With a special interest in neurological disorders, Hopstem Biotechnology Co. Ltd. closed a series A++ round to raise nearly ¥100 million (US$15.5 million) to advance hNPC-01, an off-the-shelf induced pluripotent stem cells (iPSC)-derived human forebrain neural progenitor cell product to treat chronic conditions caused by stroke and traumatic brain injuries.
Small-molecule mRNA translation expert Anima Biotech Inc. has landed a significant new preclinical research deal with Takeda Pharmaceutical Co. Ltd., covering as many as six programs for genetically defined neurological diseases. The deal starts with $120 million in up-front and preclinical research milestone payments for Anima, but altogether the two-part collaboration could hold as much as $2.3 billion.
Cancer treatment has been transformed, at its root, by a transformational change in how it is classified. These days, which organ a tumor arises in is often less important than its molecular drivers, which can be sensitive either to specific targeted treatments, or increase the chance that a tumor will respond to immunotherapy. Those successes have not escaped the notice of researchers in other areas of biomedicine, and diseases including heart failure, asthma and polycystic ovarian syndrome are being looked at with an eye to subdividing them in ways that brings diagnostics into the molecular era. Nowhere do those changes have greater potential than in disorders of the brain – in part because there is nowhere much to go but up as far as classifying neurological diseases goes.
This year there has been a significant resurgence of interest in public biopharmaceutical companies that are focused on developing therapies to treat neurological diseases. As a result, the sector got out of the gate quickly and, by the end of June, the BioWorld Neurological Diseases index, a price-weighted index of representative companies operating in that therapeutic area, had climbed in value to over 26%, well ahead of the performance of the general markets and blue-chip biopharma companies.
Although collectively the large-cap biotech companies have failed to move the valuation needle this year, those innovative mid-cap public companies engaged in areas of research such as immuno-oncology, cell and gene therapies and CNS diseases have bucked the general trend. That is illustrated by the year-to-date performance of the BioWorld Drug Developers index, which has soared in value by more than 22%, well ahead of the Dow Jones Industrial Average, which has increased 15% in the same period.
