Previous studies combining molecular techniques and genetic mouse models revealed the functional roles of several microRNAs and long noncoding RNAs (lncRNAs) in metabolic disorders. In particular, the lnc-megacluster (lncMGC), located on human chromosome 14q32.2 and hosting about 40 miRNAs, plays a role in diabetic kidney disease and pancreatic islet dysfunction. A team at the Beckman Research Institute of City of Hope investigated the regulatory role of lncMGC in obesity and adipose dysfunction.