* Applied Microbiology Inc., of Tarrytown, N.Y., agreed withNippon Shoji Kaisha Ltd. (NSK), of Osaka, Japan, to developApplied Microbiology's antimicrobial peptide nisin for hospital-acquired infections and colon infections, in Japan, certain Asiancountries, Australia and New Zealand. NSK purchased $2 million ofApplied Microbiology stock at $6.34 each, and loaned the company$2 million. The deal also includes research and milestone payments.
* CV Therapeutics, of Palo Alto, Calif., said its adenosine A1-receptor antagonist, CVT-124, was safe and well tolerated in a PhaseI trial. The company saw dose-related increases in sodium and uricacid excretion with only minimal losses of potassium.
* Cytel Corp., of San Diego, said its vaccine Theradigm, in a Phase IIstudy, safely stimulated a hepatitis B-specific immune response inchronically infected patients. The company plans to move forwardinto definitive efficacy studies.
* Immunex Corp., of Seattle, received marketing clearance foretoposide injection, a generic chemotherapy agent indicated for thetreatment of refractory testicular tumors and small cell lung cancer.The drug is available in 100 mg and 250 mg vials.
* Neurobiological Technologies Inc., of Richmond, Calif., began a100-patient Phase II trial of corticotropin-releasing factor in patientswith rheumatoid arthritis. The goal of the double-blind, placebo-controlled study is reduction of joint inflammation.
* Organogenesis Inc., of Canton, Mass., said a class action suitbrought against the company alleging securities laws violations hasbeen dismissed, without prejudice.
* SangStat Medical Corp., of Menlo Park, Calif., said underwritersfor a recent public offering exercised their overallotment option on450,000 shares, resulting in gross proceeds from the offering of $48.3million. (See BioWorld Today, March 11, 1996, p. 1.)
* Serono Laboratories Inc., of Norwell, Mass., said it is in ongoingdiscussions with the FDA regarding the new drug application forSerostim, the company's mammalian cell-derived recombinanthuman growth hormone for AIDS wasting. An FDA panel voted 8-to-7 recently against recommending approval of the product. (SeeBioWorld Today, March 5, 1996, p. 1.)
* Somatogen Inc., of Boulder, Colo., received FDA clearance tobegin initial human safety studies of its recombinant humanhemoglobin, rHb1.1, as an agent for stimulating red blood cellformation. The first study is expected to involve 50 patients with end-stage renal disease.
* Enzon Inc., of Piscataway, N.J., completed a $3 million privateplacement of common stock and convertible preferred stock with acurrent institutional investor. The same undisclosed institutionpurchased $7 million in stock and warrants in January 1996.
* Genentech Inc., of South San Francisco, submitted a supplementalproduct license application seeking approval of Activase(recombinant tPA) for treating ischemic stroke within three hours of asymptom onset. The submission was based on a Phase III program,results of which were published in The New England Journal ofMedicine in December 1995. (See BioWorld Today, Dec. 14, 1995,p. 1.)
* ImmunoTherapeutics Inc., of Fargo, N.D., entered into anagreement to sell 5 million shares of stock for $325,000 to DominionResources Inc., of Morristown, N.J.
* Pharmos Corp., of Alachua, Fla., completed Phase III studies of itsocular allergy product, loteprednol etabonate, a site-specificcorticosteroid. The product was evaluated in an acute conjunctivitistest and in pivotal seasonal allergic conjunctivitis studies. Resultsshould be available in May.
* Sparta Pharmaceuticals Inc., of Research Triangle Park, N.C.,acquired Lexin Pharmaceutical Corp., of Horsham, Pa., for up to 2.6million shares of Sparta stock (NASDAQ:SPTA), subject to certainpost-closing conditions. Lexin CEO Jerry Hooks was namedpresident, CEO and a director of Sparta. (See BioWorld Today, Jan.22, 1996, p. 1.)
* Sugen Inc., of Redwood City, Calif., said the FDA granted orphandrug status to the anticancer compound, SU101, in the treatment ofovarian cancer. The drug already was granted that designation fortreatment of malignant glioma.
* The Liposome Co., of Princeton, N.J., received approval in theU.K. to expand the approved indications for Abelcet, a lipid-basedformulation of amphotericin B, to include first-line treatment ofsevere systemic invasive candidiasis.
* Unimed Pharmaceuticals Inc., of Buffalo Grove, Ill., completedenrollment in a Phase II trial of nitazoxanide (NXT) forcryptosporidiosis in AIDS patients. The trial is expected to concludeby the end of June 1996. Also, the FDA said NXT qualifies fororphan drug status.
* Viragen Inc., of Hialeah, Fla., closed a $6 million private financingof its majority-owned subsidiary, Sector Associates Ltd., which willbe renamed Viragen (Europe) Ltd. A portion of the funds will beused to complete a European plant in Edinburgh, Scotland, where thenatural interferon product Omniferon will be manufactured.
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