Glioblastoma multiforme (GBM) is an aggressive brain tumor characterized by cellular heterogeneity, therapy-resistant glioblastoma stem cells (GSCs), and diffuse infiltration. Researchers at City of Hope have reported on targeting GBM using the CF17 oncolytic virus, delivered either directly or via human pluripotent stem cell (hPSC)-derived neural progenitor cell (NPC) carriers.