeptides


Secreted salivary polypeptides, encoding gene sequences, antibodies, binding proteins; for affecting adhesion.