Published Aug. 5 (EPO); July 30 (WO); Aug. 5 (GB)
Auspharm Intl.WO 98/32769
Pseudomonas therapeutics
Perth, Australia
Pseudomonas aeruginosa antigens; for infection diagnosis and immune response induction.
Baxter Intl.WO 98/32860
Adenoviral vector generation
Deerfield, Ill.
Efficient generation of adenoviral vectors by homologous recombination; for gene therapy.
Bioinvent Intl.WO 98/32845
Protein function evolution
Lund, Sweden
Incorporation of variant peptide motifs into scaffold sequences; for molecular evolution of protein function.
Brax GenomicsWO 98/32876
Peptide fragment generation
Cambridge, U.K.
Digesting polypeptides with a cleaving agent that recognizes specific sequences; for generating peptide fragments.
California, Univ. ofWO 98/32848
Coiled-coil protein probes
Berkeley, Calif.
Heterospecific peptide probes to coiled-coil regions of known proteins, production methods.
California, Univ. ofWO 98/32850
Glaucoma-associated gene
Oakland, Calif.
Nucleic acid sequences that can be used to diagnose glaucoma and related disorders.
Cancer Res. Camp. Technol.GB 2 321 702
Retrotransposon inhibitor screen
London
Using Ku-associated DNA repair pathway components to find inhibitors; for screening retrotransposon inhibitors.
ChugaiEPO 856 314
B cell immunosuppression
Tokyo
Antigen-treated B lymphocytes; for administering to animals to create immunosuppressed animals.
Cornell Univ.WO 98/32859
Angiogenesis gene therapy
Ithaca, N.Y.
Adenoviral vector with an angiogenic inducing gene; for blood vessel formation and treating ischemia.
Cornell Univ.WO 98/32879
Cell separation method
Ithaca, N.Y.
Transfecting cells with a cell-specific promoter controlling green fluorescent protein expression; for cell separation.
CortecsWO 98/32768
Ulcer vaccines
Isleworth, U.K.
Helicobacter pylori antigens and fragments; for diagnosis of and vaccination against ulcers.
Edinburgh, Univ. ofWO 98/32868
Transfected gene effect assay
Edinburgh, U.K.
Vector gene expression in cells having a replication factor; for assaying the effect of transfected genes.
EpimmuneWO 98/32456
HLA epitope identification
San Diego
Identification of broadly reactive or restricted HLA epitopes, algorithms to design degenerate sequence var-ants.
Flohe, L.WO 98/32862
Mycobacterial infection therapy
Wolfenbuttel, Germany
Mycobacterium marinum L-alanine dehydrogenase, encoding gene, monoclonal antibody; for infection treatment.
Fuso PharmaEPO 856 580
Anti-influenza proteins
Osaka, Japan
Recombinant conglutinin, production process; for detecting anti-influenza mannose-binding proteins.
Genetic TherapyWO 98/32842
Adenoviral immunotolerance
Gaithersburg, Md.
Adenoviruses having hexon proteins modified using portions of these proteins of another serotype; for tolerance.
Genetics Inst.WO 98/32853
Secreted protein genes
Cambridge, Mass.
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
GeronGB 2 321 642
Telomerase reverse transcriptase
Menlo Park, Calif.
Human telomerase reverse transcriptase subunit, encoding gene sequences; for diagnosis and therapy of cancers.
Human Genome SciencesWO 98/32856
Death domain peptide
Rockville, Md.
TNF receptor superfamily death domain peptide, encoding gene sequences, production method; for identifying modulators.
ImmusolWO 98/32880
Hairpin ribozyme library
San Diego
Vector-packages hairpin ribozyme library having randomized recognition sequences; for cleaving unknown RNAs.
Incyte PharmaWO 98/32851
Human galectin-5 homologs
Palo Alto, Calif.
Human galectin-5 homologs, encoding gene sequences, expression vectors, antisense, antibodies, modulators.
Incyte PharmaWO 98/32854
Apoptosis-associated protein
Palo Alto, Calif.
Human apoptosis-associated protein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.
Incyte PharmaWO 98/32865
Prostate-associated kallikrein
Palo Alto, Calif.
Human prostate-associated kallikrein, encoding gene sequences, expression vectors, antisense, antibodies, modulators.
IntrogeneEPO 856 585 & WO 98/32870
Conditional replication
Leiden, Netherlands
Conditionally replicating recombinant nucleic acid molecules rescued from the integrated state.
Japan Sci. & Technol.EPO 856 583
GDP/GTP exchange protein
Kawaguchi, Japan
GDP/GTP exchange protein active on G family proteins, encoding gene; for studying intracellular vesicle function.
Johannes Gutenberg Univ.WO 98/32772
Polyclonal tumor antibodies
Mainz, Germany
Polyclonal antibody to a tumor-associated antigen; for cancer diagnosis and therapy.
Johns Hopkins Univ.WO 98/32847
Cell cycle genes
Baltimore
Yeast genes differentially expressed during the cell cycle; for antifungals and obtaining human homologs.
Karo BioWO 98/32863
Mammalian thioredoxin
Huddinge, Sweden
Mammalian thioredoxin, encoding gene; for diagnostics and therapeutics.
Ludwig Inst.WO 98/32855
LAGE-1 tumor-associated gene
New York
LAGE-1 tumor-associated gene, fragments, allelic and splice variants, encoded proteins; for diagnosis and therapy.
Ludwig Inst.WO 98/32864
Resistant lipid kinase
London
Lipid kinase that is resistant to known inhibitors, encoding gene.
Marie Curie Cancer CareWO 98/32866
Transport fusion proteins
London
Fusion proteins for intracellular/intercellular transport of therapeutics, encoding gene sequences.
Maryland, Univ. ofWO 98/33068
Ehrlichia antigens
Baltimore
Production of Ehrlichia phagocytophila antigens by growing cells in co-culture with promyelocytic leukemia cells.
Maryland, Univ. of, Biotech. Inst.WO 98/33067
HIV transcription repression
College Park, Md.
Transcription factors that repress HIV transcription, derivatives, analogs.
Merck Sharp & DohmeEPO 856 581
GABAA recep-tor cell lines
Hoddesdon, U.K.
Stably transfected cell lines expressing human GABAA receptors; for therapeutics modulating these recep-tors.
NeurosearchWO 98/32869
CNS gene therapy vector
Glostrup, Denmark
Vectors having heterologous gene expression controlled by the ubiquitin promoter; for CNS gene therapy.
Novo NordiskWO 98/32867
Synthetic leader peptide sequences
Bagsvaerd, Denmark
Synthetic leader peptide sequences, encoding gene sequences; for use in yeast to produce recombinant proteins.
Pasteur Inst.WO 98/32849
Bo/Bor syndrome gene
Paris
Polynucleotide associated with the Bo or Bor syndrome, encoded protein; for diagnosis and therapy.
Pasteur Inst.WO 98/32861
Papillomavirus therapy
Paris
Papillomavirus E2 protein, encoding gene; for treating the infection and associated cancer.
Ribozyme PharmaWO 98/32846
c-fos ribozymes
Boulder, Colo.
Enzymatic ribozymes that cleave c-fos mRNA; for treating cancers that express this gene.
Rockefeller Univ.WO 98/32878
Obsessive-compulsive disorder
New York
Determining obsessive-compulsive disorder susceptibility using reduced catechol-O-methyltransferase assays.
ScheringWO 98/32858
Chemokines
Kenilworth, N.J.
Chemokines and 7 transmembrane receptors, encoding gene sequences, antibodies, production and purification methods.
Southern California, Univ. ofWO 98/32457
Hematopoietic cell growth
Los Angeles
Use of angiotensin and related proteins to promote hematopoietic and mesenchymal stem cell growth.
Takeda ChemicalEPO 856 582
Transcription factor inhibitor
Osaka, Japan
Transcription factor inhibitor, encoding gene sequences, antibodies.
TorayWO 98/32771
Chimeric Ig-integrins
Tokyo
Chimeric Immunoglobulin (Ig)-integrin com-plexes; for diagnostics and ligand binding assays.
Tulane Univ.WO 98/32461
Mutant enterotoxin
New Orleans
Non-toxic, mutant E. coli heat-labile enterotoxin that has retained its immunologic activity; for HIV adjuvant.
Wagner, H., et al.WO 98/32462
Immunomodulatory nucleotide composition
Eching, Germany
Immunomodulatory composition of a polynucleotide and an antigen; for vaccines.
Washington Univ.WO 98/32852
BLNK proteins
St. Louis
BLNK proteins, encoding gene sequences, antibodies.