Published Aug. 5 (EPO); July 30 (WO); Aug. 5 (GB)

Auspharm Intl.WO 98/32769

Pseudomonas therapeutics

Perth, Australia

Pseudomonas aeruginosa antigens; for infection diagnosis and immune response induction.

Baxter Intl.WO 98/32860

Adenoviral vector generation

Deerfield, Ill.

Efficient generation of adenoviral vectors by homologous recombination; for gene therapy.

Bioinvent Intl.WO 98/32845

Protein function evolution

Lund, Sweden

Incorporation of variant peptide motifs into scaffold sequences; for molecular evolution of protein function.

Brax GenomicsWO 98/32876

Peptide fragment generation

Cambridge, U.K.

Digesting polypeptides with a cleaving agent that recognizes specific sequences; for generating peptide fragments.

California, Univ. ofWO 98/32848

Coiled-coil protein probes

Berkeley, Calif.

Heterospecific peptide probes to coiled-coil regions of known proteins, production methods.

California, Univ. ofWO 98/32850

Glaucoma-associated gene

Oakland, Calif.

Nucleic acid sequences that can be used to diagnose glaucoma and related disorders.

Cancer Res. Camp. Technol.GB 2 321 702

Retrotransposon inhibitor screen


Using Ku-associated DNA repair pathway components to find inhibitors; for screening retrotransposon inhibitors.

ChugaiEPO 856 314

B cell immunosuppression


Antigen-treated B lymphocytes; for administering to animals to create immunosuppressed animals.

Cornell Univ.WO 98/32859

Angiogenesis gene therapy

Ithaca, N.Y.

Adenoviral vector with an angiogenic inducing gene; for blood vessel formation and treating ischemia.

Cornell Univ.WO 98/32879

Cell separation method

Ithaca, N.Y.

Transfecting cells with a cell-specific promoter controlling green fluorescent protein expression; for cell separation.

CortecsWO 98/32768

Ulcer vaccines

Isleworth, U.K.

Helicobacter pylori antigens and fragments; for diagnosis of and vaccination against ulcers.

Edinburgh, Univ. ofWO 98/32868

Transfected gene effect assay

Edinburgh, U.K.

Vector gene expression in cells having a replication factor; for assaying the effect of transfected genes.

EpimmuneWO 98/32456

HLA epitope identification

San Diego

Identification of broadly reactive or restricted HLA epitopes, algorithms to design degenerate sequence var-ants.

Flohe, L.WO 98/32862

Mycobacterial infection therapy

Wolfenbuttel, Germany

Mycobacterium marinum L-alanine dehydrogenase, encoding gene, monoclonal antibody; for infection treatment.

Fuso PharmaEPO 856 580

Anti-influenza proteins

Osaka, Japan

Recombinant conglutinin, production process; for detecting anti-influenza mannose-binding proteins.

Genetic TherapyWO 98/32842

Adenoviral immunotolerance

Gaithersburg, Md.

Adenoviruses having hexon proteins modified using portions of these proteins of another serotype; for tolerance.

Genetics Inst.WO 98/32853

Secreted protein genes

Cambridge, Mass.

Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.

GeronGB 2 321 642

Telomerase reverse transcriptase

Menlo Park, Calif.

Human telomerase reverse transcriptase subunit, encoding gene sequences; for diagnosis and therapy of cancers.

Human Genome SciencesWO 98/32856

Death domain peptide

Rockville, Md.

TNF receptor superfamily death domain peptide, encoding gene sequences, production method; for identifying modulators.

ImmusolWO 98/32880

Hairpin ribozyme library

San Diego

Vector-packages hairpin ribozyme library having randomized recognition sequences; for cleaving unknown RNAs.

Incyte PharmaWO 98/32851

Human galectin-5 homologs

Palo Alto, Calif.

Human galectin-5 homologs, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte PharmaWO 98/32854

Apoptosis-associated protein

Palo Alto, Calif.

Human apoptosis-associated protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

Incyte PharmaWO 98/32865

Prostate-associated kallikrein

Palo Alto, Calif.

Human prostate-associated kallikrein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.

IntrogeneEPO 856 585 & WO 98/32870

Conditional replication

Leiden, Netherlands

Conditionally replicating recombinant nucleic acid molecules rescued from the integrated state.

Japan Sci. & Technol.EPO 856 583

GDP/GTP exchange protein

Kawaguchi, Japan

GDP/GTP exchange protein active on G family proteins, encoding gene; for studying intracellular vesicle function.

Johannes Gutenberg Univ.WO 98/32772

Polyclonal tumor antibodies

Mainz, Germany

Polyclonal antibody to a tumor-associated antigen; for cancer diagnosis and therapy.

Johns Hopkins Univ.WO 98/32847

Cell cycle genes


Yeast genes differentially expressed during the cell cycle; for antifungals and obtaining human homologs.

Karo BioWO 98/32863

Mammalian thioredoxin

Huddinge, Sweden

Mammalian thioredoxin, encoding gene; for diagnostics and therapeutics.

Ludwig Inst.WO 98/32855

LAGE-1 tumor-associated gene

New York

LAGE-1 tumor-associated gene, fragments, allelic and splice variants, encoded proteins; for diagnosis and therapy.

Ludwig Inst.WO 98/32864

Resistant lipid kinase


Lipid kinase that is resistant to known inhibitors, encoding gene.

Marie Curie Cancer CareWO 98/32866

Transport fusion proteins


Fusion proteins for intracellular/intercellular transport of therapeutics, encoding gene sequences.

Maryland, Univ. ofWO 98/33068

Ehrlichia antigens


Production of Ehrlichia phagocytophila antigens by growing cells in co-culture with promyelocytic leukemia cells.

Maryland, Univ. of, Biotech. Inst.WO 98/33067

HIV transcription repression

College Park, Md.

Transcription factors that repress HIV transcription, derivatives, analogs.

Merck Sharp & DohmeEPO 856 581

GABAA recep-tor cell lines

Hoddesdon, U.K.

Stably transfected cell lines expressing human GABAA receptors; for therapeutics modulating these recep-tors.

NeurosearchWO 98/32869

CNS gene therapy vector

Glostrup, Denmark

Vectors having heterologous gene expression controlled by the ubiquitin promoter; for CNS gene therapy.

Novo NordiskWO 98/32867

Synthetic leader peptide sequences

Bagsvaerd, Denmark

Synthetic leader peptide sequences, encoding gene sequences; for use in yeast to produce recombinant proteins.

Pasteur Inst.WO 98/32849

Bo/Bor syndrome gene


Polynucleotide associated with the Bo or Bor syndrome, encoded protein; for diagnosis and therapy.

Pasteur Inst.WO 98/32861

Papillomavirus therapy


Papillomavirus E2 protein, encoding gene; for treating the infection and associated cancer.

Ribozyme PharmaWO 98/32846

c-fos ribozymes

Boulder, Colo.

Enzymatic ribozymes that cleave c-fos mRNA; for treating cancers that express this gene.

Rockefeller Univ.WO 98/32878

Obsessive-compulsive disorder

New York

Determining obsessive-compulsive disorder susceptibility using reduced catechol-O-methyltransferase assays.

ScheringWO 98/32858


Kenilworth, N.J.

Chemokines and 7 transmembrane receptors, encoding gene sequences, antibodies, production and purification methods.

Southern California, Univ. ofWO 98/32457

Hematopoietic cell growth

Los Angeles

Use of angiotensin and related proteins to promote hematopoietic and mesenchymal stem cell growth.

Takeda ChemicalEPO 856 582

Transcription factor inhibitor

Osaka, Japan

Transcription factor inhibitor, encoding gene sequences, antibodies.

TorayWO 98/32771

Chimeric Ig-integrins


Chimeric Immunoglobulin (Ig)-integrin com-plexes; for diagnostics and ligand binding assays.

Tulane Univ.WO 98/32461

Mutant enterotoxin

New Orleans

Non-toxic, mutant E. coli heat-labile enterotoxin that has retained its immunologic activity; for HIV adjuvant.

Wagner, H., et al.WO 98/32462

Immunomodulatory nucleotide composition

Eching, Germany

Immunomodulatory composition of a polynucleotide and an antigen; for vaccines.

Washington Univ.WO 98/32852

BLNK proteins

St. Louis

BLNK proteins, encoding gene sequences, antibodies.