The natural product diterpene andrographolide, from Andrographis paniculata (‘creat’ or ‘green chiretta’), shows promising antitumor activity, so researchers from Nanjing Tech University and collaborators in mainland China and Hong Kong derivatized it by enlarging the six-membered decalin ring at position 3 to generate a seven-membered ring or by annulating the decalin at positions 3 and 19 through fusion with isoxazole.