Neurogenic bladder is a disease involving inflammation and fibrosis of the bladder. Fibrosis has been linked to the type of programmed cell death known as pyroptosis, which in turn has been linked to cGAS-STING signaling and subsequent activation of the NLRP3 inflammasome. Researchers at Children’s Hospital of Chongqing Medical University wondered whether the same processes contribute to the fibrosis in neurogenic bladder.